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Journal of the American Chemical Society, ISSN 0002-7863, 10/2015, Volume 137, Issue 40, pp. 12732 - 12735
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 93, pp. 42 - 50
Combining tacrine with trolox in a single molecule, novel multifunctional hybrids have been designed and synthesized. All these hybrids showed ChE inhibitory... 
Antioxidant | Trolox | Alzheimer's disease | Hepatotoxicity | Tacrine | Cholinesterase | NO DONOR | TARGET-DIRECTED LIGANDS | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | RAT HEPATOCYTES | CHOLINESTERASE-INHIBITORS | IN-VITRO | AMYLOID-BETA | ACETYLCHOLINESTERASE INHIBITORS | DERIVATIVES | Cholinesterase Inhibitors - pharmacokinetics | Male | Cholinesterase Inhibitors - chemical synthesis | PC12 Cells | Tacrine - adverse effects | Tacrine - pharmacology | Neuroprotective Agents - pharmacology | Tacrine - pharmacokinetics | Chromans - pharmacokinetics | Chromans - pharmacology | Neuroprotective Agents - pharmacokinetics | Swine | Picrates - chemistry | Drug Design | Molecular Structure | Biphenyl Compounds - chemistry | Neuroprotective Agents - adverse effects | Chromans - chemistry | Tacrine - chemistry | Cell Survival - drug effects | Chemical and Drug Induced Liver Injury - prevention & control | Alzheimer Disease - drug therapy | Rats | Alzheimer Disease - enzymology | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Blood-Brain Barrier - metabolism | Chromans - adverse effects | Neuroprotective Agents - chemical synthesis | Animals | Cholinesterase Inhibitors - pharmacology | Alzheimer Disease - metabolism | Cholinesterase Inhibitors - adverse effects | Antioxidants - adverse effects | Molecular Docking Simulation | Kinetics | Antioxidants - pharmacokinetics | In Vitro Techniques | Antioxidants | Enzyme inhibitors | Drug therapy | Analysis | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2015, Volume 58, Issue 22, pp. 8985 - 9003
Journal Article
Organic Letters, ISSN 1523-7060, 09/2012, Volume 14, Issue 18, pp. 4806 - 4809
A diastereoselective approach to isochromans and chromans via Pd(0)-catalyzed carboiodination is reported. The transformations using this methodology display... 
Cyclization | Stereoisomerism | Chromans - chemical synthesis | Molecular Structure | Catalysis | Hydrocarbons, Iodinated - chemistry | Palladium - chemistry | Chromans - chemistry
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 10/2015, Volume 7, Issue 308, pp. 308re8 - 308re8
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2016, Volume 14, Issue 46, pp. 10783 - 10786
Total syntheses of teadenols A and B, isolated from fermented tea, were accomplished in a highly stereocontrolled manner. Key steps were an organocatalytic... 
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 2016, Volume 14, Issue 46, pp. 10783 - 10786
Total syntheses of teadenols A and B, isolated from fermented tea, were accomplished in a highly stereocontrolled manner. Key steps were an organocatalytic... 
CHEMISTRY, ORGANIC | CHIRAL CHROMANS | ALKYLATIONS
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2013, Volume 454, Issue 2, pp. 201 - 208
NAC (N-acetyl-L-cysteine) is commonly used to identify and test ROS (reactive oxygen species) inducers, and to inhibit ROS. In the present study, we identified... 
Catalase | N-acetyl-L-cysteine (NAC) | Proteasome inhibitor | Reactive oxygen species (ROS) | Forkhead box protein M1 (FOXM1) | CANCER-CELLS | TARGET | APOPTOSIS | OXIDATIVE STRESS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | reactive oxygen species (ROS) | ENDOPLASMIC-RETICULUM STRESS | BORTEZOMIB | FOXM1 | INACTIVATION | proteasome inhibitor | LACTACYSTIN | catalase | Free Radical Scavengers - pharmacology | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Acetylcysteine - metabolism | Proteasome Inhibitors - chemistry | Proteasome Inhibitors - metabolism | Viral Proteins - metabolism | Antineoplastic Agents, Phytogenic - antagonists & inhibitors | Chromans - metabolism | Proteasome Endopeptidase Complex - drug effects | Chromans - pharmacology | Dioxolanes - pharmacology | Forkhead Transcription Factors - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Ubiquitinated Proteins - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Free Radical Scavengers - metabolism | Proteasome Inhibitors - pharmacology | Catalase - genetics | Chromans - antagonists & inhibitors | Hydrogen Peroxide - pharmacology | Viral Proteins - genetics | Oxidants - antagonists & inhibitors | Dioxolanes - antagonists & inhibitors | Forkhead Transcription Factors - genetics | Catalase - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Protein Stability - drug effects | Acetylcysteine - pharmacology | Cell Line, Tumor | Cytomegalovirus - enzymology | Proteasome Endopeptidase Complex - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Forkhead Box Protein M1 | Hydrogen Peroxide - antagonists & inhibitors | N-acetyl-l-cysteine (NAC)
Journal Article
Journal Article
Chemical Communications, ISSN 1359-7345, 12/2010, Volume 46, Issue 46, pp. 8836 - 8838
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 03/2018, Volume 16, Issue 9, pp. 1598 - 1608
An organocatalytic asymmetric cascade Michael/hemiketalization/acyl transfer reaction between o-hydroxycinnamaldehydes and alpha-nitroketones is developed.... 
CATALYSIS | DOMINO REACTIONS | QUATERNARY STEREOCENTER | MICHAEL-MICHAEL CASCADE | ORTHO-QUINONE METHIDES | ALDOL REACTION | SENSITIVE POTASSIUM CHANNEL | CHEMISTRY, ORGANIC | CHIRAL CHROMANS | HIGHLY SUBSTITUTED CHROMANS | CONJUGATE ADDITIONS
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2016, Volume 59, Issue 14, pp. 6772 - 6790
Journal Article
Journal Article