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Neuroscience, ISSN 0306-4522, 2011, Volume 193, pp. 440 - 451
Abstract Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that... 
Neurology | mast cell tryptase | paclitaxel-induced pain | TRPV1 | TRPA1 | proteinase-activated receptor 2 | TRPV4 | Proteinase-activated receptor 2 | Mast cell tryptase | Paclitaxel-induced pain | NEUROSCIENCES | SENSORY NEURONS | CAPSAICIN RECEPTOR | MECHANICAL HYPERALGESIA | IN-VIVO | KINASE-C-EPSILON | ION-CHANNEL | PERIPHERAL NEUROPATHY | INFLAMMATORY PAIN | PROTEASE-ACTIVATED-RECEPTOR-2 SENSITIZES | IRRITABLE-BOWEL-SYNDROME | Tryptases - metabolism | Central Nervous System - metabolism | Capsaicin - pharmacology | Receptor, PAR-2 - metabolism | Type C Phospholipases - metabolism | Male | Neuralgia - pathology | Dose-Response Relationship, Drug | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Drug Interactions | Paclitaxel - toxicity | Time Factors | Protein Kinase C - metabolism | TRPV Cation Channels - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Neuralgia - chemically induced | Neuralgia - physiopathology | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mice, Inbred ICR | Hyperalgesia - physiopathology | Antineoplastic Agents, Phytogenic - toxicity | Gene Expression Regulation - drug effects | Pain Measurement - methods | Pyrroles - pharmacology | Animals | Analysis of Variance | Ankyrins - antagonists & inhibitors | Anilides - pharmacology | Ankyrins - metabolism | Central Nervous System - drug effects | Mice | Physical Stimulation - adverse effects | Carbazoles - pharmacology | Oligopeptides - pharmacology | Protein Kinase C - pharmacology | Enzymes | Care and treatment | Neurosciences | Paclitaxel | Phospholipases | Protein kinases | Cancer
Journal Article
Neuropsychopharmacology (New York, N.Y.), ISSN 1740-634X, 2008, Volume 34, Issue 3, pp. 593 - 606
Journal Article
Food chemistry, ISSN 0308-8146, 2016, Volume 213, pp. 196 - 205
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2008, Volume 154, Issue 5, pp. 1094 - 1103
Background and purpose: We investigated the mechanisms underlying the pruritogenic response induced by trypsin in mice, to assess the relevance of neurogenic... 
neuropeptides | Trypsin | PAR‐2 | TRPV1 | mast cells | scratching behaviour | PAR-2 | Neuropeptides | Mast cells | Scratching behaviour | PROTEINASE-ACTIVATED RECEPTOR-2 | NAFAMOSTAT MESILATE | HUMAN SKIN | PRURITUS | HUMAN KERATINOCYTES | ITCH | PAIN | IN-VIVO | HISTAMINE H-4 | PHARMACOLOGY & PHARMACY | trypsin | MAST-CELL TRYPTASE | Receptor, PAR-2 - metabolism | Male | Peptide Fragments - pharmacology | Antipruritics - pharmacology | Receptors, Calcitonin Gene-Related Peptide - metabolism | Quinolines - pharmacology | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Cromolyn Sodium - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Neurogenic Inflammation - chemically induced | Bradykinin Receptor Antagonists | Dioxoles - pharmacology | Behavior, Animal - drug effects | Pruritus - chemically induced | Disease Models, Animal | Injections, Intradermal | Pyrazoles - pharmacology | Reproducibility of Results | Plant Proteins - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Calcitonin Gene-Related Peptide - pharmacology | Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors | p-Methoxy-N-methylphenethylamine - pharmacology | Celecoxib | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mast Cells - drug effects | Trypsin - administration & dosage | TRPV Cation Channels - genetics | Mice, Knockout | Neurogenic Inflammation - prevention & control | Pruritus - metabolism | Animals | Receptors, Bradykinin - metabolism | Signal Transduction - drug effects | Nerve Fibers, Unmyelinated - metabolism | Anilides - pharmacology | Cyclooxygenase 2 - metabolism | Neurogenic Inflammation - metabolism | Pruritus - prevention & control | Mice | Oligopeptides - pharmacology | Cell Degranulation - drug effects | Index Medicus | Research Papers
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 01/2014, Volume 274, Issue 2, pp. 328 - 338
Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to... 
