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index medicus (385) 385
humans (296) 296
claudin-4 (264) 264
animals (181) 181
female (164) 164
membrane proteins - metabolism (120) 120
membrane proteins - genetics (119) 119
proteins (118) 118
claudin-4 - metabolism (112) 112
mice (105) 105
expression (97) 97
permeability (95) 95
tight junctions (95) 95
tight junctions - metabolism (94) 94
oncology (89) 89
male (86) 86
claudin-4 - genetics (85) 85
immunohistochemistry (84) 84
tight junction (83) 83
cancer (80) 80
cell line, tumor (79) 79
occludin (74) 74
claudin-3 (71) 71
clostridium-perfringens enterotoxin (71) 71
gene expression (69) 69
cell biology (65) 65
claudins (62) 62
cells (61) 61
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adult (56) 56
middle aged (56) 56
aged (55) 55
claudin-1 (53) 53
carcinoma (52) 52
pathology (52) 52
epithelial cells - metabolism (50) 50
rna, messenger - metabolism (50) 50
research (49) 49
epithelial-cells (48) 48
reverse transcriptase polymerase chain reaction (47) 47
tight junction proteins (47) 47
tumors (47) 47
gene-expression (45) 45
barrier function (44) 44
biochemistry & molecular biology (44) 44
claudins - metabolism (44) 44
gene expression regulation, neoplastic (44) 44
caco-2 cells (43) 43
tight junctions - drug effects (41) 41
analysis (40) 40
cells, cultured (38) 38
prognosis (36) 36
tight junction strands (36) 36
claudins - genetics (35) 35
pancreatic-cancer (35) 35
membrane proteins - biosynthesis (34) 34
research article (34) 34
down-regulation (33) 33
metastasis (33) 33
multidisciplinary sciences (33) 33
ovarian cancer (33) 33
rna, messenger - genetics (33) 33
up-regulation (33) 33
apoptosis (32) 32
genetic aspects (32) 32
phosphorylation (32) 32
rats (32) 32
cell line (31) 31
immunology (31) 31
biomarkers, tumor - metabolism (30) 30
endocrine system diseases (30) 30
blotting, western (29) 29
electric impedance (29) 29
physiological aspects (29) 29
urogenital system (29) 29
zonula occludens-1 protein (29) 29
signal transduction (28) 28
epithelial cells (27) 27
membrane proteins (27) 27
ovarian neoplasms - metabolism (27) 27
adenocarcinoma (26) 26
aged, 80 and over (26) 26
barrier (26) 26
claudin-1 - metabolism (26) 26
rodents (26) 26
therapy (26) 26
tight junctions - physiology (26) 26
digestive system (25) 25
dogs (25) 25
medicine (25) 25
ovarian-cancer (25) 25
physiology (25) 25
gene expression regulation (24) 24
studies (24) 24
breast cancer (23) 23
diagnosis (23) 23
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protein (23) 23
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Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 3, pp. 968 - 978
Journal Article
Neoplasia, ISSN 1476-5586, 2012, Volume 14, Issue 10, pp. 974 - IN22
Abstract The extent of tight junction (TJ) formation is one of many factors that regulate motility, invasion, and metastasis. Claudins are required for the... 
Oncology | CLDN4 | CLDN3 | claudin-4 | claudin-3 | EMT | tight junction | epithelial-to-mesenchymal transition | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | STEM-CELLS | ONCOLOGY | E-CADHERIN EXPRESSION | IN-VIVO | TRANSCRIPTION FACTOR SNAIL | GENE-EXPRESSION | CANCER-CELL INVASION | FALLOPIAN-TUBE | SEROUS OVARIAN CARCINOGENESIS | Cell Proliferation | Prognosis | Cadherins - metabolism | Claudin-4 - genetics | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Glycogen Synthase Kinase 3 beta | Uterine Cervical Neoplasms - pathology | Wound Healing | Immunoenzyme Techniques | Ovarian Neoplasms - genetics | Lung Neoplasms - secondary | Uterine Cervical Neoplasms - metabolism | Claudin-3 - genetics | Fallopian Tube Neoplasms - genetics | Tight Junctions | Claudin-4 - metabolism | Claudin-3 - metabolism | Female | Ovarian Neoplasms - metabolism | Tumor Cells, Cultured | Cadherins - genetics | Real-Time Polymerase Chain Reaction | Lung Neoplasms - genetics | Signal Transduction | RNA, Messenger - genetics | Fallopian Tube Neoplasms - pathology | Electric Impedance | Glycogen Synthase Kinase 3 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Uterine Cervical Neoplasms - genetics | Cell Adhesion | Claudin-4 - antagonists & inhibitors | beta Catenin - metabolism | Blotting, Western | beta Catenin - genetics | Glycogen Synthase Kinase 3 - genetics | Fluorescent Antibody Technique | Fallopian Tube Neoplasms - metabolism | Claudin-3 - antagonists & inhibitors | Apoptosis | Cell Movement | Index Medicus
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2015, Volume 128, Issue 12, pp. 2271 - 2286
The epithelial cholinergic system plays an important role in water, ion and solute transport. Previous studies have shown that activation of muscarinic... 
