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PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e38386 - e38386
Statins are widely prescribed for reducing LDL-cholesterol (C) and risk for cardiovascular disease (CVD), but there is considerable variation in therapeutic... 
KIDNEY-DISEASE | ALLOPURINOL | XANTHINE-OXIDASE | THERAPY | CHOLESTEROL | METABOLISM | MULTIDISCIPLINARY SCIENCES | PHARMACOGENOMICS | EXPRESSION | STATINS | GLOBAL BIOCHEMICAL APPROACH | Metabolomics | Simvastatin - therapeutic use | Gas Chromatography-Mass Spectrometry | Ornithine - blood | Xanthine - blood | Humans | alpha-Tocopherol - blood | Male | Simvastatin - pharmacology | Biomarkers, Pharmacological - blood | Succinic Acid - blood | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Stearic Acids - blood | Cystine - blood | Adult | Amino Acids, Essential - blood | Cholesterol, LDL - blood | Female | Fructose - blood | Nitric Oxide Synthase - blood | Citrulline - blood | Lauric Acids - blood | Pharmacogenetics | Low density lipoproteins | Simvastatin | Amino acids | Fructose | Cardiovascular agents | Antilipemic agents | Purines | Urea | Metabolites | Blood cholesterol | Nitric oxide | Analysis | Tocopherols | Cardiovascular diseases | Health aspects | Saturated fatty acids | Drugs | Lipoproteins (low density) | Lauric acid | Heart surgery | Genomics | Metadata | Cardiovascular disease | Cystine | Spectrometry | Microbiota | Ischemia | Arginine | Hydroxyvaleric acid | Stearic acid | Lipid metabolism | Bioinformatics | Statins | Discriminant analysis | Health risks | Pharmacology | Exposure | Citrulline | Xanthine | Metabolism | Cholesterol | Nitric-oxide synthase | Substrates | Intermediates | Studies | Gas chromatography | Lysine | Succinic acid | Biomarkers | Gastrointestinal surgery | Diabetes | Tocopherol | Ornithine | Index Medicus
Journal Article
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 11/2017, Volume 12, Issue 11, pp. 1787 - 1794
Background and objectives Causes of CKD differ in prognosis and treatment. Metabolomic indicators of CKD cause may provide clues regarding the different... 
MDRD study | Tandem mass spectrometry | Demography | Prognosis | Renal insufficiency, chronic | Homocitrulline | Metabolomic profiling | Polycystic kidney diseases | Male | Citrulline | Sulfates | Hippurates | Kidney | Glomerular filtration rate | Body mass index | Dietary proteins | Diet | Metabolites | Random allocation | Blood pressure | Kynurenic acid | Chromatography, liquid | Proteinuria | KYNURENINE | DIETARY-PROTEIN RESTRICTION | FATTY-ACID OXIDATION | UROLOGY & NEPHROLOGY | BLOOD-PRESSURE CONTROL | RENAL-DISEASE | ACCUMULATION | CHRONIC KIDNEY-DISEASE | ORGANIC ANION TRANSPORTERS | IDENTIFICATION | PROGRESSION | Guanosine - analogs & derivatives | Citrulline - analogs & derivatives | Kynurenic Acid - blood | Renal Insufficiency, Chronic - etiology | Glomerulonephritis - blood | Humans | Metabolome - physiology | Middle Aged | Deoxyglucose - blood | Guanosine - blood | Polycystic Kidney Diseases - complications | Glomerulonephritis - complications | Randomized Controlled Trials as Topic | Homovanillic Acid - blood | Renal Insufficiency, Chronic - blood | Hippurates - blood | Adult | Female | Citrulline - blood | Palmitic Acids - blood | Polycystic Kidney Diseases - blood | Index Medicus | Body Mass Index | blood pressure | Renal Insufficiency, Chronic | glomerular filtration rate | Kynurenic Acid | Polycystic Kidney Diseases | proteinuria | Random Allocation | metabolites | homocitrulline | Tandem Mass Spectrometry | kidney | Dietary Proteins | Chromatography, Liquid | Original | MDRD Study
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, pp. e66823 - e66823
Diabetes mellitus (DM) is a worldwide disease characterized by metabolic disturbances, frequently associated with high risk of atherosclerosis and renal and... 
