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Publication DateDrug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1308 - 1314
Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic...
RAT | SEVERE RHABDOMYOLYSIS | COMBINATION THERAPY | LIVER | PHARMACOLOGY & PHARMACY | CERIVASTATIN | HEPATIC-UPTAKE | TRANSPLANT RECIPIENTS | ROSUVASTATIN | POLYPEPTIDE | FAMILY | Organic Anion Transporters, Sodium-Independent - genetics | Fatty Acids, Monounsaturated - pharmacology | Cricetulus | Hypolipidemic Agents - metabolism | Hypoglycemic Agents - metabolism | Taurocholic Acid - metabolism | Humans | Hepatocytes - metabolism | Simvastatin - pharmacology | Organic Anion Transporters - metabolism | Chromans - metabolism | Hepatocytes - cytology | Indoles - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Anticholesteremic Agents - metabolism | Chromans - pharmacology | Fatty Acids, Monounsaturated - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Indoles - pharmacology | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Pravastatin - pharmacology | Recombinant Proteins - metabolism | Taurocholic Acid - pharmacology | Cell Line | Cricetinae | Pravastatin - metabolism | Simvastatin - metabolism | Gemfibrozil - pharmacokinetics | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Thiazolidinediones - metabolism | Hypoglycemic Agents - pharmacology | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Protein Binding | Fatty Acids, Monounsaturated - pharmacokinetics | Indoles - pharmacokinetics | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Anticholesteremic Agents - pharmacology | Gemfibrozil - metabolism
RAT | SEVERE RHABDOMYOLYSIS | COMBINATION THERAPY | LIVER | PHARMACOLOGY & PHARMACY | CERIVASTATIN | HEPATIC-UPTAKE | TRANSPLANT RECIPIENTS | ROSUVASTATIN | POLYPEPTIDE | FAMILY | Organic Anion Transporters, Sodium-Independent - genetics | Fatty Acids, Monounsaturated - pharmacology | Cricetulus | Hypolipidemic Agents - metabolism | Hypoglycemic Agents - metabolism | Taurocholic Acid - metabolism | Humans | Hepatocytes - metabolism | Simvastatin - pharmacology | Organic Anion Transporters - metabolism | Chromans - metabolism | Hepatocytes - cytology | Indoles - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Anticholesteremic Agents - metabolism | Chromans - pharmacology | Fatty Acids, Monounsaturated - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Indoles - pharmacology | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Pravastatin - pharmacology | Recombinant Proteins - metabolism | Taurocholic Acid - pharmacology | Cell Line | Cricetinae | Pravastatin - metabolism | Simvastatin - metabolism | Gemfibrozil - pharmacokinetics | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Thiazolidinediones - metabolism | Hypoglycemic Agents - pharmacology | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Protein Binding | Fatty Acids, Monounsaturated - pharmacokinetics | Indoles - pharmacokinetics | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Anticholesteremic Agents - pharmacology | Gemfibrozil - metabolism
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Loading RightsThe Journal of Physiology, ISSN 0022-3751, 10/2014, Volume 592, Issue 20, pp. 4575 - 4589
Prolonged skeletal muscle inactivity causes muscle fibre atrophy. Redox imbalance has been considered one of the major triggers of skeletal muscle disuse...
TIBIALIS ANTERIOR | SKELETAL-MUSCLE | GAMMA COACTIVATOR 1-ALPHA | OXIDATIVE STRESS | PHYSIOLOGY | MITOCHONDRIAL BIOGENESIS | GENE-EXPRESSION | TRANSCRIPTIONAL COACTIVATOR | UBIQUITIN LIGASES | PROTEIN-SYNTHESIS | NEUROSCIENCES | ANTIOXIDANT CAPACITY | Up-Regulation | Dynamins - metabolism | Superoxide Dismutase - genetics | Oxidative Stress | SKP Cullin F-Box Protein Ligases - genetics | Mitochondria, Muscle - metabolism | Male | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | RNA, Messenger - metabolism | Autophagy | Tripartite Motif Proteins | Chromans - pharmacology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | NF-E2-Related Factor 2 - genetics | Muscular Atrophy - prevention & control | Muscle Fibers, Skeletal - physiology | Superoxide Dismutase - metabolism | Beclin-1 | Muscular Atrophy - metabolism | Catalase - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Ubiquitin-Protein Ligases - metabolism | Dynamins - genetics | SKP Cullin F-Box Protein Ligases - metabolism | Antioxidants - pharmacology | Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Catalase - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Antioxidants - therapeutic use | Animals | Chromans - therapeutic use | Hindlimb Suspension - adverse effects | NF-E2-Related Factor 2 - metabolism | Mice | Mitochondria, Muscle - drug effects | Superoxide Dismutase-1 | Ubiquitin-Protein Ligases - genetics | Muscle
