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immunohistochemistry (38) 38
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zonula occludens-1 protein (37) 37
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endothelium, vascular - metabolism (36) 36
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apoptosis (30) 30
blood-brain barrier - pathology (30) 30
phosphorylation (30) 30
time factors (30) 30
zonula occludens-1 protein - genetics (30) 30
claudins - metabolism (29) 29
middle aged (29) 29
signal transduction (29) 29
gene expression regulation - drug effects (28) 28
science (28) 28
electric impedance (27) 27
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antigens, cd - metabolism (26) 26
endothelial cells - cytology (26) 26
mice, knockout (26) 26
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rats, sprague-dawley (26) 26
blotting, western (25) 25
biomedicine (24) 24
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phosphoproteins - metabolism (24) 24
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Free Radical Biology and Medicine, ISSN 0891-5849, 11/2017, Volume 112, pp. 336 - 349
Aberrant modulation of mitochondrial dynamic network, which shifts the balance of fusion and fission towards fission, is involved in brain damage of various... 
Mdivi-1 | Inflammation | Early brain injury | Blood-brain barrier disruption | Subarachnoid hemorrhage | Apoptosis | OXYGEN SPECIES PRODUCTION | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEX I INHIBITOR | HIPPOCAMPAL-NEURONS | RAT MODEL | MITOCHONDRIAL FISSION | CELL-DEATH | SIGNALING PATHWAY | MOUSE MODEL | ENDOCRINOLOGY & METABOLISM | NF-KAPPA-B | Interleukin-6 - antagonists & inhibitors | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Proto-Oncogene Proteins c-bcl-2 - agonists | Tumor Necrosis Factor-alpha - genetics | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | Subarachnoid Space - drug effects | Occludin - metabolism | Matrix Metalloproteinase 9 - metabolism | Interleukin-1beta - metabolism | Matrix Metalloproteinase 9 - genetics | Subarachnoid Hemorrhage - mortality | Zonula Occludens-1 Protein - metabolism | Interleukin-6 - metabolism | Subarachnoid Hemorrhage - drug therapy | Interleukin-1beta - antagonists & inhibitors | Zonula Occludens-1 Protein - genetics | NF-kappa B - antagonists & inhibitors | Endoplasmic Reticulum Stress - drug effects | Interleukin-6 - genetics | bcl-2-Associated X Protein - metabolism | Dynamins - genetics | Rats | Subarachnoid Hemorrhage - genetics | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Survival Analysis | Subarachnoid Space - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dynamins - metabolism | Mitochondrial Dynamics - genetics | Claudin-5 - metabolism | Occludin - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mitochondria - genetics | Quinazolinones - pharmacology | bcl-2-Associated X Protein - genetics | Dynamins - antagonists & inhibitors | Claudin-5 - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Subarachnoid Hemorrhage - pathology | bcl-2-Associated X Protein - antagonists & inhibitors | Blood-Brain Barrier - drug effects | Animals | Mitochondrial Dynamics - drug effects | NF-kappa B - genetics | Subarachnoid Space - pathology | Proto-Oncogene Proteins c-bcl-2 - genetics | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Stroke (Disease) | Proteins | Medical research | Brain | Neurons | Analysis | Medicine, Experimental | Brain damage | Injuries
Journal Article
MOLECULAR NEUROBIOLOGY, ISSN 0893-7648, 05/2016, Volume 53, Issue 4, pp. 2451 - 2467
Elevated plasma total homocysteine (Hcy) level is associated with an increased risk of Alzheimer's disease (AD). During transsulfuration pathways, Hcy is... 