OXIDATIVE STRESS | LIPID-PEROXIDATION | AMINO-ACID-TRANSPORT | SHEEP ERYTHROCYTES | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | RELAXING FACTOR | NITRIC-OXIDE | SICKLE-CELL-DISEASE | ARGINASE ACTIVITY | BLOOD-CELLS | Ornithine - blood | Oxidative Stress | Humans | Middle Aged | Carbon Isotopes | Hyperglycemia - complications | Male | Diabetes Mellitus, Type 2 - metabolism | Urea - blood | Case-Control Studies | Malondialdehyde - blood | Hyperglycemia - pathology | Nitrites - blood | Adult | Female | Citrulline - blood | Diabetes Mellitus, Type 2 - complications | Hemolysis | Endothelial Cells - metabolism | Hemoglobins - metabolism | Glycosylation | Hyperglycemia - metabolism | Diabetes Mellitus, Type 2 - blood | Hyperglycemia - blood | Metabolic Networks and Pathways | Models, Biological | Erythrocytes - metabolism | Aged | Diabetes Mellitus, Type 2 - pathology | Blood Glucose - metabolism | Nitric Oxide - metabolism | Arginine - metabolism | Type 2 diabetes | Urea | Hyperglycemia | Arginine | Metabolites | Blood sugar | Nitric oxide | Atherosclerosis | Physiological aspects | Diabetes therapy | Oxidative stress | Pathogenesis | Nitrites | Erythrocytes | Amino acids | Nervous system | Arginase | Polyamines | Blood | Red blood cells | Nitrogen metabolism | Rodents | Redox properties | Sickle cell disease | Hypertension | Damage assessment | Kidneys | Diabetes mellitus | Blood cells | Byproducts | Citrulline | Metabolism | Patients | Nitric-oxide synthase | Malondialdehyde | Endothelium | Serum levels | Hepatocytes | Arteriosclerosis | Catabolism | Diabetes | Ornithine | Kidney transplantation | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2013, Volume 33, Issue 8, pp. 1861 - 1871
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2011, Volume 108, Issue 42, pp. 17372 - 17377
Journal Article
Experimental Physiology, ISSN 0958-0670, 12/2017, Volume 102, Issue 12, pp. 1661 - 1671
New Findings What is the central question of this study? Does short-term supplementation with l-citrulline in order to increase l-arginine improve exercise... 
exercise | aging | citrulline | blood flow | ORAL L-CITRULLINE | PHYSIOLOGY | PERFORMANCE | NITRIC-OXIDE SYNTHESIS | HUMANS | HYPEREMIA | PRESSURE | METABOLISM | L-ARGININE | ESTRADIOL | AGE | Physiological aspects | Aged | Dextrins | Arginine | Nitric oxide | Blood flow | Women | Femoral artery | Femur | Citrulline | Doppler effect | L-citrulline | Maltodextrin | Older people | Blood pressure | Conductance | Supplementation | Ultrasound | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2018, Volume 13, Issue 1, pp. e0191231 - e0191231
Citrullinated histone H3 (H3Cit) is a central player in the neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs). NETs have... 
