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1. Full Text Molecular mechanisms of cisplatin resistance
by Galluzzi, L and Senovilla, L and Vitale, I and Michels, J and Martins, I and Kepp, O and Castedo, M and Kroemer, G
Oncogene, ISSN 0950-9232, 04/2012, Volume 31, Issue 15, pp. 1869 - 1883
Platinum-based drugs, and in particular cis-diamminedichloroplatinum(II) (best known as cisplatin), are employed for the treatment of a wide array of solid... 
ATP7B | metallothioneins | TP53 | ERCC1 | glutathione | CTR1 | ANTICANCER DRUG CISPLATIN | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADENOSINE-TRIPHOSPHATASE ATP7B | NUCLEOTIDE EXCISION-REPAIR | CELL BIOLOGY | CELL LUNG-CANCER | DNA MISMATCH REPAIR | ONCOLOGY | HAMSTER OVARY CELLS | GENETICS & HEREDITY | GENE-EXPRESSION | MULTIDRUG-RESISTANCE | SIGNAL-TRANSDUCTION PATHWAY | Cisplatin - metabolism | Drug Resistance, Neoplasm - genetics | Signal Transduction | DNA Repair | Humans | Cisplatin - pharmacology | DNA Damage | DNA Adducts - metabolism | Molecular mechanics | Research | Health aspects | Cisplatin | Genotype & phenotype | Chemotherapy | Pharmacology | Molecular biology | Cancer | Tumor cells | DNA damage | Lung cancer | Chemoresistance | chemosensitization | Malignancy | Signal transduction | Mitochondria | Molecular modelling | Urinary bladder | Head and neck | Testes | Adducts | Apoptosis
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2. Full Text Cisplatin resistance and opportunities for precision medicine
by Amable, Lauren
Pharmacological Research, ISSN 1043-6618, 04/2016, Volume 106, pp. 27 - 36
Cisplatin is one of the most commonly used chemotherapy drugs, treating a wide range of cancer types. Unfortunately, many cancers initially respond to platinum... 
Nucleotide excision repair | ABC transporters | Cisplatin resistance | ERCC1 | Copper transporters | Glutathione | ERCC1 CODON-118 POLYMORPHISM | ORGANIC CATION TRANSPORTER-2 | CASSETTE SUPERFAMILY TRANSPORTER | ADENOSINE-TRIPHOSPHATASE ATP7B | MESSENGER-RNA LEVELS | EPITHELIAL OVARIAN-CANCER | S-TRANSFERASE-PI | NUCLEOTIDE EXCISION-REPAIR | CELL LUNG-CANCER | PLATINUM-BASED CHEMOTHERAPY | PHARMACOLOGY & PHARMACY | Cisplatin - therapeutic use | Antineoplastic Agents - adverse effects | Humans | Cisplatin - adverse effects | Antineoplastic Agents - therapeutic use | Precision Medicine - methods | Drug Resistance, Neoplasm - drug effects | Neoplasms - drug therapy | Cisplatin | Antigens | Medical research | Drug resistance in microorganisms | Lung cancer, Non-small cell | T cells | DNA repair | Chemotherapy | Glutathione transferase | Medicine, Experimental | Metallothionein | Adenosine triphosphatase | Cancer
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3. Full Text Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
by Sakai, Wataru and Swisher, Elizabeth M and Karlan, Beth Y and Agarwal, Mukesh K and Higgins, Jake and Friedman, Cynthia and Villegas, Emily and Jacquemont, Céline and Farrugia, Daniel J and Couch, Fergus J and Urban, Nicole and Taniguchi, Toshiyasu
Nature, ISSN 0028-0836, 02/2008, Volume 451, Issue 7182, pp. 1116 - 1120
Ovarian carcinomas with mutations in the tumour suppressor BRCA2 are particularly sensitive to platinum compounds(1). However, such carcinomas ultimately... 
BREAST-CANCER | GENE | PATHWAY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DEFECT | HOMOLOGY-DIRECTED REPAIR | BRCA MUTANT-CELLS | OVARIAN-CANCER | INHIBITORS | FANCONI-ANEMIA | Azulenes - pharmacology | Benzodiazepines - pharmacology | Humans | Middle Aged | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Cisplatin - pharmacology | Mutation - genetics | Breast Neoplasms - drug therapy | Poly(ADP-ribose) Polymerase Inhibitors | Neoplasms - drug therapy | Ovarian Neoplasms - genetics | Pancreatic Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | BRCA2 Protein - metabolism | Breast Neoplasms - genetics | Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Genes, BRCA2 | Female | Ovarian Neoplasms - drug therapy | BRCA2 Protein - genetics | Drug Resistance, Neoplasm - drug effects | Breast cancer | Mutation | Drug resistance | Pancreatic cancer | Ovarian cancer
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4. Full Text Molecular mechanisms of drug resistance
by Longley, DB and Johnston, PG
The Journal of Pathology, ISSN 0022-3417, 01/2005, Volume 205, Issue 2, pp. 275 - 292
Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours may be intrinsically drug‐resistant or develop resistance to... 
