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The Journal of pathology, ISSN 1096-9896, 2019, Volume 248, Issue 4, pp. 396 - 408
.... Mutations in KIAA0856 have been recently identified in JS patients. Herein, we describe a novel mouse JS model with a conditional deletion of the conserved exons 11... 
sonic hedgehog | ataxia | KIAA0586 | Joubert syndrome | primary cilia | cerebellum | ENCODES | PATHOLOGY | CENTROSOMAL PROTEIN | GENE | ONCOLOGY | EXPANSION | CEREBELLAR DEVELOPMENT | CILIOPATHY | MUTATIONS | CEP290 | REVEALS | Abnormalities, Multiple - metabolism | Abnormalities, Multiple - pathology | Mice, Knockout - genetics | Sequence Deletion | Retina - metabolism | Exons | Cerebellum - abnormalities | Cell Cycle Proteins - genetics | Kidney Diseases, Cystic - genetics | Eye Abnormalities - metabolism | Abnormalities, Multiple - genetics | Disease Models, Animal | Cerebellum - metabolism | Cell Cycle Proteins - deficiency | Genetic Markers | Eye Abnormalities - genetics | Cerebellum - pathology | Kidney Diseases, Cystic - pathology | Kidney Diseases, Cystic - metabolism | Phenotype | Animals | Eye Abnormalities - pathology | Retina - abnormalities | Mice | Retina - pathology | Cerebellum | Brain | Animal models | Leukocyte migration | Congenital defects | Disorientation | Central nervous system | Neurodevelopmental disorders | Defects | Cell adhesion & migration | Genotype & phenotype | Signal transduction | Hemispheres | Clonal deletion | Clusters | Ataxia | Cilia | Phenotypes | Neurons | Granule cells | Molecular modelling | Hedgehog protein | Granular materials | Mutation | Cell migration | Synapses | Original Papers | Original Paper
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2013, Volume 210, Issue 2, pp. 269 - 285
Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus weak T cell receptor binding by self-peptide–MHC complexes. We find... 
DEVELOPING THYMOCYTES | MEDICINE, RESEARCH & EXPERIMENTAL | TISSUE-RESTRICTED ANTIGENS | SELF-PEPTIDE | RECEPTOR TRANSGENIC MICE | IN-VIVO | BIM | NEGATIVE SELECTION | C-MYC | CLONAL DELETION | IMMUNOLOGY | EXPRESSION | Autoimmunity | Cell Proliferation | NF-kappa B - immunology | Proto-Oncogene Proteins c-rel - metabolism | Proto-Oncogene Proteins - biosynthesis | Proto-Oncogene Proteins c-rel - immunology | CARD Signaling Adaptor Proteins - genetics | CD4-Positive T-Lymphocytes - immunology | Membrane Proteins - deficiency | CARD Signaling Adaptor Proteins - metabolism | Bcl-2-Like Protein 11 | Receptors, CCR7 - metabolism | Apoptosis Regulatory Proteins - deficiency | Programmed Cell Death 1 Receptor - biosynthesis | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Transcription Factors - immunology | Apoptosis Regulatory Proteins - biosynthesis | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Lymphocyte Activation | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Self Tolerance | Membrane Proteins - immunology | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Transcription Factors - biosynthesis | Proto-Oncogene Proteins - deficiency | Clonal Deletion - immunology | Mice, Knockout | Membrane Proteins - biosynthesis | Animals | Apoptosis - immunology | Proto-Oncogene Proteins c-rel - genetics | NF-kappa B - biosynthesis | Mice | Mutation | Programmed Cell Death 1 Receptor - immunology | DNA-Binding Proteins - biosynthesis | 309
Journal Article
Journal of cellular and molecular medicine, ISSN 1582-1838, 2017, Volume 21, Issue 12, pp. 3821 - 3835
Connective tissue growth factor (CTGF) is involved in inflammation, pathogenesis and progression of liver fibrosis. Matrix metalloproteinase‐13 (MMP‐13)... 
