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Biochemical Journal, ISSN 0264-6021, 11/2014, Volume 463, Issue 3, pp. 413 - 427
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 483 - 493
Activation-induced cytidine deaminase (AID) is a B-cell-specific enzyme that targets immunoglobulin genes to initiate class switch recombination and somatic... 
SUPER-ENHANCERS | INDUCED CYTIDINE DEAMINASE | DNA | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | IBRUTINIB | CLASS-SWITCH RECOMBINATION | MECHANISMS | TARGETING BTK | AID | SEQUENCING REVEALS | Isoquinolines - adverse effects | Class I Phosphatidylinositol 3-Kinases - metabolism | Humans | Lymphoma, Mantle-Cell - pathology | Phosphatidylinositol 3-Kinases - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Translocation, Genetic - drug effects | Isoquinolines - pharmacology | Antineoplastic Agents - adverse effects | Genomic Instability - drug effects | Female | Antineoplastic Agents - pharmacology | Purines - adverse effects | B-Lymphocytes - pathology | Immunoglobulin Class Switching - drug effects | Somatic Hypermutation, Immunoglobulin - drug effects | Lymphoma, Mantle-Cell - genetics | B-Lymphocytes - metabolism | Quinazolinones - pharmacology | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Enzyme Inhibitors - adverse effects | B-Lymphocytes - enzymology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | B-Lymphocytes - drug effects | Animals | Agammaglobulinaemia Tyrosine Kinase | Cytidine Deaminase - metabolism | Pyrimidines - adverse effects | Cell Line, Tumor | Mice | Immunoglobulin Heavy Chains - genetics | Quinazolinones - adverse effects | Recombination, Genetic - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 8, pp. 1982 - 1987
Journal Article
Nature communications, ISSN 2041-1723, 05/2016, Volume 7, Issue 1, p. 11579
Journal Article
Nature Communications, ISSN 2041-1723, 06/2016, Volume 7, Issue 1, p. 11971
Cancer cells often require glutamine for growth, thereby distinguishing them from most normal cells. Here we show that PIK3CA mutations reprogram glutamine... 
PHOSPHOINOSITIDE 3-KINASE PATHWAY | CELLS | DEPRIVATION | PHOSPHORYLATION | GLUCOSE | MULTIDISCIPLINARY SCIENCES | KRAS | PROLIFERATION | OPPORTUNITIES | TUMOR-GROWTH | EXPRESSION | Adenocarcinoma - pathology | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Glutamine - metabolism | Adenosine Triphosphate - biosynthesis | Adenosine Triphosphate - antagonists & inhibitors | Colorectal Neoplasms - drug therapy | Ketoglutaric Acids - antagonists & inhibitors | Transaminases - metabolism | Female | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Ketoglutaric Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Colorectal Neoplasms - enzymology | Signal Transduction | Transaminases - genetics | HCT116 Cells | Adenocarcinoma - enzymology | Citric Acid Cycle - drug effects | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Activating Transcription Factor 4 - genetics | Adenocarcinoma - drug therapy | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | HT29 Cells | Xenograft Model Antitumor Assays | Animals | Glutamine - antagonists & inhibitors | Activating Transcription Factor 4 - metabolism | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Aminooxyacetic Acid - pharmacology | Mice | Mutation | Colorectal Neoplasms - pathology
Journal Article
Annals of oncology : official journal of the European Society for Medical Oncology, ISSN 0923-7534, 2016, Volume 27, Issue 10, pp. 1928 - 1940
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2013, Volume 17, Issue 4, pp. 599 - 606
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 04/2019, Volume 15, Issue 4, pp. 348 - 357
Journal Article
Journal Article
by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | CT | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2012, Volume 55, Issue 11, pp. 5188 - 5219
A highly selective series of inhibitors of the class I phosphatidylinositol 3-kinases (PI3Ks) has been designed and synthesized. Starting from the dual... 
MAMMALIAN TARGET | RAPAMYCIN | CROSS-COUPLING REACTIONS | CHEMISTRY, MEDICINAL | PI3K | C-N | PATHWAY | KINASE INHIBITOR | MUTATIONS | CANCER | DISCOVERY | Indazoles - chemical synthesis | Pyrazoles - chemical synthesis | Pyrimidines - chemical synthesis | Humans | Microsomes, Liver - metabolism | Pyridines - pharmacokinetics | Biological Availability | Crystallography, X-Ray | Structure-Activity Relationship | Sulfones - pharmacology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Drug Design | Female | Piperazines - pharmacokinetics | Pyrazoles - pharmacokinetics | Pyrazoles - pharmacology | Sulfones - chemical synthesis | Purines - chemical synthesis | Triazines - pharmacology | Signal Transduction | Purines - pharmacology | Purines - pharmacokinetics | Pyridines - chemical synthesis | Models, Molecular | Rats | Proto-Oncogene Proteins c-akt - physiology | Pyrimidines - pharmacology | Sulfones - pharmacokinetics | Sulfonamides - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Piperazines - pharmacology | Sulfonamides - pharmacokinetics | Indazoles - pharmacology | Xenograft Model Antitumor Assays | Sulfonamides - chemical synthesis | Animals | Class I Phosphatidylinositol 3-Kinases - physiology | Indazoles - pharmacokinetics | Mice, Nude | Triazines - chemical synthesis | Pyrimidines - pharmacokinetics | Piperazines - chemical synthesis | Mice | Pyridines - pharmacology | Triazines - pharmacokinetics | DESIGN | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | PHOSPHOTRANSFERASES | IN VIVO | PROTEINS | 60 APPLIED LIFE SCIENCES
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 24, pp. 3583 - 3586
Chronic lymphocytic leukemia (CLL) displays constitutive phosphatidylinositol 3-kinase (PI3K) activation resulting from aberrant regulation of B-cell receptor... 
IBRUTINIB | MODELS | INHIBITOR | HEMATOLOGY | THERAPEUTIC TARGET | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | T-Lymphocytes - enzymology | Class Ib Phosphatidylinositol 3-Kinase - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Cell Survival - genetics | Male | Neoplasm Proteins - antagonists & inhibitors | Killer Cells, Natural - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Mutation, Missense | Neoplasm Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Isoquinolines - pharmacology | Female | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | T-Lymphocytes - pathology | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Pyrazoles - pharmacology | Cell Survival - drug effects | B-Lymphocytes - enzymology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Signal Transduction - genetics | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Killer Cells, Natural - enzymology | Drug Resistance, Neoplasm - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Lymphoid Neoplasia | Brief Report
Journal Article