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NATURE, ISSN 0028-0836, 11/2016, Volume 539, Issue 7629, pp. 437 - 442
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2011, Volume 42, Issue 1, pp. 84 - 95
Adrenergic stimulation of the heart engages cAMP and phosphoinositide second messenger signaling cascades. Cardiac phosphoinositide 3-kinase p110γ participates... 
PATHWAYS | RECRUITMENT | REGULATORY SUBUNIT RII | PRESSURE-OVERLOAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | DEPENDENT PROTEIN-KINASE | CARDIOMYOCYTES | PI3K-GAMMA | RECEPTORS | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | Phosphorylation | Phosphatidylinositol Phosphates - metabolism | Class Ib Phosphatidylinositol 3-Kinase - genetics | Humans | Molecular Sequence Data | Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit - metabolism | Quinoxalines - pharmacology | Class Ib Phosphatidylinositol 3-Kinase - chemistry | Base Sequence | Class Ib Phosphatidylinositol 3-Kinase - metabolism | Class Ib Phosphatidylinositol 3-Kinase - deficiency | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Receptors, Adrenergic, beta - metabolism | Thiazolidinediones - pharmacology | Cyclic AMP - metabolism | Peptide Fragments - genetics | A Kinase Anchor Proteins - metabolism | Second Messenger Systems | Cyclic AMP-Dependent Protein Kinases - metabolism | Amino Acid Sequence | Cell Line | Peptide Fragments - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Heart Failure - metabolism | Heart Failure - drug therapy | Mice, Knockout | Protein Interaction Mapping | DNA - genetics | Sequence Homology, Amino Acid | Peptide Fragments - chemistry | Animals | Myocytes, Cardiac - metabolism | Mice | Class Ib Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Enzyme Activation
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2010, Volume 16, Issue 20, pp. 4928 - 4937
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2013, Volume 110, Issue 47, pp. 18862 - 18867
Journal Article
Immunology, ISSN 0019-2805, 07/2019, Volume 157, Issue 3, pp. 210 - 218
Journal Article
Journal Article
Leukemia, ISSN 0887-6924, 09/2018, Volume 32, Issue 9, pp. 1958 - 1969
The PI 3-kinases (PI3K) are essential mediators of chemokine receptor signaling necessary for migration of chronic lymphocytic leukemia (CLL) cells and their... 
G-BETA-GAMMA | P110-GAMMA ISOFORM | ONCOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE | REGULATORY SUBUNITS | CHRONIC LYMPHOCYTIC-LEUKEMIA | SURVIVAL SIGNALS | ZAP-70 EXPRESSION | HEMATOLOGY | MARROW STROMAL CELLS | T-LYMPHOCYTES | DIFFERENTIAL ROLES | Leukemia, B-Cell - metabolism | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Class Ib Phosphatidylinositol 3-Kinase - genetics | Humans | Cell Survival - genetics | Lymphoma, B-Cell - genetics | Cell Movement - genetics | Gene Knockdown Techniques | CD40 Ligand - metabolism | Class Ib Phosphatidylinositol 3-Kinase - metabolism | ZAP-70 Protein-Tyrosine Kinase - metabolism | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Gene Expression Regulation, Neoplastic - drug effects | Mesenchymal Stem Cells - metabolism | B-Lymphocytes - metabolism | Quinazolinones - pharmacology | Cell Survival - drug effects | Cell Adhesion - genetics | Lymphoma, B-Cell - metabolism | Purines - pharmacology | Interleukin-4 - metabolism | Leukemia, B-Cell - pathology | Cell Adhesion - drug effects | Chemotaxis - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - drug effects | Leukemia, B-Cell - genetics | Lymphoma, B-Cell - pathology | Cytoskeleton - metabolism | Chemokines - metabolism | Class Ib Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mutation | Immunoglobulin Heavy Chains - genetics | CXCL12 protein | Leukocyte migration | Leukemia | Cytology | Adhesion tests | ZAP-70 protein | Kinases | CD40L protein | Cell morphology | Cell adhesion & migration | Interleukin 4 | Actin | Inhibition | Chronic lymphatic leukemia | Crosslinking | Lymphatic leukemia | Adhesion | 1-Phosphatidylinositol 3-kinase | Inhibitors | Lymphocytes B | Morphology | Stromal cells | Cell lines | Chemokines | Cell migration
Journal Article
PLOS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0119633 - e0119633
Experimental cerebral malaria (ECM) is characterized by a strong immune response, with leukocyte recruitment, blood-brain barrier breakdown and hemorrhage in... 