Tight junction | Claudin-4 | Paracellular permeability | Muscarinic acetylcholine receptor | PROTEIN-KINASE-C | PHOSPHORYLATION | DOWN-REGULATION | BETA-ARRESTIN | ENDOCYTOSIS | CELL BIOLOGY | DISRUPTION | PATHWAY | OCCLUDIN | EXPRESSION | TIGHT-JUNCTION BARRIER | RNA, Small Interfering - genetics | Phosphorylation | Epithelial Cells - metabolism | Claudin-4 - genetics | Molecular Sequence Data | Arrestins - genetics | Receptors, Muscarinic - metabolism | Arrestins - metabolism | Salivary Glands - cytology | Mitogen-Activated Protein Kinase 1 - genetics | Tight Junctions | Claudin-4 - metabolism | Zonula Occludens-1 Protein - metabolism | Epithelial Cells - cytology | Real-Time Polymerase Chain Reaction | Receptors, Muscarinic - genetics | Zonula Occludens-1 Protein - genetics | Amino Acid Sequence | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Down-Regulation | RNA, Messenger - genetics | Cells, Cultured | Rats | Zonula Occludens-1 Protein - antagonists & inhibitors | Electric Impedance | Permeability | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Arrestins - antagonists & inhibitors | Sequence Homology, Amino Acid | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | beta-Arrestins | Fluorescent Antibody Technique | Salivary Glands - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2015, Volume 459, Issue 3, pp. 379 - 386
Interleukin-18 (IL-18) was recently reported to have a pro-tumor effect in various cancers. Increased IL-18 levels in the serum of cancer patients correlated... 
Tight junction | Breast cancer | Claudin-12 | Migration | Interleukin-18 (IL-18) | METASTASIS | SERUM INTERLEUKIN-18 | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNE ESCAPE | HUMAN GASTRIC-CANCER | BIOPHYSICS | MESSENGER-RNA | MURINE MELANOMA-CELLS | TIGHT JUNCTION PROTEINS | EXPRESSION | CARCINOMA | N-CADHERIN | Claudin-1 - antagonists & inhibitors | RNA, Small Interfering - genetics | Interleukin-18 - physiology | Claudin-4 - genetics | Humans | Interleukin-18 - antagonists & inhibitors | Claudin-3 - physiology | Breast Neoplasms - physiopathology | Cell Movement - genetics | Cell Movement - physiology | Claudin-4 - physiology | Gene Knockdown Techniques | Tight Junctions - physiology | MCF-7 Cells | Claudin-3 - genetics | Claudin-1 - physiology | Female | Flavonoids - pharmacology | Tight Junctions - drug effects | Claudins - genetics | Claudins - physiology | Imidazoles - pharmacology | Recombinant Proteins - pharmacology | Down-Regulation - drug effects | Claudin-4 - antagonists & inhibitors | Cell Movement - drug effects | Breast Neoplasms - genetics | MAP Kinase Signaling System - drug effects | Breast Neoplasms - pathology | Claudin-1 - genetics | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Claudins - antagonists & inhibitors | Claudin-3 - antagonists & inhibitors | Interleukin-18 - genetics | Proteins | Development and progression | Metastasis | Interleukins | Melanoma | Index Medicus
Journal Article
Journal Article
Journal of Nutrition, ISSN 0022-3166, 2016, Volume 146, Issue 3, pp. 501 - 508
Background: The tight junctions (TJs) are essential for maintenance of the intestinal mucosal barrier integrity. Results of our recent work show that dietary... 