Cerebrovascular pathology | COGNITIVE PERFORMANCE | NEUROSCIENCES | MATRIX METALLOPROTEINASES | INDUCED MEMORY IMPAIRMENT | RISK-FACTOR | Blood-brain barrier dysfunction | RECEPTOR TRAFFICKING | MATRIX-METALLOPROTEINASE-9 | RAT-BRAIN | Homocysteine | Alzheimer's disease | PLASMA HOMOCYSTEINE | EXPRESSION | Dementia | Memory - drug effects | Glial Fibrillary Acidic Protein - genetics | Cadherins - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Blood-Brain Barrier - physiopathology | Claudin-5 - metabolism | Microvessels - pathology | Male | Synapses - pathology | Glial Fibrillary Acidic Protein - metabolism | RNA, Messenger - metabolism | Antigens, CD - genetics | Alzheimer Disease - pathology | Antigens, CD - metabolism | Matrix Metalloproteinase 9 - metabolism | Cadherins - genetics | Synapses - drug effects | Alzheimer Disease - physiopathology | Hydrogen Sulfide - pharmacology | Cerebrovascular Circulation - drug effects | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Alzheimer Disease - drug therapy | Microvessels - drug effects | Claudin-5 - genetics | Cystathionine beta-Synthase - metabolism | Permeability | Blood-Brain Barrier - drug effects | Nerve Tissue Proteins - genetics | Blood-Brain Barrier - metabolism | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Blood-Brain Barrier - pathology | Hydrogen Sulfide - therapeutic use | Intercellular Adhesion Molecule-1 - metabolism | Animals | Intercellular Adhesion Molecule-1 - genetics | Avoidance Learning - drug effects | Alzheimer Disease - genetics | Dizocilpine Maleate - pharmacology | Hydrogen sulfide | Methyl aspartate | Brain | RNA | Neurons | Intermediate filament proteins | cerebrovascular pathology | dementia | blood brain barrier dysfunction
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2015, Volume 125, Issue 6, pp. 2473 - 2483
Bacterial meningitis is a serious infection of the CNS that results when blood-borne bacteria are able to cross the blood-brain barrier (BBB). Group B... 
MEDICINE, RESEARCH & EXPERIMENTAL | ESCHERICHIA-COLI K1 | INVASION | ACTIVATION | TIGHT JUNCTION COMPONENTS | AGALACTIAE | ENDOTHELIUM | DOWN-REGULATION | NEUTROPHIL SIGNALING PATHWAYS | GROUP-B STREPTOCOCCI | EXPRESSION | Tight Junctions - genetics | Humans | Claudin-5 - metabolism | Streptococcal Infections - metabolism | Blood-Brain Barrier - microbiology | MAP Kinase Signaling System | Streptococcal Infections - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Streptococcal Infections - pathology | Zonula Occludens-1 Protein - metabolism | Streptococcus agalactiae | Snail Family Transcription Factors | Tight Junctions - metabolism | Zonula Occludens-1 Protein - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation - genetics | Zebrafish Proteins - metabolism | Cells, Cultured | Claudin-5 - genetics | Transcription Factors - genetics | Zebrafish - genetics | Blood-Brain Barrier - metabolism | Transcription Factors - metabolism | Blood-Brain Barrier - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Zebrafish - metabolism | Zebrafish Proteins - genetics | Tight Junctions - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Proteins | Data analysis | Bacterial infections | Blood-brain barrier | Rodents | Cloning | Laboratory animals | Gene expression | Experiments | Endothelium | Streptococcus infections | Microbiology | Infectious disease | Vascular Biology
Journal Article
Ophthalmology, ISSN 0161-6420, 2014, Volume 121, Issue 1, pp. 392 - 398
Purpose To report a new ocular manifestation of the dup22q11 syndrome and explore involved genes that may offer insight to mechanisms of pathogenesis. Design... 
