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1. Full Text Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer
by Tie, Jeanne and Wang, Yuxuan and Tomasetti, Cristian and Li, Lu and Springer, Simeon and Kinde, Isaac and Silliman, Natalie and Tacey, Mark and Wong, Hui-Li and Christie, Michael and Kosmider, Suzanne and Skinner, Iain and Wong, Rachel and Steel, Malcolm and Tran, Ben and Desai, Jayesh and Jones, Ian and Haydon, Andrew and Hayes, Theresa and Price, Tim J and Strausberg, Robert L and Diaz, Luis A and Papadopoulos, Nickolas and Kinzler, Kenneth W and Vogelstein, Bert and Gibbs, Peter
Science Translational Medicine, ISSN 1946-6234, 07/2016, Volume 8, Issue 346, pp. 346ra92 - 346ra92
Detection of circulating tumor DNA(ctDNA) after resection of stage II colon cancer may identify patients at the highest risk of recurrence and help inform... 
INTENSIVE FOLLOW-UP | ADJUVANT CHEMOTHERAPY | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | THERAPY | MARKER | COLORECTAL-CANCER | CALGB 9581 | ACQUIRED-RESISTANCE | MISMATCH REPAIR | FLUOROURACIL | CELL BIOLOGY | Circulating Tumor DNA - analysis | Colonic Neoplasms - genetics | Prospective Studies | Circulating Tumor DNA - genetics | Neoplasm, Residual - surgery | Humans | Proportional Hazards Models | Neoplasm, Residual - blood | Neoplasm, Residual - genetics | Colonic Neoplasms - surgery | Disease-Free Survival | Colonic Neoplasms - blood | Neoplasm Recurrence, Local - genetics | Neoplasm Staging | Neoplasm Recurrence, Local - blood | Index Medicus
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2. Full Text Circulating cell-free tumor DNA analysis of 50 genes by next-generation sequencing in the prospective MOSCATO trial
by Jovelet, Cécile and Ileana, Ecaterina and Le Deley, Marie-Cécile and Motté, Nelly and Rosellini, Silvia and Romero, Alfredo and Lefebvre, Celine and Pedrero, Marion and Pata-Merci, Noémie and Droin, Nathalie and Deloger, Marc and Massard, Christophe and Hollebecque, Antoine and Ferté, Charles and Boichard, Amélie and Postel-Vinay, Sophie and Ngo-Camus, Maud and De Baere, Thierry and Vielh, Philippe and Scoazec, Jean-Yves and Vassal, Gilles and Eggermont, Alexander and André, Fabrice and Soria, Jean-Charles and Lacroix, Ludovic
Clinical Cancer Research, ISSN 1078-0432, 06/2016, Volume 22, Issue 12, pp. 2960 - 2968
Purpose: Liquid biopsies based on circulating cell-free DNA (cfDNA) analysis are described as surrogate samples for molecular analysis. We evaluated the... 
HETEROGENEITY | EVOLUTION | ONCOLOGY | METASTATIC BREAST-CANCER | PLASMA DNA | BIOPSY | RESISTANCE | OPTIMIZATION | PERSONALIZED MEDICINE | BLOOD | Prospective Studies | Circulating Tumor DNA - genetics | Humans | Middle Aged | Male | DNA Mutational Analysis - methods | Molecular Targeted Therapy | Patient Selection | Biomarkers, Tumor - blood | Young Adult | Neoplasms - blood | DNA, Neoplasm - blood | Neoplasms - genetics | Adolescent | Adult | Female | Aged | Biomarkers, Tumor - genetics | High-Throughput Nucleotide Sequencing | DNA, Neoplasm - genetics | Mutation | Clinical Trials, Phase I as Topic | Index Medicus
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3. Full Text Circulating tumour DNA analysis in multiple myeloma
by Mithraprabhu, Sridurga and Spencer, Andrew
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 53, pp. 90610 - 90611
Cell-free DNA | Mutations | Circulating tumour DNA | Therapeutic monitoring | Multiple myeloma | HETEROGENEITY | multiple myeloma | mutations | circulating tumour DNA | therapeutic monitoring | cell-free DNA | CELL BIOLOGY
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4. Full Text Tracking evolution of aromatase inhibitor resistance with circulating tumour DNA analysis in metastatic breast cancer
by Fribbens, C and Garcia Murillas, I and Beaney, M and Hrebien, S and O'Leary, B and Kilburn, L and Howarth, K and Epstein, M and Green, E and Rosenfeld, N and Ring, A and Johnston, S and Turner, N
Annals of Oncology, ISSN 0923-7534, 01/2018, Volume 29, Issue 1, pp. 145 - 153
Abstract Background Selection of resistance mutations may play a major role in the development of endocrine resistance. ESR1 mutations are rare in primary... 
