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1. Full Text Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics: Part II. Strategies to reduce scar formation after dermatologic procedures
by Tziotzios, Christos and Profyris, Christos and Sterling, Jane
Journal of the American Academy of Dermatology, ISSN 0190-9622, 01/2012, Volume 66, Issue 1, pp. 13 - 24
The evidence base underpinning most traditional scar reduction approaches is limited, but some of the novel strategies are promising and accumulating. We... 
cutaneous scar reduction strategies | antiscarring agents | CONTROLLED-TRIAL | PULSED-DYE-LASER | INTRALESIONAL 5-FLUOROURACIL | ONION EXTRACT GEL | STERNOTOMY SCARS | HYPERTROPHIC SCARS | FIBROBLAST COLLAGEN-SYNTHESIS | DERMATOLOGY | COSMETIC OUTCOMES | DERMAL FIBROBLASTS | NONABSORBABLE SUTURES | Bandages | Cicatrix - prevention & control | Keloid - therapy | Humans | Risk Factors | Keloid - prevention & control | Dermatologic Agents | Keloid - physiopathology | Cicatrix - physiopathology | Cicatrix, Hypertrophic - prevention & control | Cicatrix, Hypertrophic - therapy | Skin - physiopathology | Wound Healing - drug effects | Cicatrix - therapy | Cicatrix, Hypertrophic - physiopathology
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2. Full Text Updated International Clinical Recommendations on Scar Management: Part 2—Algorithms for Scar Prevention and Treatment
by Gold, Michael H and McGuire, Michael and Mustoe, Thomas A and Pusic, Andrea and Sachdev, Mukta and Waibel, Jill and Murcia, Crystal and International Advisory Panel on Scar Management
Dermatologic Surgery, ISSN 1076-0512, 08/2014, Volume 40, Issue 8, pp. 825 - 831
BACKGROUNDIn 2002, an international advisory panel was convened to assess the scientific literature and develop evidence-based guidance for the prevention and... 
SURGERY | SCALES | HYPERTROPHIC SCARS | KELOIDS | DERMATOLOGY | Skin Physiological Phenomena | Algorithms | Cicatrix - classification | Cicatrix - prevention & control | Humans | Cicatrix - pathology | Cicatrix - therapy
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3. Full Text Improving cutaneous scar formation by controlling the mechanical environment: Large animal and phase i studies
by Gurtner, Geoffrey C and Dauskardt, Reinhold H and Wong, Victor W and Bhatt, Kirit A and Wu, Kenneth and Vial, Ivan N and Padois, Karine and Korman, Joshua M and Longaker, Michael T
Annals of Surgery, ISSN 0003-4932, 08/2011, Volume 254, Issue 2, pp. 217 - 225
Objective: To test the hypothesis that the mechanical environment of cutaneous wounds can control scar formation. Background: Mechanical forces have been... 
FIBROSIS | SURGERY | PAPER TAPE | REPAIR | MANAGEMENT | HYPERTROPHIC SCAR | SKIN | MODEL | Bandages | Humans | Middle Aged | Cicatrix, Hypertrophic - pathology | Abdominal Wall - surgery | Young Adult | Surgical Wound Dehiscence - physiopathology | Abdominal Wall - pathology | Swine | Cicatrix - physiopathology | Adult | Female | Skin - pathology | Disease Models, Animal | Compressive Strength - physiology | Risk Factors | Surgical Wound Dehiscence - pathology | Biomechanical Phenomena - physiology | Silicone Elastomers | Animals | Fibrosis | Cicatrix - pathology | Cicatrix, Hypertrophic - prevention & control | Wound Healing - physiology | Abdominal Wall - physiopathology | Skin - physiopathology | Cicatrix, Hypertrophic - physiopathology | Reconstructive Surgical Procedures
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4. Full Text Keloids and Hypertrophic Scars: Pathophysiology, Classification, and Treatment
by Berman, Brian and Maderal, Andrea and Raphael, Brian
Dermatologic Surgery, ISSN 1076-0512, 01/2017, Volume 43 Suppl 1, pp. S3 - S18
BACKGROUNDKeloid and hypertrophic scars represent an aberrant response to the wound healing process. These scars are characterized by dysregulated growth with... 
