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Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2012, Volume 55, Issue 3, pp. 1303 - 1317
Journal Article
Tetrahedron, ISSN 0040-4020, 10/2012, Volume 68, Issue 41, pp. 8523 - 8538
Journal Article
Molecular Cell, ISSN 1097-2765, 2000, Volume 6, Issue 4, pp. 909 - 919
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 08/2012, Volume 31, Issue 32, pp. 3655 - 3666
Somatic missense mutations in PIK3CA, which encodes the p110 alpha catalytic subunit of phosphoinositide 3-kinases, occur frequently in human cancers.... 
p110a | crystal structure | growth factor signalling | PIK3CA mutations | inhibitor | lipid binding | DOMAIN | P110-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE-C-ALPHA | PI3K-ALPHA | PHOSPHOINOSITIDE 3-KINASE | PHOSPHATIDYLINOSITOL 3'-KINASE | CANCER | CELL BIOLOGY | PI3K | ONCOLOGY | PATHWAY | GENETICS & HEREDITY | p110 alpha | Sequence Deletion | Class I Phosphatidylinositol 3-Kinases - genetics | Humans | Molecular Sequence Data | Crystallography, X-Ray | Cholesterol - chemistry | Class Ia Phosphatidylinositol 3-Kinase - chemistry | Enzyme Activators - chemistry | Protein Structure, Quaternary | Class Ia Phosphatidylinositol 3-Kinase - genetics | Amino Acid Sequence | Phosphopeptides - chemistry | Catalytic Domain | Protein Structure, Secondary | Class I Phosphatidylinositol 3-Kinases - chemistry | Phosphatidylserines - chemistry | Models, Molecular | Phosphatidylcholines - chemistry | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Chromones - chemistry | Liposomes - chemistry | Animals | Hydrophobic and Hydrophilic Interactions | Protein Binding | Mice | Aniline Compounds - chemistry | Enzyme Activation | Phosphatidylethanolamines - chemistry | Amino Acid Substitution | Tyrosine | Care and treatment | Peptides | Crystals | Chemical properties | Research | Structure | Cancer | Signal transduction | Lipids | Mutation | Kinases | Gene expression | Binding sites | Regulatory subunits | Hydrophobicity | Electrostatic properties | phosphoinositides | 1-Phosphatidylinositol 3-kinase | Allosteric properties | Missense mutation | Classification | Lipid kinase | Protein-tyrosine kinase receptors | Growth factors | Catalytic subunits | Crystal structure | p110alpha
Journal Article