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1. Full Text Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography–electrospray–tandem mass spectrometry
by Taylor, Paul J
Clinical Biochemistry, ISSN 0009-9120, 2005, Volume 38, Issue 4, pp. 328 - 334
High-performance liquid chromatography coupled by an electrospray ion source to a tandem mass spectrometer (HPLC–ESI–MS/MS) is the current analytical method of... 
Matrix effects | Tandem mass spectrometry | Quantitation | Electrospray | HUMAN PLASMA | electrospray | HIGH-THROUGHPUT | LC/MS/MS | quantitation | SAMPLE PREPARATION | BIOANALYTICAL METHODS | tandem mass spectrometry | matrix effects | DRUGS | URINE | ION SUPPRESSION | MEDICAL LABORATORY TECHNOLOGY | IONIZATION | HPLC | Spectrometry, Mass, Electrospray Ionization - standards | Mass Spectrometry - standards | Reproducibility of Results | Chromatography, High Pressure Liquid - standards | Sensitivity and Specificity | Ions | Physical Phenomena | Physics
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2. Full Text High performance liquid chromatographic determination of ultra traces of two tricyclic antidepressant drugs imipramine and trimipramine in urine samples after their dispersive liquid–liquid microextraction coupled with response surface optimization
by Shamsipur, Mojtaba and Mirmohammadi, Mehrosadat
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 11/2014, Volume 100, pp. 271 - 278
Dispersive liquid–liquid microextraction (DLLME) coupled with high performance liquid chromatography by ultraviolet detection (HPLC–UV) as a fast and... 
High-performance liquid chromatography–ultraviolet detection | Response surface methodology | Dispersive liquid–liquid microextraction | Tricyclic antidepressants | Urine analysis | Dispersive liquid-liquid microextraction | High-performance liquid chromatography-ultraviolet detection | CLOMIPRAMINE | CHEMISTRY, ANALYTICAL | NORTRIPTYLINE | ELECTRON | DESIGN | AMITRIPTYLINE | VALIDATION | PLASMA | PHARMACOLOGY & PHARMACY | SOLID-PHASE EXTRACTION | Trimipramine - pharmacokinetics | Imipramine - pharmacokinetics | Multivariate Analysis | Limit of Detection | Reproducibility of Results | Chromatography, High Pressure Liquid - standards | Solvents - chemistry | Antidepressive Agents, Tricyclic - pharmacokinetics | Humans | Trimipramine - urine | Linear Models | Male | Antidepressive Agents, Tricyclic - urine | Calibration | Models, Statistical | Liquid Phase Microextraction - standards | Spectrophotometry, Ultraviolet | Reference Standards | Imipramine - urine | Imipramine | Drugs | Analysis | High performance liquid chromatography
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3. Full Text Determination of 40 synthetic food colors in drinks and candies by high-performance liquid chromatography using a short column with photodiode array detection
by Yoshioka, N and Ichihashi, K
Talanta, ISSN 0039-9140, 2008, Volume 74, Issue 5, pp. 1408 - 1413
Forty synthetic food colors were determined in drinks and candies by reversed-phase high-performance liquid chromatography with photodiode array detection. The... 