Early onset of fibrosis | Precision-cut liver slices | Antifibrotic drugs | Liver fibrosis | Ex vivo model | ROSMARINIC ACID | ANGIOTENSIN-II | ANTI-FIBROTIC DRUGS | IN-VITRO | INHIBITS ACTIVATION | HEPATIC STELLATE CELLS | ENDOPLASMIC-RETICULUM | DERMAL FIBROBLASTS | GROWTH-FACTOR | IMATINIB MESYLATE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Niacinamide - analogs & derivatives | Rats, Wistar | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | Male | Valproic Acid - pharmacology | Depsides - pharmacology | Perindopril - pharmacology | Collagen Type I - genetics | Liver - drug effects | Benzamides - pharmacology | Benzylisoquinolines - pharmacology | Organ Culture Techniques | Liver Cirrhosis - drug therapy | Gene Expression | Collagen Type I - metabolism | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Down-Regulation | Liver - metabolism | Rats | Becaplermin | Transforming Growth Factor beta1 - genetics | Pyrimidines - pharmacology | Cinnamates - pharmacology | HSP47 Heat-Shock Proteins - genetics | Imatinib Mesylate | Piperazines - pharmacology | Animals | Models, Biological | Sorafenib | HSP47 Heat-Shock Proteins - metabolism | Connective Tissue Growth Factor - genetics | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Connective Tissue Growth Factor - metabolism | Pyridones - pharmacology | Proto-Oncogene Proteins c-sis - antagonists & inhibitors | Drugs | Liver diseases | Analysis | Liver | Fibrosis | Gene expression | Growth factors | Index Medicus | FIBROSIS | DRUGS | GENES | LIVER | RATS | 60 APPLIED LIFE SCIENCES | ATP
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2002, Volume 99, Issue 22, pp. 14071 - 14076
Journal Article
by Fong, P and Hao, CH and Io, CC and Sin, PI and Meng, LR
MOLECULES, ISSN 1420-3049, 10/2019, Volume 24, Issue 19, p. 3608
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 2009, Volume 29, Issue 19, pp. 6088 - 6093
On bipolar cells are connected to photoreceptors via a sign-inverting synapse. At this synapse, glutamate binds to a metabotropic receptor which couples to the... 
CAPSAICIN RECEPTOR | RETINAL GANGLION-CELLS | METABOTROPIC GLUTAMATE-RECEPTOR | PATHWAY | DESENSITIZATION | MGLUR6 | MOUSE | TRP CHANNELS | G-PROTEIN | NEUROSCIENCES | STATIONARY NIGHT BLINDNESS | Propionates - pharmacology | Transient Receptor Potential Channels - antagonists & inhibitors | Synaptic Transmission - physiology | Capsaicin - pharmacology | Receptors, Metabotropic Glutamate - metabolism | Amino Acids - pharmacology | TRPV Cation Channels - metabolism | Retinal Bipolar Cells - physiology | TRPV Cation Channels - antagonists & inhibitors | Synaptic Transmission - drug effects | Ruthenium Red - metabolism | Transient Receptor Potential Channels - metabolism | Endocannabinoids | Xanthenes - pharmacology | Membrane Potentials - drug effects | Mice, Inbred C57BL | TRPV Cation Channels - agonists | TRPM Cation Channels - agonists | Capsaicin - analogs & derivatives | Excitatory Amino Acid Antagonists - pharmacology | Membrane Potentials - physiology | Cinnamates - pharmacology | Transient Receptor Potential Channels - agonists | Arachidonic Acids - pharmacology | Mice, Knockout | Animals | TRPM Cation Channels - antagonists & inhibitors | Anilides - pharmacology | Polyunsaturated Alkamides - pharmacology | Glutamic Acid - metabolism | Mice | TRPM Cation Channels - metabolism | Receptors, Metabotropic Glutamate - agonists | Brief Communications
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 01/2019, Volume 60, Issue 1, pp. 265 - 273
Journal Article