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1. Full Text Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development
by Fenglei He and Wei Xiong and Xueyan Yu and Ramon Espinoza-Lewis and Chao Liu and Shuping Gu and Michiru Nishita and Kentaro Suzuki and Gen Yamada and Yasuhiro Minami and YiPing Chen
Development, ISSN 0950-1991, 12/2008, Volume 135, Issue 23, pp. 3871 - 3879
Tissue and molecular heterogeneities are present in the developing secondary palate along the anteroposterior (AP) axis in mice. Here, we show that Wnt5a and... 
Palatogenesis | Cleft palate | Non-canonical Wnt pathway | Ror2 | Wnt5a | Cell migration | CLEFT-PALATE | SECONDARY PALATE | LUNG DEVELOPMENT | DEVELOPMENTAL BIOLOGY | MICE EXHIBIT | MORPHOGENESIS | SIGNALING PATHWAY | DIFFERENTIATION | RECEPTOR TYROSINE KINASE | VERTEBRATE GASTRULATION | Cell Proliferation | Wnt Proteins - deficiency | Receptor Tyrosine Kinase-like Orphan Receptors | Wnt-5a Protein | Wnt Proteins - metabolism | Cleft Palate - enzymology | Wnt Proteins - genetics | Gene Expression Regulation, Developmental | Mice, Mutant Strains | Mesoderm - enzymology | Body Patterning | Mammals - embryology | Bromodeoxyuridine - metabolism | Palate - cytology | Palate - metabolism | Green Fluorescent Proteins - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Chemotaxis | Palate - embryology | Phenotype | Animals | Receptor Protein-Tyrosine Kinases - genetics | Epistasis, Genetic | Cleft Palate - pathology | Palate - enzymology | Mice | Mesoderm - pathology | Cell Movement
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2. Full Text Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis
by He, Fenglei and Xiong, Wei and Wang, Ying and Matsui, Maiko and Yu, Xueyan and Chai, Yang and Klingensmith, John and Chen, YiPing
Developmental Biology, ISSN 0012-1606, 11/2010, Volume 347, Issue 1, pp. 109 - 121
BMP signaling plays many important roles during organ development, including palatogenesis. Loss of BMP signaling leads to cleft palate formation. During... 
Noggin | Palatal epithelium | Cleft palate | Palate development | Bmp signaling | FUSION | SECONDARY PALATE | BONE MORPHOGENETIC PROTEINS | PROLIFERATION | DEVELOPMENTAL BIOLOGY | CAUSES CLEFT-PALATE | TOOTH | MUTANT MICE | CRANIAL NEURAL CREST | DIFFERENTIATION | ANTAGONISTS | Cell Proliferation | Mandible - pathology | Palate - pathology | Embryo, Mammalian - metabolism | Bone Morphogenetic Proteins - metabolism | Epithelium - embryology | Gene Expression Regulation, Developmental | Bone Morphogenetic Proteins - genetics | Mandible - abnormalities | Palate - metabolism | Epithelium - pathology | Embryo, Mammalian - pathology | Epithelium - metabolism | Signal Transduction | Cleft Palate - embryology | Mutation - genetics | Palate - embryology | Organogenesis | Phenotype | Animals | Carrier Proteins - metabolism | Palate - abnormalities | Cleft Palate - pathology | Cleft Palate - metabolism | Mice | Smad Proteins - metabolism | Apoptosis | Gene expression | Bone morphogenetic proteins | Analysis | cleft palate | palatal epithelium | palate development
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3. Full Text Molecular control of secondary palate development
by Gritli-Linde, Amel
Developmental Biology, ISSN 0012-1606, 2007, Volume 301, Issue 2, pp. 309 - 326
Compared with the embryonic development of other organs, development of the secondary palate is seemingly simple. However, each step of palatogenesis, from... 
