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1. Full Text Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase
by Bago, Ruzica and Malik, Nazma and Munson, Michael J and Prescott, Alan R and Davies, Paul and Sommer, Eeva and Shpiro, Natalia and Ward, Richard and Cross, Darren and Ganley, Ian G and Alessi, Dario R
Biochemical journal, ISSN 0264-6021, 11/2014, Volume 463, Issue 3, pp. 413 - 427
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
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2. Full Text Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy
by Yu, Xinlei and Long, Yun Chau and Shen, Han-Ming
Autophagy, ISSN 1554-8627, 10/2015, Volume 11, Issue 10, pp. 1711 - 1728
PIK3C3 | autophagy | PI3K | MTOR | PI3K inhibitor | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Multiprotein Complexes - metabolism | Animals | TOR Serine-Threonine Kinases - metabolism | Humans | Phagosomes - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositols - metabolism | Autophagy - physiology | Apoptosis Regulatory Proteins - metabolism | Mechanistic Target of Rapamycin Complex 1 | Index Medicus
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3. Full Text Mechanisms of Autophagy Initiation
by Hurley, James H and Young, Lindsey N
Annual review of biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 225 - 244
COPII | Atg1 | membrane remodeling | vesicle | tethering complex | nanoscale biology | ULK1 | Vps34 | membrane fusion | phosphatidylinositol 3-kinase | Vesicle | Membrane fusion | Membrane remodeling | Phosphatidylinositol 3-kinase | Nanoscale biology | Tethering complex | Humans | Protein Multimerization | Eukaryotic Cells - metabolism | Autophagy-Related Protein-1 Homolog - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Eukaryotic Cells - ultrastructure | Class III Phosphatidylinositol 3-Kinases - chemistry | Phagosomes - ultrastructure | Cell Membrane - metabolism | Autophagy - genetics | Intracellular Signaling Peptides and Proteins - genetics | Phosphatidylinositol 3-Kinase - metabolism | COP-Coated Vesicles - ultrastructure | Gene Expression | Signal Transduction | Phagosomes - metabolism | Gene Expression Regulation | COP-Coated Vesicles - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Cell Membrane - ultrastructure | Autophagy-Related Protein-1 Homolog - chemistry | Phosphatidylinositol 3-Kinase - chemistry | Phosphatidylinositol 3-Kinase - genetics | Class III Phosphatidylinositol 3-Kinases - genetics | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | Autophagy-Related Protein-1 Homolog - genetics | Physiological aspects | Autophagy (Cytology) | Genetic aspects | Research | Gene expression | Image resolution | Protein kinase C | Lipids | Membrane vesicles | Biosynthesis | Kinases | Autophagy | Cells | 1-Phosphatidylinositol 3-kinase | Membrane proteins | Vesicles | Protein kinase | Lipid kinase | Coat protein | Catalysis | Phagocytosis | Index Medicus
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4. Full Text Class IA PI3K p110β Subunit Promotes Autophagy through Rab5 Small GTPase in Response to Growth Factor Limitation
by Dou, Zhixun and Pan, Ji-An and Dbouk, Hashem A and Ballou, Lisa M and DeLeon, Jennifer L and Fan, Yongjun and Chen, Juei-Suei and Liang, Zhimin and Li, Guangpu and Backer, Jonathan M and Lin, Richard Z and Zong, Wei-Xing
Molecular cell, ISSN 1097-2765, 04/2013, Volume 50, Issue 1, pp. 29 - 42
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Class I Phosphatidylinositol 3-Kinases - genetics | Signal Transduction | Humans | Class III Phosphatidylinositol 3-Kinases - metabolism | Guanosine Triphosphate - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Autophagy | rab5 GTP-Binding Proteins - metabolism | Class I Phosphatidylinositol 3-Kinases - deficiency | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Animals | Transfection | Phosphatidylinositol 3-Kinases - deficiency | HEK293 Cells | Mice | Intercellular Signaling Peptides and Proteins - deficiency | Mutation | Index Medicus
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5. Full Text Inhibition of Human Class I vs Class III Phosphatidylinositol 3′-Kinases
by Hassett, Matthew R and Sternberg, Anna R and Roepe, Paul D
Biochemistry (Easton), ISSN 0006-2960, 08/2017, Volume 56, Issue 33, pp. 4326 - 4334
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Class I Phosphatidylinositol 3-Kinases - metabolism | Sulfonamides - chemistry | Class I Phosphatidylinositol 3-Kinases - chemistry | Enzyme Inhibitors - chemistry | Humans | Quinolines - chemistry | Imidazoles - chemistry | Class III Phosphatidylinositol 3-Kinases - metabolism | Class III Phosphatidylinositol 3-Kinases - chemistry | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol Phosphates | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphates | Usage | Chemical reactions | Chemical properties | Research | Biological assay | Adenosine triphosphatase | Index Medicus
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6. Full Text The Phosphatidylinositol 3‐kinase Class III Complex Containing TcVps15 and TcVps34 Participates in Autophagy in Trypanosoma cruzi
by Schoijet, Alejandra C and Sternlieb, Tamara and Alonso, Guillermo D
The Journal of eukaryotic microbiology, ISSN 1066-5234, 05/2017, Volume 64, Issue 3, pp. 308 - 321
vesicular acidification | Vps34 | Autophagy | Vps15 | Trypanosoma cruzi | Life Sciences & Biomedicine | Microbiology | Science & Technology | Phosphatidylinositol 3-Kinases - metabolism | Protozoan Proteins - genetics | Trypanosoma cruzi - enzymology | Life Cycle Stages | Cadaverine - metabolism | Protozoan Proteins - metabolism | Transfection | Cloning, Molecular | Cell Membrane - metabolism | Cell Culture Techniques | Class III Phosphatidylinositol 3-Kinases - physiology | Mutagenesis, Site-Directed | Vacuolar Sorting Protein VPS15 - genetics | Cadaverine - analogs & derivatives | Trypanosoma cruzi - metabolism | Phagosomes - metabolism | Trypanosoma cruzi - genetics | Class III Phosphatidylinositol 3-Kinases - metabolism | Enzyme Assays | Protozoan Proteins - biosynthesis | DNA, Protozoan | Gene Expression Regulation, Enzymologic | Phosphatidylinositol 3-Kinases - genetics | Two-Hybrid System Techniques | Animals | Vacuolar Sorting Protein VPS15 - metabolism | Class III Phosphatidylinositol 3-Kinases - genetics | Phosphatidylinositol 3-Kinases - physiology | Vacuoles - metabolism | Vacuolar Sorting Protein VPS15 - physiology | Sequence Analysis | Trypanosoma cruzi - cytology | Pathogens | Protozoa | Membranes | Nutrient deficiency | Cloning | Phagosomes | Cell membranes | Parasites | Cells | Stress | 1-Phosphatidylinositol 3-kinase | Pathogenicity | Proteins | Components | Protists | Enzymatic activity | Energy | Localization | Vacuoles | Phagocytosis | Index Medicus
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