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Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1013 - 1019
Vps34 is a phosphoinositide 3-kinase (PI3K) class III isoform that has attracted major attention over the recent years because of its role in autophagy. Herein... 
KINASE VPS34 | LIPID KINASE | PHOSPHATIDYLINOSITOL 3-PHOSPHATE | T-CELL HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | MECHANISMS | OPTIMIZATION | MAMMALIAN-CELLS | MTOR | REVEALS | Kidney - pathology | Antineoplastic Agents - chemical synthesis | Humans | Kidney - enzymology | Sirolimus - chemical synthesis | Autophagy - drug effects | Endosomes - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Lysosomes - metabolism | TOR Serine-Threonine Kinases - genetics | Adenosine Triphosphate - metabolism | Endosomes - drug effects | Class III Phosphatidylinositol 3-Kinases - chemistry | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Autophagy - genetics | Pyrimidinones - chemical synthesis | Everolimus | Lysosomes - drug effects | Protein Kinase Inhibitors - chemical synthesis | Catalytic Domain | Gene Expression | Sirolimus - analogs & derivatives | Signal Transduction | Pyridines - chemical synthesis | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Sirolimus - pharmacology | Drug Synergism | TOR Serine-Threonine Kinases - chemistry | Class III Phosphatidylinositol 3-Kinases - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Kinetics | Adenosine Triphosphate - chemistry | Proteins | Lipids | Kinases | Autophagy | Binding sites | Adenosine triphosphatase | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2014, Volume 463, Issue 3, pp. 413 - 427
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2013, Volume 19, Issue 11, pp. 1478 - 1488
Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms in the heart through inhibition of autophagy. Stress-induced... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | PROTEIN AGGREGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | KINASE | STARVATION-INDUCED AUTOPHAGY | CELL BIOLOGY | HEMODYNAMIC STRESS | PATHWAY | X-L | CARDIAC-HYPERTROPHY | TUMOR-SUPPRESSOR | Cardiomyopathy, Dilated - pathology | Phosphorylation | Humans | Middle Aged | Protein Multimerization | Molecular Sequence Data | Male | Autophagy - physiology | Young Adult | Proto-Oncogene Proteins c-bcl-2 - metabolism | Myocardial Infarction - pathology | Apoptosis Regulatory Proteins - genetics | Hepatocyte Growth Factor - genetics | Adult | Female | Membrane Proteins - metabolism | Beclin-1 | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Myocytes, Cardiac - cytology | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | Mice, Inbred C57BL | bcl-2-Associated X Protein - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Models, Molecular | Rats | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Myocardial Infarction - metabolism | Proto-Oncogene Proteins - deficiency | Cardiomyopathy, Dilated - metabolism | Apoptosis Regulatory Proteins - metabolism | Hepatocyte Growth Factor - metabolism | Mice, Knockout | Hepatocyte Growth Factor - deficiency | Animals | Membrane Proteins - chemistry | Myocytes, Cardiac - metabolism | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Mice | Apoptosis - physiology | Autophagy (Cytology) | Heart cells | Physiological aspects | Research | Properties | Phosphotransferases | Apoptosis | Cardiomyocytes | Kinases | Cardiomyopathy | Autophagy | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 10/2014, Volume 16, Issue 11, pp. 1069 - 1079
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 01/2015, Volume 58, Issue 1, pp. 376 - 400
Journal Article
Journal Article
Cell Cycle, ISSN 1538-4101, 06/2016, Volume 15, Issue 12, pp. 1611 - 1619
Journal Article
Traffic, ISSN 1398-9219, 08/2013, Volume 14, Issue 8, pp. 933 - 948
Journal Article
Immunology, ISSN 0019-2805, 11/2017, Volume 152, Issue 3, pp. 517 - 525
The importance of extracellular traps ( ET s) in innate immunity is well established, but the molecular mechanisms responsible for their formation remain... 
eosinophils | extracellular traps | autophagy | neutrophil extracellular traps | neutrophils | Eosinophils - metabolism | Reactive Oxygen Species - metabolism | Eosinophils - drug effects | Extracellular Traps - metabolism | Autophagy-Related Protein 5 - genetics | Eosinophils - immunology | Autophagy - drug effects | Extracellular Traps - immunology | Extracellular Traps - drug effects | Eosinophils - pathology | Autophagy-Related Protein 5 - immunology | Neutrophils - metabolism | Neutrophils - pathology | Immunity, Innate - drug effects | Mice, Inbred C57BL | Neutrophils - drug effects | Cells, Cultured | Neutrophils - immunology | Class III Phosphatidylinositol 3-Kinases - metabolism | Genotype | Mice, Knockout | Phenotype | Animals | Autophagy-Related Protein 5 - deficiency | Autophagy-Related Protein 5 - metabolism | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Proteins | Physiological aspects | Mice | DNA | Genetically modified organisms | Reactive oxygen species | Low concentrations | Chloroquine | Innate immunity | Autophagy | Immunity | Cascades | Rodents | Bacteria | Pretreatment | Genetic modification | Deoxyribonucleic acid--DNA | Killing | Leukocytes (eosinophilic) | Abnormalities | Neutrophils | Leukocytes (neutrophilic) | 1-Phosphatidylinositol 3-kinase | Signaling | Molecular modelling | Inhibitors | Wortmannin | Scaffolds | Phagocytosis | Eosinophils | Index Medicus | Original
Journal Article