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Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 8011 - 13
The three-dimensional organization of the genome in mammalian interphase nuclei is intrinsically linked to the regulation of gene expression. Whole chromosome... 
Lupus | Dosage compensation | Cell lineage | Genomes | Gene expression | Nuclei | Embryogenesis | Systemic lupus erythematosus | Functional morphology | Lymphocytes | Somatic cells | X Chromosomes | Chromosomes
Journal Article
MOLECULAR CYTOGENETICS, ISSN 1755-8166, 08/2019, Volume 12, Issue 1, pp. 37 - 5
Long telomeres, the protective caps of eukaryotic chromosomes, which erode during aging, have been the symbol of youth and regenerative potential. It therefore... 
Telomere erosion | Telomeres | ANEUPLOIDY | GENETICS & HEREDITY | Paternal age at conception | PATERNAL AGE | Transgenerational | Birth-cohort effect | Germline | Youth | Teenagers | Telomerase | Analysis | Natural selection | Yeast | Aging | Chromosomes | Geriatrics | Erosion
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 10554 - 10
The human kidney embryonic 293 cell line (293 cells) is extensively used in biomedical and pharmaceutical research. These cells exhibit a number of numerical... 
HEK293 | MULTIDISCIPLINARY SCIENCES | PHENOTYPE | FISH | M5 CELLS | ABERRATIONS | CANCER | CHROMOSOMAL INSTABILITY | Breakpoints | Chromosome translocations | Ionizing radiation | Chromosome number | Fluorescence in situ hybridization | Cytogenetics | Hybridization | Chromosome rearrangements | Chromosomes | Embryos
Journal Article
Journal Article
by Han, HM and Liu, WH and Zhang, JP and Zhou, SH and Yang, XM and Li, XQ and Li, LH
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 9712 - 9
Agropyron cristatum (L.) Gaertn. (P genome) is cultivated as pasture fodder and can provide many desirable genes for wheat improvement. With the development of... 
HOMOEOLOGOUS RELATIONSHIP | DNA-SEQUENCES | HEXAPLOID WHEAT | MULTIDISCIPLINARY SCIENCES | IN-SITU HYBRIDIZATION | REPETITIVE SEQUENCES | REARRANGEMENTS | GAERTN | INTROGRESSION | PROBES | OLIGONUCLEOTIDES | DNA probes | Pasture | Fluorescence in situ hybridization | Genomes | Hybridization | Phylogeny | Chromosomes
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 08/2019, Volume 9, Issue 1, pp. 11944 - 8
Aneuploidy, defined as abnormal chromosome number or somatic DNA copy number, is a characteristic of many aggressive tumors and is thought to drive... 
GENOMIC INSTABILITY | IMPACT | MULTIDISCIPLINARY SCIENCES | CELL-CYCLE | CHECKPOINT | CANCER | CHROMOSOMAL INSTABILITY | Aneuploidy | Tumorigenesis | Gene expression | Copy number | Chromosome number
Journal Article
Journal Article
BMC Genomics, ISSN 1471-2164, 04/2019, Volume 20, Issue 1, pp. 290 - 12
Background: Diverse stresses including genotoxic therapy can induce proliferating cancer cells to undergo cellular senescence and take on the characteristic... 
Radiation-induced senescence | Transcriptome analysis | Connectivity map analysis | DNA damage foci | Upstream regulator factors | Small molecule inhibitors | Differential expression genes | p21-induced senescence | CANCER-CELLS | OXIDATIVE STRESS | SECRETORY PHENOTYPE | PROTEIN | BIOMARKER | CONNECTIVITY MAP | DRUG DISCOVERY | PROLIFERATION | RADIATION | INHIBITION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | Cellular Senescence - genetics | Small Molecule Libraries - pharmacology | Computational Biology - methods | MCF-7 Cells | Humans | Cellular Senescence - drug effects | Transcriptome - drug effects | p21-Activated Kinases - metabolism | Ionizing radiation | Care and treatment | DNA microarrays | Genes | Vorinostat | Estrogen | Histones | Genetic transcription | Health aspects | DNA repair | Fulvestrant | Cancer | Aging | Research | Gene expression | Systems biology | Analysis | Cancer cells | Therapy | Oxidative stress | Regulators | Senescence | Transcription | Genomics | Estrogens | DNA damage | Genotoxicity | Radiation | Systems analysis | Kinases | Cancer therapies | Cyclin-dependent kinase | Genotype & phenotype | Cell cycle | Deoxyribonucleic acid--DNA | Inducers | Predictive control | Phenotypes | Cyclin-dependent kinases | Cloning | Breast cancer | Histone acetyltransferase | Cyclin-dependent kinase inhibitor p21 | Inhibitors | Irradiation | Connectivity | Radiation damage | Chromosome aberrations
Journal Article
MOLECULAR CYTOGENETICS, ISSN 1755-8166, 07/2019, Volume 12, Issue 1, pp. 32 - 5
BackgroundAcute promyelocytic leukemia (APL) is characterized by fusion of PML/RAR alpha genes as a result of t(15;17)(q24;q21). APL is now one of the curable... 
LOCALIZATION | ABNORMALITIES | Molecular cytogenetics | c-myc gene | TRANS-RETINOIC ACID | T(7/8)(Q34,Q21) | Painting | RELAPSE | Acute promyelocytic leukemia | Chromosome 8 | DISEASE | GENETICS & HEREDITY | FISH | SITES | EXTRAMEDULLARY INVOLVEMENT
Journal Article