TIBIALIS ANTERIOR | SKELETAL-MUSCLE | GAMMA COACTIVATOR 1-ALPHA | OXIDATIVE STRESS | PHYSIOLOGY | MITOCHONDRIAL BIOGENESIS | GENE-EXPRESSION | TRANSCRIPTIONAL COACTIVATOR | UBIQUITIN LIGASES | PROTEIN-SYNTHESIS | NEUROSCIENCES | ANTIOXIDANT CAPACITY | Up-Regulation | Dynamins - metabolism | Superoxide Dismutase - genetics | Oxidative Stress | SKP Cullin F-Box Protein Ligases - genetics | Mitochondria, Muscle - metabolism | Male | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | RNA, Messenger - metabolism | Autophagy | Tripartite Motif Proteins | Chromans - pharmacology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | NF-E2-Related Factor 2 - genetics | Muscular Atrophy - prevention & control | Muscle Fibers, Skeletal - physiology | Superoxide Dismutase - metabolism | Beclin-1 | Muscular Atrophy - metabolism | Catalase - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Ubiquitin-Protein Ligases - metabolism | Dynamins - genetics | SKP Cullin F-Box Protein Ligases - metabolism | Antioxidants - pharmacology | Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Catalase - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Antioxidants - therapeutic use | Animals | Chromans - therapeutic use | Hindlimb Suspension - adverse effects | NF-E2-Related Factor 2 - metabolism | Mice | Mitochondria, Muscle - drug effects | Superoxide Dismutase-1 | Ubiquitin-Protein Ligases - genetics | Muscle
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Loading RightsThe EMBO Journal, ISSN 0261-4189, 12/2007, Volume 26, Issue 24, pp. 5020 - 5032
The signaling lipid molecule 15‐deoxy‐delta 12,14‐prostaglandin J2 (15d‐PGJ2) has multiple cellular functions, including anti‐inflammatory and antineoplastic...
15d‐PGJ2 | translation | proliferation | inflammation | eIF4A | Translation | Inflammation | Proliferation | 15d-PGJ2 | TRANSFORMATION SUPPRESSOR PDCD4 | KAPPA-B ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | BINDING-PROTEIN | INITIATION CODON | CELL BIOLOGY | HEPATITIS-C VIRUS | PATHWAY | STRESS GRANULE FORMATION | PRODUCT PATEAMINE-A | RNA HELICASE EIF4A | Tumor Necrosis Factor-alpha - metabolism | Arachidonic Acid - metabolism | Protein Biosynthesis | Sodium Compounds - metabolism | Hypoglycemic Agents - metabolism | Humans | TNF Receptor-Associated Factor 2 - genetics | Cytoplasmic Granules - chemistry | PPAR gamma - metabolism | Anti-Inflammatory Agents - metabolism | Chromans - metabolism | Poly(A)-Binding Proteins - metabolism | Prostaglandin D2 - metabolism | Cytoplasmic Granules - metabolism | Eukaryotic Initiation Factor-2 - metabolism | Prostaglandin D2 - analogs & derivatives | T-Cell Intracellular Antigen-1 | Eukaryotic Initiation Factor-4A - genetics | Emetine - metabolism | Enzyme Inhibitors - metabolism | Poly(A)-Binding Proteins - genetics | Gene Expression Regulation | TNF Receptor-Associated Factor 2 - metabolism | Protein Synthesis Inhibitors - metabolism | Thiazolidinediones - metabolism | Arsenites - metabolism | Dinoprostone - metabolism | Eukaryotic Initiation Factor-2 - genetics | Inflammation - genetics | Cyclopentanes - metabolism | Signal Transduction - physiology | Prostaglandins A - metabolism | HeLa Cells | Eukaryotic Initiation Factor-4A - metabolism | Lipids | Cellular biology | Molecular biology | Binding sites | Inflammatory diseases
15d‐PGJ2 | translation | proliferation | inflammation | eIF4A | Translation | Inflammation | Proliferation | 15d-PGJ2 | TRANSFORMATION SUPPRESSOR PDCD4 | KAPPA-B ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | BINDING-PROTEIN | INITIATION CODON | CELL BIOLOGY | HEPATITIS-C VIRUS | PATHWAY | STRESS GRANULE FORMATION | PRODUCT PATEAMINE-A | RNA HELICASE EIF4A | Tumor Necrosis Factor-alpha - metabolism | Arachidonic Acid - metabolism | Protein Biosynthesis | Sodium Compounds - metabolism | Hypoglycemic Agents - metabolism | Humans | TNF Receptor-Associated Factor 2 - genetics | Cytoplasmic Granules - chemistry | PPAR gamma - metabolism | Anti-Inflammatory Agents - metabolism | Chromans - metabolism | Poly(A)-Binding Proteins - metabolism | Prostaglandin D2 - metabolism | Cytoplasmic Granules - metabolism | Eukaryotic Initiation Factor-2 - metabolism | Prostaglandin D2 - analogs & derivatives | T-Cell Intracellular Antigen-1 | Eukaryotic Initiation Factor-4A - genetics | Emetine - metabolism | Enzyme Inhibitors - metabolism | Poly(A)-Binding Proteins - genetics | Gene Expression Regulation | TNF Receptor-Associated Factor 2 - metabolism | Protein Synthesis Inhibitors - metabolism | Thiazolidinediones - metabolism | Arsenites - metabolism | Dinoprostone - metabolism | Eukaryotic Initiation Factor-2 - genetics | Inflammation - genetics | Cyclopentanes - metabolism | Signal Transduction - physiology | Prostaglandins A - metabolism | HeLa Cells | Eukaryotic Initiation Factor-4A - metabolism | Lipids | Cellular biology | Molecular biology | Binding sites | Inflammatory diseases
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Loading RightsToxicology, ISSN 0300-483X, 2005, Volume 216, Issue 2, pp. 154 - 167
Many adverse drug reactions are caused by the cytochrome P450 (CYP) dependent activation of drugs into reactive metabolites. In order to reduce attrition due...
