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Science, ISSN 0036-8075, 10/2010, Volume 330, Issue 6001, pp. 239 - 243
For proper partitioning of chromosomes in mitosis, the chromosomal passenger complex (CPC) including Aurora B and survivin must be localized at the center of... 
Yeasts | Phosphorylation | Heterochromatin | Kinetochores | REPORTS | Centromeres | HeLa cells | Histones | Antibodies | Chromosomes | Genetic mutation | SISTER-CHROMATID COHESION | LOCALIZATION | ATTACHMENT | MITOTIC CHROMOSOME | KINETOCHORE | MULTIDISCIPLINARY SCIENCES | MEIOSIS | SPINDLE | CHECKPOINT | SHUGOSHIN | AURORA-B | Chromatin - metabolism | Chromosomes, Human - physiology | Microtubule-Associated Proteins - metabolism | Mitosis | Humans | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Centromere - metabolism | Threonine - metabolism | Schizosaccharomyces - genetics | Aurora Kinase B | Heterochromatin - metabolism | Schizosaccharomyces pombe Proteins - metabolism | Protein Interaction Domains and Motifs | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Chromosomes, Fungal - physiology | Amino Acid Sequence | Chromosome Segregation | Schizosaccharomyces pombe Proteins - genetics | Chromosomal Proteins, Non-Histone - metabolism | Inhibitor of Apoptosis Proteins | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nucleosomes - metabolism | Aurora Kinases | Serine - metabolism | Schizosaccharomyces - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | HeLa Cells | Histones - metabolism | Mutation | Proteins | Cell division | Biochemistry | Index Medicus
Journal Article
Developmental Cell, ISSN 1534-5807, 2005, Volume 8, Issue 6, pp. 949 - 961
REC8 is a key component of the meiotic cohesin complex. During meiosis, cohesin is required for the establishment and maintenance of sister-chromatid cohesion,... 
MALE-FERTILITY | RECOMBINATION | FISSION YEAST | MEIOTIC PROPHASE | SMC PROTEINS | CHROMOSOME SYNAPSIS | DEVELOPMENTAL BIOLOGY | AXIAL ELEMENTS | SACCHAROMYCES-CEREVISIAE | SYNAPTONEMAL COMPLEXES | SCHIZOSACCHAROMYCES-POMBE | CELL BIOLOGY | Meiosis - physiology | Acetaminophen - metabolism | Testis - metabolism | Pachytene Stage - physiology | Spermatogenesis - genetics | Microscopy, Electron, Transmission - methods | Humans | Male | Phosphoproteins - metabolism | Chromatids - metabolism | DNA-Binding Proteins - metabolism | Chromosome Pairing - physiology | Indoles - metabolism | Nuclear Proteins - deficiency | Cloning, Molecular - methods | Chromosomes - metabolism | Chromatids - ultrastructure | Female | Phosphoproteins - physiology | Nuclear Proteins - genetics | Saccharin - metabolism | Ovary - metabolism | Saccharin - analogs & derivatives | Acetaminophen - analogs & derivatives | Rad51 Recombinase | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Chondroitin Sulfate Proteoglycans - metabolism | Nuclear Proteins - metabolism | Testis - ultrastructure | In Situ Nick-End Labeling - methods | Meiotic Prophase I - physiology | Phosphoproteins - genetics | Electroporation - methods | Chromosome Painting - methods | Mice, Knockout | Immunohistochemistry - methods | Chromosomes - ultrastructure | Animals | Cell Death - physiology | Models, Biological | Phosphoproteins - deficiency | Oncorhynchus kisutch - metabolism | Trans-Activators - metabolism | Mice | Nuclear Proteins - physiology | Chromosomes, Human, Pair 10 - metabolism | Proliferating Cell Nuclear Antigen - metabolism | Cell research | Research | Oncology, Experimental | Cancer | Index Medicus
Journal Article
Science, ISSN 0036-8075, 1/2010, Volume 327, Issue 5962, pp. 172 - 177
Bub1 is a multi-task protein kinase required for proper chromosome segregation in eukaryotes. Impairment of Bubl in humans may lead to chromosomal instability... 