Signaling pathways | Cleft palate | Epithelial–mesenchymal interactions | Mouse mutations | Palate patterning | Palate development | Epithelial-mesenchymal interactions | EXHIBIT ABNORMAL-DEVELOPMENT | epithelial-mesenchymal interactions | palate patterning | MEDIAL EDGE EPITHELIUM | mouse mutations | cleft palate | DEVELOPMENTAL BIOLOGY | CAUSES CLEFT-PALATE | palate development | MICE LACKING | PROGRAMMED CELL-DEATH | signaling pathways | EPITHELIAL-MESENCHYMAL TRANSFORMATION | CRANIAL NEURAL CREST | EPIDERMAL-GROWTH-FACTOR | CRANIOFACIAL DEVELOPMENT | GAMMA-AMINOBUTYRIC-ACID | Animals | Epithelial Cells - metabolism | Signal Transduction | Humans | Cleft Palate - embryology | Cleft Palate - metabolism | Mutation - genetics | Stem Cells - metabolism
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4. Full Text Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip ± cleft palate and cleft palate only
by Ludwig, Kerstin U and Böhmer, Anne C and Bowes, John and Nikolić, Miloš and Ishorst, Nina and Wyatt, Niki and Hammond, Nigel L and Gölz, Lina and Thieme, Frederic and Barth, Sandra and Schuenke, Hannah and Klamt, Johanna and Spielmann, Malte and Aldhorae, Khalid and Rojas-Martinez, Augusto and Nöthen, Markus M and Rada-Iglesias, Alvaro and Dixon, Michael J and Knapp, Michael and Mangold, Elisabeth
Human Molecular Genetics, ISSN 0964-6906, 02/2017, Volume 26, Issue 4, pp. 829 - 842
Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common human birth defects with multifactorial etiology. Here, we present... 
Genome-Wide Association Study | Chromosomes, Human - genetics | Humans | Databases, Genetic | Male | Cleft Palate - genetics | Genetic Loci | Cleft Lip - metabolism | Cleft Lip - genetics | Animals | Cleft Lip - pathology | Cleft Palate - pathology | Female | Cleft Palate - metabolism | Mice | Polymorphism, Single Nucleotide | Association Studies
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5. Full Text Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice
by Thomason, H.A and Zhou, H and Kouwenhoven, E.N and Dotto, G.P and Restivo, G and Nguyen, B.C and Little, H and Dixon, M.J and Bokhoven, J.H.L.M. van and Dixon, J
Journal of Clinical Investigation, ISSN 0021-9738, 2010, Volume 120, Issue 5, pp. 1561 - 1569
Cleft palate is a common congenital disorder that affects up to 1 in 2,500 live human births and results in considerable morbidity to affected individuals and... 
MEDICINE, RESEARCH & EXPERIMENTAL | VARIANTS CONTRIBUTE | P53-FAMILY MEMBERS P63 | THYROID AGENESIS | IN-VIVO | GENE-EXPRESSION | CAUSE VAN | POPLITEAL PTERYGIUM SYNDROME | P53 HOMOLOG | WOUDE SYNDROME | DIRECT TARGET | Transcriptional Activation | Interferon Regulatory Factors - metabolism | Interferon Regulatory Factors - genetics | Keratinocytes - cytology | Phosphoproteins - genetics | Phosphoproteins - metabolism | Genetic Variation | Animals | Enhancer Elements, Genetic | Epistasis, Genetic | Gene Expression Regulation, Developmental | Models, Biological | Trans-Activators - genetics | Heterozygote | Trans-Activators - metabolism | Cleft Palate - metabolism | Mice | Mutation | Binding Sites | Prevention | Embryonic development | Cleft palate | Transcription factors | Genetic aspects | Biological response modifiers | Properties | Risk factors
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6. Full Text Golgb1 regulates protein glycosylation and is crucial for mammalian palate development
by Lan, Yu and Zhang, Nian and Liu, Han and Xu, Jingyue and Jiang, Rulang
Development (Cambridge), ISSN 0950-1991, 07/2016, Volume 143, Issue 13, pp. 2344 - 2355
Cleft palate is a common major birth defect for which currently known causes account for less than 30% of pathology in humans. In this study, we carried out... 
CRISPR | Cleft palate | Craniofacial | Genome editing | Glycosylation | Golgi | Mutation | ENU | P115 | FUSION | GLYCOSAMINOGLYCANS | GM130 | DEVELOPMENTAL BIOLOGY | GIANTIN | GENE | INTERACTS | OSTEOCHONDRODYSPLASIA | ENDOPLASMIC-RETICULUM | NEURAL CREST | RNA Editing - genetics | Cell Count | Cleft Palate - genetics | Mesoderm - cytology | RNA, Messenger - metabolism | Embryo, Mammalian - metabolism | Lectins - metabolism | Mice, Mutant Strains | Base Sequence | RNA Splicing - genetics | Mammals - embryology | Ethylnitrosourea | Female | Membrane Proteins - metabolism | Golgi Apparatus - ultrastructure | Palate - metabolism | Mesoderm - embryology | RNA Splice Sites - genetics | Membrane Proteins - genetics | RNA, Messenger - genetics | Mutation - genetics | CRISPR-Cas Systems - genetics | Palate - embryology | Animals | Hyaluronic Acid - metabolism | Fluorescent Antibody Technique | Golgi Apparatus - metabolism | Genome
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7. Full Text Impaired FGF Signaling Contributes to Cleft Lip and Palate
by Bridget M. Riley and M. Adela Mansilla and Jinghong Ma and Sandra Daack-Hirsch and Brion S. Maher and Lisa M. Raffensperger and Erilynn T. Russo and Alexandre R. Vieira and Catherine Dodé and Moosa Mohammadi and Mary L. Marazita and Jeffrey C. Murray
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2007, Volume 104, Issue 11, pp. 4512 - 4517
Nonsyndromic cleft lip and palate (NS CLP) is a complex birth defect resulting from a combination of genetic and environmental factors. Several members of the... 
