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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 03/2017, Volume 61, Issue 3
The efficacy of antimicrobial drugs against Mycobacterium tuberculosis, an intracellular bacterial pathogen, is generally first established by testing... 
Lysosomal trapping | Tuberculosis | Mycobacterium tuberculosis | Ion trapping | Mycobacteria | Antimicrobial agents | Acidic compartment accumulating | Pharmacokinetics | Accumulation | ACQUIRED-IMMUNODEFICIENCY-SYNDROME | ion trapping | PHAGOSOME MATURATION | accumulation | tuberculosis | PSYCHOTROPIC-DRUGS | MICROBIOLOGY | PERITONEAL-MACROPHAGES | CLOFAZIMINE CRYSTALS | mycobacteria | DRUG-RESISTANT TUBERCULOSIS | acidic compartment accumulating | SEROTONIN REUPTAKE INHIBITORS | antimicrobial agents | lysosomal trapping | CULTURED MACROPHAGES | pharmacokinetics | ALVEOLAR MACROPHAGES | WEAK BASES | PHARMACOLOGY & PHARMACY | Protons | Humans | Mycobacterium tuberculosis - drug effects | Anesthetics, Local - pharmacology | Microbial Sensitivity Tests | Ammonium Chloride - pharmacology | Hydrogen-Ion Concentration - drug effects | Macrolides - pharmacology | Biological Transport - drug effects | Anesthetics, Local - metabolism | Macrophages - microbiology | Sertraline - metabolism | Serotonin Uptake Inhibitors - metabolism | Fluoxetine - pharmacology | Sertraline - pharmacology | Clofazimine - metabolism | Dibucaine - metabolism | Macrophages - metabolism | Dibucaine - pharmacology | Antitubercular Agents - pharmacokinetics | Clofazimine - pharmacokinetics | Fluoxetine - metabolism | Macrophages - drug effects | Antitubercular Agents - metabolism | Serotonin Uptake Inhibitors - pharmacology | Mycobacterium tuberculosis - growth & development
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 09/2016, Volume 73, Issue 17, pp. 3401 - 3417
Mycobacterium tuberculosis codes for a HAD-phosphatase, Rv3042c (MtSerB2), that has earlier been characterized as a metabolic enzyme. Here we demonstrate that... 
MAPK p38 | Clofazimine | Mycobacterium tuberculosis | Phosphoserine phosphatase | Actin dynamics | Secretory protein | Drug target | Riminophenazine | Immune evasion | MYCOBACTERIUM-TUBERCULOSIS | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | TYROSINE-PHOSPHATASE | COFILIN | CELL BIOLOGY | BACTERIAL PATHOGENS | PORPHYROMONAS-GINGIVALIS SERB | NF-KAPPA-B | CELL | Humans | Actins - metabolism | Bacterial Proteins - chemistry | Tuberculosis - microbiology | Recombinant Proteins - biosynthesis | Mycobacterium tuberculosis - drug effects | Tuberculosis - diagnosis | Recombinant Proteins - isolation & purification | Actin Cytoskeleton - drug effects | Protein Structure, Quaternary | Bronchoalveolar Lavage Fluid - cytology | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-8 - metabolism | Binding Sites | Dimerization | Mycobacterium tuberculosis - metabolism | Macrophages - microbiology | Cell Line | Phosphoric Monoester Hydrolases - genetics | Heat-Shock Proteins - metabolism | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Macrophages - cytology | Down-Regulation - drug effects | Tuberculosis - immunology | Macrophages - metabolism | Transcription Factor RelA - metabolism | Bacterial Proteins - metabolism | Molecular Docking Simulation | Bronchoalveolar Lavage Fluid - chemistry | Phosphoric Monoester Hydrolases - metabolism | Heat-Shock Proteins - chemistry | Phosphoric Monoester Hydrolases - chemistry | Enzymes | Tuberculosis | Phosphatases | Interleukins | Actin | Heat shock proteins | Research institutes | Pharmaceutical industry | Muscle proteins | Inflammation | Phosphatase | Immune system
Journal Article
Scientific Reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, p. 10333
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2008, Volume 3, Issue 12, pp. e4009 - e4009
The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including... 