Reactive metabolites | Cytotoxicity | Metabolism-mediated toxicity | CYP3A4 | In vitro screening | Adverse drug reactions (ADRs) | CYTOCHROME-P450 | MEDIATED CYTOTOXICITY | HUMAN HEPATOCYTE CULTURES | in vitro screening | CARBAMAZEPINE | adverse drug reactions (ADRs) | STABLE EXPRESSION | INDUCTION | metabolism-mediated toxicity | IDIOSYNCRATIC DRUG-REACTIONS | CHINESE-HAMSTER CELLS | HEPG2 CELLS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | reactive metabolites | HUMAN-LIVER-MICROSOMES | cytotoxicity | Microsomes - metabolism | Thiazoles - metabolism | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 CYP3A | Coculture Techniques | Humans | Thiazolidinediones - toxicity | Cytochrome P-450 Enzyme System - metabolism | Isoniazid - toxicity | Xenobiotics - toxicity | Chromans - metabolism | Flutamide - metabolism | Triazolam - toxicity | Microsomes - drug effects | Triazolam - metabolism | Adenosine Triphosphate - metabolism | Carbamazepine - toxicity | Toxicity Tests - methods | Xenobiotics - metabolism | Cell Culture Techniques | Cell Survival - drug effects | Albendazole - toxicity | Tamoxifen - toxicity | Dapsone - metabolism | Dapsone - toxicity | Cell Line, Tumor | Glutathione - chemistry | Troglitazone | Buthionine Sulfoximine - pharmacology | Quinidine - toxicity | Amitriptyline - toxicity | Glutathione - metabolism | Flutamide - toxicity | Substrate Specificity | Piperazines - metabolism | Piperazines - toxicity | Ochratoxins - metabolism | Xenobiotics - chemistry | Tetrazolium Salts - metabolism | Carbamazepine - metabolism | Quinidine - metabolism | Tamoxifen - metabolism | Amitriptyline - metabolism | Glutathione - antagonists & inhibitors | Enzyme Activation - drug effects | Thiazolidinediones - metabolism | Ochratoxins - toxicity | Thiazoles - toxicity | Animals | Albendazole - metabolism | Chromans - toxicity | Isoniazid - metabolism | Phosphates | Metabolites | Ketoconazole | Cytochrome P-450 | Control systems | Xenobiotics | Glutathione
Reactive metabolites | Cytotoxicity | Metabolism-mediated toxicity | CYP3A4 | In vitro screening | Adverse drug reactions (ADRs) | CYTOCHROME-P450 | MEDIATED CYTOTOXICITY | HUMAN HEPATOCYTE CULTURES | in vitro screening | CARBAMAZEPINE | adverse drug reactions (ADRs) | STABLE EXPRESSION | INDUCTION | metabolism-mediated toxicity | IDIOSYNCRATIC DRUG-REACTIONS | CHINESE-HAMSTER CELLS | HEPG2 CELLS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | reactive metabolites | HUMAN-LIVER-MICROSOMES | cytotoxicity | Microsomes - metabolism | Thiazoles - metabolism | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 CYP3A | Coculture Techniques | Humans | Thiazolidinediones - toxicity | Cytochrome P-450 Enzyme System - metabolism | Isoniazid - toxicity | Xenobiotics - toxicity | Chromans - metabolism | Flutamide - metabolism | Triazolam - toxicity | Microsomes - drug effects | Triazolam - metabolism | Adenosine Triphosphate - metabolism | Carbamazepine - toxicity | Toxicity Tests - methods | Xenobiotics - metabolism | Cell Culture Techniques | Cell Survival - drug effects | Albendazole - toxicity | Tamoxifen - toxicity | Dapsone - metabolism | Dapsone - toxicity | Cell Line, Tumor | Glutathione - chemistry | Troglitazone | Buthionine Sulfoximine - pharmacology | Quinidine - toxicity | Amitriptyline - toxicity | Glutathione - metabolism | Flutamide - toxicity | Substrate Specificity | Piperazines - metabolism | Piperazines - toxicity | Ochratoxins - metabolism | Xenobiotics - chemistry | Tetrazolium Salts - metabolism | Carbamazepine - metabolism | Quinidine - metabolism | Tamoxifen - metabolism | Amitriptyline - metabolism | Glutathione - antagonists & inhibitors | Enzyme Activation - drug effects | Thiazolidinediones - metabolism | Ochratoxins - toxicity | Thiazoles - toxicity | Animals | Albendazole - metabolism | Chromans - toxicity | Isoniazid - metabolism | Phosphates | Metabolites | Ketoconazole | Cytochrome P-450 | Control systems | Xenobiotics | Glutathione
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Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 07/2006, Volume 291, Issue 1, pp. 175 - 181
Thiazolidinediones (TZDs) are insulin-sensitizing agents used in the treatment of type 2 diabetes. A widely held view is that their action is secondary to...
