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Journal Article
Pharmaceutical Statistics, ISSN 1539-1604, 09/2018, Volume 17, Issue 5, pp. 504 - 514
Journal Article
Journal Article
Journal Article
Statistics in Medicine, ISSN 0277-6715, 01/2015, Volume 34, Issue 2, pp. 249 - 264
Developing sophisticated statistical methods for go/no‐go decisions is crucial for clinical trials, as planning phase III or phase IV trials is costly and time... 
fitting prior | power prior | average probability of success | marginal likelihood | simulation | linear regression | validation prior | Fitting prior | Validation prior | Simulation | Linear regression | Power prior | Average probability of success | Marginal likelihood | MEDICINE, RESEARCH & EXPERIMENTAL | MECHANISM | MEDICAL INFORMATICS | SAFETY | REGRESSION-MODELS | STATISTICS & PROBABILITY | IMMUNOGENICITY | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | ZOSTAVAX | MATHEMATICAL & COMPUTATIONAL BIOLOGY | SAMPLE-SIZE | Herpes Zoster - prevention & control | Humans | Herpesvirus 3, Human - immunology | Male | Clinical Trials, Phase III as Topic - methods | Likelihood Functions | Clinical Trials, Phase III as Topic - statistics & numerical data | Antibodies, Viral - analysis | Computer Simulation | Clinical Trials, Phase II as Topic - statistics & numerical data | Female | Herpes Zoster Vaccine - immunology | Decision Making | Herpes Zoster - immunology | Data Interpretation, Statistical | Clinical Trials, Phase II as Topic - economics | Probability | Linear Models | Logistic Models | Herpes Zoster Vaccine - administration & dosage | Analysis of Variance | Clinical Trials, Phase III as Topic - economics | Bayes Theorem | Antibodies, Viral - immunology | Aged | Clinical Trials, Phase II as Topic - methods | Clinical trials
Journal Article
British Journal of Cancer, ISSN 0007-0920, 09/2012, Volume 107, Issue 6, pp. 910 - 917
BACKGROUND: Many clinical trials show no overall benefit. We examined futility analyses applied to trials with different effect sizes. METHODS: Ten randomised... 
clinical trials | futility analysis | conditional power | early stopping | CELL LUNG-CANCER | ONCOLOGY | FOLLOW-UP | Clinical Study
Journal Article
Nature medicine, ISSN 1078-8956, 2014, Volume 20, Issue 4, pp. 321 - 321
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 08/2006, Volume 24, Issue 24, pp. 3933 - 3938
Journal Article