Breast cancer | KRAS | ESR1 | ctDNA | ONCOLOGY | CLONAL HEMATOPOIESIS | COLORECTAL-CANCER | breast cancer | ANTI-EGFR THERAPY | MUTATIONS | ESTROGEN-RECEPTOR | Prospective Studies | Circulating Tumor DNA - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Middle Aged | Breast Neoplasms - drug therapy | Disease Progression | Drug Resistance, Neoplasm - genetics | Neoplasm Metastasis | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Breast Neoplasms - pathology | Aged, 80 and over | Breast Neoplasms - blood | Adult | Female | Aged | Circulating Tumor DNA - blood | Mutation | Aromatase Inhibitors - therapeutic use | Index Medicus
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5. Full Text Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer
by Nong, Jingying and Gong, Yuhua and Guan, Yanfang and Yi, Xin and Yi, Yuting and Chang, Lianpeng and Yang, Ling and Lv, Jialin and Guo, Zhirong and Jia, Hongyan and Chu, Yuxing and Liu, Tao and Chen, Ming and Byers, Lauren and Roarty, Emily and Lam, Vincent K and Papadimitrakopoulou, Vassiliki A and Wistuba, Ignacio and Heymach, John V and Glisson, Bonnie and Liao, Zhongxing and Lee, J. Jack and Futreal, P. Andrew and Zhang, Shucai and Xia, Xuefeng and Zhang, Jianjun and Wang, Jinghui
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3114 - 8
Subclonal architecture and genomic evolution of small-cell lung cancer (SCLC) under treatment has not been well studied primarily due to lack of tumor... 
SURVIVAL | MULTICENTER | GENE | MULTIDISCIPLINARY SCIENCES | MUTATIONS | COMBINATION | NIVOLUMAB | BLOCKADE | BURDEN | IPILIMUMAB | Lung Neoplasms - genetics | Signal Transduction | Gene Frequency | Genomics | Humans | Middle Aged | Male | Small Cell Lung Carcinoma - genetics | Circulating Tumor DNA | Small Cell Lung Carcinoma - blood | Point Mutation | Biopsy | DNA Mutational Analysis | DNA Repair | Adult | Female | Aged | High-Throughput Nucleotide Sequencing | Lung Neoplasms - blood | DNA, Neoplasm - genetics | Mutation | DNA, Complementary - metabolism | Evolution, Molecular | Small cell lung carcinoma | Architecture | Lung cancer | Biological evolution | DNA repair | Depth profiling | Survival | Gene sequencing | Gene frequency | Evolution | Pretreatment | Deoxyribonucleic acid--DNA | DNA sequencing | Tumors | Cancer | Index Medicus
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6. Full Text Circulating tumor DNA analysis enables molecular characterization of pediatric renal tumors at diagnosis
by Jiménez, Irene and Chicard, Mathieu and Colmet‐Daage, Léo and Clément, Nathalie and Danzon, Adrien and Lapouble, Eve and Pierron, Gaelle and Bohec, Mylène and Baulande, Sylvain and Berrebi, Dominique and Fréneaux, Paul and Coulomb, Aurore and Galmiche‐Rolland, Louise and Sarnacki, Sabine and Audry, Georges and Philippe‐Chomette, Pascale and Brisse, Hervé J and Doz, François and Michon, Jean and Delattre, Olivier and Schleiermacher, Gudrun
International Journal of Cancer, ISSN 0020-7136, 01/2019, Volume 144, Issue 1, pp. 68 - 79
Circulating tumor DNA (ctDNA) is a powerful tool for the molecular characterization of cancer. The most frequent pediatric kidney tumors (KT) are Wilms’ tumors... 
Pediatrics | Wilms’ tumors | Renal tumors | cell‐free DNA | Kidney tumors | circulating tumor DNA | cell-free DNA | READ ALIGNMENT | CATENIN | WT1 MUTATIONS | 16Q | WILMS-TUMOR | Wilms' tumors | ONCOLOGY | COPY NUMBER | ANAPLASIA | ALLELE LOSS | CHILDRENS-CANCER | GAIN | Chemotherapy | Analysis | DNA | Genetic research | Diagnosis | Children | Health aspects | Tumors | Cancer | Copy number | Medical treatment | Patients | Gene sequencing | Alterations | Nephrectomy | Genetic analysis | Deoxyribonucleic acid--DNA | DNA sequencing | Index Medicus
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7. Full Text Advances in Circulating Tumor DNA Analysis
by Perakis, Samantha and Auer, Martina and Belic, Jelena and Heitzer, Ellen
Advances in Clinical Chemistry, ISSN 0065-2423, 2017, Volume 80, pp. 73 - 153
The analysis of cell-free circulating tumor DNA (ctDNA) is a very promising tool and might revolutionize cancer care with respect to early detection,... 
