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science & technology (213) 213
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hydroxyquinolines - pharmacology (20) 20
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proteasome inhibitors (14) 14
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1. Full Text Coordination of Hydroxyquinolines to a Ruthenium Bis-dimethyl-phenanthroline Scaffold Radically Improves Potency for Potential as Antineoplastic Agents
by Heidary, David K and Howerton, Brock S and Glazer, Edith C
Journal of medicinal chemistry, ISSN 0022-2623, 11/2014, Volume 57, Issue 21, pp. 8936 - 8946
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Proteasome Inhibitors - pharmacology | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Copper - pharmacology | Structure-Activity Relationship | Hydroxyquinolines - chemical synthesis | Clioquinol - pharmacology | Quinolines - pharmacology | Ruthenium - pharmacology | Quinolines - chemical synthesis | Cell Line, Tumor | Coordination Complexes - chemical synthesis | Coordination Complexes - pharmacology | HL-60 Cells | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Hydroxyquinolines - pharmacology | Index Medicus
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2. Full Text Administration of zinc chelators improves survival of mice infected with Aspergillus fumigatus both in monotherapy and in combination with caspofungin
by Laskaris, Paris and Atrouni, Ahmad and Calera, José Antonio and D'Enfert, Christophe and Munier-Lehmann, Hélène and Cavaillon, Jean-Marc and Latgé, Jean-Paul and Ibrahim-Granet, Oumaïma
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 10/2016, Volume 60, Issue 10, pp. 5631 - 5639
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Aspergillus fumigatus - drug effects | Lipopeptides - pharmacology | Pneumonia - pathology | Male | Phenanthrolines - pharmacology | Aspergillosis - mortality | Drug Therapy, Combination | Echinocandins - pharmacology | Aspergillosis - drug therapy | Antifungal Agents - pharmacology | Immune Sera - pharmacology | Ethylamines - pharmacology | Treatment Outcome | Pneumonia - microbiology | Chelating Agents - pharmacology | Aspergillus fumigatus - pathogenicity | Clioquinol - pharmacology | Zinc | Animals | Aspergillosis - microbiology | Aspergillus fumigatus - growth & development | Mice, Inbred BALB C | Pyridines - pharmacology | Immunocompromised Host | Aspergillosis - immunology | Index Medicus | Life Sciences | Microbiology and Parasitology | Mycology
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3. Full Text Forging New Antibiotic Combinations under Iron-Limiting Conditions
by Chan, Derek C. K and Guo, Irene and Burrows, Lori L
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 03/2020, Volume 64, Issue 3
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Index Medicus
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4. Full Text In Vitro Activity of Combinations of Zinc Chelators with Amphotericin B and Posaconazole against Six Mucorales Species
by Leonardelli, Florencia and Macedo, Daiana and Dudiuk, Catiana and Theill, Laura and Cabeza, Matias S and Gamarra, Soledad and Garcia-Effron, Guillermo
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 05/2019, Volume 63, Issue 5
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Antifungal Agents - pharmacology | Microbial Sensitivity Tests | Triazoles - pharmacology | Phenanthrolines - pharmacology | Amphotericin B - pharmacology | Mucorales - drug effects | Chelating Agents - pharmacology | Zinc - chemistry | Clioquinol - pharmacology | Index Medicus
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5. Full Text The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid β-protein accumulation
by Xie, Zhongcong and Dong, Yuanlin and Maeda, Uta and Moir, Robert D and Xia, Weiming and Culley, Deborah J and Crosby, Gregory and Tanzi, Rudolph E
The Journal of neuroscience, ISSN 0270-6474, 02/2007, Volume 27, Issue 6, pp. 1247 - 1254