Photodiode array detection | Drinks and candies | Short column | HPLC | Synthetic food colors | synthetic food colors | CHEMISTRY, ANALYTICAL | photodiode array detection | THIN-LAYER CHROMATOGRAPHY | IDENTIFICATION | SOFT DRINKS | short column | SPECTROPHOTOMETRY | drinks and candies | SUBSIDIARY COLORS | PRODUCTS | CAPILLARY-ELECTROPHORESIS | SOLID-PHASE EXTRACTION | COAL-TAR DYES | Carbonated Beverages - analysis | Chromatography, High Pressure Liquid - methods | Candy - analysis | Chromatography, High Pressure Liquid - standards | Food Coloring Agents - analysis | Chromatography, High Pressure Liquid - instrumentation | Equipment Design | Beverages - analysis
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4. Full Text Development of a hydrophilic liquid interaction chromatography-high- performance liquid chromatography-tandem mass spectrometry based stable isotope dilution analysis and pharmacokinetic studies on bioactive pyridines in human plasma and urine after coffee consumption
by Lang, Roman and Wahl, Anika and Skurk, Thomas and FiratYagar, Erkan and Schmiech, Ludger and Eggers, Rudolf and Hauner, Hans and Hofmann, Thomas
Analytical Chemistry, ISSN 0003-2700, 02/2010, Volume 82, Issue 4, pp. 1486 - 1497
The paper reports on the development of an accurate hydrophilic liquid interaction chromatography tandem mass spectrometry (HILIC-MS/MS) based stable isotope... 
Reproducibility of Results | Tandem Mass Spectrometry - standards | Chromatography, High Pressure Liquid - methods | Administration, Oral | Alkaloids - pharmacokinetics | Chromatography, High Pressure Liquid - standards | Humans | Pyridines - pharmacokinetics | Drinking | Male | Coffee - metabolism | Young Adult | Pyridines - blood | Reference Standards | Pyridines - metabolism | Alkaloids - urine | Alkaloids - blood | Hydrophobic and Hydrophilic Interactions | Adult | Female | Alkaloids - metabolism | Pyridines - urine | Isotopes | Tandem Mass Spectrometry - methods | Urine | Composition | Chemistry, Analytic | Liquid chromatography | Research | Blood plasma | Technology application | Dilution | Pyridine | Chemical properties | Quantitative | Mass spectrometry | Identification and classification | Methods
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5. Full Text Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. II: Analysis of biological samples
by Nováková, Lucie and Rentsch, Marco and Grand-Guillaume Perrenoud, Alexandre and Nicoli, Raul and Saugy, Martial and Veuthey, Jean‑Luc and Guillarme, Davy
Analytica Chimica Acta, ISSN 0003-2670, 01/2015, Volume 853, Issue 1, pp. 647 - 659
The potential and applicability of UHPSFC–MS/MS for anti-doping screening in urine samples were tested for the first time. For this purpose, a group of 110... 
Urine | Ultra high performance supercritical fluid chromatography | Matrix effects | Doping agents | Biological samples | Ultra high performance liquid chromatography | CHEMISTRY, ANALYTICAL | HUMAN PLASMA | VALIDATION | PHARMACEUTICAL COMPOUNDS | LABELED INTERNAL STANDARD | LIQUID-CHROMATOGRAPHY | HUMAN URINE | STIMULANTS | Performance-Enhancing Substances - analysis | Ions - chemistry | Tandem Mass Spectrometry - standards | Antidepressive Agents - analysis | Chromatography, High Pressure Liquid - standards | Humans | Anesthetics, Local - analysis | Antidepressive Agents - standards | Reference Standards | Anesthetics, Local - standards | Performance-Enhancing Substances - standards | Chromatography, Supercritical Fluid - standards | Doping in Sports | Medical screening | Mass spectrometry | Analysis | High performance liquid chromatography | Screening | Coupling agents | Mathematical analysis | Doping | Strategy | Selectivity | Acceptability
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6. Full Text Accurate prediction of retention in hydrophilic interaction chromatography by back calculation of high pressure liquid chromatography gradient profiles
by Wang, Nu and Boswell, Paul G
Journal of Chromatography A, ISSN 0021-9673, 10/2017, Volume 1520, pp. 75 - 82
Gradient retention times are difficult to project from the underlying retention factor ( ) vs. solvent composition ( ) relationships. A major reason for this... 