Cleft palate | Phenotypes | Receptors | Genes | Chickens | Rats | Genetic mutation | Sequencing | Cleft lip and palate | Structural analysis | Fibroblast growth factor | Single-nucleotide polymorphism | Fibroblast growth factor receptor | single-nucleoticle polymorphism | MULTIDISCIPLINARY SCIENCES | MOUSE | PHENOTYPE | cleft palate | CELL PROLIFERATION | APERT SYNDROME | fibroblast growth factor | GENE | fibroblast growth factor receptor | STRUCTURAL BASIS | GROWTH | KALLMANN-SYNDROME | MUTATIONS | HYPOGONADOTROPIC HYPOGONADISM | Amino Acid Sequence | Signal Transduction | Humans | Fibroblast Growth Factors - genetics | Models, Molecular | Molecular Sequence Data | Male | Cleft Palate - genetics | Cleft Lip - metabolism | Sequence Homology, Amino Acid | Fibroblast Growth Factors - metabolism | Cleft Lip - genetics | Animals | Pedigree | Female | Cleft Palate - metabolism | Polymorphism, Single Nucleotide | Mutation | Fibroblast growth factors | Cellular signal transduction | Genetic aspects | Research | Single nucleotide polymorphisms | Structure | Biological Sciences | single-nucleotide polymorphism
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8. Full Text Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis
by Wu, Bill X and Li, Anqi and Lei, Liming and Kaneko, Satoshi and Wallace, Caroline and Li, Xue and Li, Zihai and O'Neill, Luke
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 44, pp. 18091 - 18097
Glycoprotein A repetitions predominant (GARP) (encoded by the gene) plays important roles in cell-surface docking and activation of TGFβ. However, GARP's role... 
Phosphorylation | Transforming Growth Factor beta3 - genetics | Humans | Protein Multimerization | Palate - pathology | Recombinant Fusion Proteins - metabolism | Transforming Growth Factor beta3 - metabolism | Embryo, Mammalian - metabolism | Gene Expression Regulation, Developmental | Transforming Growth Factor beta3 - chemistry | HEK293 Cells | Female | Membrane Proteins - metabolism | Animals, Newborn | Palate - metabolism | Embryo, Mammalian - pathology | Signal Transduction | Membrane Proteins - genetics | Smad2 Protein - metabolism | Cleft Palate - embryology | Recombinant Fusion Proteins - chemistry | Embryo, Mammalian - abnormalities | Palate - embryology | Gene Knock-In Techniques | Mice, Knockout | Organogenesis | Protein Transport | Pregnancy | Animals | Membrane Proteins - chemistry | Palate - abnormalities | Cleft Palate - pathology | Heterozygote | Cleft Palate - metabolism | Protein Processing, Post-Translational | Transforming Growth Factor beta3 - agonists | Apoptosis | development | GARP, palatogenesis | cell signaling | TGFβ | apoptosis | embryo | Developmental Biology
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9. Full Text Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice
by Zhang, Jian and Yang, Rui and Liu, Ziyi and Hou, Congzhe and Zong, Wen and Zhang, Aizhen and Sun, Xiaoyang and Gao, Jiangang
Human Molecular Genetics, ISSN 0964-6906, 2015, Volume 24, Issue 21, pp. 6174 - 6185
In mammals, embryonic development are highly regulated morphogenetic processes that are tightly controlled by genetic elements. Failure of any one of these... 
