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Molecular Neurobiology, ISSN 0893-7648, 5/2016, Volume 53, Issue 4, pp. 2451 - 2467
Elevated plasma total homocysteine (Hcy) level is associated with an increased risk of Alzheimer’s disease (AD). During transsulfuration pathways, Hcy is... 
Cerebrovascular pathology | Neurology | Neurosciences | Biomedicine | Blood–brain barrier dysfunction | Alzheimer’s disease | Neurobiology | Homocysteine | Cell Biology | Dementia | COGNITIVE PERFORMANCE | NEUROSCIENCES | MATRIX METALLOPROTEINASES | INDUCED MEMORY IMPAIRMENT | RISK-FACTOR | Blood-brain barrier dysfunction | RECEPTOR TRAFFICKING | MATRIX-METALLOPROTEINASE-9 | RAT-BRAIN | Alzheimer's disease | PLASMA HOMOCYSTEINE | EXPRESSION | Memory - drug effects | Glial Fibrillary Acidic Protein - genetics | Cadherins - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Blood-Brain Barrier - physiopathology | Claudin-5 - metabolism | Microvessels - pathology | Male | Synapses - pathology | Glial Fibrillary Acidic Protein - metabolism | RNA, Messenger - metabolism | Antigens, CD - genetics | Alzheimer Disease - pathology | Antigens, CD - metabolism | Matrix Metalloproteinase 9 - metabolism | Cadherins - genetics | Synapses - drug effects | Alzheimer Disease - physiopathology | Hydrogen Sulfide - pharmacology | Cerebrovascular Circulation - drug effects | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Alzheimer Disease - drug therapy | Microvessels - drug effects | Claudin-5 - genetics | Cystathionine beta-Synthase - metabolism | Permeability | Blood-Brain Barrier - drug effects | Nerve Tissue Proteins - genetics | Blood-Brain Barrier - metabolism | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Blood-Brain Barrier - pathology | Hydrogen Sulfide - therapeutic use | Intercellular Adhesion Molecule-1 - metabolism | Animals | Intercellular Adhesion Molecule-1 - genetics | Avoidance Learning - drug effects | Alzheimer Disease - genetics | Dizocilpine Maleate - pharmacology | Hydrogen sulfide | Methyl aspartate | Brain | RNA | Neurons | Intermediate filament proteins | cerebrovascular pathology | dementia | blood brain barrier dysfunction
Journal Article
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 1559-7016, 2006, Volume 27, Issue 4, pp. 697 - 709
Matrix metalloproteinases (MMPs) disrupt the blood—brain barrier (BBB) during reperfusion. Occludin and claudins are recently described tight junction proteins... 
Blood-brain barrier opening | Claudin-5 | Matrix metalloproteinases | Rat | Middle cerebral artery occlusion | Occludin | CLAUDIN | ACTIVATION | rat | PERMEABILITY | REPERFUSION | PROTEOLYSIS | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | occludin | STRANDS | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | MATRIX-METALLOPROTEINASE-9 | HEMATOLOGY | matrix metalloproteinases | blood-brain barrier opening | middle cerebral artery occlusion | claudin-5 | Enzyme Activators - pharmacology | Immunohistochemistry | Cerebral Veins - metabolism | Sucrose | Brain Ischemia - metabolism | Male | Cerebral Arteries - drug effects | Protease Inhibitors - pharmacology | RNA, Messenger - biosynthesis | Gelatinases - metabolism | Membrane Proteins - metabolism | Matrix Metalloproteinases - biosynthesis | Tight Junctions - drug effects | Rats, Inbred SHR | Tight Junctions - metabolism | Astrocytes - drug effects | Furin - biosynthesis | Cerebral Veins - drug effects | Reperfusion Injury - pathology | Endothelial Cells - metabolism | Matrix Metalloproteinase 2 - metabolism | Rats | Infarction, Middle Cerebral Artery - pathology | Reverse Transcriptase Polymerase Chain Reaction | Blood-Brain Barrier - drug effects | Blotting, Western | Nerve Tissue Proteins - metabolism | Animals | Evans Blue | Cerebral Arteries - metabolism | Brain Ischemia - drug therapy | Matrix Metalloproteinase Inhibitors | Matrix Metalloproteinases - physiology | Astrocytes - metabolism | Endothelial Cells - drug effects
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 3, p. e0174596
Mild hypothermia improves survival and neurological recovery after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). However, the mechanism... 