Gradient delay | Back calculation | HILIC | Retention projection | Prediction error | CHEMISTRY, ANALYTICAL | NUCLEOSIDES | BIOCHEMICAL RESEARCH METHODS | IDENTIFICATION | PROJECTION | METABOLOMICS | PEPTIDES | MODELS | FLOW-RATES | OPTIMIZATION | SEPARATION | INSTRUMENTS | Hydrophobic and Hydrophilic Interactions | Reproducibility of Results | Chromatography, High Pressure Liquid - standards | Solvents - chemistry | Analysis | High performance liquid chromatography | back calculation | gradient delay | retention projection | prediction error
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7. Full Text Determination of organophosphorus pesticides in environmental water samples by dispersive liquid–liquid microextraction with solidification of floating organic droplet followed by high-performance liquid chromatography
by Wu, Chunxia and Liu, Huimin and Liu, Weihua and Wu, Qiuhua and Wang, Chun and Wang, Zhi
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 7/2010, Volume 397, Issue 6, pp. 2543 - 2549
A simple dispersive liquid–liquid microextraction based on solidification of floating organic droplet coupled with high-performance liquid chromatography–diode... 
Chemistry | Analytical Chemistry | Food Science | Ecotoxicology | Dispersive liquid–liquid microextraction based on solidification of floating organic droplet | Physical Chemistry | Water samples | Organophosphorus pesticides | Inorganic Chemistry | High-performance liquid chromatography | Dispersive liquid-liquid microextraction based on solidification of floating organic droplet | PRECONCENTRATION | CHEMISTRY, ANALYTICAL | DETECTOR | BIOCHEMICAL RESEARCH METHODS | TRAP MASS-SPECTROMETRY | TRIAZINE HERBICIDES | Dispersive liquid-liquid microextraction based | GAS-CHROMATOGRAPHY | on solidification of floating organic droplet | FLAME PHOTOMETRIC DETECTION | ELECTRON-CAPTURE | SOLID-PHASE EXTRACTION | Solvents | Limit of Detection | Reproducibility of Results | Chromatography, High Pressure Liquid - methods | Chromatography, High Pressure Liquid - standards | Organophosphorus Compounds - analysis | Calibration | Pesticides - analysis | Water Pollutants, Chemical - analysis | Water | High performance liquid chromatography | Droplets | Liquid chromatography | Mathematical analysis | Pesticides | Solidification | Index Medicus
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8. Full Text Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. I: Investigation of mobile phase and MS conditions
by Nováková, Lucie and Grand-Guillaume Perrenoud, Alexandre and Nicoli, Raul and Saugy, Martial and Veuthey, Jean-Luc and Guillarme, Davy
Analytica Chimica Acta, ISSN 0003-2670, 01/2015, Volume 853, Issue 1, pp. 637 - 646
The conditions for the analysis of selected doping substances by UHPSFC–MS/MS were optimized to ensure suitable peak shapes and maximized MS responses. A... 
Ultra high performance supercritical fluid chromatography | Doping agents | Make-up solvent | Mobile phase | Ultra high performance liquid chromatography | CHEMISTRY, ANALYTICAL | LIQUID-CHROMATOGRAPHY | URINE | Performance-Enhancing Substances - analysis | Chromatography, Supercritical Fluid - methods | Carbon Dioxide - chemistry | Ions - chemistry | Tandem Mass Spectrometry - standards | Chromatography, High Pressure Liquid - methods | Chromatography, High Pressure Liquid - standards | Reference Standards | Water - chemistry | Performance-Enhancing Substances - standards | Chromatography, Supercritical Fluid - standards | Methanol - chemistry | Tandem Mass Spectrometry - methods | Doping in Sports | Hydrogen-Ion Concentration | Medical screening | Mass spectrometry | Analysis | Investigations | Chromatography | High performance liquid chromatography | Urine | Mathematical analysis | Reagents | Carbon dioxide | Doping | Ethyl alcohol | Optimization
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9. Full Text An overview of experimental designs in HPLC method development and validation
by Sahu, Prafulla Kumar and Ramisetti, Nageswara Rao and Cecchi, Teresa and Swain, Suryakanta and Patro, Chandra Sekhar and Panda, Jagadeesh
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 01/2018, Volume 147, pp. 590 - 611
Chemometric approaches have been increasingly viewed as precious complements to high performance liquid chromatographic practices, since a large number of... 