NEUTROPHIL EXTRACELLULAR TRAPS | DNA TRAPS | NETOSIS | PLASMA | CIRCULATING TUMOR-CELLS | ELASTASE | MULTIDISCIPLINARY SCIENCES | CATHEPSIN-G | SERUM | PROMOTE | INNATE IMMUNITY | Citrullination | Prognosis | Neutrophil Activation | Extracellular Traps - metabolism | Histones - chemistry | Humans | Middle Aged | Neutrophils - immunology | Neoplasms - mortality | Male | Case-Control Studies | Histones - blood | Biomarkers, Tumor - blood | Extracellular Traps - immunology | Neoplasms - blood | Interleukin-6 - blood | Neoplasms - immunology | Aged, 80 and over | Female | Aged | Biomarkers, Tumor - chemistry | Interleukin-8 - blood | Neutrophils - metabolism | Histones | Physiological aspects | Genetic aspects | Research | Diagnosis | Biological markers | Cancer | Chromatin | Disease | Interleukin | Inflammatory response | Biology | Medical diagnosis | Blood | Inflammatory diseases | Interleukin 6 | Cell activation | Immunology | Peroxidase | Elastase | Deoxyribonucleic acid--DNA | Immune system | Cytokines | Internal medicine | Neutrophils | Health risks | Leukocytes (neutrophilic) | Inflammation | Citrulline | Patients | Thrombosis | Medicine | Hospitals | Medical prognosis | Diagnostic systems | Histone H3 | Apoptosis | Tumors | Index Medicus | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Gastroenterologi | Cancer and Oncology | Klinisk medicin | Gastroenterology and Hepatology | Cancer och onkologi | Deoxyribonucleic acid | DNA
Journal Article
Journal of Periodontology, ISSN 0022-3492, 12/2013, Volume 84, Issue 12, pp. e74 - e84
Journal Article
European Journal of Applied Physiology, ISSN 1439-6319, 9/2010, Volume 110, Issue 2, pp. 341 - 351
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 8/2019, Volume 458, Issue 1, pp. 133 - 142
Changes in the ecto-5′-nucleotidase activity—an extracellular nucleotide catabolic enzyme may lead to the inflammation and endothelial dysfunction. We... 
Life Sciences | Biochemistry, general | Adenosine | l -Arginine metabolism | Endothelial dysfunction | Medical Biochemistry | Oncology | Cardiology | Ecto-5′-nucleotidase | Nucleotide metabolism | Endothelium | CD73 | Ecto-5 '-nucleotidase | MUSCLE | MECHANISMS | ASYMMETRIC DIMETHYLARGININE ADMA | l-Arginine metabolism | DELETION | CELL BIOLOGY | ADENOSINE GENERATION | INFLAMMATION | NITRIC-OXIDE | CD39 | ATP | Adenosine Diphosphate - genetics | Interleukin-6 - genetics | Adenosine Triphosphate - genetics | 5'-Nucleotidase - deficiency | Adenosine Triphosphate - blood | Nitric Oxide Synthase Type III - genetics | Mice, Knockout | Vascular Cell Adhesion Molecule-1 - blood | Adenosine Diphosphate - blood | Nitric Oxide Synthase Type III - blood | Animals | Endothelium, Vascular - metabolism | Interleukin-6 - blood | Arginine - blood | Arginine - genetics | Intercellular Adhesion Molecule-1 - genetics | Endothelium, Vascular - pathology | Intercellular Adhesion Molecule-1 - blood | Vascular Cell Adhesion Molecule-1 - genetics | Mice | Ethylenediaminetetraacetic acid | Interleukins | Arginine | Nitric oxide | Analysis | Physiological aspects | Inflammation | Adenylic acid | Nucleotidases | Nucleotidase | Vascular cell adhesion molecule 1 | Interleukin | Erythrocytes | Amino acids | Arginase | Blood | Cell adhesion molecules | Cell adhesion & migration | Interleukin 6 | Red blood cells | Clonal deletion | Cell adhesion | Deletion | Aorta | CD73 antigen | Age | Level (quantity) | AMP | Intercellular adhesion molecule 1 | Adenine | Citrulline | Metabolism | Adhesion | Nitric-oxide synthase | Endothelial cells | Blood levels | Lungs | Ornithine | Index Medicus
Journal Article