APP | Anesthesia | Alzheimer's disease | Isoflurane | Apoptosis | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neuroglia - ultrastructure | Isoflurane - pharmacology | Apoptosis - drug effects | Amyloid beta-Peptides - pharmacology | Humans | Caspase 3 - metabolism | Isoflurane - adverse effects | Peptide Fragments - pharmacology | Cell Line, Tumor - drug effects | Anesthetics, Inhalation - adverse effects | Recombinant Fusion Proteins - metabolism | Neuroglia - drug effects | Amyloid beta-Peptides - genetics | Ganglioglioma - pathology | Isoflurane - toxicity | Amyloid beta-Peptides - metabolism | Alzheimer Disease - chemically induced | Copper | Anesthetics, Inhalation - toxicity | Anesthetics, Inhalation - pharmacology | Aspartic Acid Endopeptidases - drug effects | Chelating Agents - pharmacology | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Clioquinol - pharmacology | Zinc | Amyloid Precursor Protein Secretases - metabolism | Amyloid Precursor Protein Secretases - drug effects | Aspartic Acid Endopeptidases - metabolism | Cysteine Proteinase Inhibitors - pharmacology | Neuroglia - metabolism | Amyloid beta-Peptides - chemistry | Oligopeptides - pharmacology | Index Medicus | apoptosis | isoflurane | anesthesia
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6. Full Text Small-molecule aggregates inhibit amyloid polymerization
by Toyama, Brandon H and Prusiner, Stanley B and Collins, Sean R and Wille, Holger and Shoichet, Brian K and Colby, David W and Feng, Brian Y and Weissman, Jonathan and May, Barnaby C H
Nature chemical biology, ISSN 1552-4450, 03/2008, Volume 4, Issue 3, pp. 197 - 199
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Molecular Weight | Detergents - chemistry | Microscopy, Electron, Transmission - methods | Phthalimides - chemistry | Structure-Activity Relationship | Benzopyrans - chemistry | Saccharomyces cerevisiae - metabolism | Clioquinol - chemistry | Phthalimides - pharmacology | Flavanones - chemistry | Sensitivity and Specificity | Acetophenones - pharmacology | Molecular Structure | Prions - pharmacokinetics | beta-Lactamase Inhibitors | Benzopyrans - pharmacology | Saccharomyces cerevisiae Proteins - pharmacokinetics | Recombinant Proteins - metabolism | Prions - metabolism | Recombinant Proteins - antagonists & inhibitors | Phenolphthaleins - chemistry | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Congo Red - pharmacology | Flavanones - pharmacology | Recombinant Proteins - chemistry | Prions - chemistry | Clioquinol - pharmacology | Prions - antagonists & inhibitors | Saccharomyces cerevisiae - chemistry | Particle Size | Phenolphthaleins - pharmacology | beta-Lactamases - chemistry | Animals | Acetophenones - chemistry | Peptide Termination Factors | Mice | Congo Red - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Biochemistry | Inhibitor drugs | Molecular biology | Prions | Index Medicus
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7. Full Text Forging New Antibiotic Combinations under Iron-Limiting Conditions
by Chan, Derek C K and Guo, Irene and Burrows, Lori L
Antimicrobial agents and chemotherapy, 02/2020, Volume 64, Issue 3
Microbial Sensitivity Tests | Gallium - pharmacology | Iron - deficiency | Doxycycline - pharmacology | Anti-Bacterial Agents - pharmacology | Ciclopirox - pharmacology | Pseudomonas aeruginosa - drug effects | Tropolone - pharmacology | Acinetobacter baumannii - drug effects | Clioquinol - pharmacology | Iron - metabolism
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8. Full Text Novel Proteasome Inhibitors to Overcome Bortezomib Resistance
by Ruschak, Amy M and Slassi, Malik and Kay, Lewis E and Schimmer, Aaron D
JNCI : Journal of the National Cancer Institute, ISSN 0027-8874, 2011, Volume 103, Issue 13, pp. 1007 - 1017
