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American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 08/2013, Volume 305, Issue 3, pp. C276 - C289
Gain-of-function mutations in the transient receptor potential (TRP) cation channel subfamily C member 6 (TRPC6) gene and mutations in the NPHS2 gene encoding... 
Podocyte | Glomerular filtration | TRPC6 | Mechanosensitive | Slit diaphragm | glomerular filtration | BKCA CHANNELS | PHYSIOLOGY | PROTEIN | mechanosensitive | NEPHRIN | CAPILLARY WALL | SURFACE EXPRESSION | RECEPTOR | CELL BIOLOGY | GLOMERULAR SLIT DIAPHRAGM | CATION CHANNELS | podocyte | slit diaphragm | MUTATIONS | NEPHROTIC SYNDROME | ortho-Aminobenzoates - pharmacology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Spider Venoms - pharmacology | Cytochalasin D - pharmacology | Type C Phospholipases - antagonists & inhibitors | Nephrotic Syndrome | Diglycerides - pharmacology | RNA Interference | Estrenes - pharmacology | Pyrrolidinones - pharmacology | HEK293 Cells | Kidney Glomerulus - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | TRPC Cation Channels - genetics | Intracellular Signaling Peptides and Proteins - genetics | Phospholipase A2 Inhibitors | Guanosine Diphosphate - pharmacology | Cell Line | Podocytes - metabolism | Membrane Proteins - genetics | Phosphodiesterase Inhibitors - pharmacology | Rats | Imidazoles - pharmacology | Thionucleotides - pharmacology | Calcium Channel Blockers - pharmacology | Cinnamates - pharmacology | Peptides - pharmacology | Animals | Guanosine Diphosphate - analogs & derivatives | TRPC Cation Channels - metabolism | Chlorobenzoates - pharmacology | Mice | RNA, Small Interfering | Mutation | Ion Channel Gating | Membranes | T cell receptors | Biochemistry | Ribonucleic acid--RNA | Genes | Index Medicus
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 02/2009, Volume 34, Issue 3, pp. 593 - 606
Journal Article
Neuroscience, ISSN 0306-4522, 2011, Volume 193, pp. 440 - 451
Abstract Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that... 
Neurology | mast cell tryptase | paclitaxel-induced pain | TRPV1 | TRPA1 | proteinase-activated receptor 2 | TRPV4 | Proteinase-activated receptor 2 | Mast cell tryptase | Paclitaxel-induced pain | NEUROSCIENCES | SENSORY NEURONS | CAPSAICIN RECEPTOR | MECHANICAL HYPERALGESIA | IN-VIVO | KINASE-C-EPSILON | ION-CHANNEL | PERIPHERAL NEUROPATHY | INFLAMMATORY PAIN | PROTEASE-ACTIVATED-RECEPTOR-2 SENSITIZES | IRRITABLE-BOWEL-SYNDROME | Tryptases - metabolism | Central Nervous System - metabolism | Capsaicin - pharmacology | Receptor, PAR-2 - metabolism | Type C Phospholipases - metabolism | Male | Neuralgia - pathology | Dose-Response Relationship, Drug | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Drug Interactions | Paclitaxel - toxicity | Time Factors | Protein Kinase C - metabolism | TRPV Cation Channels - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Neuralgia - chemically induced | Neuralgia - physiopathology | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mice, Inbred ICR | Hyperalgesia - physiopathology | Antineoplastic Agents, Phytogenic - toxicity | Gene Expression Regulation - drug effects | Pain Measurement - methods | Pyrroles - pharmacology | Animals | Analysis of Variance | Ankyrins - antagonists & inhibitors | Anilides - pharmacology | Ankyrins - metabolism | Central Nervous System - drug effects | Mice | Physical Stimulation - adverse effects | Carbazoles - pharmacology | Oligopeptides - pharmacology | Protein Kinase C - pharmacology | Enzymes | Care and treatment | Neurosciences | Paclitaxel | Phospholipases | Protein kinases | Cancer | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2008, Volume 154, Issue 5, pp. 1094 - 1103
Background and purpose: We investigated the mechanisms underlying the pruritogenic response induced by trypsin in mice, to assess the relevance of neurogenic... 