Ophthalmology | MENTAL-RETARDATION | GENOMIC DISORDERS | PROTEIN-KINASE INHIBITOR | DUPLICATION SYNDROME | CLINICAL VARIABILITY | OPHTHALMOLOGY | TANDEM DUPLICATION | CAT-EYE SYNDROME | DELETION SYNDROME | GROWTH-FACTOR-I | COGNITIVE DEFICITS | Retinal Diseases - genetics | Blepharoptosis - genetics | Humans | Qb-SNARE Proteins - genetics | Male | Chromosome Duplication - genetics | Nervous System Diseases - genetics | Nervous System Diseases - diagnosis | Retinal Vessels - pathology | Chromosomes, Human, Pair 22 - genetics | Heart Defects, Congenital - genetics | Microarray Analysis | Mitogen-Activated Protein Kinase 1 - genetics | Jaw Abnormalities - diagnosis | Duane Retraction Syndrome - genetics | Child | Abnormalities, Multiple - genetics | DiGeorge Syndrome - genetics | Duane Retraction Syndrome - diagnosis | Retinal Diseases - diagnosis | Intraocular Pressure | Claudin-5 - genetics | Blepharoptosis - diagnosis | Glaucoma - diagnosis | Reflex, Abnormal - genetics | DiGeorge Syndrome - diagnosis | Comparative Genomic Hybridization | Abnormalities, Multiple - diagnosis | Chromosome Aberrations | Qc-SNARE Proteins - genetics | Heart Defects, Congenital - diagnosis | Polymorphism, Single Nucleotide | Glaucoma - genetics | Jaw Abnormalities - genetics | Glaucoma | Medicine, Experimental | Medical research | Single nucleotide polymorphisms
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 09/2017, Volume 1863, Issue 9, pp. 2240 - 2254
Journal Article
by Debette, Stéphanie and Ibrahim Verbaas, Carla A and Bressler, Jan and Schuur, Maaike and Smith, Albert and Bis, Joshua C and Davies, Gail and Wolf, Christiane and Gudnason, Vilmundur and Chibnik, Lori B and Yang, Qiong and deStefano, Anita L and de Quervain, Dominique J.F and Srikanth, Velandai and Lahti, Jari and Grabe, Hans J and Smith, Jennifer A and Priebe, Lutz and Yu, Lei and Karbalai, Nazanin and Hayward, Caroline and Wilson, James F and Campbell, Harry and Petrovic, Katja and Fornage, Myriam and Chauhan, Ganesh and Yeo, Robin and Boxall, Ruth and Becker, James and Stegle, Oliver and Mather, Karen A and Chouraki, Vincent and Sun, Qi and Rose, Lynda M and Resnick, Susan and Oldmeadow, Christopher and Kirin, Mirna and Wright, Alan F and Jonsdottir, Maria K and Au, Rhoda and Becker, Albert and Amin, Najaf and Nalls, Mike A and Turner, Stephen T and Kardia, Sharon L.R and Oostra, Ben and Windham, Gwen and Coker, Laura H and Zhao, Wei and Knopman, David S and Heiss, Gerardo and Griswold, Michael E and Gottesman, Rebecca F and Vitart, Veronique and Hastie, Nicholas D and Zgaga, Lina and Rudan, Igor and Polasek, Ozren and Holliday, Elizabeth G and Schofield, Peter and Choi, Seung Hoan and Tanaka, Toshiko and An, Yang and Perry, Rodney T and Kennedy, Richard E and Sale, Michèle M and Wang, Jing and Wadley, Virginia G and Liewald, David C and Ridker, Paul M and Gow, Alan J and Pattie, Alison and Starr, John M and Porteous, David and Liu, Xuan and Thomson, Russell and Armstrong, Nicola J and Eiriksdottir, Gudny and Assareh, Arezoo A and Kochan, Nicole A and Widen, Elisabeth and Palotie, Aarno and Hsieh, Yi-Chen and Eriksson, Johan G and Vogler, Christian and van Swieten, John C and Shulman, Joshua M and Beiser, Alexa and Rotter, Jerome and Schmidt, Carsten O and Hoffmann, Wolfgang and Nöthen, Markus M and Ferrucci, Luigi and Attia, John and Uitterlinden, Andre G and Amouyel, Philippe and Dartigues, Jean-François and Amieva, Hélène and Räikkönen, Katri and Garcia, Melissa and ... and Cohorts Heart & Aging Res in Genom and Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
Biological Psychiatry, ISSN 0006-3223, 2015, Volume 77, Issue 8, pp. 749 - 763
Journal Article
Brain, ISSN 0006-8950, 11/2015, Volume 138, Issue 11, pp. 3206 - 3220
X-linked adrenoleukodystrophy is caused by mutations in the ABCD1 gene leading to accumulation of very long chain fatty acids. Its most severe neurological... 