Acetyl-coenzyme A carboxylase | Diabetes | Metabolism | Insulin sensitivity | Adiponectin | RAT SKELETAL-MUSCLE | adiponectin | PHYSIOLOGY | RECEPTOR-GAMMA | acetyl-coenzyme A carboxylase | insulin sensitivity | GLUCOSE-METABOLISM | MALONYL-COA | INSULIN-RESISTANCE | OB GENE-EXPRESSION | IN-VIVO | ENDOCRINOLOGY & METABOLISM | PPAR-GAMMA | ADIPOCYTE DIFFERENTIATION | metabolism | diabetes | ADIPOSE-TISSUE | Swiss 3T3 Cells | Multienzyme Complexes - metabolism | Male | Muscle, Skeletal - metabolism | PPAR gamma - metabolism | AMP-Activated Protein Kinases | Chromans - pharmacology | Adenosine Triphosphate - metabolism | Muscle, Skeletal - drug effects | Thiazolidinediones - pharmacology | Fatty Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Muscle, Skeletal - enzymology | Oxidation-Reduction | Adenosine Monophosphate - metabolism | Rats | Rats, Sprague-Dawley | Hypoglycemic Agents - pharmacology | Animals | Glucose - metabolism | Mice | Adenosine Diphosphate - metabolism | Enzyme Activation | In Vitro Techniques | Acetyl-CoA Carboxylase - metabolism
Acetyl-coenzyme A carboxylase | Diabetes | Metabolism | Insulin sensitivity | Adiponectin | RAT SKELETAL-MUSCLE | adiponectin | PHYSIOLOGY | RECEPTOR-GAMMA | acetyl-coenzyme A carboxylase | insulin sensitivity | GLUCOSE-METABOLISM | MALONYL-COA | INSULIN-RESISTANCE | OB GENE-EXPRESSION | IN-VIVO | ENDOCRINOLOGY & METABOLISM | PPAR-GAMMA | ADIPOCYTE DIFFERENTIATION | metabolism | diabetes | ADIPOSE-TISSUE | Swiss 3T3 Cells | Multienzyme Complexes - metabolism | Male | Muscle, Skeletal - metabolism | PPAR gamma - metabolism | AMP-Activated Protein Kinases | Chromans - pharmacology | Adenosine Triphosphate - metabolism | Muscle, Skeletal - drug effects | Thiazolidinediones - pharmacology | Fatty Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Muscle, Skeletal - enzymology | Oxidation-Reduction | Adenosine Monophosphate - metabolism | Rats | Rats, Sprague-Dawley | Hypoglycemic Agents - pharmacology | Animals | Glucose - metabolism | Mice | Adenosine Diphosphate - metabolism | Enzyme Activation | In Vitro Techniques | Acetyl-CoA Carboxylase - metabolism
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Loading RightsBiochemical Journal, ISSN 0264-6021, 09/2013, Volume 454, Issue 2, pp. 201 - 208
NAC (N-acetyl-L-cysteine) is commonly used to identify and test ROS (reactive oxygen species) inducers, and to inhibit ROS. In the present study, we identified...