PROTEIN | GENE | CLONING | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | MUTATION | GENETICS & HEREDITY | SPONDYLOEPIPHYSEAL DYSPLASIA | STICKLER-SYNDROME | BETA-AMINOPROPIONITRILE | COLLAGEN-II | TRANSGENIC MICE | Eye - metabolism | Palate - metabolism | Eye - pathology | Gene Targeting | Lung - pathology | Amino Acid Oxidoreductases - physiology | Diaphragm - pathology | Hydroxyproline - metabolism | Mice, Inbred C57BL | Cleft Palate - embryology | Embryonic Development - physiology | Myocardium - pathology | Amino Acid Oxidoreductases - genetics | Aorta - pathology | Spine - abnormalities | Trachea - pathology | Collagen - metabolism | Thoracic Vertebrae - embryology | Animals | Desmosine - metabolism | Mice | Amino Acid Oxidoreductases - biosynthesis | Craniofacial Abnormalities - genetics
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10. Full Text Computational Model of Secondary Palate Fusion and Disruption
by Hutson, M. Shane and Leung, Maxwell C. K and Baker, Nancy C and Spencer, Richard M and Knudsen, Thomas B
Chemical Research in Toxicology, ISSN 0893-228X, 04/2017, Volume 30, Issue 4, pp. 965 - 979
Morphogenetic events are driven by cell-generated physical forces and complex cellular dynamics. To improve our capacity to predict developmental effects from... 
CLEFT-PALATE | CHEMISTRY, MEDICINAL | TGF-BETA | EPITHELIAL DIFFERENTIATION | CHEMISTRY, MULTIDISCIPLINARY | RETINOIC ACID | GLUCOCORTICOID-RECEPTOR | EPIDERMAL-GROWTH-FACTOR | POTTS-MODEL | TOXICOLOGY | CELL-DIFFERENTIATION | EMBRYONIC PALATE | SPEMANN ORGANIZER | Mesenchymal Stromal Cells - enzymology | Palate - metabolism | Mesenchymal Stromal Cells - drug effects | Fibroblast Growth Factor 10 - metabolism | Signal Transduction | Epidermal Growth Factor - metabolism | Mesenchymal Stromal Cells - cytology | Animals | Transforming Growth Factor beta - genetics | Models, Biological | Cell Differentiation | Mice | Monte Carlo Method | Transforming Growth Factor beta - metabolism | Apoptosis | Cell Movement | Index Medicus | CompuCell3D | Predictive Toxicology | Children’s Health | Morphogenetic Fusion | Developmental toxicity | Agent-Based Model | Computational Biology
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11. Full Text Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization
by Vincent S. Tagliabracci and James L. Engel and Jianzhong Wen and Sandra E. Wiley and Carolyn A. Worby and Lisa N. Kinch and Junyu Xiao and Nick V. Grishin and Jack E. Dixon
Science, ISSN 0036-8075, 6/2012, Volume 336, Issue 6085, pp. 1150 - 1153
Protein phosphorylation is a fundamental mechanism regulating nearly every aspect of cellular life. Several secreted proteins are phosphorylated, but the... 
Proteins | T lymphocytes | Phosphorylation | Biomineralogy | Secretion | Phosphoproteins | REPORTS | Immunoblotting | Cellular immunity | Physiological regulation | Siblings | OSTEOPONTIN | INHIBITION | MULTIDISCIPLINARY SCIENCES | PHOSPHOPROTEOME | PURIFICATION | SEQUENCE | GOLGI-APPARATUS | SPECIFICITY DETERMINANTS | MASS-SPECTROMETRY | APPARATUS CASEIN KINASE | LACTATING MAMMARY-GLAND | Abnormalities, Multiple - metabolism | Golgi Apparatus - enzymology | Microcephaly - genetics | Humans | Secretory Pathway | Caseins - metabolism | Glycoproteins - metabolism | Molecular Sequence Data | Substrate Specificity | Cleft Palate - genetics | Casein Kinase I | Recombinant Fusion Proteins - metabolism | Extracellular Matrix Proteins - secretion | Cattle | Exophthalmos - genetics | HEK293 Cells | Osteosclerosis - metabolism | Osteosclerosis - genetics | Abnormalities, Multiple - genetics | Extracellular Matrix Proteins - metabolism | Amino Acid Sequence | Extracellular Matrix Proteins - chemistry | Milk - enzymology | Extracellular Matrix Proteins - genetics | Microcephaly - metabolism | Osteopontin | Recombinant Fusion Proteins - chemistry | Protein Sorting Signals | Amino Acid Motifs | Animals | Calcification, Physiologic | Casein Kinases - metabolism | Exophthalmos - metabolism | Cell Line, Tumor | Recombinant Fusion Proteins - secretion | Cleft Palate - metabolism | HeLa Cells | Mutation | Physiological aspects | Biomineralization | Extracellular matrix | Research | Phosphotransferases | Mineralogy | Cells | Mutations | Casein | Genes | Bones | Kinases
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12. Full Text Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis
by Zhou, Jing and Gao, Yang and Lan, Yu and Jia, Shihai and Jiang, Rulang
Development (Cambridge), ISSN 0950-1991, 12/2013, Volume 140, Issue 23, pp. 4709 - 4718
Cleft palate is one of the most common birth defects in humans. Whereas gene knockout studies in mice have shown that both the Osr2 and Pax9 transcription... 