AMPK | Tight junction | CaMKK2 | L-glutamine | Intestinal epithelial cells | intestinal epithelial cells | PERMEABILITY | MEMBRANE | BARRIER FUNCTION | COMPONENTS | CALCIUM REGULATION | SUPPLEMENTATION | NUTRITION & DIETETICS | AMINO-ACIDS | HEALTH | EXPRESSION | tight junction | CACO-2 CELLS | Intestines - drug effects | AMP-Activated Protein Kinases - metabolism | Intestinal Mucosa - metabolism | Phosphorylation | Epithelial Cells - metabolism | Claudin-4 - genetics | Enterocytes - metabolism | Epithelial Cells - drug effects | Zonula Occludens-2 Protein - metabolism | Intestinal Mucosa - drug effects | Occludin - metabolism | Occludin - genetics | Swine | Claudin-4 - metabolism | Cell Membrane - metabolism | Glutamine - pharmacology | Zonula Occludens-1 Protein - metabolism | Cell Membrane - drug effects | Tight Junctions - drug effects | Animals, Newborn | Tight Junctions - metabolism | Zonula Occludens-1 Protein - genetics | Signal Transduction | Enterocytes - cytology | Gene Expression Regulation | Calcium-Calmodulin-Dependent Protein Kinase Kinase - genetics | Zonula Occludens-2 Protein - genetics | Animals | Enterocytes - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism | Junctional Adhesion Molecules - genetics | Cell Proliferation - drug effects | AMP-Activated Protein Kinases - genetics | Junctional Adhesion Molecules - metabolism | Intestines - cytology | Physiological aspects | Dosage and administration | Food and nutrition | Protein kinases | Intestinal mucosa | Methods | Glutamine | Permeability | Dietary supplements | Membrane proteins | Index Medicus
Journal Article
Journal of Nutrition, ISSN 0022-3166, 2015, Volume 145, Issue 6, pp. 1156 - 1162
Background: Besides serving as a substrate for protein synthesis, L-tryptophan (L-Trp) is used via serotonin-, kynurenine-, and niacin-synthetic pathways to... 
Cell proliferation | Tryptophan | Tight junction | Intestinal epithelial cells | Mammalian target of rapamycin | Pig | intestinal epithelial cells | cell proliferation | AMINO-ACID-TRANSPORT | DEFICIENCY | pig | mammalian target of rapamycin | NUTRITION & DIETETICS | METABOLISM | LIVER | SEROTONIN | NUTRITION | HEALTH | ABSORPTION | NURSERY PIGS | EFFICIENCY | tryptophan | tight junction | Intestines - drug effects | Up-Regulation | Tight Junction Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Claudin-4 - genetics | Enterocytes - metabolism | Multiprotein Complexes - genetics | Intestines - metabolism | RNA, Messenger - metabolism | Occludin - metabolism | Mechanistic Target of Rapamycin Complex 1 | Occludin - genetics | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Claudin-1 - metabolism | Swine | Claudin-4 - metabolism | Tight Junction Proteins - metabolism | Tight Junctions - drug effects | Tight Junctions - metabolism | Signal Transduction | RNA, Messenger - genetics | Cells, Cultured | Animals | Enterocytes - drug effects | Intestine, Small - drug effects | Claudin-1 - genetics | Cell Proliferation - drug effects | Tryptophan - pharmacology | Intestine, Small - metabolism | Intestines - cytology | Epithelial cells | Physiological aspects | Homeostasis | Protein biosynthesis | Rapamycin | Research | Index Medicus
Journal Article
Journal Article
Respiratory Research, ISSN 1465-9921, 2016, Volume 17, Issue 1, pp. 50 - 50
Journal Article
European Journal of Nutrition, ISSN 1436-6207, 6/2016, Volume 55, Issue 4, pp. 1445 - 1454
Fructooligosaccharides (FOS) are used as functional foods due to their prebiotic effects. Intestinal anti-inflammatory activity has been established in most,... 
Inflammatory bowel disease | Alkaline phosphatase | Chemistry | Nutrition | Fructooligosaccharides | Colitis | CD4+ CD62L+ T cell | Prebiotic | ACTIVATION | NONDIGESTIBLE OLIGOSACCHARIDES | ALKALINE-PHOSPHATASE | CD4+CD62L+T cell | TRANSGENIC RATS | FRUCTO-OLIGOSACCHARIDES | MOUSE MODELS | NUTRITION & DIETETICS | INFLAMMATORY-BOWEL-DISEASE | HAPTEN-INDUCED COLITIS | EPITHELIAL-CELLS | RESISTANT STARCH | Intestines - drug effects | Tumor Necrosis Factor-alpha - metabolism | Calgranulin A - metabolism | Claudin-4 - genetics | Tumor Necrosis Factor-alpha - genetics | Alkaline Phosphatase - metabolism | Claudin-5 - metabolism | Intestines - metabolism | Calgranulin A - genetics | Interferon-gamma - metabolism | Interleukin-1beta - genetics | Occludin - metabolism | L-Selectin - metabolism | Dose-Response Relationship, Drug | Occludin - genetics | Oligosaccharides - pharmacology | Interleukin-1beta - metabolism | Claudin-4 - metabolism | Interleukin-10 - metabolism | Female | Colitis - drug therapy | Interferon-gamma - genetics | Disease Models, Animal | Lactobacillus | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Gastrointestinal Microbiome | Gene Expression Regulation | Interleukin-17 - genetics | Claudin-5 - genetics | Interleukin-17 - metabolism | Animals | Intestines - microbiology | Interleukin-10 - genetics | Mice | Peroxidase - metabolism | Phosphatases | Anti-inflammatory drugs | Functional foods | Analysis | Gastrointestinal diseases | Polymerization | T cells | Index Medicus
Journal Article