Catalase | N-acetyl-L-cysteine (NAC) | Proteasome inhibitor | Reactive oxygen species (ROS) | Forkhead box protein M1 (FOXM1) | CANCER-CELLS | TARGET | APOPTOSIS | OXIDATIVE STRESS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | reactive oxygen species (ROS) | ENDOPLASMIC-RETICULUM STRESS | BORTEZOMIB | FOXM1 | INACTIVATION | proteasome inhibitor | LACTACYSTIN | catalase | Free Radical Scavengers - pharmacology | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Acetylcysteine - metabolism | Proteasome Inhibitors - chemistry | Proteasome Inhibitors - metabolism | Viral Proteins - metabolism | Antineoplastic Agents, Phytogenic - antagonists & inhibitors | Chromans - metabolism | Proteasome Endopeptidase Complex - drug effects | Chromans - pharmacology | Dioxolanes - pharmacology | Forkhead Transcription Factors - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Ubiquitinated Proteins - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Free Radical Scavengers - metabolism | Proteasome Inhibitors - pharmacology | Catalase - genetics | Chromans - antagonists & inhibitors | Hydrogen Peroxide - pharmacology | Viral Proteins - genetics | Oxidants - antagonists & inhibitors | Dioxolanes - antagonists & inhibitors | Forkhead Transcription Factors - genetics | Catalase - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Protein Stability - drug effects | Acetylcysteine - pharmacology | Cell Line, Tumor | Cytomegalovirus - enzymology | Proteasome Endopeptidase Complex - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Forkhead Box Protein M1 | Hydrogen Peroxide - antagonists & inhibitors | N-acetyl-l-cysteine (NAC)
Catalase | N-acetyl-L-cysteine (NAC) | Proteasome inhibitor | Reactive oxygen species (ROS) | Forkhead box protein M1 (FOXM1) | CANCER-CELLS | TARGET | APOPTOSIS | OXIDATIVE STRESS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | reactive oxygen species (ROS) | ENDOPLASMIC-RETICULUM STRESS | BORTEZOMIB | FOXM1 | INACTIVATION | proteasome inhibitor | LACTACYSTIN | catalase | Free Radical Scavengers - pharmacology | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Acetylcysteine - metabolism | Proteasome Inhibitors - chemistry | Proteasome Inhibitors - metabolism | Viral Proteins - metabolism | Antineoplastic Agents, Phytogenic - antagonists & inhibitors | Chromans - metabolism | Proteasome Endopeptidase Complex - drug effects | Chromans - pharmacology | Dioxolanes - pharmacology | Forkhead Transcription Factors - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Ubiquitinated Proteins - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Free Radical Scavengers - metabolism | Proteasome Inhibitors - pharmacology | Catalase - genetics | Chromans - antagonists & inhibitors | Hydrogen Peroxide - pharmacology | Viral Proteins - genetics | Oxidants - antagonists & inhibitors | Dioxolanes - antagonists & inhibitors | Forkhead Transcription Factors - genetics | Catalase - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Protein Stability - drug effects | Acetylcysteine - pharmacology | Cell Line, Tumor | Cytomegalovirus - enzymology | Proteasome Endopeptidase Complex - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Forkhead Box Protein M1 | Hydrogen Peroxide - antagonists & inhibitors | N-acetyl-l-cysteine (NAC)
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Loading RightsDiabetes, ISSN 0012-1797, 03/2009, Volume 58, Issue 3, pp. 673 - 681
Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion Corinne Leloup 1 , Cécile Tourrel-Cuzin 2 , Christophe...
B-CELLS | CYCLIC ADP-RIBOSE | ACTIVATION | CYTOSOLIC CA2 | ISLETS | METABOLISM | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | CHANNELS | RELEASE | H2O2 | Islets of Langerhans - drug effects | Islets of Langerhans - physiology | Reactive Oxygen Species - metabolism | Rats, Wistar | Signal Transduction | Calcium - metabolism | Rats | Male | Glucose - pharmacology | Mitochondria - drug effects | Insulin - metabolism | Animals | Chromans - pharmacology | Islets of Langerhans - metabolism | Adenosine Triphosphate - metabolism | Superoxides - metabolism | Thapsigargin - pharmacology | Kinetics | Mitochondria - physiology | Insulin Secretion | NAD - metabolism | Superoxide Dismutase - metabolism | Physiological aspects | Homeostasis | Glucose metabolism | Genetic aspects | Research | Active oxygen | Index Medicus | Abridged Index Medicus | Life Sciences | Food and Nutrition | Islet Studies
B-CELLS | CYCLIC ADP-RIBOSE | ACTIVATION | CYTOSOLIC CA2 | ISLETS | METABOLISM | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | CHANNELS | RELEASE | H2O2 | Islets of Langerhans - drug effects | Islets of Langerhans - physiology | Reactive Oxygen Species - metabolism | Rats, Wistar | Signal Transduction | Calcium - metabolism | Rats | Male | Glucose - pharmacology | Mitochondria - drug effects | Insulin - metabolism | Animals | Chromans - pharmacology | Islets of Langerhans - metabolism | Adenosine Triphosphate - metabolism | Superoxides - metabolism | Thapsigargin - pharmacology | Kinetics | Mitochondria - physiology | Insulin Secretion | NAD - metabolism | Superoxide Dismutase - metabolism | Physiological aspects | Homeostasis | Glucose metabolism | Genetic aspects | Research | Active oxygen | Index Medicus | Abridged Index Medicus | Life Sciences | Food and Nutrition | Islet Studies
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Loading RightsJournal of Biological Chemistry, ISSN 0021-9258, 2005, Volume 280, Issue 46, pp. 38317 - 38327
Agonists for the nuclear receptor peroxisomal proliferator-activated receptor-gamma (PPAR gamma) and its heterodimeric partner, retinoid X receptor (RXR), are...