Assessment of treatment response | Identification of minimal residual disease | Monitoring tumor evolution | Predictive | Cell-free circulating tumor DNA | ctDNA | Prognostic biomarker | LOW-ABUNDANCE MUTATIONS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | BLOOD-PROCESSING PROTOCOLS | PRIMARY BREAST-CANCER | FREE NUCLEIC-ACIDS | FACTOR RECEPTOR MUTATIONS | MEDICAL LABORATORY TECHNOLOGY | FREE PLASMA DNA | METASTATIC COLORECTAL-CANCER | CELL-FREE DNA | COPY NUMBER ABERRATIONS | Biomarkers, Tumor - blood | Predictive Value of Tests | DNA, Neoplasm - blood | Neoplasms - genetics | Humans | Biomarkers, Tumor - genetics | Neoplasms - diagnosis | DNA, Neoplasm - genetics | Genetic Markers | Mutation | Index Medicus
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8. Full Text DNA breathing enables closed-tube mutant allele enrichment for circulating tumor DNA analysis
by Dobrovic, Alexander
Clinical Chemistry, ISSN 0009-9147, 10/2017, Volume 63, Issue 10, pp. e1 - e3
[...]any enrichment precludes the absolute quantification of mutant alleles. [...]as proportional enrichment increases, the lower the level ofthe variant... 
PCR | MUTATIONS | MEDICAL LABORATORY TECHNOLOGY | Circulating Tumor DNA - blood | Circulating Tumor DNA - genetics | DNA Mutational Analysis - methods | Humans | Alleles | Genetic research | Care and treatment | Gene mutations | DNA | Tumors | Temperature | Cold | Biopsy | Medical prognosis | DNA methylation | Mutation | Breathing | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
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9. Full Text Reproducibility of digital PCR assays for circulating tumor DNA analysis in advanced breast cancer
by Hrebien, Sarah and O'Leary, Ben and Beaney, Matthew and Schiavon, Gaia and Fribbens, Charlotte and Bhambra, Amarjit and Johnson, Richard and Garcia-Murillas, Isaac and Turner, Nicholas
PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, pp. e0165023 - e0165023
Circulating tumor DNA (ctDNA) analysis has the potential to allow non-invasive analysis of tumor mutations in advanced cancer. In this study we assessed the... 
BLOOD COLLECTION | ACQUIRED-RESISTANCE | SAMPLE STORAGE | PLASMA | CELLULAR-DNA | MULTIDISCIPLINARY SCIENCES | Multiplex Polymerase Chain Reaction - methods | Reproducibility of Results | Prognosis | Humans | Middle Aged | Multiplex Polymerase Chain Reaction - instrumentation | Biomarkers, Tumor - blood | Breast Neoplasms - genetics | DNA, Neoplasm - blood | MCF-7 Cells | Breast Neoplasms - pathology | Cell Line, Tumor | Female | Biomarkers, Tumor - genetics | Mutation | Automatic Data Processing | Oncology, Experimental | DNA | Breast cancer | Genetic aspects | Research | Diagnosis | Cancer | Plasma | Cell culture | Tracking | Lung cancer | Metastasis | Assaying | Blood | ESR1 protein | Tubes | Deoxyribonucleic acid--DNA | Medical research | AKT1 protein | Invasiveness | Discordance | Plasma processing | ErbB-2 protein | Polymerase chain reaction | Gene frequency | Reproducibility | Alleles | Breast | Stochasticity | Tumors | Index Medicus | Deoxyribonucleic acid
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10. Full Text Circulating tumour dna analysis for tumour genome characterisation and monitoring disease burden in extramedullary multiple myeloma
by Mithraprabhu, Sridurga and Sirdesai, Shreerang and Chen, Maoshan and Khong, Tiffany and Spencer, Andrew
International Journal of Molecular Sciences, ISSN 1661-6596, 07/2018, Volume 19, Issue 7, p. 1858
Mutational characterisation in extramedullary multiple myeloma (EM-MM) patients is challenging due to inaccessible EM plasmacytomas, unsafe nature of multiple... 