connective tissue growth factor | MMP‐13 | hepatic fibrosis | N‐nitrosodimethylamine | NDMA | MMP-13 | N-nitrosodimethylamine | MEDICINE, RESEARCH & EXPERIMENTAL | FACTOR CTGF/CCN2 | INDUCED HEPATIC-FIBROSIS | TGF-BETA | FIBROTIC LIVER | HYALURONIC-ACID | CELL BIOLOGY | MATRIX METALLOPROTEINASES | TISSUE GROWTH-FACTOR | EXPERIMENTAL RAT | EXTRACELLULAR-MATRIX | EXPRESSION | Liver - pathology | Actins - metabolism | Hepatic Stellate Cells - metabolism | Male | Alanine Transaminase - blood | Hepatic Stellate Cells - cytology | Liver Cirrhosis - chemically induced | Actins - genetics | Matrix Metalloproteinase 13 - deficiency | Collagen Type I - genetics | Proteolysis | Dimethylnitrosamine | Liver Cirrhosis - metabolism | Female | Hyaluronic Acid - blood | Chemical and Drug Induced Liver Injury - pathology | Transforming Growth Factor beta1 - blood | Liver Cirrhosis - genetics | Hepatic Stellate Cells - drug effects | Chemical and Drug Induced Liver Injury - prevention & control | Collagen Type I - metabolism | Liver Cirrhosis - prevention & control | Signal Transduction | Liver - metabolism | Matrix Metalloproteinase 13 - genetics | Gene Expression Regulation | Injections, Intraperitoneal | Chemical and Drug Induced Liver Injury - genetics | Mice, Knockout | Animals | Aspartate Aminotransferases - blood | Chemical and Drug Induced Liver Injury - metabolism | Connective Tissue Growth Factor - genetics | Mice | Primary Cell Culture | Connective Tissue Growth Factor - metabolism | Liver diseases | Transforming growth factors | Liver | Fibrosis | Stellate cells | Collagen (type I) | Pathogenesis | Downstream effects | Body weight | Fragments | Connective tissue growth factor | mRNA | Matrix metalloproteinase | N-Nitrosodimethylamine | Collagenase 3 | Gelatinase B | Gelatinase A | Fibers | Connective tissues | Clonal deletion | Rodents | Collagen | Metalloproteinase | Hyaluronic acid | Original
Journal Article
Cancer Research, ISSN 0008-5472, 08/2017, Volume 77, Issue 15, pp. 4014 - 4025
... occurring with increased incidence in carcinogen-treated subjects. Igfbp7 deletion increased proliferation and decreased senescence of hepatocytes and mouse embryonic fibroblasts, effects that were blocked by treatment with IGF1 receptor inhibitor... 
CELLS | ONCOLOGY | GROWTH-FACTORS | LIVER | COMPENSATORY PROLIFERATION | ANTITUMOR IMMUNITY | NF-KAPPA-B | CANCER | POTENTIAL TUMOR-SUPPRESSOR | PROGRESSION | HEPATOCARCINOGENESIS | Immunohistochemistry | Insulin-Like Growth Factor Binding Proteins - genetics | Insulin-Like Growth Factor Binding Proteins - immunology | Liver Neoplasms - genetics | Mice, Inbred C57BL | Liver Neoplasms - immunology | Mice, SCID | Blotting, Western | Mice, Knockout | Animals | Flow Cytometry | Carcinoma, Hepatocellular - genetics | Carcinoma, Hepatocellular - pathology | Fluorescent Antibody Technique | Liver Neoplasms - pathology | Carcinoma, Hepatocellular - immunology | Mice | Real-Time Polymerase Chain Reaction | Insulin-Like Growth Factor Binding Proteins - deficiency | Disease Models, Animal | Senescence | Insulin-like growth factor I | CD8 antigen | Liver | Hepatocellular carcinoma | Lymphocytes T | Insulin-like growth factors | Gene deletion | Liver cancer | Angiogenesis | Carcinogens | Clonal deletion | Lymphocytes | Rodents | Fibroblasts | Inhibition | Immune system | Binding | Antigen presentation | Immune response | Dendritic cells | Immunosurveillance | Inflammation | Embryo fibroblasts | Insulin | Embryos | CD4 antigen | Signaling | Immunosuppression | Hepatocytes | Lungs | Tumor suppressor genes | Antitumor activity | Microenvironments | Tumors | Apoptosis | Cancer | IGF signaling | tumor suppression | antigen presentation | mouse model | inflammation
Journal Article
The lancet oncology, ISSN 1470-2045, 2017, Volume 18, Issue 8, pp. 1009 - 1021
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2011, Volume 365, Issue 16, pp. 1502 - 1508
Journal Article
Scientific reports, ISSN 2045-2322, 2020, Volume 10, Issue 1, pp. 424 - 13
.... We investigated the effect of HDAC10 in murine Tregs. HDAC10 deletion had no adverse effect on the health of mice, which retained normal CD4 and CD8 T cell function... 
Histone deacetylase | Transcription factors | Transplants & implants | Syngeneic grafts | CD8 antigen | Heart transplantation | Lymphocytes T | CD4 antigen | Inflammatory bowel disease | Major histocompatibility complex | Clonal deletion | Lysine | Immunotherapy | RAG1 protein | Post-translation | Foxp3 protein | Acetylation | Colitis
Journal Article