X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (428) 428
humans (388) 388
animals (301) 301
mice (223) 223
class ia phosphatidylinositol 3-kinase - metabolism (198) 198
signal transduction (176) 176
class ia phosphatidylinositol 3-kinase - genetics (158) 158
female (156) 156
cell biology (134) 134
mutation (128) 128
phosphatidylinositol 3-kinases - genetics (123) 123
cancer (122) 122
male (117) 117
proto-oncogene proteins c-akt - metabolism (114) 114
cell line, tumor (113) 113
phosphoinositide 3-kinase (113) 113
activation (105) 105
phosphatidylinositol 3-kinases - metabolism (104) 104
phosphorylation (103) 103
class i phosphatidylinositol 3-kinases (100) 100
phosphatidylinositol 3-kinase (100) 100
kinases (98) 98
oncology (98) 98
biochemistry & molecular biology (92) 92
multidisciplinary sciences (89) 89
research article (89) 89
article (87) 87
1-phosphatidylinositol 3-kinase (78) 78
pi3k (74) 74
mice, knockout (72) 72
proteins (71) 71
expression (69) 69
medicine (68) 68
science (65) 65
class ia phosphatidylinositol 3-kinase - antagonists & inhibitors (64) 64
biology (62) 62
apoptosis (61) 61
research (61) 61
signal transduction - drug effects (60) 60
genetic aspects (59) 59
mice, inbred c57bl (57) 57
cell proliferation (56) 56
immunology (56) 56
tumors (55) 55
class i phosphatidylinositol 3-kinases - genetics (54) 54
cells, cultured (49) 49
gene expression (49) 49
middle aged (49) 49
cell line (48) 48
pathway (46) 46
phosphatidylinositol 3-kinases - antagonists & inhibitors (43) 43
protein binding (43) 43
adult (42) 42
signaling (42) 42
proto-oncogene proteins c-akt - genetics (41) 41
class i phosphatidylinositol 3-kinases - metabolism (39) 39
growth (39) 39
inflammation (39) 39
mutations (39) 39
aged (38) 38
akt protein (38) 38
analysis (38) 38
breast neoplasms - genetics (38) 38
breast cancer (36) 36
breast-cancer (36) 36
gene expression regulation, neoplastic (35) 35
neoplasms (35) 35
antineoplastic agents - pharmacology (34) 34
disease models, animal (34) 34
in-vivo (34) 34
rna interference (34) 34
kinase (33) 33
protein kinase inhibitors - pharmacology (33) 33
pten phosphohydrolase - genetics (33) 33
rodents (33) 33
cell growth (32) 32
gene (32) 32
inhibition (32) 32
blotting, western (31) 31
breast neoplasms - pathology (31) 31
cell proliferation - drug effects (31) 31
physiological aspects (31) 31
rats (31) 31
tor serine-threonine kinases - metabolism (31) 31
akt (30) 30
hek293 cells (30) 30
pik3ca (30) 30
signal transduction - genetics (30) 30
abridged index medicus (29) 29
gene expression regulation (29) 29
genetics & heredity (29) 29
pten (29) 29
genetics (28) 28
signal transduction - physiology (28) 28
survival (28) 28
biochemistry (27) 27
class ia phosphatidylinositol 3-kinase - chemistry (27) 27
inhibitors (27) 27
molecular cell biology (27) 27
cell cycle (26) 26
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Clinical Cancer Research, ISSN 1078-0432, 06/2017, Volume 23, Issue 11, pp. 2795 - 2805
Purpose: Determine the roles of the PI3K isoforms p110 alpha and p110 beta in PTEN-deficient, estrogen receptor a (ER)-positive breast cancer, and the... 
RAPAMYCIN | PIK3CA MUTATIONS | ONCOLOGY | PHOSPHORYLATION | PI3K PATHWAY | ANTIESTROGEN RESISTANCE | GROWTH | SENSITIVITY | SUPPRESSION | EXPRESSION | CARCINOMA | PTEN Phosphohydrolase - genetics | Class I Phosphatidylinositol 3-Kinases - genetics | Apoptosis - drug effects | Humans | Thiazoles - administration & dosage | Breast Neoplasms - drug therapy | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Animals | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Retinoblastoma Protein - genetics | Cell Line, Tumor | Female | Cell Proliferation - drug effects | Mice | Gene Expression Regulation, Neoplastic - drug effects | Class Ia Phosphatidylinositol 3-Kinase - genetics | Phosphorylation | Estrogens | Estrogen | Estrogen receptors | Cytotoxicity | AKT protein | Activation | Fulvestrant | Xenografts | Cytostatic agents | Bioindicators | Inhibition | Growth factors | Regression | Breast cancer | Tumor cell lines | 1-Phosphatidylinositol 3-kinase | Signaling | Inhibitors | Experimental design | Isoforms | Cell lines | Biomarkers | Breast | Cytotoxic agents | PTEN protein | Cancer | Apoptosis | PTEN | p110-beta | breast cancer | anti-estrogen | PI3K
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 11/2010, Volume 191, Issue 4, pp. 827 - 843
Autophagy is an evolutionarily conserved cell renewal process that depends on phosphatidylinositol 3-phosphate (PtdIns(3)P). In metazoans, autophagy is... 