SURGERY | IN-VITRO | IMIQUIMOD 5-PERCENT CREAM | COLLAGEN BIOSYNTHESIS | BEAM RADIATION-THERAPY | EPIDERMAL-GROWTH-FACTOR | FETAL WOUND REPAIR | GENE-EXPRESSION | DOXORUBICIN-INDUCED INHIBITION | INTRALESIONAL TRIAMCINOLONE ACETONIDE | EXCISED KELOIDS | DERMATOLOGY | Cicatrix, Hypertrophic - classification | Keloid - physiopathology | Keloid - classification | Algorithms | Keloid - therapy | Cicatrix - physiopathology | Humans | Cicatrix, Hypertrophic - therapy | Wound Healing - physiology | Cicatrix, Hypertrophic - physiopathology
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5. Full Text Hypertrophic scarring: the greatest unmet challenge after burn injury
by Finnerty, Celeste C, Dr and Jeschke, Marc G, Prof and Branski, Ludwik K, MD and Barret, Juan P, Prof and Dziewulski, Peter, FRCS and Herndon, David N, Prof
Lancet, The, ISSN 0140-6736, 2016, Volume 388, Issue 10052, pp. 1427 - 1436
Summary Improvements in acute burn care have enabled patients to survive massive burns that would have once been fatal. Now up to 70% of patients develop... 
Internal Medicine | NUDE-MOUSE MODEL | MEDICINE, GENERAL & INTERNAL | SKIN SUBSTITUTE | STEM-CELLS | RISK-FACTORS | SCARS | MANAGEMENT | EX-VIVO EVALUATION | DERMAL SUBSTITUTE | CULTURED SKIN | ASSESSMENT SCALE | Dermatologic Agents - administration & dosage | Humans | Laser Therapy | Visual Analog Scale | Transplantation, Autologous | Administration, Cutaneous | Wound Healing | Transplantation, Homologous | Patient Satisfaction | Burns - metabolism | Pruritus - etiology | Burns - complications | Disease Models, Animal | Cicatrix, Hypertrophic - etiology | Surgical Mesh - utilization | Skin Transplantation - trends | Treatment Outcome | Skin Transplantation - methods | Phototherapy | Animals | Burns - pathology | Quality of Life | Burns - physiopathology | Cicatrix, Hypertrophic - therapy | Cicatrix, Hypertrophic - surgery | Cicatrix, Hypertrophic - physiopathology | Compression Bandages | Burns and scalds | Surgery, Plastic | Care and treatment | Health aspects | Wounds and injuries | Children's hospitals | Scars | Wound healing | Collagen | Fibroblasts | Plastic surgery | Burns | Patients | Burn treatment
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6. Full Text Understanding the origin, activation and regulation of matrix‐producing myofibroblasts for treatment of fibrotic disease
by Kramann, Rafael and DiRocco, Derek P and Humphreys, Benjamin D
The Journal of Pathology, ISSN 0022-3417, 11/2013, Volume 231, Issue 3, pp. 273 - 289
Fibrosis and scar formation results from chronic progressive injury in virtually every tissue and affects a growing number of people around the world.... 
interstitium | fibrosis | pericyte | myofibroblast | TGF-BETA | BLEOMYCIN-INDUCED PNEUMONOPATHY | PATHOLOGY | FACTOR-ALPHA | GROWTH-FACTOR RECEPTOR | AMELIORATES RENAL FIBROSIS | TO-MESENCHYMAL TRANSITION | ONCOLOGY | MARROW-DERIVED CELLS | INTERSTITIAL FIBROSIS | ALVEOLAR MACROPHAGES | PULMONARY-FIBROSIS | Myofibroblasts - pathology | Cell Proliferation | Cicatrix - immunology | Signal Transduction | Myofibroblasts - immunology | Humans | Pericytes - metabolism | Extracellular Matrix - metabolism | Myofibroblasts - metabolism | Cell Lineage | Cicatrix - metabolism | Pericytes - immunology | Animals | Pericytes - pathology | Fibrosis | Cell Transdifferentiation | Cicatrix - pathology | Extracellular Matrix - pathology | Cicatrix - therapy | Stem cells
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7. Full Text Effect of skin graft thickness on scar development in a porcine burn model
by DeBruler, Danielle M and Blackstone, Britani N and McFarland, Kevin L and Baumann, Molly E and Supp, Dorothy M and Bailey, J. Kevin and Powell, Heather M
Burns, ISSN 0305-4179, 06/2018, Volume 44, Issue 4, pp. 917 - 930
Animal models provide a way to investigate scar therapies in a controlled environment. It is necessary to produce uniform, reproducible scars with high... 
