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Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 10/2016, Volume 94, pp. 59 - 71
Develop a minimal mechanistic model based on in vitro–in vivo extrapolation (IVIVE) principles to predict extent of passive tubular reabsorption. Assess the... 
Renal excretion clearance | Tubular reabsorption | In vitro–in vivo extrapolation | ANTIPYRINE | PERMEABILITY | TRANSPORTERS | URINE FLOW | GLUCURONIDATION | GLOMERULAR-FILTRATION-RATE | IN-VITRO | MATHEMATICAL-MODEL | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | In vitro-in vivo extrapolation | LIPOPHILICITY | Renal Elimination - physiology | Kidney Tubules - drug effects | Humans | Renal Elimination - drug effects | Glomerular Filtration Rate - physiology | Metabolic Clearance Rate - physiology | Glomerular Filtration Rate - drug effects | Pharmaceutical Preparations - metabolism | Models, Biological | Metabolic Clearance Rate - drug effects | Clinical Trials as Topic - methods | Kidney Tubules - metabolism | Pharmaceutical Preparations - administration & dosage | Analysis | Permeability | PT, proximal tubule | LogD, octanol-buffer distribution coefficient | P-gp, P-glycoprotein | CLR, filt, renal filtration clearance | OCT, organic cation transporter | DT, distal tubule | OCTN, organic cation | GFR, glomerular filtration rate | gmfe, geometric mean fold error | OAT, organic anion transporter | OATP, organic anion-transporting peptides | CD, collecting duct | Freab, fraction of the drug reabsorbed in the renal tubule | TSA, tubular surface area | CLR,sec, renal secretion clearance | AUC, area under the plasma concentration-time profile | CLR, int,reab, intrinsic permeability clearance in renal tubule | fu,p, fraction of drug unbound in plasma | l-carnitine transporter | PBPK, physiologically-based pharmacokinetic | Freab’, intermediate model parameter, representing the fraction of the equilibrium reached between unbound drug concentration in the plasma and urine | Cp, plasma concentration | Papp, apparent permeability | RMSE, root mean squared error | TFR, tubular flow rate | BCRP, breast cancer resistance protein | IVIVE, in vitro–in vivo extrapolation | LoH, loop of Henle | MATE, multidrug and toxin extrusion protein | MRP, multidrug resistance protein | CLR, renal excretion clearance
Journal Article
Journal Article
Journal Article
2017, 1, ISBN 9781859466315, xx, 234 pages
The problem of creating affordable, adequate housing for a growing population is not a new one. This book, aimed at anyone with a professional or personal... 
Housing | History | Professional Practice | Sustainable Architecture | Urban Design | Dwellings
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Journal Article