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European Journal of Pharmacology, ISSN 0014-2999, 2007, Volume 572, Issue 1, pp. 12 - 22
Pulmonary fibroblast to myofibroblast conversion is a pathophysiological feature of idiopathic pulmonary fibrosis and COPD. This conversion is induced by... 
TGF-β | Sildenafil | Lung fibroblast | Fibrosis | Phosphodiesterase | lung fibroblast | CELLS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | PROLIFERATION | sildenafil | CARDIAC FIBROBLASTS | TGF-beta | GROWTH-FACTOR-BETA | DISEASE | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | fibrosis | phosphodiesterase | DIFFERENTIATION | IDIOPATHIC PULMONARY-FIBROSIS | EXPRESSION | Enzyme Activators - pharmacology | Immunohistochemistry | Cyclic GMP - pharmacology | Humans | Actins - metabolism | Lung - cytology | Natriuretic Peptide, Brain - pharmacology | Sulfones - pharmacology | Quinoxalines - pharmacology | Sildenafil Citrate | Nitroso Compounds - pharmacology | Isoenzymes - metabolism | Oxadiazoles - pharmacology | Benzamides - pharmacology | Nitric Oxide Donors - pharmacology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Fibroblasts - metabolism | Dinoprostone - pharmacology | Purines - pharmacology | Cells, Cultured | Transforming Growth Factor beta - physiology | Phosphodiesterase Inhibitors - pharmacology | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Piperazines - pharmacology | Blotting, Western | Drug Synergism | Transforming Growth Factor beta - pharmacology | Cell Differentiation - drug effects | Fibroblasts - drug effects | Benzoates - pharmacology | Fibroblasts - cytology | Pyridines - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2008, Volume 47, Issue 2, pp. 422 - 431
Journal Article
The Journal of Sexual Medicine, ISSN 1743-6095, 04/2013, Volume 10, Issue 4, pp. 960 - 971
Prevalence of erectile dysfunction (ED) increases progressively with aging, but the ED pathophysiology at its early stages is still poorly investigated. This... 
Erectile Dysfunction | Antioxidant Therapy | Oxidative Stress | Corpus Cavernosum | Apocynin | Superoxide Dismutase | STIMULATOR BAY 41-2272 | HUMAN CORPUS CAVERNOSUM | RELAXATION | DIABETIC-RATS | PHOSPHODIESTERASE TYPE-5 INHIBITORS | SOLUBLE GUANYLATE-CYCLASE | SMOOTH-MUSCLE | CARDIOVASCULAR-DISEASE | UROLOGY & NEPHROLOGY | ENDOGENOUS NITRIC-OXIDE | Blood Pressure | Free Radical Scavengers - pharmacology | Cyclic GMP - pharmacology | Up-Regulation | Electric Stimulation | Membrane Glycoproteins - metabolism | NADPH Oxidases - metabolism | Male | Nitroprusside - pharmacology | RNA, Messenger - metabolism | Sulfones - pharmacology | Penile Erection | Sildenafil Citrate | Cyclic GMP - analogs & derivatives | Acetophenones - pharmacology | NADPH Oxidases - genetics | Phosphodiesterase 5 Inhibitors - pharmacology | Superoxide Dismutase - metabolism | Pyrazoles - pharmacology | Superoxide Dismutase - pharmacology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Purines - pharmacology | Down-Regulation | Enzyme Inhibitors - pharmacology | Rats | Muscle Relaxation | NADPH Oxidase 2 | Piperazines - pharmacology | Erectile Dysfunction - metabolism | Membrane Glycoproteins - genetics | Animals | Aging - physiology | Cyclic GMP - metabolism | Endothelium, Vascular - metabolism | Nitric Oxide Synthase - metabolism | Pyridines - pharmacology | Superoxide Dismutase-1 | Prevention | Oxidases | Antioxidants | Impotence | Nitric oxide | Sodium nitroferricyanide | Superoxide
Journal Article
Respiratory Research, ISSN 1465-9921, 12/2011, Volume 12, Issue 1, pp. 1 - 8
The development of bronchial hyperreactivity (BHR) subsequent to precapillary pulmonary hypertension (PHT) was prevented by acting on the major signalling... 
Medicine & Public Health | Pneumology/Respiratory System | PARENCHYMAL MECHANICS | LUNG | METHACHOLINE-INDUCED BRONCHOCONSTRICTION | AIRWAY | THERAPY | VASOACTIVE-INTESTINAL-PEPTIDE | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | INHALATION | NITRIC-OXIDE | VIP | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Airway Resistance - drug effects | Iloprost - pharmacology | Bronchial Provocation Tests | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Male | Endothelins - metabolism | Sulfones - pharmacology | Lung Volume Measurements | Sildenafil Citrate | Time Factors | Vasoactive Intestinal Peptide - pharmacology | Bronchoconstriction - drug effects | Bronchial Hyperreactivity - physiopathology | Bronchial Hyperreactivity - metabolism | Blood Pressure - drug effects | Hypertension, Pulmonary - drug therapy | Lung - metabolism | Phosphodiesterase 5 Inhibitors - pharmacology | Endothelin Receptor Antagonists | Disease Models, Animal | Bronchial Hyperreactivity - etiology | Prostaglandins I - metabolism | Bronchial Hyperreactivity - therapy | Infusion Pumps, Implantable | Vasodilator Agents - pharmacology | Administration, Oral | Purines - pharmacology | Receptors, Endothelin - metabolism | Infusions, Parenteral | Rats | Hypertension, Pulmonary - metabolism | Lung - physiopathology | Piperazines - pharmacology | Rats, Sprague-Dawley | Animals | Analysis of Variance | Signal Transduction - drug effects | Lung - drug effects | Pyridines - pharmacology | Lung - blood supply | Nitric Oxide - metabolism | Vasodilator Agents - administration & dosage | Hypertension, Pulmonary - complications | Bronchi | Physiological aspects | Development and progression | Respiratory agents | Research | Drug therapy | Health aspects | Pulmonary hypertension | Prevention | Nitric oxide
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2005, Volume 517, Issue 3, pp. 224 - 231
Hypercholesterolaemia promotes erectile dysfunction through increased superoxide formation and negation of nitric oxide (NO) bioactivity in cavernosal tissue.... 