PATHOGENESIS | ACTIVATING-FACTOR RECEPTOR | MODELS | PLAYS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DYSFUNCTION | PARASITE | CD8(+) T-CELLS | Malaria, Cerebral - pathology | Plasmodium berghei - immunology | Malaria, Cerebral - enzymology | Malaria, Cerebral - parasitology | Class Ib Phosphatidylinositol 3-Kinase - genetics | Lung - parasitology | Humans | Extracellular Matrix - immunology | Extracellular Matrix - parasitology | Malaria, Cerebral - immunology | Lung - enzymology | Quinoxalines - pharmacology | Animals | Class Ib Phosphatidylinositol 3-Kinase - metabolism | Survival Analysis | Female | Mice | Class Ib Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Thiazolidinediones - pharmacology | Brain - immunology | Disease Models, Animal | Laboratories | Toxicity | Pathogenesis | CD8 antigen | Central nervous system | Cytotoxicity | Lymphocytes T | Infections | Lethality | Biochemistry | Kinases | Hemorrhage | Proteins | Cell activation | Granzyme B | Immunology | Blood-brain barrier | Lymphocytes | CD44 antigen | Rodents | Extracellular matrix | Parasitemia | Animal care | Immune system | Vector-borne diseases | Edema | Immune response | Malaria | CD3 antigen | Inflammation | Interdisciplinary aspects | 1-Phosphatidylinositol 3-kinase | Microglia | White blood cells | Signaling | Inhibitors | Lymphocytes B | Pharmacy | Diabetes | Index Medicus
Journal Article
Cancer Discovery, ISSN 2159-8274, 08/2016, Volume 6, Issue 8, pp. 870 - 885
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a low 5-year survival rate, yet new immunotherapeutic modalities may offer hope for this... 
CELLS | ACTIVATION | PI3K | ONCOLOGY | MICE | INHIBITOR | CANCER | TUMOR INFLAMMATION | GEMCITABINE | DISCOVERY | CHECKPOINT BLOCKADE | Macrophage Activation - genetics | Pancreatic Neoplasms - metabolism | Class Ib Phosphatidylinositol 3-Kinase - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Male | Platelet-Derived Growth Factor - genetics | Cell Movement - genetics | Carcinoma, Pancreatic Ductal - genetics | Neoplasm Metastasis | Heterografts | Class Ib Phosphatidylinositol 3-Kinase - metabolism | Antineoplastic Agents - pharmacology | Carcinoma, Pancreatic Ductal - immunology | Macrophages - immunology | Disease Models, Animal | Phenols - pharmacology | Gene Expression | Pteridines - pharmacology | Immunomodulation | Macrophage Activation - immunology | Mortality | Pancreatic Neoplasms - pathology | Mice, Transgenic | Pancreatic Neoplasms - genetics | Gene Knockout Techniques | Carcinoma, Pancreatic Ductal - pathology | Disease Progression | Mice, Knockout | Xenograft Model Antitumor Assays | Macrophages - metabolism | Platelet-Derived Growth Factor - metabolism | Animals | Pancreatic Neoplasms - immunology | Biomarkers | Cell Line, Tumor | Mice | Class Ib Phosphatidylinositol 3-Kinase - antagonists & inhibitors | macrophages | transcription | desmoplasia | metastasis | PDGF | Arginase | gemcitabine | PI3Kγ | immune suppression | chemotherapy | pancreatic ductal adenocarcinoma
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2013, Volume 14, Issue 2, pp. 162 - 171
Signaling through the G protein-coupled receptors for the complement fragments C3a and C5a (C3aR and C5aR, respectively) by dendritic cells and CD4(+) cells... 
Forkhead Transcription Factors - immunology | Cell Communication - immunology | T-Lymphocytes, Regulatory - metabolism | TOR Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta1 - metabolism | Complement C5a - metabolism | Receptors, Complement - metabolism | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Transforming Growth Factor beta1 - immunology | Forkhead Transcription Factors - metabolism | Class Ib Phosphatidylinositol 3-Kinase - metabolism | T-Lymphocytes, Regulatory - cytology | Interleukin-10 - metabolism | Receptor, Anaphylatoxin C5a - immunology | Cell Differentiation | Proto-Oncogene Proteins c-akt - metabolism | Complement C3a - metabolism | Interleukin-6 - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Receptors, Chemokine - metabolism | Gene Expression Regulation | Mice, Transgenic | Receptors, Chemokine - immunology | Receptor Cross-Talk - immunology | TOR Serine-Threonine Kinases - immunology | Animals | Proto-Oncogene Proteins c-akt - immunology | Receptors, Complement - immunology | Cyclic AMP-Dependent Protein Kinases - immunology | Interleukin-6 - immunology | Mice | Complement C3a - immunology | Complement C5a - immunology | Class Ib Phosphatidylinositol 3-Kinase - immunology | Interleukin-10 - immunology | Receptor, Anaphylatoxin C5a - metabolism
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 10/2016, Volume 53, Issue 8, pp. 5468 - 5479
Journal Article