Autograft thickness | Mesh ratio | Scar | Porcine model | SURGERY | ACTIVATES TGF-BETA | FACTOR-I | HUMAN HYPERTROPHIC SCAR | DERMATOLOGY | RED DUROC PIG | GROWTH-FACTOR-BETA | PRESSURE GARMENT THERAPY | ENHANCED EXPRESSION | MESSENGER-RNA | DERMAL FIBROBLASTS | SPLIT-THICKNESS | CRITICAL CARE MEDICINE | Cicatrix, Hypertrophic - etiology | Cicatrix - etiology | Matrix Metalloproteinase 2 - metabolism | Cicatrix, Hypertrophic - metabolism | Transforming Growth Factor beta1 - metabolism | Organ Size | Skin Transplantation - methods | Cicatrix, Hypertrophic - pathology | Autografts - anatomy & histology | Cicatrix - metabolism | Animals | Swine | Burns - surgery | Cicatrix - pathology | Autografts - metabolism | Burns - complications | Sus scrofa | Insulin-Like Growth Factor I - metabolism | Bone morphogenetic proteins | Skin | Transforming growth factors | Analysis
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8. Full Text Suppressed inflammatory gene expression during human hypertrophic scar compared to normotrophic scar formation
by van den Broek, L.J and van der Veer, W.M and de Jong, E.H and Gibbs, S and Niessen, F.B
Experimental dermatology, ISSN 0906-6705, 2015, Volume 24, Issue 8, pp. 623 - 629
Hypertrophic scar formation is a result of adverse cutaneous wound healing. The pathogenesis of hypertrophic scar formation is still poorly understood. A... 
hypertrophic | normotrophic | scar | inflammation | human | Human | Inflammation | Hypertrophic | Scar | Normotrophic | GROWTH-FACTOR-BETA | 14-3-3 PROTEINS | CHEMOKINES | KERATINOCYTES | DERMAL FIBROBLASTS | DERMATOLOGY | Angiogenic Proteins - genetics | 14-3-3 Proteins - biosynthesis | Extracellular Matrix Proteins - biosynthesis | Cicatrix, Hypertrophic - metabolism | Humans | Postoperative Complications - metabolism | Cicatrix, Hypertrophic - pathology | Cicatrix - metabolism | Cicatrix, Hypertrophic - genetics | Inflammation Mediators - metabolism | Postoperative Complications - genetics | Wound Healing - genetics | Cytokines - genetics | Real-Time Polymerase Chain Reaction | Angiogenic Proteins - biosynthesis | 14-3-3 Proteins - genetics | Postoperative Complications - pathology | Macrophages - physiology | Sternotomy | Neovascularization, Physiologic - genetics | Extracellular Matrix Proteins - genetics | Gene Expression Regulation | Cicatrix - genetics | Biopsy | Cicatrix - pathology | Cytokines - biosynthesis
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9. Full Text The lived experience and quality of life with burn scarring—The results from a large-scale online survey
by Brewin, M.P and Homer, S.J
Burns, ISSN 0305-4179, 11/2018, Volume 44, Issue 7, pp. 1801 - 1810
A large-scale online survey was designed to both inform and direct the development of an online community healthcare hub for people living with scarring.... 
Burn scar | Psychosocial | Survey | Psychology | Themes | Scarring | Content analysis | Quality of life | SURGERY | SCARS | POSTTRAUMATIC-STRESS | DERMATOLOGY | RUMINATION | GROWTH | CRITICAL CARE MEDICINE | Cicatrix - etiology | Keloid - etiology | Humans | Middle Aged | Male | Cicatrix - psychology | Young Adult | Cicatrix - physiopathology | Adult | Female | Surveys and Questionnaires | Social Distance | Burns - complications | Cicatrix, Hypertrophic - etiology | Anxiety - psychology | Social Support | Physical Appearance, Body | Cicatrix, Hypertrophic - psychology | Keloid - physiopathology | Burns - psychology | Aftercare | Keloid - psychology | Adolescent | Quality of Life | Burns - physiopathology | Internet | Qualitative Research | Cicatrix, Hypertrophic - physiopathology | Adaptation, Psychological | Surveys | Social networks | Health care industry | Burns and scalds | Information management
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10. Full Text The effects of conservative treatments on burn scars: A systematic review
by Anthonissen, Mieke and Daly, Daniel and Janssens, Thaïs and Van den Kerckhove, Eric
Burns, ISSN 0305-4179, 2015, Volume 42, Issue 3, pp. 508 - 518
Highlights • Pressure and silicone therapy are evidence-based treatments of hypertrophic scars. • Pressure therapy improves thickness and probably decreases... 
Critical Care | Burn scar | Systematic review | Conservative treatment | SURGERY | MANAGEMENT | GUIDELINES | PREVENTION | MASSAGE | TOPICAL SILICONE GEL | RANDOMIZED CONTROLLED-TRIAL | HYPERTROPHIC SCARS | DERMATOLOGY | PRESSURE GARMENT THERAPY | REHABILITATION | CICA-CARE | CRITICAL CARE MEDICINE | Cicatrix, Hypertrophic - etiology | Cicatrix - etiology | Humans | Conservative Treatment | Silicone Gels - therapeutic use | Pruritus - therapy | Skin Cream - therapeutic use | Burns - therapy | Pruritus - etiology | Pruritus - prevention & control | Cicatrix, Hypertrophic - prevention & control | Cicatrix, Hypertrophic - therapy | Massage | Burns - complications | Cicatrix - therapy | Compression Bandages | Burns and scalds | Surgery, Plastic | Toiletries industry | Usage | Silicones | Analysis
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