SURVIVAL | PATHOGENESIS | MULTIDISCIPLINARY SCIENCES | RATS | INJURY | GLOBAL CEREBRAL-ISCHEMIA | HOSPITAL CARDIAC-ARREST | VASCULAR-PERMEABILITY | EXPRESSION | NEUROPROTECTION | NEUROLOGICAL FUNCTION | Cardiopulmonary Resuscitation - methods | Cadherins - metabolism | Claudin-5 - metabolism | Heart Arrest - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Antigens, CD - genetics | Adherens Junctions - metabolism | Occludin - metabolism | Antigens, CD - metabolism | Brain - metabolism | Brain Edema - genetics | Occludin - genetics | Brain - blood supply | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 9 - genetics | Swine | Hypothermia, Induced - methods | Brain - ultrastructure | Zonula Occludens-1 Protein - metabolism | Cadherins - genetics | Disease Models, Animal | Tight Junctions - metabolism | Zonula Occludens-1 Protein - genetics | Microscopy, Electron, Transmission | Gene Expression | Brain Edema - metabolism | Ribonuclease, Pancreatic - genetics | Heart Arrest - genetics | Claudin-5 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Blood-Brain Barrier - metabolism | Tight Junctions - ultrastructure | Animals | Ribonuclease, Pancreatic - metabolism | Adherens Junctions - ultrastructure | Heart Arrest - therapy | Care and treatment | Usage | Cardiac arrest | Physiological aspects | CPR (First aid) | Genetic aspects | Research | Vascular endothelial growth factor | Hypothermia | Membrane permeability | Emergency medical care | Matrix metalloproteinase | Angiogenin | Cardiopulmonary resuscitation--CPR | Ventricular fibrillation | Fibrillation | Blood-brain barrier | Moisture content | Temperature effects | Rodents | Water content | Breakdown | Attenuation | Metalloproteinase | Heart diseases | Resuscitation | Edema | Tight junctions | Cortex | Adherens junctions | Permeability | Gene expression | Cadherin | Survival | Catheters | Zonula occludens-1 protein | Gelatinase B | Livestock | Disruption | Ventricle | CPR | Cardiopulmonary resuscitation
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 3, p. e0122358
Hypoglycemia impairs blood-brain barrier (BBB) endothelial function; a major hallmark in the pathogenesis of various CNS disorders. Previously, we have... 
MITOCHONDRIAL OXIDATIVE STRESS | CELLS | RESPONSES | DEFENSE PATHWAY | GLUCOSE | STABILITY | MULTIDISCIPLINARY SCIENCES | EXPRESSION | JUNCTION PROTEINS | VASCULAR-DISEASE | PROTECTS | NF-E2-Related Factor 2 - antagonists & inhibitors | Cadherins - metabolism | Humans | Claudin-5 - metabolism | Ubiquitin-Protein Ligases - antagonists & inhibitors | Hypoglycemia - pathology | NAD(P)H Dehydrogenase (Quinone) - genetics | RNA, Messenger - metabolism | Antigens, CD - metabolism | RNA Interference | Female | NF-E2-Related Factor 2 - genetics | Zonula Occludens-1 Protein - metabolism | Nuclear Proteins - genetics | Cell Line | Endothelial Cells - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Permeability | Down-Regulation - drug effects | Hypoglycemia - metabolism | Blood-Brain Barrier - metabolism | Up-Regulation - drug effects | Leupeptins - pharmacology | Endothelial Cells - cytology | NF-E2-Related Factor 2 - metabolism | Nuclear Proteins - antagonists & inhibitors | NAD(P)H Dehydrogenase (Quinone) - metabolism | Ubiquitin-Protein Ligases - genetics | RNA, Small Interfering - metabolism | Ubiquitin | Dextran | RNA | Proteases | Genetic engineering | Glucose | Dextrose | Monomolecular films | Endothelium | Health sciences | Oxidative stress | Pathogenesis | Central nervous system | Membrane permeability | Homeostasis | Degradation | Proteins | Cerebrovascular system | Dextrans | Blood-brain barrier | Physiology | Pretreatment | NRF2 protein | Pharmaceutical sciences | Ubiquitin-protein ligase | Injuries | RNA-mediated interference | Inflammation | Proteinase inhibitors | Exposure | Pharmacology | Hypoglycemia | Cadherin | Ribonucleic acid--RNA | Zonula occludens-1 protein | Molecular chains | Endothelial cells | Signaling | Molecular modelling | Monolayers | Proteasomes | Hypoxia | Gene manipulation | Microvasculature | Diabetes | Destabilization | Integrity | Ribonucleic acid
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 06/2015, Volume 125, Issue 6, pp. 2473 - 2483
Bacterial meningitis is a serious infection of the CNS that results when blood-borne bacteria are able to cross the blood-brain barrier (BBB). Group B... 