chemotherapy | cancer | drug resistance | Drug resistance | Chemotherapy | Cancer | PATHOLOGY | MESSENGER-RNA LEVELS | NUCLEOTIDE EXCISION-REPAIR | COLON-CARCINOMA CELLS | ADVANCED COLORECTAL-CANCER | CELL LUNG-CANCER | CISPLATIN-BASED CHEMOTHERAPY | DNA MISMATCH REPAIR | GROWTH-FACTOR RECEPTOR | ONCOLOGY | NF-KAPPA-B | HUMAN OVARIAN-CANCER | Cell Cycle - genetics | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | Signal Transduction - drug effects | Apoptosis - drug effects | DNA Repair | Humans | Apoptosis - genetics | Antineoplastic Agents - therapeutic use | DNA Damage | Cell Cycle - drug effects | Neoplasms - drug therapy
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5. Full Text Silence of  lncRNA UCA1 rescues drug resistance of cisplatin to non–small‐cell lung cancer cells
by Liu, Xiaojing and Huang, Zhisheng and Qian, Wei and Zhang, Qing and Sun, Jian
Journal of Cellular Biochemistry, ISSN 0730-2312, 06/2019, Volume 120, Issue 6, pp. 9243 - 9249
The aim of this study was to investigate the effect of long noncoding RNA (lncRNA) urogenital carcinoma antigen 1 (UCA1) on drug resistance in A549/DDP cell... 
migration | invasion | cisplatin | urogenital carcinoma antigen 1 | epithelial‐mesenchymal transition | non–small‐cell lung cancer cells | non–small-cell lung cancer cells | epithelial-mesenchymal transition | OVEREXPRESSION | non-small-cell lung cancer cells | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Antimitotic agents | Drug resistance | Lung cancer, Non-small cell | Antineoplastic agents | Cancer cells | Vimentin | Polymerase chain reaction | Mesenchyme | Lung cancer | Inhibition | Ribonucleic acid--RNA | Cisplatin | Cell migration | Cell adhesion & migration | Cancer
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6. Full Text Head neck squamous cell carcinoma c‐Met+ cells display cancer stem cell properties and are responsible for cisplatin‐resistance and metastasis
by Sun, Shuyang and Wang, Zuolin
International Journal of Cancer, ISSN 0020-7136, 11/2011, Volume 129, Issue 10, pp. 2337 - 2348
c‐Met, the tyrosine kinase receptor for hepatocyte growth factor, is overexpressed in a variety of tumors in which it plays a central role in malignant... 
c‐Met | head neck squamous cell carcinoma | chemoresistance | cancer stem cell marker | metastasis | c-Met | BMI-1 | ALDEHYDE DEHYDROGENASE | TYROSINE KINASE | PANCREATIC-CANCER | IDENTIFICATION | BREAST-CANCER | INVASIVE GROWTH | ONCOLOGY | THERAPEUTIC TARGET | STEM/PROGENITOR CELLS | Proto-Oncogene Proteins c-met - metabolism | Neoplasm Transplantation | Biomarkers, Tumor - analysis | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Drug Resistance, Neoplasm | Mice, SCID | Head and Neck Neoplasms - metabolism | Head and Neck Neoplasms - pathology | Neoplasm Metastasis | Animals | Cisplatin - therapeutic use | Cell Division | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Mice, Inbred NOD | Mice
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7. Full Text ATP11B mediates platinum resistance in ovarian cancer
by Moreno-Smith, Myrthala and Halder, J.B and Meltzer, Paul S and Gonda, Tamas A and Mangala, Lingegowda S and Rupaimoole, Rajesha and Lu, Chunhua and Nagaraja, Archana S and Gharpure, Kshipra M and Kang, Yu and Rodriguez-Aguayo, Cristian and Vivas-Mejia, Pablo E and Zand, Behrouz and Schmandt, Rosemarie and Wang, Hua and Langley, Robert R and Jennings, Nicholas B and Ivan, Cristina and Coffin, Jeremy E and Armaiz, Guillermo N and Bottsford-Miller, Justin and Kim, Sang Bae and Halleck, Margaret S and Hendrix, Mary J.C and Bornman, William and Bar-Eli, Menashe and Lee, Ju-Seog and Siddik, Zahid H and Lopez-Berestein, Gabriel and Sood, Anil K
Journal of Clinical Investigation, ISSN 0021-9738, 05/2013, Volume 123, Issue 5, pp. 2119 - 2130
Platinum compounds display clinical activity against a wide variety of solid tumors; however, resistance to these agents is a major limitation in cancer... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOLOGICAL FUNCTIONS | P-TYPE ATPASES | CARCINOMA CELLS | TRANS-GOLGI NETWORK | CISPLATIN RESISTANCE | ADENOCARCINOMA CELL-LINES | AMINOPHOSPHOLIPID TRANSLOCASE | VESICLE TRAFFICKING | DRUG-RESISTANCE | TRANSPORTER ATP7B | Care and treatment | Platinum compounds | Genetic aspects | Properties | Health aspects | Adenosine triphosphatase | Ovarian cancer | Cancer | Proteins | Medical research | Chemotherapy
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8. Full Text Cisplatin resistance: Preclinical findings and clinical implications
by Köberle, Beate and Tomicic, Maja T and Usanova, Svetlana and Kaina, Bernd
BBA - Reviews on Cancer, ISSN 0304-419X, 2010, Volume 1806, Issue 2, pp. 172 - 182
Cisplatin is used for the treatment of many types of solid cancers. While testicular cancers respond remarkably well to cisplatin, the therapeutic efficacy of... 
DNA damage repair | DNA damage bypass | Drug resistance | DNA damage response | Cisplatin | Cancer | ADVANCED BREAST-CANCER | ANTICANCER DRUG CISPLATIN | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | COPPER TRANSPORTER CTR1 | DNA ADDUCT FORMATION | NUCLEOTIDE EXCISION-REPAIR | CELL LUNG-CANCER | BIOPHYSICS | ONCOLOGY | PLATINUM-BASED CHEMOTHERAPY | GLUTATHIONE-S-TRANSFERASE | HUMAN OVARIAN-CANCER
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