REXINOIDS | METABOLISM | FEMALE RATS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | SENSITIVITY | ALPHA | NUCLEAR FACTOR-3 | MICE | HETERODIMERS | INDUCED INSULIN-RESISTANCE | Oligonucleotide Array Sequence Analysis | Humans | Transcriptional Activation | Muscle, Skeletal - metabolism | PPAR gamma - metabolism | RNA, Messenger - metabolism | Time Factors | Radioimmunoassay | Proto-Oncogene Proteins c-akt - metabolism | Thiazolidinediones - pharmacology | Cyclic AMP - metabolism | Dimerization | Hepatocyte Nuclear Factor 3-beta - metabolism | Signal Transduction | Down-Regulation | Liver - metabolism | Rats | Nicotinic Acids - pharmacology | Genetic Techniques | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Rats, Zucker | Hyperinsulinism - pathology | Insulin - metabolism | Models, Biological | Tetrahydronaphthalenes - pharmacology | Cell Line, Tumor | Glucose - metabolism | Ligands | Mice | Blood Glucose - metabolism | Troglitazone | GTP-Binding Proteins - metabolism | Luciferases - metabolism | Fatty Acid Synthases - metabolism | Diabetes Mellitus, Type 2 - metabolism | Phosphoproteins - metabolism | Dose-Response Relationship, Drug | Glycogen - metabolism | Transfection | Chromans - pharmacology | Hepatocyte Nuclear Factor 3-gamma - metabolism | Insulin Receptor Substrate Proteins | Polymerase Chain Reaction | Female | Retinoid X Receptors - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Cell Line | Mice, Inbred C57BL | Gene Expression Regulation | Intracellular Signaling Peptides and Proteins | Fatty Acids, Unsaturated - pharmacology | Blotting, Northern | Animals
REXINOIDS | METABOLISM | FEMALE RATS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | SENSITIVITY | ALPHA | NUCLEAR FACTOR-3 | MICE | HETERODIMERS | INDUCED INSULIN-RESISTANCE | Oligonucleotide Array Sequence Analysis | Humans | Transcriptional Activation | Muscle, Skeletal - metabolism | PPAR gamma - metabolism | RNA, Messenger - metabolism | Time Factors | Radioimmunoassay | Proto-Oncogene Proteins c-akt - metabolism | Thiazolidinediones - pharmacology | Cyclic AMP - metabolism | Dimerization | Hepatocyte Nuclear Factor 3-beta - metabolism | Signal Transduction | Down-Regulation | Liver - metabolism | Rats | Nicotinic Acids - pharmacology | Genetic Techniques | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Rats, Zucker | Hyperinsulinism - pathology | Insulin - metabolism | Models, Biological | Tetrahydronaphthalenes - pharmacology | Cell Line, Tumor | Glucose - metabolism | Ligands | Mice | Blood Glucose - metabolism | Troglitazone | GTP-Binding Proteins - metabolism | Luciferases - metabolism | Fatty Acid Synthases - metabolism | Diabetes Mellitus, Type 2 - metabolism | Phosphoproteins - metabolism | Dose-Response Relationship, Drug | Glycogen - metabolism | Transfection | Chromans - pharmacology | Hepatocyte Nuclear Factor 3-gamma - metabolism | Insulin Receptor Substrate Proteins | Polymerase Chain Reaction | Female | Retinoid X Receptors - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Cell Line | Mice, Inbred C57BL | Gene Expression Regulation | Intracellular Signaling Peptides and Proteins | Fatty Acids, Unsaturated - pharmacology | Blotting, Northern | Animals
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Loading RightsLife Sciences, ISSN 0024-3205, 2006, Volume 78, Issue 8, pp. 803 - 811
-carnitine plays an important regulatory role in the mitochondrial transport of long-chain free fatty acids. In this study, the antioxidant activity of...
Reducing power | DPPH | l-carnitine | Metal chelating | Antioxidant activity | Radical scavenging | L-carnitine | MEDICINE, RESEARCH & EXPERIMENTAL | ACETYL-L-CARNITINE | LIPID-PEROXIDATION | PREVENTION | FLAVONOIDS | antioxidant activity | metal chelating | OXYGEN | radical scavenging | IN-VITRO | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | INHIBITORS | reducing power | SEED EXTRACTS | BRAIN | Antioxidants - chemistry | Free Radical Scavengers - metabolism | Free Radical Scavengers - chemistry | Free Radicals - chemistry | Linoleic Acid - metabolism | Antioxidants - metabolism | Carnitine - chemistry | Linoleic Acid - chemistry | Carnitine - metabolism | Biphenyl Compounds - metabolism | Hydrazines - metabolism | Chromans - metabolism | Hydrogen Peroxide - metabolism | Hydrogen Peroxide - chemistry | Hydrazines - chemistry | Free Radicals - metabolism | Picrates | Biphenyl Compounds - chemistry | alpha-Tocopherol - metabolism | In Vitro Techniques | Lipid Peroxidation | Chromans - chemistry | alpha-Tocopherol - chemistry | Antioxidants | Unsaturated fatty acids | Hydrogen peroxide | Iron compounds | Levocarnitine | Superoxide | Essential fatty acids
Reducing power | DPPH | l-carnitine | Metal chelating | Antioxidant activity | Radical scavenging | L-carnitine | MEDICINE, RESEARCH & EXPERIMENTAL | ACETYL-L-CARNITINE | LIPID-PEROXIDATION | PREVENTION | FLAVONOIDS | antioxidant activity | metal chelating | OXYGEN | radical scavenging | IN-VITRO | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | INHIBITORS | reducing power | SEED EXTRACTS | BRAIN | Antioxidants - chemistry | Free Radical Scavengers - metabolism | Free Radical Scavengers - chemistry | Free Radicals - chemistry | Linoleic Acid - metabolism | Antioxidants - metabolism | Carnitine - chemistry | Linoleic Acid - chemistry | Carnitine - metabolism | Biphenyl Compounds - metabolism | Hydrazines - metabolism | Chromans - metabolism | Hydrogen Peroxide - metabolism | Hydrogen Peroxide - chemistry | Hydrazines - chemistry | Free Radicals - metabolism | Picrates | Biphenyl Compounds - chemistry | alpha-Tocopherol - metabolism | In Vitro Techniques | Lipid Peroxidation | Chromans - chemistry | alpha-Tocopherol - chemistry | Antioxidants | Unsaturated fatty acids | Hydrogen peroxide | Iron compounds | Levocarnitine | Superoxide | Essential fatty acids
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Loading RightsGastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 6, pp. 2136 - 2145.e7
Background & Aims The infiltrating ductal adenocarcinoma of the pancreas is among the most lethal of all solid malignancies, largely owing to a high frequency...
