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Leukemia, ISSN 1476-5551, 2018, Volume 32, Issue 9, pp. 1958 - 1969
The PI 3-kinases (PI3K) are essential mediators of chemokine receptor signaling necessary for migration of chronic lymphocytic leukemia (CLL... 
G-BETA-GAMMA | P110-GAMMA ISOFORM | ONCOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE | REGULATORY SUBUNITS | CHRONIC LYMPHOCYTIC-LEUKEMIA | SURVIVAL SIGNALS | ZAP-70 EXPRESSION | HEMATOLOGY | MARROW STROMAL CELLS | T-LYMPHOCYTES | DIFFERENTIAL ROLES | Leukemia, B-Cell - metabolism | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Class Ib Phosphatidylinositol 3-Kinase - genetics | Humans | Cell Survival - genetics | Lymphoma, B-Cell - genetics | Cell Movement - genetics | Gene Knockdown Techniques | CD40 Ligand - metabolism | Class Ib Phosphatidylinositol 3-Kinase - metabolism | ZAP-70 Protein-Tyrosine Kinase - metabolism | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Gene Expression Regulation, Neoplastic - drug effects | Mesenchymal Stem Cells - metabolism | B-Lymphocytes - metabolism | Quinazolinones - pharmacology | Cell Survival - drug effects | Cell Adhesion - genetics | Lymphoma, B-Cell - metabolism | Purines - pharmacology | Interleukin-4 - metabolism | Leukemia, B-Cell - pathology | Cell Adhesion - drug effects | Chemotaxis - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - drug effects | Leukemia, B-Cell - genetics | Lymphoma, B-Cell - pathology | Cytoskeleton - metabolism | Chemokines - metabolism | Class Ib Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mutation | Immunoglobulin Heavy Chains - genetics | CXCL12 protein | Chronic lymphatic leukemia | Leukocyte migration | Leukemia | Cytology | Adhesion tests | Crosslinking | ZAP-70 protein | Lymphatic leukemia | Kinases | CD40L protein | Adhesion | Cell morphology | 1-Phosphatidylinositol 3-kinase | Cell adhesion & migration | Interleukin 4 | Inhibitors | Lymphocytes B | Actin | Morphology | Stromal cells | Inhibition | Chemokines | Cell migration
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 10, p. e76405
Journal Article
Biochemical journal, ISSN 1470-8728, 2014, Volume 463, Issue 3, pp. 413 - 427
We characterize VPS34-IN, a potent and selective inhibitor of class III Vps34 PI3K. Using VPS34-IN1, we demonstrate that PtdIns(3)P, produced by Vps34 controls... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12256 - 12266
Class IA PI3Ks are involved in the generation of the key lipid signaling molecule phosphatidylinositol 3,4,5-trisphosphate (PIP3... 
EXCHANGE MASS-SPECTROMETRY | G-BETA-GAMMA | P110-ALPHA | PROTEIN | SPECIFICITY | RAS MUTATIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT | FUNCTIONAL-ANALYSIS | PHOSPHOLIPASE A | BINDING | Class I Phosphatidylinositol 3-Kinases - genetics | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Phosphatidylinositol 3-Kinases - metabolism | Spodoptera | Deuterium Exchange Measurement | Sf9 Cells | Proto-Oncogene Proteins p21(ras) - chemistry | Protein Interaction Domains and Motifs | Peptide Fragments - genetics | Second Messenger Systems | Proto-Oncogene Proteins p21(ras) - metabolism | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Class I Phosphatidylinositol 3-Kinases - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Protein Transport | Phosphatidylinositol 3-Kinases - genetics | Point Mutation | Peptide Fragments - chemistry | Animals | Protein Conformation | Enzyme Activation | Lipid Bilayers - metabolism | Liposomes | Amino Acid Substitution | hydrogen exchange mass spectrometry | Signal Transduction | lipid–protein interaction | Ras protein | phosphatidylinositide 3-kinase (PI 3-kinase) | lipid signaling | phosphoinositide
Journal Article
Nature reviews. Immunology, ISSN 1474-1741, 2016, Volume 16, Issue 11, pp. 702 - 714
Primary immunodeficiencies are inherited disorders of the immune system, often caused by the mutation of genes required for lymphocyte development and... 
Signal Transduction | Humans | Gene Expression Regulation | Lymphocytes/cytology | Immune System/cytology | Molecular Targeted Therapy | Immunity | Immunologic Deficiency Syndromes/etiology | Cellular Senescence/genetics | Phosphatidylinositol 3-Kinases/antagonists & inhibitors | Animals | Lymphocyte Activation/genetics | Protein Subunits/genetics | Cell Differentiation/genetics | Enzyme Activation | Mutation | T-CELL RESPONSES | IMPAIRED B-CELL | GAIN-OF-FUNCTION | TRANSCRIPTION FACTOR FOXO1 | PHOSPHATIDYLINOSITOL 3-KINASE | PHOSPHOINOSITIDE 3-KINASE P110-DELTA | HYPER IGM SYNDROME | P85-ALPHA SUBUNIT | IMMUNOLOGY | CLASS-IA PI3K | CUTTING EDGE | Immunologic Deficiency Syndromes - etiology | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Protein Subunits - metabolism | Cell Differentiation - genetics | Cellular Senescence - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Lymphocytes - immunology | Immune System - immunology | Protein Subunits - genetics | Lymphocytes - metabolism | Cellular Senescence - genetics | Immunologic Deficiency Syndromes - therapy | Phosphatidylinositol 3-Kinases - chemistry | Lymphocytes - cytology | Immune System - cytology | Phosphatidylinositol 3-Kinases - genetics | Cell Differentiation - immunology | Immune System - metabolism | Immunologic Deficiency Syndromes - metabolism
Journal Article
Annual review of biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 225 - 244
...) protein kinase complex and the PI3KC3-C1 (class III phosphatidylinositol 3-kinase complex... 
COPII | Atg1 | membrane remodeling | vesicle | tethering complex | nanoscale biology | ULK1 | Vps34 | membrane fusion | phosphatidylinositol 3-kinase | Vesicle | Membrane fusion | Membrane remodeling | Phosphatidylinositol 3-kinase | Nanoscale biology | Tethering complex | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHAGOPHORE ASSEMBLY SITE | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | REGULATES AUTOPHAGY | MAMMALIAN AUTOPHAGY | BECLIN 1 PHOSPHORYLATION | SACCHAROMYCES-CEREVISIAE | SELECTIVE AUTOPHAGY | ATG1 KINASE COMPLEX | ENDOPLASMIC-RETICULUM | ULK1 COMPLEX | Humans | Protein Multimerization | Eukaryotic Cells - metabolism | Autophagy-Related Protein-1 Homolog - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Eukaryotic Cells - ultrastructure | Class III Phosphatidylinositol 3-Kinases - chemistry | Phagosomes - ultrastructure | Cell Membrane - metabolism | Autophagy - genetics | Intracellular Signaling Peptides and Proteins - genetics | Phosphatidylinositol 3-Kinase - metabolism | COP-Coated Vesicles - ultrastructure | Gene Expression | Signal Transduction | Phagosomes - metabolism | Gene Expression Regulation | COP-Coated Vesicles - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Cell Membrane - ultrastructure | Autophagy-Related Protein-1 Homolog - chemistry | Phosphatidylinositol 3-Kinase - chemistry | Phosphatidylinositol 3-Kinase - genetics | Class III Phosphatidylinositol 3-Kinases - genetics | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | Autophagy-Related Protein-1 Homolog - genetics | Physiological aspects | Autophagy (Cytology) | Genetic aspects | Research | Gene expression
Journal Article