MULTIDISCIPLINARY SCIENCES | Skin Transplantation - immunology | Humans | Clofazimine - pharmacology | Kv1.3 Potassium Channel - genetics | Transfection | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Calcium Signaling - immunology | Kv1.3 Potassium Channel - metabolism | Drug Evaluation, Preclinical | Interleukin-2 - metabolism | Jurkat Cells | NFATC Transcription Factors - metabolism | Cells, Cultured | Clofazimine - metabolism | Anti-Bacterial Agents - metabolism | Kv1.3 Potassium Channel - antagonists & inhibitors | Animals | Calcium Signaling - drug effects | Models, Biological | Protein Binding | Anti-Bacterial Agents - pharmacology | Mice | Immunologic Factors - metabolism | Immunologic Factors - pharmacology | Protein Multimerization - drug effects | Calcium channels | Multiple sclerosis | Clofazimine | Interleukins | Type 1 diabetes | Genetic transcription | T cells | Animal models | Biomedical research | Calcium | Calcineurin | Interleukin | Effector cells | Clinical trials | Intracellular signalling | Lymphocytes T | Arthritis | Diabetes mellitus (insulin dependent) | Biochemistry | NF-AT protein | Phosphatase | Dermatitis | T-cell receptor | Signal transduction | Cell activation | Interleukin 2 | Lymphocytes | Human immunodeficiency virus--HIV | Gastroenterology | Potassium channels (voltage-gated) | Libraries | Skin grafts | Drug therapy | Lupus | Immunological memory | Memory cells | Psoriasis | Cytokines | Channel gating | Immunomodulation | Diabetes mellitus | T cell receptors | Pharmacology | Crohns disease | Graft rejection | Medicine | Inflammatory bowel disease | Inhibitors | Antibiotics | Skin | Autoimmune diseases | Molecular biology | Potassium | Human immunodeficiency virus | HIV
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2016, Volume 60, Issue 11, pp. 6460 - 6470
Mycobacterium tuberculosis remains a global health threat largely due to the lengthy duration of curative antibiotic treatment, contributing to medical... 
INORGANIC POLYPHOSPHATE | STOCHASTIC INDUCTION | PERSISTER CELLS | PSEUDOMONAS-AERUGINOSA | GROWTH | POLYPHOSPHATE KINASE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INFECTION | DRUG-RESISTANCE | ANTIBIOTIC TOLERANCE | EXPRESSION | Tuberculosis, Multidrug-Resistant - immunology | Isoniazid - pharmacology | Phosphotransferases (Phosphate Group Acceptor) - genetics | Biofilms - growth & development | Glycerophosphates - metabolism | Clofazimine - pharmacology | Mycobacterium tuberculosis - drug effects | Vaccines, DNA - administration & dosage | Phosphotransferases (Phosphate Group Acceptor) - deficiency | Tuberculosis, Multidrug-Resistant - microbiology | Tuberculosis, Multidrug-Resistant - prevention & control | Acid Anhydride Hydrolases - genetics | Xylose - analogs & derivatives | Drug Resistance, Bacterial - genetics | Disease Models, Animal | Acid Anhydride Hydrolases - deficiency | Biofilms - drug effects | Gene Expression | Xylose - metabolism | Isoenzymes - genetics | Tuberculosis Vaccines - administration & dosage | Antitubercular Agents - pharmacology | Naphthoquinones - pharmacology | Isoenzymes - deficiency | Thienamycins - pharmacology | Polyphosphates - metabolism | Citric Acid Cycle - genetics | Animals | Mycobacterium tuberculosis - enzymology | Mice | Mycobacterium tuberculosis - genetics | Mycobacterium tuberculosis - growth & development | Tuberculosis, Multidrug-Resistant - drug therapy
Journal Article
Journal Article