Proteins | Yeasts | Phosphorylation | Germ cells | Metaphase | Centromeres | HeLa cells | Antibodies | Meiosis | Chromosomes | Research Article | SISTER-CHROMATID COHESION | SPINDLE CHECKPOINT | MITOSIS | KINASE-ACTIVITY | LOCALIZATION | KINETOCHORE | MULTIDISCIPLINARY SCIENCES | CENTROMERIC PROTECTION | PROTEIN PHOSPHATASE 2A | MEIOSIS-I | FISSION YEAST BUB1 | Mitosis | Saccharomyces cerevisiae - genetics | Humans | Centromere - metabolism | Saccharomyces cerevisiae - metabolism | Schizosaccharomyces - genetics | Chromosomes, Fungal - metabolism | Schizosaccharomyces pombe Proteins - metabolism | Chromosomal Instability | Protein-Serine-Threonine Kinases - metabolism | Recombinant Proteins - metabolism | Chromosome Segregation | Schizosaccharomyces pombe Proteins - genetics | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Protein-Serine-Threonine Kinases - genetics | Nucleosomes - metabolism | Saccharomyces cerevisiae Proteins - genetics | Serine - metabolism | Chromosomal Proteins, Non-Histone - genetics | Schizosaccharomyces - metabolism | Animals | Saccharomyces cerevisiae Proteins - metabolism | Mice | Histones - metabolism | Schizosaccharomyces - cytology | Chromosome abnormalities | Physiological aspects | Genetic aspects | Research | Protein kinases | Risk factors | Biochemistry | Yeast | Cellular biology | Kinases | Index Medicus
Journal Article
Developmental Cell, ISSN 1534-5807, 03/2010, Volume 18, Issue 3, pp. 397 - 409
During meiosis, two rounds of chromosome segregation after a single round of DNA replication produce haploid gametes from diploid precursors. At meiosis I,... 
CELLBIO | FISSION YEAST | CENTROMERIC COHESION | HOMOLOGOUS CHROMOSOMES | YEAST MEIOSIS | SUBUNIT SCC1 | DEVELOPMENTAL BIOLOGY | SISTER-CHROMATID SEPARATION | PROTEIN PHOSPHATASE 2A | SEGREGATION | POLO-LIKE KINASE | DNA-REPLICATION | CELL BIOLOGY | Protein Kinases - metabolism | Casein Kinase Idelta - metabolism | Chromatin - metabolism | Meiosis - physiology | Phosphorylation | Protein Kinases - genetics | Casein Kinase I - genetics | Saccharomyces cerevisiae - genetics | Green Fluorescent Proteins - genetics | Centromere - metabolism | Recombinant Fusion Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Casein Kinase Iepsilon - metabolism | Cell Cycle Proteins - genetics | Genes, Fungal | Casein Kinase Iepsilon - genetics | Nuclear Proteins - genetics | Binding Sites | Casein Kinase Idelta - genetics | Protein-Serine-Threonine Kinases - metabolism | Endopeptidases - metabolism | Green Fluorescent Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Separase | Cell Cycle Proteins - metabolism | Protein Phosphatase 2 - genetics | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Saccharomyces cerevisiae Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Saccharomyces cerevisiae - cytology | Meiosis - genetics | Endopeptidases - genetics | Models, Biological | Protein Phosphatase 2 - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Recombinant Fusion Proteins - genetics | Casein Kinase I - metabolism | Mutation | Chromosomal Proteins, Non-Histone - chemistry | Saccharomyces cerevisiae Proteins - chemistry | DNA replication | Phosphatases | Casein | Phosphotransferases | Protein binding | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 10/2010, Volume 467, Issue 7316, pp. 719 - 723
Successful partition of replicated genomes at cell division requires chromosome attachment to opposite poles of mitotic spindle (bi-orientation). Any defects... 
SISTER-CHROMATID COHESION | CELL-DIVISION | FISSION YEAST | PASSENGER COMPLEX | MULTIDISCIPLINARY SCIENCES | MICROTUBULE ATTACHMENT | MITOTIC SPINDLE | INNER CENTROMERE | MEIOSIS-I | SCHIZOSACCHAROMYCES-POMBE | AURORA-B | Phosphorylation | Microtubule-Associated Proteins - metabolism | Humans | Molecular Sequence Data | Substrate Specificity | Centromere - metabolism | CDC2 Protein Kinase - metabolism | Schizosaccharomyces - genetics | Aurora Kinase B | Multiprotein Complexes - metabolism | Cyclin B - genetics | Chromosomes, Fungal - metabolism | Schizosaccharomyces pombe Proteins - metabolism | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Sequence | Cell Line | Schizosaccharomyces pombe Proteins - genetics | Chromosomal Proteins, Non-Histone - metabolism | Inhibitor of Apoptosis Proteins | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Aurora Kinases | Chromosomes, Human - metabolism | Carrier Proteins - genetics | Schizosaccharomyces - metabolism | Multiprotein Complexes - chemistry | Animals | Carrier Proteins - metabolism | Protein Binding | Cyclin B - metabolism | Schizosaccharomyces - cytology | Physiological aspects | Genetic aspects | Research | Genetic regulation | Phosphotransferases | Chromosomes | Proteins | Cell division | Mutation | Relocation | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2012, Volume 489, Issue 7415, pp. 313 - 317
Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital malformation disorder, caused by mutations in the cohesin-loading protein NIPBL1,2 for... 
