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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2006, Volume 103, Issue 7, pp. 2328 - 2333
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2015, Volume 112, Issue 39, pp. 12163 - 12168
Pathologic ocular neovascularization commonly causes blindness. It is critical to identify the factors altered in pathologically proliferating versus normally... 
MiR-150 | MicroRNA | Retinopathy | Neovascularization | Endothelial cells | B-CELL DEVELOPMENT | PROLIFERATIVE RETINOPATHY | endothelial cells | ANGIOGENESIS | OXYGEN-INDUCED RETINOPATHY | MULTIDISCIPLINARY SCIENCES | neovascularization | MOUSE | C-MYB | MODEL | HYPOXIA | retinopathy | microRNA | miR-150 | INDUCED CHOROIDAL NEOVASCULARIZATION | Intravitreal Injections | Humans | 3' Untranslated Regions - genetics | Laser Capture Microdissection | Molecular Sequence Data | MicroRNAs - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Retinal Neovascularization - metabolism | MicroRNAs - pharmacology | Luciferases | Base Sequence | HEK293 Cells | Retinal Vessels - cytology | Receptors, CXCR4 - genetics | Retinal Neovascularization - genetics | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | MicroRNAs - administration & dosage | Frizzled Receptors - metabolism | Mice, Knockout | Receptors, CXCR4 - metabolism | Gene Expression Regulation - drug effects | Cell Movement - drug effects | Animals | Choroidal Neovascularization - metabolism | Frizzled Receptors - genetics | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Choroidal Neovascularization - genetics | Physiological aspects | Genetic aspects | Blindness | Pathology | Angiogenesis | MicroRNAs | Blood vessels | Physiology | Gene expression | Index Medicus | Biological Sciences
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1855 - 8
LbCpf1, derived from Lachnospiraceae bacterium ND2006, is a CRISPR RNA-guided endonuclease and holds promise for therapeutic applications. Here we show that... 
CELLS | SPECIFICITIES | ENDONUCLEASE | EFFICACY | INJECTION | MULTIDISCIPLINARY SCIENCES | CPF1 | CRISPR-CAS | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | NUCLEASES | Dependovirus - genetics | Endonucleases - genetics | Genetic Vectors - administration & dosage | Intravitreal Injections | RNA, Guide - genetics | Humans | Choroidal Neovascularization - therapy | Choroidal Neovascularization - etiology | Male | Vascular Endothelial Growth Factor A - genetics | Retinal Pigment Epithelium - pathology | Choroidal Neovascularization - pathology | Endonucleases - administration & dosage | Retinal Pigment Epithelium - blood supply | Clostridiales - genetics | Retinal Pigment Epithelium - radiation effects | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Disease Models, Animal | Lasers - adverse effects | Macular Degeneration - etiology | Cell Line | Specific Pathogen-Free Organisms | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Bacterial Proteins - genetics | Treatment Outcome | Bacterial Proteins - administration & dosage | Genetic Vectors - genetics | Animals | Macular Degeneration - genetics | Macular Degeneration - therapy | Gene Editing - methods | Mice | Choroidal Neovascularization - genetics | Genetic Therapy - methods | Macular Degeneration - pathology | CRISPR | Therapeutic applications | Medical treatment | Viruses | Retina | Genomes | Ribonucleic acid--RNA | Epithelium | Retinal pigment epithelium | Vascularization | Macular degeneration | Angiogenesis | Gene disruption | Hypoxia | Degeneration | Endonuclease | Vascular endothelial growth factor | Genetic modification | Age | Index Medicus
Journal Article
Immunology, ISSN 0019-2805, 04/2016, Volume 147, Issue 4, pp. 414 - 428
Neovascularization ( NV ), as a cardinal complication of several ocular diseases, has been intensively studied, and research has shown its close association... 
vascular endothelial cells | M1, M2 macrophage polarization | interleukin‐17A | vascular endothelial growth factor | ocular neovascularization | Vascular endothelial cells | Interleukin-17A | Ocular neovascularization | Vascular endothelial growth factor | IL-17 RECEPTOR | ANGIOGENESIS | IMMUNOLOGY | CHOROIDAL NEOVASCULARIZATION | INHIBITION | vascular endothelial growth actor | SQUAMOUS-CELL CARCINOMA | interleukin-17A | TUMOR-ASSOCIATED MACROPHAGES | RETINOPATHY | ocular eovascularization | EXPRESSION | T-CELLS | ENDOTHELIAL GROWTH-FACTOR | Retina - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Retinal Neovascularization - immunology | Retina - immunology | Retinal Neovascularization - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Choroidal Neovascularization - pathology | Inflammation Mediators - metabolism | Retinal Neovascularization - genetics | Cytokines - genetics | Macrophages - immunology | Disease Models, Animal | Cell Line | Gene Expression | Cytokines - metabolism | Signal Transduction | Antibodies, Monoclonal - pharmacology | Choroidal Neovascularization - immunology | Antibodies, Neutralizing - pharmacology | Mice, Transgenic | Interleukin-17 - deficiency | Disease Progression | Interleukin-17 - metabolism | Macrophages - metabolism | Phenotype | Animals | Choroidal Neovascularization - metabolism | Interleukin-17 - antagonists & inhibitors | Mice | Choroidal Neovascularization - genetics | Retina - pathology | Retinal Neovascularization - pathology | Neovascularization | Interleukins | Macrophages | Endothelium | Angiogenesis | Cytokines | Rodents | Index Medicus | Original
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2016, Volume 36, Issue 1, pp. 19 - 24
OBJECTIVE—Ocular neovascularization (ONV) is a pathological feature of sight-threatening human diseases, such as diabetic retinopathy and age-related macular... 