Immunoprecipitation | HT29 cells | Quantification | Liver | Cell lines | Antibodies | Fluorescence | Physiological regulation | Microscopes | Phosphatidylinositols | RAB5 EFFECTORS | COMPLEX | PATHWAY | ROLES | DISEASE | GROWTH | STARVATION | MICE | MACROAUTOPHAGY | MAMMALIAN-CELLS | CELL BIOLOGY | Autophagy-Related Proteins | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Phosphatidylinositol Phosphates - metabolism | Fibroblasts - physiology | Heart - physiology | Humans | Adaptor Proteins, Vesicular Transport - genetics | Autophagy - physiology | Adaptor Proteins, Vesicular Transport - metabolism | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Embryo, Mammalian - anatomy & histology | HEK293 Cells | Apoptosis Regulatory Proteins - genetics | Class Ia Phosphatidylinositol 3-Kinase - genetics | Proto-Oncogene Proteins c-akt - metabolism | Beclin-1 | Enzyme Inhibitors - metabolism | Phagosomes - metabolism | Cells, Cultured | Class III Phosphatidylinositol 3-Kinases - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Embryo, Mammalian - physiology | Animals | Class III Phosphatidylinositol 3-Kinases - genetics | Liver - physiology | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Fibroblasts - cytology | Liver - cytology | Mice
Journal Article
Genes and Development, ISSN 0890-9369, 12/2014, Volume 28, Issue 23, pp. 2621 - 2635
Journal Article
Cancer Discovery, ISSN 2159-8274, 06/2011, Volume 1, Issue 2, pp. 170 - 185
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2017, Volume 474, Issue 11, pp. 1867 - 1877
Until recently, one of the major limitations of hydrogen/deuterium exchange mass spectrometry (HDX-MS) was the peptide-level resolution afforded by proteolytic... 
ACTIVATION | AMIDE HYDROGENS | PROTEIN | HDX-MS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRAMOLECULAR MIGRATION | KINASE | IDENTIFICATION | CAPTURE DISSOCIATION | BINDING | Oligonucleotides - genetics | Oligonucleotides - chemistry | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Electron Transport | Molecular Weight | Humans | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Oligonucleotides - antagonists & inhibitors | Signal Processing, Computer-Assisted | Binding Sites | Peptide Fragments - genetics | Drug Evaluation, Preclinical - methods | Triazines - metabolism | Triazines - pharmacology | Indazoles - chemistry | Enzyme Inhibitors - metabolism | Purines - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Indazoles - metabolism | Recombinant Fusion Proteins - chemistry | Sulfonamides - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Indazoles - pharmacology | Oligonucleotides - metabolism | Peptide Fragments - chemistry | Class I Phosphatidylinositol 3-Kinases | Purines - chemistry | Peptide Fragments - antagonists & inhibitors | Protein Conformation | Quinazolinones - chemistry | Quinazolinones - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Tandem Mass Spectrometry | Class Ia Phosphatidylinositol 3-Kinase - chemistry | Deuterium Exchange Measurement | Triazines - chemistry | Antineoplastic Agents - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - genetics | Quinazolinones - pharmacology | Peptide Fragments - metabolism | Reproducibility of Results | Sulfonamides - chemistry | Purines - pharmacology | Quinolines - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Antineoplastic Agents - chemistry | Phosphatidylinositol 3-Kinases - genetics | Quinolines - metabolism | Sulfonamides - metabolism | ETD | PI3K
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 04/2016, Volume 106, pp. 56 - 69
Class IA phosphoinositide 3-kinases (PI3Ks) are essential to function of normal and tumor cells, and to modulate immune responses. T lymphocytes express high... 