MEDICINE, RESEARCH & EXPERIMENTAL | ESCHERICHIA-COLI K1 | INVASION | ACTIVATION | TIGHT JUNCTION COMPONENTS | AGALACTIAE | ENDOTHELIUM | DOWN-REGULATION | NEUTROPHIL SIGNALING PATHWAYS | GROUP-B STREPTOCOCCI | EXPRESSION | Tight Junctions - genetics | Humans | Claudin-5 - metabolism | Streptococcal Infections - metabolism | Blood-Brain Barrier - microbiology | MAP Kinase Signaling System | Streptococcal Infections - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Streptococcal Infections - pathology | Zonula Occludens-1 Protein - metabolism | Streptococcus agalactiae | Snail Family Transcription Factors | Tight Junctions - metabolism | Zonula Occludens-1 Protein - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation - genetics | Zebrafish Proteins - metabolism | Cells, Cultured | Claudin-5 - genetics | Transcription Factors - genetics | Zebrafish - genetics | Blood-Brain Barrier - metabolism | Transcription Factors - metabolism | Blood-Brain Barrier - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Zebrafish - metabolism | Zebrafish Proteins - genetics | Tight Junctions - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Proteins | Data analysis | Bacterial infections | Blood-brain barrier | Rodents | Cloning | Laboratory animals | Gene expression | Experiments | Endothelium | Streptococcus infections | Microbiology | Infectious disease | Vascular Biology
Journal Article
Journal of cerebral blood flow and metabolism, ISSN 1559-7016, 2014, Volume 34, Issue 11, pp. 1826 - 1836
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 7, p. e39398
Previously, we showed that insulin growth factor (IGF)-1 binding protein-3 (IGFBP-3), independent of IGF-1, reduces pathological angiogenesis in a mouse model... 
PATHWAYS | BREAST-CANCER CELLS | APOPTOSIS | ACTIVATION | SCAVENGER RECEPTOR | IGFBP-3 | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | SHEAR-STRESS | EXPRESSION | Insulin-Like Growth Factor Binding Protein 3 - genetics | Retinal Diseases - genetics | Cadherins - metabolism | Calcium - metabolism | Claudin-5 - metabolism | Male | Retinal Diseases - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Cerebral Arteries - drug effects | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Fura-2 | Nitric Oxide Synthase Type III - metabolism | Cadherins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Disease Models, Animal | Retinal Vessels - metabolism | Signal Transduction | Endothelial Cells - metabolism | Intercellular Junctions - metabolism | Rats | Claudin-5 - genetics | Blood-Retinal Barrier - pathology | Retinal Vessels - drug effects | Nitric Oxide | Intercellular Junctions - genetics | Rats, Sprague-Dawley | Nitric Oxide Synthase Type III - antagonists & inhibitors | Blood-Retinal Barrier - metabolism | Animals | Cerebral Arteries - metabolism | Intercellular Junctions - drug effects | Protein Binding | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Scavenger Receptors, Class B - metabolism | Insulin-Like Growth Factor I - metabolism | Endothelial Cells - drug effects | Viral antibodies | Diabetic retinopathy | Nitric oxide | Antibodies | Calcium-binding proteins | Vascular endothelial growth factor | Protein kinases | Protein binding | Endothelium | Phosphorylation | Calcium | Insulin-like growth factor I | Horseradish peroxidase | AKT protein | Retina | Insulin-like growth factors | Activation | Dephosphorylation | Shear stresses | Kinases | Blood | Arteries | Vasodilation | Angiogenesis | Rodents | Calcium-binding protein | Insulin-like growth factor-binding protein 3 | Eye (anatomy) | Peroxidase | Dissociation | Calmodulin | Oxygen | Calcium (intracellular) | Serotonin | Complications | Diabetes mellitus | Insulin | Endothelial cells | 1-Phosphatidylinositol 3-kinase | NG-Nitroarginine methyl ester | Microvasculature | Calcium ions | Ca2+/calmodulin-dependent protein kinase II | Integrity
Journal Article