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Tumors | Neoplasms - metabolism | Apoptosis - drug effects | Humans | Antineoplastic Agents - therapeutic use | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | Lactones - pharmacology | Chloroquine - pharmacology | Protease Inhibitors - pharmacology | Ubiquitination - drug effects | Antineoplastic Agents - pharmacology | Protease Inhibitors - therapeutic use | Ubiquitinated Proteins - metabolism | Hydroxyquinolines - pharmacology | Bortezomib | Allosteric Site - drug effects | Proteasome Endopeptidase Complex - chemistry | Clioquinol - pharmacology | Neoplasms - drug therapy | Threonine - analogs & derivatives | Pyrroles - pharmacology | Animals | Threonine - pharmacology | Cell Line, Tumor | Proteasome Endopeptidase Complex - metabolism | Oligopeptides - pharmacology | Proteasome Inhibitors | Pyrazines - pharmacology | Boronic Acids - pharmacology | Drug Resistance, Neoplasm - drug effects | Research | Drug therapy | Drug resistance | Health aspects | Multiple myeloma | Proteins | Inhibitor drugs | FDA approval | Clinical outcomes | Index Medicus
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9. Full Text Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity
by Mitrovi, Ana and Kljun, Jakob and Sosi, Izidor and Gobec, Stanislav and Turel, Iztok and Kos, Janko
Dalton transactions : an international journal of inorganic chemistry, ISSN 1477-9226, 10/2016, Volume 45, Issue 42, pp. 16913 - 16921
Physical Sciences | Chemistry, Inorganic & Nuclear | Chemistry | Science & Technology | Neoplasms - metabolism | Clioquinol - analogs & derivatives | Humans | Neoplasm Invasiveness - prevention & control | Enzyme Inhibitors - pharmacology | Cathepsin B - antagonists & inhibitors | Cathepsin B - metabolism | Antineoplastic Agents - chemistry | Clioquinol - pharmacology | Ruthenium - chemistry | Ruthenium - pharmacology | Neoplasms - drug therapy | Monoterpenes - pharmacology | Neoplasm Invasiveness - pathology | Enzyme Inhibitors - chemistry | Cell Line, Tumor | Monoterpenes - chemistry | Organometallic Compounds - chemistry | Antineoplastic Agents - pharmacology | Neoplasms - pathology | Organometallic Compounds - pharmacology | Index Medicus | Peptidases | Cysteine | Ruthenium | Cathepsin B | Real time | Spheroids | Tumors | Anticancer properties
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10. Full Text Inhibition of aminoglycoside 6′-N-acetyltransferase type Ib-mediated amikacin resistance by zinc complexed with clioquinol, an ionophore active against tumors and neurodegenerative diseases
by Chiem, Kevin and Hue, Fong and Magallon, Jesus and Tolmasky, Marcelo E
International journal of antimicrobial agents, ISSN 0924-8579, 02/2018, Volume 51, Issue 2, pp. 271 - 273
Pharmacology & Pharmacy | Infectious Diseases | Life Sciences & Biomedicine | Microbiology | Science & Technology | Acetyltransferases - metabolism | Amikacin - pharmacology | Neurodegenerative Diseases - drug therapy | Zinc - chemistry | Clioquinol - pharmacology | Ionophores | Microbial Sensitivity Tests | Clioquinol - chemistry | Acetyltransferases - antagonists & inhibitors | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Zinc - pharmacology | Acinetobacter baumannii - drug effects | Drug Resistance, Bacterial - genetics | Index Medicus
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11. Full Text Insights into Zn2+ homeostasis in neurons from experimental and modeling studies
by Robert A. Colvin and Ashley I. Bush and Irene Volitakis and Charles P. Fontaine and Dustin Thomas and Kazuya Kikuchi and William R. Holmes
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 03/2008, Volume 294, Issue 3, pp. 726 - 742
Zinc buffering | Metal ion transport and homeostasis | Computational model | Muffler | Metallothionein | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Metallothionein - metabolism | Zinc - metabolism | Homeostasis | Cerebral Cortex - cytology | Cerebral Cortex - metabolism | Computer Simulation | Edetic Acid - pharmacology | Neurons - metabolism | Cerebral Cortex - drug effects | Neurons - drug effects | Reproducibility of Results | Cells, Cultured | Rats | Spectrometry, Fluorescence | Chelating Agents - pharmacology | Clioquinol - pharmacology | Rats, Sprague-Dawley | Ethylenediamines - pharmacology | Animals | Cerebral Cortex - embryology | Protein Binding | Pyridines - pharmacology | Kinetics | Models, Neurological | Thiones - pharmacology | Mass Spectrometry - methods | Index Medicus
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