T lymphocytes | CD28 | ICOS | Phosphatidyl inositol-3 kinase | PI3K inhibitors | Rheumatoid arthritis | RHEUMATOID-ARTHRITIS | SELECTIVE-INHIBITION | SYSTEMIC-LUPUS-ERYTHEMATOSUS | HELPER-CELLS | INDUCIBLE COSTIMULATOR | MOLECULE ICOS | INTERFERON-GAMMA | IN-VIVO | PHARMACOLOGY & PHARMACY | GERMINAL-CENTERS | CELL-ACTIVATION | Arthritis, Experimental - drug therapy | Lymph Nodes - pathology | Protein Subunits - immunology | T-Box Domain Proteins - immunology | CD4-Positive T-Lymphocytes - enzymology | CD4-Positive T-Lymphocytes - pathology | Class Ia Phosphatidylinositol 3-Kinase - immunology | Extracellular Signal-Regulated MAP Kinases - genetics | Extracellular Signal-Regulated MAP Kinases - immunology | Proto-Oncogene Proteins c-akt - genetics | Arthritis, Experimental - pathology | CD4-Positive T-Lymphocytes - immunology | Lymph Nodes - enzymology | CD3 Complex - genetics | Interleukin-2 - immunology | NFATC Transcription Factors - immunology | CD28 Antigens - genetics | Lymph Nodes - drug effects | Interferon-gamma - genetics | Class Ia Phosphatidylinositol 3-Kinase - genetics | Protein Subunits - genetics | Gene Expression | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Arthritis, Experimental - immunology | CD28 Antigens - immunology | Imidazoles - pharmacology | Lymph Nodes - immunology | T-Box Domain Proteins - genetics | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Antibodies - pharmacology | Interleukin-2 - genetics | Animals | Proto-Oncogene Proteins c-akt - immunology | Lymphocyte Activation - drug effects | Interferon-gamma - immunology | Interleukin-10 - genetics | CD3 Complex - immunology | Mice | Protein Subunits - antagonists & inhibitors | Arthritis, Experimental - enzymology | Pyrazines - pharmacology | Interleukin-10 - immunology | CD4-Positive T-Lymphocytes - drug effects | NFATC Transcription Factors - genetics
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 2014, Volume 34, Issue 7, pp. 1363 - 1377
Stat5 (signal transducer and activator of transcription 5) is an essential mediator of cytokine receptor signaling and plays important roles in the... 
JANUS KINASE 2 | CELLS IN-VIVO | ACTIVATION | EPITHELIAL-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | CONDITIONAL KNOCKOUT | INVOLUTION | NUCLEAR FACTOR | AKT ISOFORMS | TRANSGENIC MICE | CELL BIOLOGY | Precancerous Conditions - etiology | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Hamartoma Syndrome, Multiple - metabolism | Humans | Precancerous Conditions - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Mammary Neoplasms, Experimental - metabolism | RNA, Messenger - metabolism | Mammary Neoplasms, Experimental - genetics | Proto-Oncogene Proteins c-akt - genetics | Mammary Glands, Animal - growth & development | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Mice, Mutant Strains | Janus Kinase 2 - metabolism | Female | STAT5 Transcription Factor - deficiency | Class Ia Phosphatidylinositol 3-Kinase - genetics | Proto-Oncogene Proteins c-akt - metabolism | Cell Line | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | Hamartoma Syndrome, Multiple - genetics | Signal Transduction | RNA, Messenger - genetics | PTEN Phosphohydrolase - metabolism | Mice, Transgenic | Gene Knockout Techniques | Precancerous Conditions - genetics | Mice, Knockout | Hamartoma Syndrome, Multiple - etiology | Phosphatidylinositol 3-Kinases - genetics | Pregnancy | Animals | Mammary Glands, Animal - metabolism | Mice | Mammary Neoplasms, Experimental - etiology | Index Medicus
Journal Article
Journal Article
Infection and Immunity, ISSN 0019-9567, 06/2016, Volume 84, Issue 6, pp. 1826 - 1841
Many bacterial pathogens subvert mammalian type IA phosphoinositide 3-kinase (PI3K) in order to induce their internalization into host cells. How PI3K promotes... 
LISTERIA-MONOCYTOGENES | MICROTUBULE PLUS ENDS | INFECTIOUS DISEASES | ENTRY | PHOSPHATIDYLINOSITOL 3-KINASES | CELL INVASION | GUANINE-NUCLEOTIDE EXCHANGE | INLB | FOCAL ADHESION KINASE | BACTERIAL INVASION | IMMUNOLOGY | GTPASE-ACTIVATING PROTEIN | Focal Adhesion Kinase 1 - genetics | RNA, Small Interfering - genetics | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Actin Cytoskeleton - microbiology | TOR Serine-Threonine Kinases - metabolism | Adhesins, Bacterial - genetics | Humans | rac GTP-Binding Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Adhesins, Bacterial - metabolism | TOR Serine-Threonine Kinases - genetics | rac GTP-Binding Proteins - genetics | Listeria monocytogenes - metabolism | Phospholipase D - genetics | Class Ia Phosphatidylinositol 3-Kinase - genetics | Focal Adhesion Kinase 1 - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Actin Cytoskeleton - metabolism | Signal Transduction | Gene Expression Regulation | Listeria monocytogenes - growth & development | Receptors, Cytoplasmic and Nuclear - genetics | Nerve Tissue Proteins - genetics | Phospholipase D - metabolism | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Host-Pathogen Interactions | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Carrier Proteins - metabolism | Yersinia enterocolitica - genetics | Adaptor Proteins, Signal Transducing - genetics | Yersinia enterocolitica - metabolism | Listeria monocytogenes - genetics | Yersinia enterocolitica - growth & development | HeLa Cells | Actin Cytoskeleton - ultrastructure | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism
Journal Article