Gastroenterology and Hepatology | BREAST-CANCER | ZEBRAFISH EMBRYOS | TUMOR INVASION | ANGIOGENESIS | CLUSTERS | ADENOCARCINOMA | GENE-EXPRESSION | E-CADHERIN | MICRORNAS | CELL-LINES | GASTROENTEROLOGY & HEPATOLOGY | Up-Regulation | Pancreatic Neoplasms - metabolism | Cadherins - metabolism | alpha Catenin - metabolism | Homeodomain Proteins - metabolism | Humans | Oligonucleotides, Antisense - metabolism | MicroRNAs - metabolism | Zebrafish - embryology | Receptors, Retinoic Acid - genetics | Pancreatic Neoplasms - secondary | Adenocarcinoma - metabolism | Transfection | Chromans - pharmacology | RNA Interference | Adenocarcinoma - genetics | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Invasiveness | Receptors, Retinoic Acid - antagonists & inhibitors | Morpholines - metabolism | Pancreatic Neoplasms - genetics | Receptors, Retinoic Acid - metabolism | beta Catenin - metabolism | Adenocarcinoma - secondary | Homeodomain Proteins - genetics | Xenograft Model Antitumor Assays | Blotting, Northern | Animals | Adenocarcinoma - therapy | Benzoates - pharmacology | Cell Line, Tumor | Retinoids - pharmacology | Genetic Therapy - methods | Pancreatic Neoplasms - therapy | RNA, Small Interfering - metabolism | Polymerase chain reaction | Phosphates | Espionage, German | Pancreatic cancer | Dimethyl sulfoxide | Fluorescence | Metastasis
Gastroenterology and Hepatology | BREAST-CANCER | ZEBRAFISH EMBRYOS | TUMOR INVASION | ANGIOGENESIS | CLUSTERS | ADENOCARCINOMA | GENE-EXPRESSION | E-CADHERIN | MICRORNAS | CELL-LINES | GASTROENTEROLOGY & HEPATOLOGY | Up-Regulation | Pancreatic Neoplasms - metabolism | Cadherins - metabolism | alpha Catenin - metabolism | Homeodomain Proteins - metabolism | Humans | Oligonucleotides, Antisense - metabolism | MicroRNAs - metabolism | Zebrafish - embryology | Receptors, Retinoic Acid - genetics | Pancreatic Neoplasms - secondary | Adenocarcinoma - metabolism | Transfection | Chromans - pharmacology | RNA Interference | Adenocarcinoma - genetics | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Invasiveness | Receptors, Retinoic Acid - antagonists & inhibitors | Morpholines - metabolism | Pancreatic Neoplasms - genetics | Receptors, Retinoic Acid - metabolism | beta Catenin - metabolism | Adenocarcinoma - secondary | Homeodomain Proteins - genetics | Xenograft Model Antitumor Assays | Blotting, Northern | Animals | Adenocarcinoma - therapy | Benzoates - pharmacology | Cell Line, Tumor | Retinoids - pharmacology | Genetic Therapy - methods | Pancreatic Neoplasms - therapy | RNA, Small Interfering - metabolism | Polymerase chain reaction | Phosphates | Espionage, German | Pancreatic cancer | Dimethyl sulfoxide | Fluorescence | Metastasis
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Loading RightsAnnals of the New York Academy of Sciences, ISSN 0077-8923, 05/2002, Volume 962, Issue 1, pp. 242 - 259
A bstract : Peroxynitrite is implicated in numerous human diseases. Hence, there is considerable interest in potential therapeutic peroxynitrite scavengers. It...
