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1. Full Text Thermally induced solid-state transformation of cimetidine. A multi-spectroscopic/chemometrics determination of the kinetics of the process and structural elucidation of one of the products as a stable N.sub.3-enamino tautomer
by Calvo, Natalia L and Simonetti, Sebastian O and Maggio, RubeN M and Kaufman, Teodoro S
Analytica Chimica Acta, ISSN 0003-2670, 05/2015, Volume 875, p. 22
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Cimetidine
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2. Full Text Hypertensive response to stress: The role of histaminergic H.sub.1 and H.sub.2 receptors in the medial amygdala
by De Almeida, Daniela Oliveira and Ferreira, Hilda Silva and Pereira, Luana Bomfim and Fregoneze, Josmara Bartolomei
Physiology & Behavior, ISSN 0031-9384, 05/2015, Volume 144, p. 95
Different brain areas seem to be involved in the cardiovascular responses to stress. The medial amygdala (MeA) has been shown to participate in cardiovascular... 
Hypertension | Cimetidine
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3. Full Text Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen–cimetidine mixtures prepared by mechanical activation
by Allesø, Morten and Chieng, Norman and Rehder, Sönke and Rantanen, Jukka and Rades, Thomas and Aaltonen, Jaakko
Journal of Controlled Release, ISSN 0168-3659, 2009, Volume 136, Issue 1, pp. 45 - 53
Naproxen, a non-steroidal anti-inflammatory drug (NSAID), is a biopharmaceutics classification system (BCS) class II drug whose bioavailability is rate-limited... 
Amorphous | Intrinsic dissolution | Stability | Naproxen–cimetidine | Milling | Naproxen-cimetidine | FEASIBILITY | RAMAN-SPECTROSCOPY | INDOMETHACIN | DOSAGE FORMS | CYCLODEXTRINS | CHEMISTRY, MULTIDISCIPLINARY | SOLID-STATE | SOLUBILITY | PHYSICOCHEMICAL PROPERTIES | PHARMACOLOGY & PHARMACY | CRYSTALLINE | Drug Compounding | Cimetidine - chemistry | Drug Stability | Drug Combinations | Solubility | Naproxen - chemistry | Raman spectroscopy | Naproxen | Cimetidine
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4. Full Text Benefit-and-cost analysis of medical interventions
: the case of cimetidine and peptic ulcer disease
by Fineberg, Harvey V and Pearlman, Laurie A and United States. Congress.Office of Technology Assessment
1981, The Implications of cost-effectiveness analysis of medical technology. Background paper, Volume no. 2. Case studies of medical technologies ; no. 11
economics | Medical technology | drug therapy | Cost effectiveness | Medical instruments and apparatus | Cost-Benefit Analysis | Cimetidine | Peptic ulcer | Guanidines | therapeutic use
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5. Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney
by Ito, Sumito and Kusuhara, Hiroyuki and Yokochi, Miyu and Toyoshima, Junko and Inoue, Katsuhisa and Yuasa, Hiroaki and Sugiyama, Yuichi
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 393 - 403
Cimetidine, an H 2 receptor antagonist, has been used to investigate the tubular secretion of organic cations in human kidney. We report a systematic... 
