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Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2007, Volume 27, Issue 6, pp. 1247 - 1254
The anesthetic isoflurane has been reported to induce apoptosis and increase A beta generation and aggregation. However, the molecular mechanism underlying... 
APP | Anesthesia | Alzheimer's disease | Isoflurane | Apoptosis | PRESENILIN | GAMMA | ALZHEIMERS-DISEASE | INVOLVEMENT | apoptosis | NEURONAL CELL-DEATH | CLEAVAGE | NEUROSCIENCES | PEPTIDE | anesthesia | A beta | CALCIUM | PRECURSOR PROTEIN | isoflurane | CEREBRAL-ISCHEMIA | Neuroglia - ultrastructure | Isoflurane - pharmacology | Apoptosis - drug effects | Amyloid beta-Peptides - pharmacology | Humans | Caspase 3 - metabolism | Isoflurane - adverse effects | Peptide Fragments - pharmacology | Cell Line, Tumor - drug effects | Anesthetics, Inhalation - adverse effects | Recombinant Fusion Proteins - metabolism | Neuroglia - drug effects | Amyloid beta-Peptides - genetics | Ganglioglioma - pathology | Isoflurane - toxicity | Amyloid beta-Peptides - metabolism | Alzheimer Disease - chemically induced | Copper | Anesthetics, Inhalation - toxicity | Anesthetics, Inhalation - pharmacology | Aspartic Acid Endopeptidases - drug effects | Chelating Agents - pharmacology | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Clioquinol - pharmacology | Zinc | Amyloid Precursor Protein Secretases - metabolism | Amyloid Precursor Protein Secretases - drug effects | Aspartic Acid Endopeptidases - metabolism | Cysteine Proteinase Inhibitors - pharmacology | Neuroglia - metabolism | Amyloid beta-Peptides - chemistry | Oligopeptides - pharmacology | Index Medicus
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 03/2008, Volume 4, Issue 3, pp. 197 - 199
Many amyloid inhibitors resemble molecules that form chemical aggregates, which are known to inhibit many proteins. Eight known chemical aggregators inhibited... 
FIBRIL FORMATION | YEAST | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | PROMISCUOUS INHIBITORS | NEUROTOXICITY | Molecular Weight | Detergents - chemistry | Microscopy, Electron, Transmission - methods | Phthalimides - chemistry | Structure-Activity Relationship | Benzopyrans - chemistry | Saccharomyces cerevisiae - metabolism | Clioquinol - chemistry | Phthalimides - pharmacology | Flavanones - chemistry | Sensitivity and Specificity | Acetophenones - pharmacology | Molecular Structure | Prions - pharmacokinetics | beta-Lactamase Inhibitors | Benzopyrans - pharmacology | Saccharomyces cerevisiae Proteins - pharmacokinetics | Recombinant Proteins - metabolism | Prions - metabolism | Recombinant Proteins - antagonists & inhibitors | Phenolphthaleins - chemistry | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Congo Red - pharmacology | Flavanones - pharmacology | Recombinant Proteins - chemistry | Prions - chemistry | Clioquinol - pharmacology | Prions - antagonists & inhibitors | Saccharomyces cerevisiae - chemistry | Particle Size | Phenolphthaleins - pharmacology | beta-Lactamases - chemistry | Animals | Acetophenones - chemistry | Peptide Termination Factors | Mice | Congo Red - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Biochemistry | Inhibitor drugs | Molecular biology | Prions | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 06/2014, Volume 4, Issue 1, pp. 5240 - 5240
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, pp. e0153416 - e0153416
The development of copper-drug complexes (CDCs) is hindered due to their very poor aqueous solubility. Diethyldithiocarbamate (DDC) is the primary metabolite... 
DISULFIRAM | LARGE UNILAMELLAR VESICLES | BREAST-CANCER CELLS | INHIBITION | REACTIVATES LATENT HIV-1 | ANTICANCER AGENTS | MULTIDISCIPLINARY SCIENCES | PH GRADIENTS | RNA-POLYMERASE I | SODIUM DIETHYLDITHIOCARBAMATE | LIPOSOMAL SYSTEMS | Antioxidants - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Ditiocarb - metabolism | Clioquinol - chemistry | Copper - chemistry | Copper - metabolism | Female | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Cell Survival - drug effects | Naphthyridines - chemistry | Quercetin - chemistry | Benzothiazoles - pharmacology | Antioxidants - pharmacology | Clioquinol - pharmacology | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Ditiocarb - chemistry | Animals | Quercetin - pharmacology | Benzothiazoles - chemistry | Mice | Liposomes | Neoplasms - pathology | Nanotechnology | Naphthyridines - pharmacology | Drugs | Complications and side effects | Drug delivery systems | Alcoholism | Disulfiram | Dosage and administration | Research | Drug therapy | Vehicles | Drug abuse | Medical research | Laboratories | Research & development--R&D | Clioquinol | Cytotoxicity | Drug development | Anticancer properties | Antitumor agents | Quercetin | Antitumor activity | Copper | Alzheimers disease | Coordination compounds | Chemical synthesis | Pharmaceutical sciences | Cancer | Index Medicus | Naturvetenskap | Natural Sciences | Kemi | Annan kemi | Chemical Sciences | Other Chemistry Topics | Research & development | R&D
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 47, pp. 34181 - 34189
Journal Article
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 4/2018, Volume 35, Issue 4, pp. 1 - 12
Journal Article