SISTER-CHROMATID COHESION | NIPPED-B | COMPLEX | NIPBL | HUMAN GENOME | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | X-CHROMOSOME-INACTIVATION | S-PHASE | PROTEINS | BINDING | Chromatin - metabolism | Chondroitin Sulfate Proteoglycans - chemistry | Humans | Crystallography, X-Ray | Male | Phosphoproteins - metabolism | Cell Cycle Proteins - chemistry | Chromatin Immunoprecipitation | Repressor Proteins - deficiency | De Lange Syndrome - metabolism | Fibroblasts | Female | Transcription, Genetic | Acetylation | Binding Sites | Repressor Proteins - metabolism | De Lange Syndrome - genetics | Repressor Proteins - chemistry | Chromosomal Proteins, Non-Histone - metabolism | Histone Deacetylases - genetics | Cell Cycle Proteins - metabolism | Chondroitin Sulfate Proteoglycans - metabolism | Histone Deacetylases - chemistry | Histone Deacetylases - deficiency | Mutant Proteins - genetics | Prophase | Models, Molecular | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Mutation - genetics | Proteins - genetics | Mutant Proteins - chemistry | Protein Conformation | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Anaphase | Chromatin - genetics | Chromosomal Proteins, Non-Histone - chemistry | Genetics | De Lange syndrome | Genetic aspects | Research | Mutation (Biology) | Proteins | Cell culture | Genes | Cell cycle | Mutation | Females | Chromosomes | Crystal structure | Index Medicus | Chromatin | Repressor Proteins | Life Sciences | Phosphoproteins | Chromosomal Proteins, Non-Histone | Histone Deacetylases | De Lange Syndrome | Chondroitin Sulfate Proteoglycans | Nuclear Proteins | Mutant Proteins | Adaptor Proteins, Signal Transducing | Development Biology | Cell Cycle Proteins
Journal Article
The EMBO Journal, ISSN 0261-4189, 2003, Volume 22, Issue 12, pp. 2934 - 2947
Genetic evidence is mounting that survivin plays a crucial role in mitosis, but its exact role in human cell division remains elusive. We show that mammalian... 
checkpoint | mitosis | survivin | Mitosis | Checkpoint | Survivin | KINASE-ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN-CELLS | KINETOCHORE LOCALIZATION | SMALL-MOLECULE INHIBITOR | CELL BIOLOGY | APOPTOSIS FAMILY | CELL-DIVISION | SISTER CHROMATIDS | MITOTIC SPINDLE | CHROMOSOME SEGREGATION | AURORA-B | Paclitaxel - metabolism | Protein Kinases - metabolism | Protein Kinases - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Repressor Proteins | Cysteine Proteinase Inhibitors - metabolism | Stress, Mechanical | Thiones - metabolism | Recombinant Fusion Proteins - metabolism | Pyrimidines - metabolism | Aurora Kinase B | Spindle Apparatus - metabolism | Neoplasm Proteins | Cell Cycle Proteins - genetics | Spectrin - genetics | Antineoplastic Agents, Phytogenic - metabolism | Mad2 Proteins | Spectrin - metabolism | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Calcium-Binding Proteins - metabolism | Cell Line | Inhibitor of Apoptosis Proteins | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Aurora Kinases | Chromosomes, Human - metabolism | Animals | Mitosis - physiology | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Mice | Chromosomes, Mammalian - metabolism | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 09/2011, Volume 194, Issue 5, pp. 721 - 735
Although pericentromeric heterochromatin is essential for chromosome segregation, its role in humans remains controversial. Dissecting the function of... 
FISSION YEAST | ACCESSORY PROTEIN | P300 | GENE-EXPRESSION | COHESIN | KINETOCHORE PROTEIN | CHROMOSOME SEGREGATION | HUMAN-IMMUNODEFICIENCY-VIRUS | CENTROMERE | MAMMALIAN-CELLS | CELL BIOLOGY | Chromatin - metabolism | RNA, Small Interfering - genetics | Autoantigens - metabolism | p300-CBP Transcription Factors - antagonists & inhibitors | Interphase - physiology | Microtubule-Associated Proteins - metabolism | Epigenesis, Genetic | Humans | Aneuploidy | Centromere - metabolism | Phosphoproteins - metabolism | Chromatids - metabolism | Centromere Protein A | Heterochromatin - metabolism | Lymphocytes - virology | p300-CBP Transcription Factors - genetics | Gene Deletion | Chromosome Segregation - physiology | vpr Gene Products, Human Immunodeficiency Virus - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Chondroitin Sulfate Proteoglycans - metabolism | Nuclear Proteins - metabolism | Lymphocytes - cytology | Aurora Kinases | HIV-1 - genetics | Chromosomal Proteins, Non-Histone - genetics | Proteins - genetics | p300-CBP Transcription Factors - metabolism | Proteins - metabolism | Mitosis - physiology | Chromatids - drug effects | HeLa Cells | Anacardic Acids - pharmacology | vpr Gene Products, Human Immunodeficiency Virus - genetics | Proteins | Epigenetic inheritance | Chromatin | Physiological aspects | Genetic aspects | Research | HIV (Viruses) | Health aspects | Epigenetics | Heterochromatin | Enzyme kinetics | Chromosomes | Index Medicus
Journal Article