Erectile dysfunction | Superoxide | NADPH oxidase | Cholesterol | RISK-FACTORS | ENDOTHELIUM-DEPENDENT RELAXATION | ATHEROSCLEROSIS | PULMONARY-ARTERY | erectile dysfunction | SMOOTH-MUSCLE | IN-VITRO | CORPUS CAVERNOSUM | CYCLIC-GMP | cholesterol | PHARMACOLOGY & PHARMACY | superoxide | CGMP PHOSPHODIESTERASE INHIBITOR | Uncoupling Agents - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Male | Nitroprusside - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Sildenafil Citrate | Penis - drug effects | Purines | Oxadiazoles - pharmacology | Acetophenones - pharmacology | Rotenone - pharmacology | Superoxides - metabolism | Nitric Oxide Donors - pharmacology | Sulfones | Xanthine Oxidase - antagonists & inhibitors | NG-Nitroarginine Methyl Ester - pharmacology | Rabbits | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Penis - physiopathology | Phosphodiesterase Inhibitors - pharmacology | Onium Compounds - pharmacology | Piperazines - pharmacology | Carbachol - pharmacology | Animals | Cyclic GMP - metabolism | Penis - metabolism | Allopurinol - pharmacology | Hypercholesterolemia - physiopathology | Muscle Relaxation - drug effects | In Vitro Techniques | Oxidases | Hypercholesterolemia | Impotence | Analysis | Nitric oxide | Sodium nitroferricyanide | Sildenafil | Guanylate cyclase
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2008, Volume 587, Issue 1, pp. 129 - 134
The present study was performed to examine the involvement of nitric oxide (NO) signaling pathway in the anti-convulsant effect of adenosine against... 
Sodium nitroprusside | Adenosine | L-NAME | Aminoguanidine | Pentylenetetrazol | 7-NI | Seizure threshold | Sildenafil | L-arginine | Methylene blue | pentylenetetrazol | seizure threshold | RAT | POSSIBLE INVOLVEMENT | aminoguanidine | RELEASE | FORCED SWIMMING TEST | sildenafil | GUANYLATE-CYCLASE | adenosine | methylene blue | sodium nitroprusside | CONVULSIVE BEHAVIOR | ARGININE | PHARMACOLOGY & PHARMACY | CGMP PATHWAY | BRAIN | Seizures - prevention & control | Phosphodiesterase 5 Inhibitors | Guanidines - pharmacology | Male | Nitroprusside - pharmacology | Sulfones - pharmacology | Anticonvulsants - pharmacology | Seizures - chemically induced | Cyclic AMP - physiology | Sildenafil Citrate | Cyclic Nucleotide Phosphodiesterases, Type 5 - physiology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Nitric Oxide Donors - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Nitric Oxide - physiology | Adenosine - pharmacology | Methylene Blue - pharmacology | Piperazines - pharmacology | Indazoles - pharmacology | Animals | Signal Transduction - drug effects | Arginine - pharmacology | Convulsants | Mice | Pentylenetetrazole | Sodium nitroferricyanide | Cyanides | Seizures (Medicine) | Nitric oxide | Index Medicus
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2013, Volume 347, Issue 3, pp. 626 - 634
Journal Article
Neuroscience, ISSN 0306-4522, 2014, Volume 268, pp. 236 - 246
Highlights • l -NAME, aminoguanidine and sildenafil prevent LPS-induced depressive-like behavior. • l -Arginine, a NO precursor, did not prevent LPS-induced... 
Neurology | nitric oxide | depressive-like behavior | neuroinflammation | BDNF | LPS | oxidative stress | Depressive-like behavior | Oxidative stress | Neuroinflammation | Nitric oxide | ACTIVATION | GUANOSINE-MONOPHOSPHATE PATHWAY | PREPULSE INHIBITION | NITROSATIVE STRESS | MAJOR DEPRESSION | KAPPA-B | NEUROSCIENCES | L-TRYPTOPHAN | ANIMAL-MODEL | ACOUSTIC STARTLE | PITUITARY-ADRENAL AXIS | Oxidative Stress - physiology | Nitric Oxide Synthase - antagonists & inhibitors | Depressive Disorder - drug therapy | Guanidines - pharmacology | Male | Sulfones - pharmacology | Lipopolysaccharides | Brain - metabolism | Sildenafil Citrate | Interleukin-1beta - metabolism | Behavior, Animal - drug effects | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | Disease Models, Animal | NG-Nitroarginine Methyl Ester - pharmacology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Behavior, Animal - physiology | Depressive Disorder - metabolism | Piperazines - pharmacology | Brain - drug effects | Animals | Cyclic GMP - metabolism | Signal Transduction - drug effects | Arginine - pharmacology | Depressive Disorder - prevention & control | Signal Transduction - physiology | Mice | Nitric Oxide Synthase - metabolism | Oxidative Stress - drug effects | Imipramine - pharmacology | Nitric Oxide - metabolism | Antidepressants | Mitogens | Depression, Mental | Index Medicus
Journal Article