Method development/validation | Quality by design | Optimization designs | Mathematical modelling | Screening designs | Chemometry | Six sigma | CHEMISTRY, ANALYTICAL | QBD-DRIVEN DEVELOPMENT | RESPONSE-SURFACE METHODOLOGY | STATISTICAL EXPERIMENTAL-DESIGN | SUPERCRITICAL-FLUID CHROMATOGRAPHY | STABILITY-INDICATING METHOD | GREEN ANALYTICAL-CHEMISTRY | PERFORMANCE LIQUID-CHROMATOGRAPHY | CENTRAL COMPOSITE DESIGN | QUALITY-BY-DESIGN | PHARMACOLOGY & PHARMACY | EXCHANGE MEMBRANE CHROMATOGRAPHY | Models, Theoretical | Reproducibility of Results | Tandem Mass Spectrometry - standards | Chromatography, High Pressure Liquid - methods | Chromatography, High Pressure Liquid - standards | Chromatography, Liquid - standards | Chromatography, Liquid - methods | Pharmaceutical Preparations - analysis | Tandem Mass Spectrometry - methods | Drugstores | Analysis | Pharmacy | High performance liquid chromatography | Methods | Usage | Mass spectrometry
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10. Full Text Evaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil by ultra-high performance liquid chromatography tandem mass spectrometry
by Pacifici, Roberta and Marchei, Emilia and Salvatore, Francesco and Guandalini, Luca and Busardò, Francesco Paolo and Pichini, Simona
Clinical Chemistry and Laboratory Medicine (CCLM), ISSN 1434-6621, 08/2017, Volume 55, Issue 10, pp. 1555 - 1563
Background: Cannabis has been used since ancient times to relieve neuropathic pain, to lower intraocular pressure, to increase appetite and finally to decrease... 
cannabinoids recovery | cannabinoids stability | medical cannabis | UHPLC-MS/MS | cannabis oil | cannabis tea | ACID | TETRAHYDROCANNABINOL | SUNCUS-MURINUS | RATS | THC | SATIVA | DELTA-TETRAHYDROCANNABINOL | ANTICIPATORY NAUSEA | MEDICAL LABORATORY TECHNOLOGY | Cannabinoids - isolation & purification | Cannabis - chemistry | Reference Standards | Tandem Mass Spectrometry - standards | Temperature | Chromatography, High Pressure Liquid - standards | Cannabinoids - standards | Cannabis - metabolism | Cannabinoids - analysis | Plant Oils - chemistry | Tea - chemistry | Medical services | Neuropathy | Alkaloids | Cannabis | Cannabinoids | Pain | Coverings | Vomiting | Ambient temperature | Flowering | Tetrahydrocannabinol | Appetite | Evaluation | Spectroscopy | Mass spectroscopy | Nausea | Pharmacology | Stability analysis | Liquid chromatography | High-performance liquid chromatography | Boiling | Chromatography | Tea | Oil | Decarboxylation | Tops | Marijuana | Scientific imaging | Continuity | Mass spectrometry | High performance liquid chromatography | Intraocular pressure
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11. Full Text Determination of cannabinoid and synthetic cannabinoid metabolites in wastewater by liquid–liquid extraction and ultra‐high performance supercritical fluid chromatography‐tandem mass spectrometry
by González‐Mariño, Iria and Thomas, Kevin V and Reid, Malcolm J
Drug Testing and Analysis, ISSN 1942-7603, 01/2018, Volume 10, Issue 1, pp. 222 - 228
For the first time, ultra‐high performance supercritical fluid chromatography (UHPSFC) coupled to tandem mass spectrometry has been used to determine... 