blood-brain barrier | neurodegeneration | leukodystrophy | genetics | neuroinflammation | demyelination | LESION PROGRESSION | C-MYC | X-LINKED ADRENOLEUKODYSTROPHY | NEUROSCIENCES | CLINICAL NEUROLOGY | BARRIER DISRUPTION | TIGHT JUNCTIONS | IN-VITRO | APPEARING WHITE-MATTER | MULTIPLE-SCLEROSIS | CNS MYELOID CELLS | CENTRAL-NERVOUS-SYSTEM | Up-Regulation | Humans | Middle Aged | Microvessels - metabolism | Microvessels - pathology | Male | RNA, Messenger - metabolism | Gene Knockdown Techniques | Brain - metabolism | Young Adult | ATP-Binding Cassette Transporters - genetics | Aged, 80 and over | Zonula Occludens-1 Protein - metabolism | Child | Multiple Sclerosis, Relapsing-Remitting - metabolism | Zonula Occludens-1 Protein - genetics | Endothelial Cells - metabolism | ATP Binding Cassette Transporter, Sub-Family D, Member 1 | Reverse Transcriptase Polymerase Chain Reaction | Blood-Brain Barrier - metabolism | Microscopy, Confocal | Intercellular Adhesion Molecule-1 - metabolism | Endothelium, Vascular - metabolism | Intercellular Adhesion Molecule-1 - genetics | Adolescent | Brain - pathology | Endothelium, Vascular - pathology | Proto-Oncogene Proteins c-myc - genetics | Endothelial Cells - pathology | Vascular Cell Adhesion Molecule-1 - metabolism | Human Umbilical Vein Endothelial Cells | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Claudin-5 - metabolism | Adrenoleukodystrophy - pathology | Demyelinating Diseases - metabolism | Case-Control Studies | DNA-Binding Proteins - metabolism | Brain - blood supply | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Adult | Female | Vascular Cell Adhesion Molecule-1 - genetics | Demyelinating Diseases - pathology | Fatty Acids - metabolism | Microvessels - cytology | Multiple Sclerosis, Relapsing-Remitting - pathology | Cells, Cultured | Claudin-5 - genetics | DNA-Binding Proteins - genetics | Proto-Oncogene Proteins c-myc - metabolism | Adrenoleukodystrophy - metabolism | Homozygote | Heterozygote | Aged | Adrenoleukodystrophy - genetics | blood–brain barrier | Original | 1050
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0174596
Mild hypothermia improves survival and neurological recovery after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). However, the mechanism... 
SURVIVAL | PATHOGENESIS | MULTIDISCIPLINARY SCIENCES | RATS | INJURY | GLOBAL CEREBRAL-ISCHEMIA | HOSPITAL CARDIAC-ARREST | VASCULAR-PERMEABILITY | EXPRESSION | NEUROPROTECTION | NEUROLOGICAL FUNCTION | Cardiopulmonary Resuscitation - methods | Cadherins - metabolism | Claudin-5 - metabolism | Heart Arrest - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Antigens, CD - genetics | Adherens Junctions - metabolism | Occludin - metabolism | Antigens, CD - metabolism | Brain - metabolism | Brain Edema - genetics | Occludin - genetics | Brain - blood supply | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 9 - genetics | Swine | Hypothermia, Induced - methods | Brain - ultrastructure | Zonula Occludens-1 Protein - metabolism | Cadherins - genetics | Disease Models, Animal | Tight Junctions - metabolism | Zonula Occludens-1 Protein - genetics | Microscopy, Electron, Transmission | Gene Expression | Brain Edema - metabolism | Ribonuclease, Pancreatic - genetics | Heart Arrest - genetics | Claudin-5 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Blood-Brain Barrier - metabolism | Tight Junctions - ultrastructure | Animals | Ribonuclease, Pancreatic - metabolism | Adherens Junctions - ultrastructure | Heart Arrest - therapy | Care and treatment | Usage | Cardiac arrest | Physiological aspects | CPR (First aid) | Genetic aspects | Research | Vascular endothelial growth factor | Hypothermia | Membrane permeability | Emergency medical care | Matrix metalloproteinase | Angiogenin | Cardiopulmonary resuscitation--CPR | Ventricular fibrillation | Fibrillation | Blood-brain barrier | Moisture content | Temperature effects | Rodents | Water content | Breakdown | Attenuation | Metalloproteinase | Heart diseases | Resuscitation | Edema | Tight junctions | Cortex | Adherens junctions | Permeability | Gene expression | Cadherin | Survival | Catheters | Zonula occludens-1 protein | Gelatinase B | Livestock | Disruption | Ventricle | CPR | Cardiopulmonary resuscitation
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 11/2014, Volume 34, Issue 11, pp. 1826 - 1836
Journal Article