neuropeptides | Trypsin | PAR‐2 | TRPV1 | mast cells | scratching behaviour | PAR-2 | Neuropeptides | Mast cells | Scratching behaviour | PROTEINASE-ACTIVATED RECEPTOR-2 | NAFAMOSTAT MESILATE | HUMAN SKIN | PRURITUS | HUMAN KERATINOCYTES | ITCH | PAIN | IN-VIVO | HISTAMINE H-4 | PHARMACOLOGY & PHARMACY | trypsin | MAST-CELL TRYPTASE | Receptor, PAR-2 - metabolism | Male | Peptide Fragments - pharmacology | Antipruritics - pharmacology | Receptors, Calcitonin Gene-Related Peptide - metabolism | Quinolines - pharmacology | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Cromolyn Sodium - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Neurogenic Inflammation - chemically induced | Bradykinin Receptor Antagonists | Dioxoles - pharmacology | Behavior, Animal - drug effects | Pruritus - chemically induced | Disease Models, Animal | Injections, Intradermal | Pyrazoles - pharmacology | Reproducibility of Results | Plant Proteins - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Calcitonin Gene-Related Peptide - pharmacology | Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors | p-Methoxy-N-methylphenethylamine - pharmacology | Celecoxib | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mast Cells - drug effects | Trypsin - administration & dosage | TRPV Cation Channels - genetics | Mice, Knockout | Neurogenic Inflammation - prevention & control | Pruritus - metabolism | Animals | Receptors, Bradykinin - metabolism | Signal Transduction - drug effects | Nerve Fibers, Unmyelinated - metabolism | Anilides - pharmacology | Cyclooxygenase 2 - metabolism | Neurogenic Inflammation - metabolism | Pruritus - prevention & control | Mice | Oligopeptides - pharmacology | Cell Degranulation - drug effects | Index Medicus | Research Papers
Journal Article
Food Chemistry, ISSN 0308-8146, 12/2016, Volume 213, pp. 196 - 205
Journal Article
Neuropharmacology, ISSN 0028-3908, 2004, Volume 46, Issue 1, pp. 133 - 149
Vanilloid receptor-1 (TRPV1) is a non-selective cation channel, predominantly expressed by peripheral sensory neurones, which is known to play a key role in... 
TRPV | Pain | TRPV1 | VR1 | Ion channel | Capsaicin | pain | PROTEIN-KINASE-C | 1 VR1 | RAT | ROOT GANGLION NEURONS | INTRACELLULAR CALCIUM | IODO-RESINIFERATOXIN | SPINAL-CORD | NEUROSCIENCES | CAPSAICIN RECEPTOR | NEUROPATHIC PAIN | ACTIVATED ION-CHANNEL | ion channel | capsaicin | PHARMACOLOGY & PHARMACY | Norepinephrine - pharmacology | Aniline Compounds - metabolism | Calcium - metabolism | Capsaicin - pharmacology | Embryo, Mammalian | Humans | Anilides - chemistry | Excitatory Postsynaptic Potentials - drug effects | Kidney | Patch-Clamp Techniques - methods | N-Methylaspartate - pharmacology | Serotonin Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Drug Interactions | Xanthenes - metabolism | Carrier Proteins - pharmacology | Neuropeptides - pharmacology | Protein Binding - drug effects | Radioligand Assay - methods | Cinnamates - chemistry | Acids - pharmacology | Membrane Potentials - drug effects | Cell Line | Orexins | Intracellular Signaling Peptides and Proteins | Rats | Capsaicin - analogs & derivatives | Excitatory Amino Acid Agonists - pharmacology | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Hot Temperature | Cinnamates - pharmacology | Receptors, Drug - chemistry | Animals | Anilides - pharmacology | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Receptors, Drug - antagonists & inhibitors | Index Medicus
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 01/2019, Volume 162, pp. 225 - 233
The genus has received much interest with regards to its traditional uses against eczema, psoriasis, and mastitis. Yet, the medicinal properties of some... 
S. lucida | Phenolic | Docking | Antioxidant | Anti-inflammatory | Tyrosinase | CHOLINESTERASE | ROSMARINIC ACID | CANINA | CHEMISTRY, ANALYTICAL | PROTEIN | SPECIFICITY | PROLIFERATION | DIFFERENT EXTRACTS | PHENYLPROPANOID GLYCOSIDES | ASSAYS | PHARMACOLOGY & PHARMACY | Depsides - isolation & purification | Plant Extracts - chemistry | Antioxidants - chemistry | Plant Extracts - pharmacology | Scrophularia - classification | Solvents - chemistry | Glycoside Hydrolase Inhibitors - isolation & purification | Acetates - chemistry | Monophenol Monooxygenase - antagonists & inhibitors | Scrophularia - chemistry | Structure-Activity Relationship | Chromatography, High Pressure Liquid | Hesperidin - isolation & purification | Depsides - pharmacology | Monophenol Monooxygenase - metabolism | Amylases - metabolism | Cinnamates - isolation & purification | Computer Simulation | Enzyme Inhibitors - chemistry | Kaempferols - isolation & purification | Anti-Inflammatory Agents - isolation & purification | Cholinesterase Inhibitors - isolation & purification | Molecular Structure | Methanol - chemistry | Anti-Inflammatory Agents - pharmacology | Plant Components, Aerial - chemistry | Enzyme Inhibitors - pharmacology | Plant Extracts - isolation & purification | Antioxidants - pharmacology | Glycoside Hydrolase Inhibitors - pharmacology | Luteolin - pharmacology | Cinnamates - pharmacology | Molecular Dynamics Simulation | Enzyme Inhibitors - isolation & purification | Luteolin - isolation & purification | Macrophages - metabolism | Amylases - antagonists & inhibitors | Animals | Cholinesterase Inhibitors - pharmacology | Antioxidants - isolation & purification | Plant Roots - chemistry | Hesperidin - pharmacology | Macrophages - drug effects | RAW 264.7 Cells | Kaempferols - pharmacology | Mice | Molecular Docking Simulation | Nitric Oxide - metabolism | Antioxidants | Esters | Anti-inflammatory drugs | High performance liquid chromatography | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 01/2014, Volume 274, Issue 2, pp. 328 - 338
Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to... 