nitric oxide | nitrosative stress | peroxynitrite | uric acid | 3‐nitrotyrosine | oxidative stress | Oxidative stress | 3-nitrotyrosine | Peroxynitrite | Uric acid | Nitrosative stress | Nitric oxide | POLY(ADP-RIBOSE) SYNTHETASE | ACTIVATED PROTEIN-KINASE | HUMAN BLOOD-PLASMA | MULTIDISCIPLINARY SCIENCES | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS | HYDROXYL RADICAL PRODUCTION | NITRIC-OXIDE | DEPENDENT TYROSINE NITRATION | NEUROBLASTOMA SH-SY5Y CELLS | CARBON-DIOXIDE | Pyrogallol - metabolism | Uric Acid - metabolism | Glutathione - metabolism | Reactive Nitrogen Species - metabolism | Antioxidants - metabolism | Humans | Serine Proteinase Inhibitors - metabolism | Sulfonic Acids - metabolism | Ascorbic Acid - metabolism | Chromans - metabolism | Guanine - metabolism | Pyrogallol - analogs & derivatives | Indicators and Reagents - metabolism | Tyrosine - metabolism | Coloring Agents - metabolism | Peroxynitrous Acid - metabolism | Bicarbonates - metabolism | alpha 1-Antitrypsin - metabolism | Benzothiazoles
nitric oxide | nitrosative stress | peroxynitrite | uric acid | 3‐nitrotyrosine | oxidative stress | Oxidative stress | 3-nitrotyrosine | Peroxynitrite | Uric acid | Nitrosative stress | Nitric oxide | POLY(ADP-RIBOSE) SYNTHETASE | ACTIVATED PROTEIN-KINASE | HUMAN BLOOD-PLASMA | MULTIDISCIPLINARY SCIENCES | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS | HYDROXYL RADICAL PRODUCTION | NITRIC-OXIDE | DEPENDENT TYROSINE NITRATION | NEUROBLASTOMA SH-SY5Y CELLS | CARBON-DIOXIDE | Pyrogallol - metabolism | Uric Acid - metabolism | Glutathione - metabolism | Reactive Nitrogen Species - metabolism | Antioxidants - metabolism | Humans | Serine Proteinase Inhibitors - metabolism | Sulfonic Acids - metabolism | Ascorbic Acid - metabolism | Chromans - metabolism | Guanine - metabolism | Pyrogallol - analogs & derivatives | Indicators and Reagents - metabolism | Tyrosine - metabolism | Coloring Agents - metabolism | Peroxynitrous Acid - metabolism | Bicarbonates - metabolism | alpha 1-Antitrypsin - metabolism | Benzothiazoles
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Loading RightsChemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 81, pp. 11387 - 11390
In this study, we developed a multi-signal mitochondria-targeted fluorescent probe (NIR-Cys) for simultaneous detection of Cys and its metabolite, SO2. In the...
THIOLS | RAT | IN-VIVO | CYS | CHEMISTRY, MULTIDISCIPLINARY | SULFUR-DIOXIDE DERIVATIVES | SULFITE | Fluorescent Dyes - chemical synthesis | Coumarins - metabolism | Sulfur Dioxide - analysis | Humans | Fluorescence | Fluorescent Dyes - metabolism | Coumarins - chemistry | Chromans - metabolism | Acrylates - metabolism | Acrylates - chemical synthesis | Cysteine - metabolism | Coumarins - toxicity | Chromans - chemistry | Fluorescent Dyes - chemistry | Limit of Detection | Acrylates - chemistry | Cysteine - analysis | Liver - metabolism | Sulfur Dioxide - metabolism | Zebrafish | Mitochondria - metabolism | Acrylates - toxicity | Microscopy, Confocal - methods | Sulfites - chemistry | Animals | Fluorescent Dyes - toxicity | Microscopy, Fluorescence - methods | Coumarins - chemical synthesis | Sulfites - analysis | Cell Line, Tumor | Chromans - chemical synthesis | Mice | Chromans - toxicity
THIOLS | RAT | IN-VIVO | CYS | CHEMISTRY, MULTIDISCIPLINARY | SULFUR-DIOXIDE DERIVATIVES | SULFITE | Fluorescent Dyes - chemical synthesis | Coumarins - metabolism | Sulfur Dioxide - analysis | Humans | Fluorescence | Fluorescent Dyes - metabolism | Coumarins - chemistry | Chromans - metabolism | Acrylates - metabolism | Acrylates - chemical synthesis | Cysteine - metabolism | Coumarins - toxicity | Chromans - chemistry | Fluorescent Dyes - chemistry | Limit of Detection | Acrylates - chemistry | Cysteine - analysis | Liver - metabolism | Sulfur Dioxide - metabolism | Zebrafish | Mitochondria - metabolism | Acrylates - toxicity | Microscopy, Confocal - methods | Sulfites - chemistry | Animals | Fluorescent Dyes - toxicity | Microscopy, Fluorescence - methods | Coumarins - chemical synthesis | Sulfites - analysis | Cell Line, Tumor | Chromans - chemical synthesis | Mice | Chromans - toxicity
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