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Journal of Experimental Medicine, ISSN 0022-1007, 02/2013, Volume 210, Issue 2, pp. 269 - 285
Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus weak T cell receptor binding by self-peptide-MHC complexes. We find... 
DEVELOPING THYMOCYTES | MEDICINE, RESEARCH & EXPERIMENTAL | TISSUE-RESTRICTED ANTIGENS | SELF-PEPTIDE | RECEPTOR TRANSGENIC MICE | IN-VIVO | BIM | NEGATIVE SELECTION | C-MYC | CLONAL DELETION | IMMUNOLOGY | EXPRESSION | Autoimmunity | Cell Proliferation | NF-kappa B - immunology | Proto-Oncogene Proteins c-rel - metabolism | Proto-Oncogene Proteins - biosynthesis | Proto-Oncogene Proteins c-rel - immunology | CARD Signaling Adaptor Proteins - genetics | CD4-Positive T-Lymphocytes - immunology | Membrane Proteins - deficiency | CARD Signaling Adaptor Proteins - metabolism | Bcl-2-Like Protein 11 | Receptors, CCR7 - metabolism | Apoptosis Regulatory Proteins - deficiency | Programmed Cell Death 1 Receptor - biosynthesis | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Transcription Factors - immunology | Apoptosis Regulatory Proteins - biosynthesis | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Lymphocyte Activation | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Self Tolerance | Membrane Proteins - immunology | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Transcription Factors - biosynthesis | Proto-Oncogene Proteins - deficiency | Clonal Deletion - immunology | Mice, Knockout | Membrane Proteins - biosynthesis | Animals | Apoptosis - immunology | Proto-Oncogene Proteins c-rel - genetics | NF-kappa B - biosynthesis | Mice | Mutation | Programmed Cell Death 1 Receptor - immunology | DNA-Binding Proteins - biosynthesis | 309
Journal Article
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2015, Volume 194, Issue 6, pp. 2643 - 2653
Negative selection, primarily mediated through clonal deletion of self-reactive thymocytes, is critical for establishing self-tolerance and preventing... 
CYTOCHROME-C | APOPTOSIS | BCL-2 | ORPHAN STEROID-RECEPTOR | POSITIVE SELECTION | SELECTION IN-VIVO | NEGATIVE SELECTION | AUTOREACTIVE THYMOCYTES | CENTRAL TOLERANCE | IMMUNOLOGY | T-CELL DEVELOPMENT | Antigens, CD - immunology | Clonal Deletion - genetics | Proto-Oncogene Proteins c-bcl-2 - immunology | Thymocytes - metabolism | Caspase 3 - metabolism | Lectins, C-Type - immunology | Caspase 3 - immunology | Apoptosis - genetics | Male | Nuclear Receptor Subfamily 4, Group A, Member 1 - immunology | Enzyme Activation - immunology | Antigens, CD - metabolism | Lectins, C-Type - metabolism | Membrane Proteins - deficiency | Proto-Oncogene Proteins c-bcl-2 - metabolism | Signal Transduction - immunology | Flow Cytometry | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Female | Receptors, Antigen, T-Cell - immunology | Apoptosis Regulatory Proteins - immunology | Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics | Antigens, Differentiation, T-Lymphocyte - immunology | Receptors, Antigen, T-Cell - metabolism | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Antigens, Differentiation, T-Lymphocyte - metabolism | Membrane Proteins - immunology | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Proto-Oncogene Proteins - deficiency | Clonal Deletion - immunology | Mice, Knockout | Nuclear Receptor Subfamily 4, Group A, Member 1 - deficiency | Thymocytes - immunology | Animals | Apoptosis - immunology | Autoantigens - immunology | Thymocytes - cytology | Receptors, Antigen, T-Cell - genetics
Journal Article