Cell-free DNA | Spatial heterogeneity | Digital PCR | CtDNA | Whole exome sequencing | Extramedullary MM | extramedullary MM | digital PCR | PROGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, MULTIDISCIPLINARY | ctDNA | whole exome sequencing | HETEROGENEITY | RELAPSE | EVOLUTION | cell-free DNA | PLASMA-CELL LEUKEMIA | spatial heterogeneity | MUTATIONS | SOFT-TISSUE PLASMACYTOMAS | REVEALS | Circulating Tumor DNA - genetics | Humans | Middle Aged | Plasmacytoma - genetics | Plasma Cells - pathology | Multiple Myeloma - therapy | Female | Plasma Cells - metabolism | Membrane Proteins - blood | Multiple Myeloma - blood | Multiple Myeloma - diagnostic imaging | Membrane Proteins - genetics | Hematopoietic Stem Cell Transplantation | Plasmacytoma - blood | Disease Progression | Whole Exome Sequencing | Biomarkers, Tumor - blood | Positron Emission Tomography Computed Tomography | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | GTP Phosphohydrolases - genetics | Plasmacytoma - diagnostic imaging | Plasmacytoma - therapy | Biomarkers, Tumor - genetics | Circulating Tumor DNA - blood | GTP Phosphohydrolases - blood | Mutation | Multiple Myeloma - genetics | Clonal Evolution | Heterogeneity | Markers | Multiple myeloma | Genomes | Drug resistance | Blood | Monitoring | Deoxyribonucleic acid--DNA | Tumors
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11. Full Text Landscape of somatic mutations in different subtypes of advanced breast cancer with circulating tumor DNA analysis
by Yi, Zongbi and Ma, Fei and Li, Chunxiao and Chen, Rongrong and Yuan, Lifang and Sun, Xiaoying and Guan, Xiuwen and Li, Lixi and Liu, Binliang and Guan, Yanfang and Qian, Haili and Xu, Binghe
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 5995 - 8
It is particularly important to provide precise therapies and understand tumor heterogeneity based on the molecular typing of mutational landscape. However,... 
HETEROGENEITY | PIK3CA MUTATIONS | GENE | MULTIDISCIPLINARY SCIENCES | DISEASE | RESISTANCE | RECURRENCE | MECHANISMS | SYSTEMS BIOLOGY | Breast Neoplasms - classification | Multivariate Analysis | Circulating Tumor DNA - genetics | Humans | Middle Aged | DNA Copy Number Variations - genetics | Point Mutation - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | DNA Mutational Analysis | Adult | Female | Genome, Human | Neoplasm Staging | Breast cancer | Typing | Mutation | Copy number | Deoxyribonucleic acid--DNA | Index Medicus
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12. Full Text Circulating tumor DNA analysis as a real-time method for monitoring tumor burden in melanoma patients undergoing treatment with immune checkpoint blockade
by Lipson, Evan J and Velculescu, Victor E and Pritchard, Theresa S and Sausen, Mark and Pardoll, Drew M and Topalian, Suzanne L and Diaz, Luis A
Journal for ImmunoTherapy of Cancer, ISSN 2051-1426, 12/2014, Volume 2, Issue 1, pp. 42 - 42
Assessment of therapeutic activity of drugs blocking immune checkpoints such as CTLA-4 and PD-1/PD-L1 can be challenging, as tumors may seem to enlarge or... 
Biomarker | Anti-PD-1 | Checkpoint blockade | Immunotherapy | Ipilimumab | Circulating tumor DNA | Medical research | Medicine, Experimental | Metastasis | Drug therapy | Health aspects | Methods
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13. Full Text Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates
by Kis, Olena and Kaedbey, Rayan and Chow, Signy and Danesh, Arnavaz and Dowar, Mark and Li, Tiantian and Li, Zhihua and Liu, Jessica and Mansour, Mark and Masih-Khan, Esther and Zhang, Tong and Bratman, Scott V and Oza, Amit M and Kamel-Reid, Suzanne and Trudel, Suzanne and Pugh, Trevor J
Nature Communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 15086 - 15086
The requirement for bone-marrow aspirates for genomic profiling of multiple myeloma poses an obstacle to enrolment and retention of patients in clinical... 