cannabis | liquid–liquid extraction | supercritical fluid based chromatography | sewage analysis | synthetic cannabinoids | CHEMISTRY, ANALYTICAL | PHARMACEUTICALS | liquid-liquid extraction | BIOCHEMICAL RESEARCH METHODS | METHODOLOGY | PHARMACOLOGY & PHARMACY | ILLICIT DRUGS | SEPARATION | SAMPLES | Chromatography, Supercritical Fluid - methods | Tandem Mass Spectrometry - standards | Chromatography, High Pressure Liquid - methods | Chromatography, High Pressure Liquid - standards | Waste Water - analysis | Water Pollutants, Chemical - analysis | Water Pollutants, Chemical - metabolism | Liquid-Liquid Extraction - methods | Chromatography, Supercritical Fluid - standards | Cannabinoids - analysis | Cannabinoids - metabolism | Liquid-Liquid Extraction - standards | Tandem Mass Spectrometry - methods | Liquid chromatography | Metabolites | Wastewater | Mass spectrometry | Analysis
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12. Full Text Standard line slopes as a measure of a relative matrix effect in quantitative HPLC–MS bioanalysis
by Matuszewski, B.K
Journal of Chromatography B, ISSN 1570-0232, 2006, Volume 830, Issue 2, pp. 293 - 300
A simple experimental approach for studying and identifying the relative matrix effect (for example “plasma-to-plasma” and/or “urine-to-urine”) in quantitative... 
Relative matrix effect | Tandem mass spectroscopy | Standard line slopes | Bioanalysis | HPLC | CHEMISTRY, ANALYTICAL | tandem mass spectroscopy | HUMAN PLASMA | standard line slopes | BIOCHEMICAL RESEARCH METHODS | bioanalysis | TANDEM MASS-SPECTROMETRY | MS/MS | SIGNAL SUPPRESSION | PERFORMANCE LIQUID-CHROMATOGRAPHY | URINE | ION SUPPRESSION | SAMPLES | SEPARATION | relative matrix effect | ELECTROSPRAY-IONIZATION | Spectrometry, Mass, Electrospray Ionization - standards | Reference Standards | Reproducibility of Results | Chromatography, High Pressure Liquid - methods | Chromatography, High Pressure Liquid - standards | Spectrometry, Mass, Electrospray Ionization - methods | Humans | Body Fluids - chemistry | Calibration
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13. Full Text Identification and quantification of arsenolipids using reversed-phase HPLC coupled simultaneously to high-resolution ICPMS and high-resolution electrospray MS without species-specific standards
by Amayo, Kenneth O and Petursdottir, Asta and Newcombe, Chris and Gunnlaugsdottir, Helga and Raab, Andrea and Krupp, Eva M and Feldmann, Jörg
Analytical Chemistry, ISSN 0003-2700, 05/2011, Volume 83, Issue 9, pp. 3589 - 3595
Although it has been known for decades that arsenic forms fat-soluble arsenic compounds, only recent attempts to identify the compounds have been successful by... 
ABSOLUTE | CHEMISTRY, ANALYTICAL | PEPTIDES | OIL | PLASMA-MASS-SPECTROMETRY | LIQUID-CHROMATOGRAPHY | ARSENIC-CONTAINING HYDROCARBONS | NATURAL CONSTITUENTS | Osmeriformes | Chromatography, High Pressure Liquid - methods | Chromatography, High Pressure Liquid - standards | Chromatography, Reverse-Phase - methods | Arsenic - analysis | Arsenic - metabolism | Chromatography, Reverse-Phase - standards | Lipids - isolation & purification | Spectrometry, Mass, Electrospray Ionization - standards | Tandem Mass Spectrometry | Lipids - chemistry | Animals | Time Factors | Spectrometry, Mass, Electrospray Ionization - methods | Hydrophobic and Hydrophilic Interactions | Lipids - analysis | Quality Control | Composition | Lipids | Chemical properties | Mass spectrometry | Identification and classification | Methods | High performance liquid chromatography | Arsenic compounds
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