X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (4970) 4970
Newsletter (2128) 2128
Publication (508) 508
Newspaper Article (265) 265
Book Chapter (67) 67
Magazine Article (60) 60
Book Review (44) 44
Book / eBook (33) 33
Transcript (17) 17
Conference Proceeding (11) 11
Data Set (9) 9
Dissertation (8) 8
Trade Publication Article (3) 3
Streaming Video (2) 2
Web Resource (2) 2
Library Holding (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
huntington's chorea (5529) 5529
humans (2894) 2894
medical research (2204) 2204
research (2185) 2185
medicine, experimental (2134) 2134
index medicus (1916) 1916
genetic aspects (1716) 1716
male (1572) 1572
female (1463) 1463
neurosciences (1294) 1294
nervous system diseases (1243) 1243
animals (1113) 1113
reports (1054) 1054
analysis (1049) 1049
clinical neurology (1018) 1018
huntington disease - genetics (989) 989
huntington's disease (988) 988
adult (967) 967
chorea (962) 962
middle aged (802) 802
universities and colleges (787) 787
mice (698) 698
mutation (635) 635
neurology (616) 616
chorea - genetics (602) 602
brain (562) 562
nerve tissue proteins - genetics (553) 553
huntington disease (548) 548
movement disorders (527) 527
genetic research (494) 494
huntingtin protein (493) 493
care and treatment (492) 492
disease models, animal (492) 492
huntington disease - pathology (492) 492
neurons (489) 489
development and progression (479) 479
physiological aspects (479) 479
child (453) 453
huntington disease - metabolism (429) 429
huntingtons disease (429) 429
proteins (428) 428
diagnosis (426) 426
health aspects (417) 417
huntington disease - physiopathology (416) 416
aged (413) 413
nuclear proteins - genetics (409) 409
adolescent (407) 407
neurodegeneration (364) 364
genes (354) 354
genetic engineering (350) 350
physical fitness (350) 350
genetics & heredity (346) 346
disease (338) 338
mice, transgenic (334) 334
neurodegenerative diseases (332) 332
mutant huntingtin (331) 331
risk factors (331) 331
gene (326) 326
gene expression (320) 320
phenotype (301) 301
huntingtons-disease (296) 296
huntington disease - diagnosis (292) 292
biochemistry & molecular biology (287) 287
nerve tissue proteins - metabolism (287) 287
brain - pathology (284) 284
nervous system (281) 281
chorea - diagnosis (279) 279
pedigree (267) 267
psychiatry (262) 262
multidisciplinary sciences (261) 261
article (259) 259
basal ganglia (259) 259
models (259) 259
genetics (254) 254
magnetic resonance imaging (252) 252
huntingtin (249) 249
parkinson's disease (239) 239
dystonia (237) 237
cell biology (235) 235
mouse model (229) 229
child, preschool (226) 226
cognition disorders (223) 223
alzheimer's disease (221) 221
gene mutations (216) 216
nuclear proteins - metabolism (215) 215
transgenic mice (213) 213
polyglutamine (212) 212
research article (207) 207
rats (205) 205
parkinsons-disease (201) 201
disease progression (200) 200
mental disorders (197) 197
neurons - metabolism (195) 195
genetic disorders (190) 190
expression (185) 185
chorea - physiopathology (184) 184
huntington disease - psychology (184) 184
brain - metabolism (182) 182
degeneration (179) 179
diagnosis, differential (179) 179
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (17) 17
Collection Dvlpm't (Acquisitions) - Vendor file (5) 5
Online Resources - Online (3) 3
Credit Valley Hospital - Online (1) 1
Media Commons - Audio Visual (1) 1
Providence Healthcare - Reference (1) 1
Providence Healthcare - Stacks (1) 1
Robarts - Stacks (1) 1
Sunnybrook Health Sciences Centre - Online (1) 1
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (1) 1
UofT Schools - Stacks (1) 1
UofT at Mississauga - Stacks (1) 1
UofT at Scarborough - Stacks (1) 1
Victoria University E.J. Pratt - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (7386) 7386
German (36) 36
Japanese (31) 31
French (25) 25
Spanish (21) 21
Italian (11) 11
Portuguese (9) 9
Polish (4) 4
Chinese (2) 2
Czech (2) 2
Finnish (2) 2
Hungarian (2) 2
Russian (2) 2
Norwegian (1) 1
Turkish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Neuroscience, ISSN 1097-6256, 05/2012, Volume 15, Issue 5, pp. 713 - 721
The Huntington's disease gene product, huntingtin, is indispensable for neural tube formation, but its role is obscure. We studied neurulation in htt-null... 