CELL LUNG-CANCER | DIAGNOSIS | IMPACT | TRAMETINIB | MULTIDISCIPLINARY SCIENCES | MUTATIONS | SAMPLES | PLASMA-CELLS | Receptor, Epidermal Growth Factor - genetics | Class I Phosphatidylinositol 3-Kinases - genetics | Circulating Tumor DNA - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Proto-Oncogene Proteins p21(ras) - blood | Sensitivity and Specificity | Class I Phosphatidylinositol 3-Kinases - blood | Receptor, Epidermal Growth Factor - blood | Membrane Proteins - blood | Multiple Myeloma - blood | Multiple Myeloma - diagnosis | Membrane Proteins - genetics | Gene Frequency | Bone Marrow Cells - pathology | Proto-Oncogene Proteins B-raf - blood | Sequence Analysis, DNA | Biomarkers, Tumor - blood | Multiple Myeloma - pathology | GTP Phosphohydrolases - genetics | Proto-Oncogene Proteins B-raf - genetics | Alleles | Biomarkers, Tumor - genetics | High-Throughput Nucleotide Sequencing | Circulating Tumor DNA - blood | GTP Phosphohydrolases - blood | Mutation | Biopsy - ethics | Bone Marrow Cells - metabolism | Multiple Myeloma - genetics | Index Medicus
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14. Assessment of basal-like breast cancer by circulating tumor DNA analysis
by Wei, Wei and Zhang, Xianyu and Sun, Shanshan and Xia, Bingshu and Liang, Xiaoshuan and Cui, Yan and Gao, Song and Pang, Da
Oncology Letters, ISSN 1792-1074, 05/2018, Volume 15, Issue 5, pp. 7389 - 7396
Standardized methods for the detection and assessment of circulating tumor DNA (ctDNA) in breast cancer are not sufficient. In the present study, the method... 
Liquid biopsy | Breast cancer | Circulating nucleotide | Circulating tumor DNA | THERAPY | circulating nucleotide | ONCOLOGY | PLASMA DNA | RESISTANCE | breast cancer | liquid biopsy | circulating tumor DNA
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15. Full Text Circulating tumour DNA analyses reveal novel resistance mechanisms to CDK inhibition in metastatic breast cancer
by Abbosh, C and Swanton, C and Birkbak, N J
Annals of Oncology, ISSN 0923-7534, 03/2018, Volume 29, Issue 3, pp. 535 - 537
ONCOLOGY | Drug Resistance, Neoplasm | Protein Kinase Inhibitors | Mutation | Breast Neoplasms | Circulating Tumor DNA | Humans
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16. Full Text Analysis of circulating tumor DNA
by Mithraprabhu, Sridurga and Spencer, Andrew
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1792, pp. 129 - 145
Circulating tumor DNA (ctDNA) analysis is currently gaining momentum as an innovative methodology for characterizing the tumor genome and monitoring... 
Peripheral blood plasma | Multiple myeloma | Cell-free DNA | Liquid biopsy | Droplet digital PCR | Circulating cell-free nucleic acids | Circulating tumor DNA | Liquid Biopsy | Neoplasms - genetics | DNA Mutational Analysis | DNA, Neoplasm | Humans | Neoplasms - diagnosis | Mutation | Circulating Tumor DNA | Biomarkers, Tumor | Polymerase Chain Reaction - methods | Index Medicus
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17. Full Text Efficient treatment of a metastatic melanoma patient with a combination of BRAF and MEK inhibitors based on circulating tumor DNA analysis: A case report
by Quéreux, Gaelle and Herbreteau, Guillaume and Knol, Anne-Chantal and Vallée, Audrey and Khammari, Amir and Théoleyre, Sandrine and Saint-Jean, Mélanie and Dréno, Brigitte and Denis, Marc G
BMC Research Notes, ISSN 1756-0500, 07/2017, Volume 10, Issue 1, pp. 320 - 320
Fixed tissues are the standard samples used in routine practice for molecular testing. But sometimes tissues are lacking or difficult to obtain. In these... 
Case report | BRAF | Circulating tumor DNA | Melanoma | Melanoma - blood | Skin Neoplasms - pathology | Skin Neoplasms - drug therapy | Humans | Middle Aged | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Tomography, X-Ray Computed | Treatment Outcome | Melanoma - pathology | Mutation - genetics | Skin Neoplasms - blood | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasm Metastasis | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Female | Circulating Tumor DNA - blood | Proto-Oncogene Proteins B-raf - metabolism | Care and treatment | Gene mutations | Analysis | DNA | Genetic research | Hostages | Metastasis | Drug therapy | Cancer | Plasma | Tumor cells | Lung cancer | MEK inhibitors | FDA approval | Patients | Metastases | Biomarkers | Mutation | Deoxyribonucleic acid--DNA | Tumors | Index Medicus | Life Sciences
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