Early onset of fibrosis | Precision-cut liver slices | Antifibrotic drugs | Liver fibrosis | Ex vivo model | ROSMARINIC ACID | ANGIOTENSIN-II | ANTI-FIBROTIC DRUGS | IN-VITRO | INHIBITS ACTIVATION | HEPATIC STELLATE CELLS | PHARMACOLOGY & PHARMACY | ENDOPLASMIC-RETICULUM | DERMAL FIBROBLASTS | TOXICOLOGY | GROWTH-FACTOR | IMATINIB MESYLATE | Niacinamide - analogs & derivatives | Rats, Wistar | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | Male | Valproic Acid - pharmacology | Depsides - pharmacology | Perindopril - pharmacology | Collagen Type I - genetics | Liver - drug effects | Benzamides - pharmacology | Benzylisoquinolines - pharmacology | Organ Culture Techniques | Liver Cirrhosis - drug therapy | Gene Expression | Collagen Type I - metabolism | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Down-Regulation | Liver - metabolism | Rats | Transforming Growth Factor beta1 - genetics | Pyrimidines - pharmacology | Cinnamates - pharmacology | HSP47 Heat-Shock Proteins - genetics | Imatinib Mesylate | Piperazines - pharmacology | Animals | Models, Biological | HSP47 Heat-Shock Proteins - metabolism | Connective Tissue Growth Factor - genetics | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Connective Tissue Growth Factor - metabolism | Pyridones - pharmacology | Proto-Oncogene Proteins c-sis - antagonists & inhibitors | Drugs | Liver diseases | Analysis | Liver | Fibrosis | Gene expression | Growth factors | Index Medicus | FIBROSIS | DRUGS | GENES | LIVER | RATS | 60 APPLIED LIFE SCIENCES | ATP
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2002, Volume 99, Issue 22, pp. 14071 - 14076
Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic development and can initiate or transmit... 
COS cells | Proteins | Molecules | Biological Sciences | 3T3 cells | NIH 3T3 cells | Ungulates | HEK293 cells | Cell lines | Agonists | Inhibitory concentration 50 | CUBITUS-INTERRUPTUS | SONIC HEDGEHOG | MULTIDISCIPLINARY SCIENCES | MEMBRANE-PROTEIN | RECEPTOR | CYCLOPAMINE | MUTATIONS | GENE ENCODES | HEDGEHOG SIGNAL-TRANSDUCTION | Pyridines - chemistry | Humans | Sulfides - chemistry | Piperazines - chemistry | Benzimidazoles - chemistry | Receptors, Cell Surface - antagonists & inhibitors | Hedgehog Proteins | Pyrazoles - chemistry | Piperidines - pharmacology | Cyclohexylamines - pharmacology | Smoothened Receptor | Benzamides - pharmacology | Cinnamates - chemistry | Binding Sites | Benzamides - chemistry | Pyrazoles - pharmacology | Sulfides - pharmacology | Cell Line | Piperidines - chemistry | Cyclohexylamines - chemical synthesis | Receptors, G-Protein-Coupled | Thiophenes - pharmacology | Cinnamates - pharmacology | Piperazines - pharmacology | Trans-Activators - agonists | Thiophenes - chemical synthesis | Animals | Benzimidazoles - pharmacology | Mice | Pyridines - pharmacology | GTP-Binding Proteins | 3T3 Cells | Hedgehogs | Alkaloids | Embryology, Experimental | Ligands (Biochemistry) | Analysis | Physiological aspects | Biochemistry | Research | G proteins | Cells | Embryos | Tumors | Index Medicus
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 2010, Volume 131, Issue 2, pp. 451 - 458
This paper aimed to elucidate the traditional use of through the investigation of cholinergic activities and neuronal differentiation in rat pheochromocytoma... 
PC12 cell | Rosmarinic acid | ERK1/2 | Cholinergic activities | Rosmarinus officinalis | Carnosic acid | ACETYLCHOLINESTERASE ACTIVITY | CHEMISTRY, MEDICINAL | NEURONAL DIFFERENTIATION | NERVE GROWTH-FACTOR |