RENAL TUBULAR SECRETION | METFORMIN | CLEARANCE | PROCAINAMIDE | MEMBRANE | IN-VIVO | HUMANS | ELIMINATION | PHARMACOLOGY & PHARMACY | FUNCTIONAL-CHARACTERIZATION | RANITIDINE | Tetraethylammonium - pharmacokinetics | Cimetidine - pharmacokinetics | Humans | Cephalexin - metabolism | Male | Organic Cation Transporter 1 - metabolism | Metformin - metabolism | Organic Cation Transporter 2 | Organic Cation Transporter 1 - genetics | Dose-Response Relationship, Drug | Kidney - metabolism | Organic Cation Transport Proteins - antagonists & inhibitors | Transfection | Liver - drug effects | Metformin - urine | Organic Cation Transport Proteins - drug effects | Tetraethylammonium - urine | 3-Iodobenzylguanidine - metabolism | HEK293 Cells | Biological Transport - drug effects | 1-Methyl-4-phenylpyridinium - metabolism | Metformin - administration & dosage | Cimetidine - administration & dosage | Metformin - blood | Binding, Competitive - physiology | Kidney - drug effects | Metformin - pharmacokinetics | Organic Cation Transport Proteins - metabolism | Tetraethylammonium - administration & dosage | Cephalexin - administration & dosage | Liver - metabolism | Cephalexin - urine | Mice, Inbred Strains | Tetraethylammonium - blood | Animals | Pyridines - metabolism | Tetraethylammonium - metabolism | Drug Interactions - physiology | Organic Cation Transporter 1 - antagonists & inhibitors | Cimetidine - pharmacology | Cimetidine - metabolism | Mice | Organic Cation Transporter 1 - drug effects | Kinetics | Organic Cation Transport Proteins - genetics | Cephalexin - blood | Cephalexin - pharmacokinetics
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6. Full Text Inhibition of brain [ 3H]cimetidine binding by improgan-like antinociceptive drugs
by Stadel, Rebecca and Carpenter, Amanda B and Nalwalk, Julia W and de Esch, Iwan J.P and Janssen, Elwin and Hough, Lindsay B
European Journal of Pharmacology, ISSN 0014-2999, 2010, Volume 632, Issue 1, pp. 33 - 38
[ H]cimetidine, a radiolabeled histamine H receptor antagonist, binds with high affinity to an unknown hemoprotein in the brain which is not the histamine H... 
Binding | 3[H]cimetidine | Antinociception | Histamine H 2 receptor | Improgan | Cimetidine | receptor | Histamine H | [H]cimetidine | H-2-RECEPTOR | Histamine H-2 receptor | RODENT ANTINOCICEPTION | CIMETIDINE ANALOG | OPIOID RECEPTOR | AFFINITY | PHARMACOLOGY & PHARMACY | MICE | RAT-BRAIN | HISTAMINE | ANTAGONISTS | RECEPTOR-BINDING | Analgesics - pharmacology | Rats | Male | Pain - metabolism | Rats, Sprague-Dawley | Brain - metabolism | Dose-Response Relationship, Drug | Histamine - metabolism | Histamine H2 Antagonists - metabolism | Animals | Analgesics - chemistry | Cimetidine - antagonists & inhibitors | Cimetidine - chemistry | Cimetidine - analogs & derivatives | Cimetidine - pharmacology | Molecular Structure | Binding Sites
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7. Full Text Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models
by Hansmann, Simone and Darwich, Adam and Margolskee, Alison and Aarons, Leon and Dressman, Jennifer
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 12/2016, Volume 68, Issue 12, pp. 1501 - 1515
ObjectivesThe aim of this study was (1) to determine how closely physiologically based pharmacokinetic (PBPK) models can predict oral bioavailability using a... 
biopharmaceutics classification system | absorption | bioavailability | permeability | physiologically based pharmacokinetics | NIFEDIPINE | PHARMACOLOGY & PHARMACY | Nifedipine - pharmacokinetics | Furosemide - administration & dosage | Cimetidine - pharmacokinetics | Humans | Biological Availability | Bisoprolol - pharmacokinetics | Bisoprolol - chemistry | Nifedipine - administration & dosage | Biotransformation | Cimetidine - chemistry | Computer Simulation | Drug Compounding | Cimetidine - administration & dosage | Nifedipine - chemistry | Reproducibility of Results | Gastrointestinal Absorption | Administration, Oral | Furosemide - pharmacokinetics | Permeability | Forecasting | Furosemide - chemistry | Bisoprolol - administration & dosage | Administration, Intravenous | Furosemide - classification | Animals | Models, Biological | Biopharmaceutics - methods | Nifedipine - classification | Cimetidine - classification | Bisoprolol - classification | Antihypertensive drugs | Forecasts and trends | Models | Analysis | Cimetidine | Classification
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8. Full Text Antinociceptive activity of CC44, a biotinylated improgan congener
by Hoerbelt, Paul and Nalwalk, Julia W and Phillips, James G and Wentland, Mark P and Shan, Zhixing and Hough, Lindsay B
European Journal of Pharmacology, ISSN 0014-2999, 08/2013, Volume 714, Issue 1-3, pp. 464 - 471
Improgan, a non-opioid, antinociceptive drug, activates descending analgesic circuits following brain administration, but the improgan receptor remains... 