TARGETED DISRUPTION | ZEBRAFISH | LACKING HUNTINGTIN | EMBRYONIC STEM-CELLS | MUTANT HUNTINGTIN | ADAM10 | MICE | DISEASE GENE HOMOLOG | WILD-TYPE HUNTINGTIN | NEUROSCIENCES | N-CADHERIN CLEAVAGE | Body Patterning - drug effects | Guanylate Kinases - genetics | Amyloid Precursor Protein Secretases - genetics | RNA, Small Interfering - genetics | Wnt1 Protein - genetics | Brain - embryology | PAX2 Transcription Factor - metabolism | Cadherins - metabolism | Apoptosis - drug effects | Embryo, Mammalian | Hedgehog Proteins - metabolism | Apoptosis - genetics | Green Fluorescent Proteins - genetics | Brain - metabolism | NFI Transcription Factors - metabolism | Cadherins - genetics | Tissue Inhibitor of Metalloproteinase-1 - pharmacology | Discs Large Homolog 1 Protein | Membrane Proteins - genetics | Gene Expression Regulation, Developmental - drug effects | PAX2 Transcription Factor - genetics | Cell Adhesion - drug effects | Mutation - genetics | Biological Evolution | Brain - drug effects | Huntingtin Protein | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Analysis of Variance | Membrane Proteins - antagonists & inhibitors | Cell Adhesion - physiology | Embryo, Nonmammalian | Guanylate Kinases - metabolism | Neuroepithelial Cells - physiology | Mice | Zebrafish Proteins - genetics | ADAM Proteins - genetics | Cerebral Ventricles - cytology | Drosophila melanogaster | Neuroepithelial Cells - drug effects | Embryonic Stem Cells - metabolism | Nestin | Immunoprecipitation | Gene Expression Regulation, Developmental - genetics | Wnt1 Protein - metabolism | Zebrafish - embryology | Cell Differentiation - genetics | Transfection | Hedgehog Proteins - genetics | Intermediate Filament Proteins - genetics | Neurons - physiology | Membrane Proteins - metabolism | Cerebral Ventricles - embryology | Neurons - drug effects | Nuclear Proteins - genetics | Hydroxamic Acids - pharmacology | Green Fluorescent Proteins - metabolism | Brain - cytology | ADAM Proteins - antagonists & inhibitors | Animals, Genetically Modified | Zebrafish Proteins - metabolism | Dipeptides - pharmacology | Cells, Cultured | ADAM10 Protein | Morpholines - pharmacology | Nuclear Proteins - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Dictyostelium | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Body Patterning - genetics | Huntington's chorea | Physiological aspects | Cadherins | Genetic aspects | Research | Embryonic stem cells | Risk factors
Journal Article
Neuron, ISSN 0896-6273, 12/2009, Volume 64, Issue 6, pp. 828 - 840
The N-terminal 17 amino acids of huntingtin (NT17) can be phosphorylated on serines 13 and 16; however, the significance of these modifications in Huntington's... 
humdisease | molneuro | NEURONAL INTRANUCLEAR INCLUSIONS | NUCLEAR | PHOSPHORYLATION | EXPANSION | NEURODEGENERATION | TOXICITY | PATHOLOGY | TRANSGENIC MOUSE MODEL | NEUROSCIENCES | AGGREGATION | TRINUCLEOTIDE REPEAT | Molecular Weight | Humans | Nerve Degeneration - physiopathology | Nerve Degeneration - genetics | Alanine - chemistry | Amino Acid Sequence - genetics | Nerve Degeneration - metabolism | Aspartic Acid - genetics | Nerve Tissue Proteins - chemistry | Alanine - genetics | Amyloid - metabolism | Nuclear Proteins - genetics | Huntington Disease - physiopathology | Disease Models, Animal | Amyloid - genetics | Genetic Predisposition to Disease - genetics | Gene Expression Regulation - genetics | Serine - genetics | Alanine - metabolism | Mice, Transgenic | Protein Structure, Tertiary - genetics | Mutation - genetics | Nuclear Proteins - chemistry | Serine - chemistry | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Serine - metabolism | Huntingtin Protein | Phenotype | Animals | Huntington Disease - genetics | Trinucleotide Repeat Expansion - genetics | Amino Acid Substitution - genetics | Aspartic Acid - metabolism | Mice | Aspartic Acid - chemistry | Proteins | Medical colleges | Alanine | Nervous system diseases | Neurosciences | Huntington's chorea | Neurons | Physiological aspects | Aspartate | Huntingtons disease | Phosphorylation | Neurodegeneration | Pathogenesis | Neuropathology | Rodents | Mutation
Journal Article
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 03/2013, Volume 92, Issue 3, pp. 345 - 353
Journal Article
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 01/2012, Volume 90, Issue 1, pp. 152 - 160
Journal Article
PLoS Genetics, ISSN 1553-7390, 12/2009, Volume 5, Issue 12, pp. e1000749 - e1000749
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 06/2008, Volume 27, Issue 11, pp. 2803 - 2820
Journal Article
Nature, ISSN 0028-0836, 06/2008, Volume 453, Issue 7197, pp. 921 - 924
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2008, Volume 31, Issue 3, pp. 298 - 308
Abstract Transcriptional dysregulation has emerged as a central pathogenic mechanism in Huntington's disease (HD), which is associated with neuropathological... 
Neurology | Promoter | Striatum | Specificity | Interaction | Huntington's disease | Transcription factor | Gene expression | transcription factor | EXPANDED POLYGLUTAMINE | MUTANT HUNTINGTIN | NEURONAL LOSS | NEUROSCIENCES | striatum | CREB-BINDING PROTEIN | REPRESSION | MOUSE MODEL | interaction | specificity | promoter | MICE | COUP-TF | gene expression | BRAIN | Transcriptional Activation - genetics | Humans | Middle Aged | Male | RNA, Messenger - metabolism | Corpus Striatum - metabolism | Promoter Regions, Genetic - genetics | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Tumor Suppressor Proteins - genetics | Female | Nuclear Proteins - genetics | Huntington Disease - physiopathology | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Corpus Striatum - physiopathology | Gene Expression Regulation - genetics | Repressor Proteins - genetics | Mice, Transgenic | Nuclear Proteins - metabolism | Binding Sites - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Down-Regulation - genetics | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Phenotype | Animals | Huntington Disease - genetics | Mice | Transcription, Genetic - genetics | Cell Line, Transformed | Genetic research | Genetic aspects | Promoters (Genetics) | Huntington's chorea | Protein binding | Index Medicus
Journal Article