Bmp4 | Osr2 | Cleft palate | Shh | Mouse | Pax9 | SECONDARY PALATE | DEVELOPMENTAL BIOLOGY | CAUSES CLEFT-PALATE | MICE EXHIBIT | EXPRESSION PATTERNS | MUTANT MICE | CRANIAL NEURAL CREST | DROSOPHILA EMBRYOGENESIS | GENES | SONIC-HEDGEHOG | Paired Box Transcription Factors - genetics | Palate - metabolism | Fibroblast Growth Factor 10 - metabolism | Cell Proliferation | Morphogenesis - genetics | Mice, Inbred C57BL | Hedgehog Proteins - metabolism | Mice, Transgenic | Cleft Palate - genetics | Signal Transduction - genetics | Bone Morphogenetic Protein 4 - metabolism | Palate - embryology | Palate - growth & development | Transcription Factors - metabolism | Animals | Gene Expression Regulation, Developmental | MSX1 Transcription Factor - genetics | Mice | MSX1 Transcription Factor - metabolism | Body Patterning - genetics | Paired Box Transcription Factors - metabolism | MSX1 Transcription Factor - biosynthesis
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13. Full Text SUMO1 Haploinsufficiency Leads to Cleft Lip and Palate
by Fowzan S. Alkuraya and Irfan Saadi and Jennifer J. Lund and Annick Turbe-Doan and Cynthia C. Morton and Richard L. Maas
Science, ISSN 0036-8075, 9/2006, Volume 313, Issue 5794, pp. 1751 - 1751
The posttranslational modification sumoylation can have multiple effects on its substrate proteins. We studied a patient with isolated cleft lip and palate and... 
Cleft palate | Palatal consonants | Palate | Epithelium | Haploinsufficiency | Cleft lip and palate | Brevia | GENE | SATB2 | MULTIDISCIPLINARY SCIENCES | Translocation, Genetic | Humans | Child, Preschool | Protein Tyrosine Phosphatases - metabolism | SUMO-1 Protein - physiology | Cleft Palate - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Stem Cells - metabolism | Embryo, Mammalian - metabolism | Small Ubiquitin-Related Modifier Proteins - physiology | Morphogenesis | Small Ubiquitin-Related Modifier Proteins - genetics | Protein Tyrosine Phosphatases - genetics | In Situ Hybridization | SUMO-1 Protein - genetics | Gene Expression Regulation, Developmental | Karyotyping | Adult | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Palate - metabolism | Cell Line | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Gene Dosage | Palate - embryology | Cleft Lip - genetics | Animals | Embryo, Mammalian - cytology | Mice | Research | Craniofacial abnormalities | Analysis
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14. Full Text Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth
by Yu Lan and Rulang Jiang
Development, ISSN 0950-1991, 04/2009, Volume 136, Issue 8, pp. 1387 - 1396
The mammalian secondary palate arises by outgrowth from the oral side of the paired maxillary processes flanking the primitive oral cavity. Palatal growth... 
Osr2 | CLEFT-PALATE | Cleft palate | Tissue-specific gene inactivation | SECONDARY PALATE | KIDNEY DEVELOPMENT | PROLIFERATION | DEVELOPMENTAL BIOLOGY | Palate development | Fgf10 | EXPRESSION PATTERNS | MORPHOGENESIS | Shh | Smo | GROWTH | MICE | DIFFERENTIATION | Osr2-IresCre | GENE-FUNCTION | Palate - metabolism | Cyclin D1 - metabolism | Fibroblast Growth Factor 10 - metabolism | Cell Proliferation | Epithelial Cells - metabolism | Mesoderm - embryology | Signal Transduction | Hedgehog Proteins - metabolism | Mesoderm - cytology | Mutation - genetics | Bone Morphogenetic Protein 4 - metabolism | Palate - embryology | Cyclin D2 | Animals | Cyclins - metabolism | Hedgehog Proteins - genetics | Bone Morphogenetic Protein 2 - metabolism | Integrases - metabolism | Mesoderm - metabolism | Mice | Fibroblast Growth Factor 10 - genetics | Epithelial Cells - cytology | Integrases - genetics | Development and Disease
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