Analgesia | Biotin | Pain | Improgan | Neuropathic pain | NERVOUS-SYSTEM | LIGAND-BINDING | MORPHINE | RATS | CIMETIDINE ANALOG | DEPENDENT MULTIVITAMIN TRANSPORTER | PHARMACOLOGY & PHARMACY | HISTAMINE-ANTAGONISTS | ANALGESICS | CB1 RECEPTORS | Cimetidine - therapeutic use | Analgesics - pharmacology | Analgesics - therapeutic use | Neurons - pathology | Biotinylation | Analgesics - metabolism | Rats | Male | Avidin - metabolism | Animals | Hyperalgesia - drug therapy | Streptavidin - metabolism | Analgesics - chemistry | Cimetidine - chemistry | Cimetidine - analogs & derivatives | Cimetidine - pharmacology | Cimetidine - metabolism | Medulla Oblongata - pathology | Mice | Neurons - drug effects | Analgesics | Analysis | improgan | pain | neuropathic pain | analgesia | biotin
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9. Full Text Influence of cimetidine and experimental diabetes mellitus on gabapentin pharmacokinetics in rats
by de Lima Benzi, Jhohann Richard and Yamamoto, Priscila Akemi and Baviera, Amanda Martins and de Moraes, Natalia Valadares
Toxicology Letters, ISSN 0378-4274, 10/2017, Volume 280, pp. S109 - S109
Diabetes | Gabapentin | Drug therapy | Cimetidine
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10. Full Text Segmental-dependent membrane permeability along the intestine following oral drug administration: Evaluation of a triple single-pass intestinal perfusion (TSPIP) approach in the rat
by Dahan, Arik and West, Brady T and Amidon, Gordon L
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 02/2009, Volume 36, Issue 2-3, pp. 320 - 329
In this paper we evaluate a modified approach to the traditional single-pass intestinal perfusion (SPIP) rat model in investigating segmental-dependent... 
Intestinal absorption | Oral administration | Rat perfusion | Segmental-dependent permeability | DIFFERENT REGIONS | VIVO | GASTROINTESTINAL-TRACT | CLASSIFICATION | PH-METRIC SOLUBILITY | PREDICTION | PHYSICOCHEMICAL PROPERTIES | IN-VITRO | TRANSPORT | PHARMACOLOGY & PHARMACY | ABSORPTION | Rats, Wistar | Administration, Oral | Cimetidine - pharmacokinetics | Ileum - metabolism | Rats | Male | Metoprolol - administration & dosage | Permeability | Intestinal Absorption | Jejunum - metabolism | Propranolol - pharmacokinetics | Metoprolol - pharmacokinetics | Perfusion - methods | Algorithms | Animals | Propranolol - administration & dosage | Propranolol - metabolism | Cimetidine - metabolism | Metoprolol - metabolism | Models, Animal | Intestine, Small - metabolism | Cimetidine - administration & dosage | Propranolol hydrochloride | Metoprolol | Cimetidine
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11. Full Text A method to determine pharmacokinetic parameters based on andante constant-rate intravenous infusion
by Yu, Rui-Hong and Cao, Yong-Xiao
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 13279 - 8
On account of the disturbance from the distribution phase, the concentration-time curve of drugs cannot fully reflect the characteristics of elimination, and... 
MULTIDISCIPLINARY SCIENCES | Models, Theoretical | Tissue Distribution | Algorithms | Animals | Time Factors | Cimetidine - pharmacokinetics | Dogs | Infusions, Intravenous | Kinetics | Cimetidine - administration & dosage | Data processing | Mathematical models | Intravenous administration | Calculi | Cimetidine | Blood levels
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12. Full Text Interventions for cutaneous molluscum contagiosum
by van der Wouden, Johannes C and van der Sande, Renske and Kruithof, Emma J and Sollie, Annet and van Suijlekom-Smit, Lisette W.A and Koning, Sander
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 05/2017, Volume 2017, Issue 5, p. CD004767
Background Molluscum contagiosum is a common skin infection that is caused by a pox virus and occurs mainly in children. The infection usually resolves within... 