myeloid cells | diabetic retinopathy | choroidal neovascularization | vascular endothelial growth factor A | macular degeneration | CELLS | ANGIOGENESIS | OXYGEN-INDUCED RETINOPATHY | VEGF | MOUSE | VITREAL MACROPHAGES | ROLES | EXPERIMENTAL CHOROIDAL NEOVASCULARIZATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | RETINAL-PIGMENT EPITHELIUM | Vascular Endothelial Growth Factor A - deficiency | Retinal Neovascularization - metabolism | Vascular Endothelial Growth Factor A - metabolism | Retinopathy of Prematurity - genetics | Vascular Endothelial Growth Factor A - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - deficiency | Retinal Vessels - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Choroidal Neovascularization - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Retinal Neovascularization - genetics | Basic Helix-Loop-Helix Transcription Factors - deficiency | Disease Models, Animal | Animals, Newborn | Oxygen | Basic Helix-Loop-Helix Transcription Factors - genetics | Retinal Vessels - metabolism | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Retinopathy of Prematurity - chemically induced | Mice, Knockout | Animals | Choroidal Neovascularization - metabolism | Myeloid Cells - metabolism | Retinal Neovascularization - chemically induced | Retinopathy of Prematurity - metabolism | Myeloid Cells - pathology | Choroidal Neovascularization - genetics | Retinal Neovascularization - pathology | Retinopathy of Prematurity - pathology | Index Medicus | 10011 | 10033 | 10012 | 10014 | Basic Sciences | 10028
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 20, Issue 6, pp. 768 - 780
Angiogenesis is regulated by the balance of proangiogenic VEGF and antiangiogenic VEGF b splice isoforms. Mutations in , the Wilms' tumor suppressor gene,... 
PROTEIN | ONCOLOGY | ANTIANGIOGENIC ISOFORMS | IN-VIVO | VEGFB | SUPPRESSOR GENE WT1 | NEOVASCULARIZATION | VARIANT | WILMS-TUMOR | ENDOTHELIAL GROWTH-FACTOR | DENYS-DRASH-SYNDROME | CELL BIOLOGY | Neoplasm Transplantation | Luciferases, Renilla - genetics | Humans | Gene Expression Regulation, Neoplastic | Denys-Drash Syndrome - genetics | Luciferases, Renilla - biosynthesis | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Choroidal Neovascularization - pathology | RNA Interference | RNA Splicing - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | WT1 Proteins - genetics | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Promoter Regions, Genetic | Gene Expression | Podocytes - metabolism | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Neoplasms - blood supply | Nuclear Proteins - metabolism | Denys-Drash Syndrome - metabolism | Protein Transport | Animals | Choroidal Neovascularization - metabolism | Vascular Endothelial Growth Factor B - metabolism | Mice, Nude | Serine-Arginine Splicing Factors | Cell Line, Tumor | Protein Binding | Neovascularization, Pathologic - genetics | Vascular Endothelial Growth Factor B - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Choroidal Neovascularization - genetics | Denys-Drash Syndrome - pathology | RNA-Binding Proteins - metabolism | Protein Isoforms - genetics | Physiological aspects | RNA | Developmental biology | Vascular endothelial growth factor | Tumors | Protein binding | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 4, pp. 2742 - 2748
Choroidal neovascularization (CNV) is a type of wet age-related macular degeneration (AMD) which is a major cause of blindness in elder patients. Tumor... 
Tumor necrosis factor receptor-associated factor 6 (TRAF6) | Hypoxia-inducible factor 1α (HIF-1α) | Vascular endothelial growth factor (VEGF) | Choroidal neovascularization (CNV) | Macrophage | Microglia | RECEPTOR-ASSOCIATED FACTOR-6 | CELLS | ACTIVATION | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACULAR DEGENERATION | AUTOPHAGY | BIOPHYSICS | Hypoxia-inducible factor 1 alpha (HIF-1 alpha) | HIF-1-ALPHA | NF-KAPPA-B | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Microglia - metabolism | RNA, Small Interfering - genetics | Humans | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Choroidal Neovascularization - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Lasers | Microglia - pathology | TNF Receptor-Associated Factor 6 - genetics | Disease Models, Animal | Light Coagulation | Macrophages - pathology | Microglia - drug effects | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Angiogenesis Inhibitors - pharmacology | Choroidal Neovascularization - prevention & control | Ranibizumab - pharmacology | Macrophages - metabolism | Animals | Choroidal Neovascularization - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Mice | Choroidal Neovascularization - genetics | RNA, Small Interfering - metabolism | Macular degeneration | Yuan (China) | Endothelial growth factors | Analysis | Blindness | Ophthalmology | Neovascularization | Macrophages | Endothelium | Index Medicus
Journal Article