HUMAN IMMUNODEFICIENCY VIRUS | MEDICINE, GENERAL & INTERNAL | TOPICAL CIDOFOVIR | POTASSIUM HYDROXIDE SOLUTION | IMIQUIMOD 5-PERCENT CREAM | LIDOCAINE-PRILOCAINE CREAM | FACIAL MOLLUSCUM | ESSENTIAL OIL | DOUBLE-BLIND | ORAL CIMETIDINE | CHILDREN | Cimetidine - therapeutic use | Molluscum Contagiosum - therapy | Anti-Infective Agents, Local - therapeutic use | Benzoyl Peroxide - therapeutic use | Imiquimod | Humans | Molluscum Contagiosum - drug therapy | Plant Oils - therapeutic use | Myrtus | Randomized Controlled Trials as Topic | Povidone-Iodine - therapeutic use | Salicylic Acid - therapeutic use | Sodium Nitrite - therapeutic use | Olive Oil - therapeutic use | Remission, Spontaneous | Potassium Compounds - therapeutic use | Hydroxides - therapeutic use | Phytotherapy - methods | Adjuvants, Immunologic - therapeutic use | Aminoquinolines - therapeutic use
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13. Full Text Qualitative and simultaneous quantitative analysis of cimetidine polymorphs by ultraviolet–visible and shortwave near-infrared diffuse reflectance spectroscopy and multivariate calibration models
by Feng, Yuyan and Li, Hui and Li, Xiangling and Xu, Kailin and Zou, Huayu and Liang, Bing
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 02/2015, Volume 104, pp. 112 - 121
The object of the present study was to investigate the feasibility of applying ultraviolet-visible and shortwave near-infrared diffuse reflectance spectroscopy... 
Ultraviolet–visible and shortwave near-infrared diffuse reflectance spectroscopy | Partial least squares | Cimetidine polymorphs | Least squares-support vector machine | Ultraviolet-visible and shortwave near-infrared diffuse reflectance spectroscopy | DRUG | SUPPORT VECTOR MACHINES | CHEMISTRY, ANALYTICAL | SOLID-STATE NMR | QUANTIFICATION | RAMAN-SPECTROSCOPY | CARBAMAZEPINE | FORMS | NIR | DIFFRACTION | PHARMACOLOGY & PHARMACY | RAY-POWDER DIFFRACTOMETRY | Photoelectron Spectroscopy - methods | Cimetidine - chemistry | Calibration | Spectroscopy, Near-Infrared - methods | X-Ray Diffraction - methods | Cimetidine - analysis | Crystallization - methods | Analysis | Cimetidine | Index Medicus
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14. Full Text OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine
by Wang, Zhi-Jun and Yin, Ophelia Q.P and Tomlinson, Brian and Chow, Moses S.S
Pharmacogenetics and Genomics, ISSN 1744-6872, 07/2008, Volume 18, Issue 7, pp. 637 - 645
PURPOSEGenetic polymorphisms of organic cation transporter 2 (OCT2) have been recently described, but their genotype–phenotype relationship in humans is... 
Organic cation transporter 2 polymorphism | Genotype-phenotype relationship | Metformin | Cimetidine | ORGANIC CATION TRANSPORTER | HUMAN PLASMA | ORGANIC-CATION-TRANSPORTER-1 | metformin | genotype-phenotype relationship | IDENTIFICATION | organic cation transporter 2 polymorphism | HUMAN KIDNEY | DIABETES-MELLITUS | THERAPY | PHARMACOKINETICS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | cimetidine | PHARMACOLOGY & PHARMACY | SECRETION | EXPRESSION | Kidney - physiology | Hypoglycemic Agents - pharmacokinetics | Kidney - drug effects | Metformin - pharmacokinetics | Gene Frequency | Humans | Male | Organic Cation Transporter 2 | Kidney - metabolism | Drug Interactions - genetics | Organic Cation Transport Proteins - antagonists & inhibitors | DNA Mutational Analysis | China | Cimetidine - pharmacology | Adult | Metabolic Clearance Rate - drug effects | Polymorphism, Single Nucleotide | Metformin - administration & dosage | Cimetidine - administration & dosage | Organic Cation Transport Proteins - genetics | Index Medicus
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15. Full Text A DFT study of the chemical reactivity of cimetidine A, C and D in the gas, H2O, MeOH and EtOH solvents
by Mendoza, Huizar and Salgado-Morán, Guillermo and Cardona-Villada, Wilson and Pacheco, Alison and Glossman-Mitnik, Daniel
Journal of the Serbian Chemical Society, ISSN 0352-5139, 2017, Volume 82, Issue 1, pp. 25 - 37
% Fukui % DFT s KR nema In the present work, we have analyzed the chemical reactivity of cimetidine A, C and D in different solvents; through the evaluation of... 
reactivity | Cimetidine | HS
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