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Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 299 - 305
For most types of cancers, the cell at the origin of tumour initiation is still unknown. Here, we used mouse genetics to identify cells at the origin of basal... 
POPULATION | STEM-CELLS | SONIC HEDGEHOG | EPIDERMIS | HAIR FOLLICLE BULGE | KERATINOCYTES | CANCER | EXPRESSION | HUMAN HOMOLOG | MOUSE SKIN | CELL BIOLOGY | Epithelial Cells - metabolism | Cadherins - metabolism | Receptors, G-Protein-Coupled - metabolism | Skin - metabolism | Cell Count | Ear, External - pathology | Integrin beta4 - metabolism | Tail - pathology | Hair Follicle - pathology | Hedgehog Proteins - genetics | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Neoplastic Stem Cells - pathology | Cell Differentiation | Patched Receptors | Skin - pathology | Keratin-10 - metabolism | Epidermis - metabolism | Epidermis - pathology | RNA, Untranslated | Bacterial Proteins - genetics | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Genes, Reporter - genetics | Mice, Transgenic | Carcinoma, Basal Cell - pathology | Mice, Inbred Strains | Clone Cells - metabolism | Keratin-14 - genetics | Carcinoma, Basal Cell - metabolism | Keratin-15 - metabolism | Keratin-19 - genetics | Proteins - genetics | Cell Lineage | Animals | Clone Cells - pathology | Proteins - metabolism | Models, Biological | Hair Follicle - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Integrases - genetics | Keratin-15 - genetics | Luminescent Proteins - metabolism | Basal cell carcinoma | Stem cells | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 16062 - 16067
Gliomas contain a small number of treatment-resistant glioma stem cells (GSCs), and it is thought that tumor regrowth originates from GSCs, thus rendering GSCs... 
Lactates | Cellular metabolism | Glioma | Stem cells | Cell lines | Glycolysis | Progenitor cells | Cellular differentiation | Tumors | Cancer | INITIATING CELLS | PYRUVATE-KINASE | PATHWAY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | ISOFORM | IDENTIFICATION | TUMOR-GROWTH | CANCER | RADIATION | GLIOBLASTOMA PATIENTS | Immunohistochemistry | Reactive Oxygen Species - metabolism | Uncoupling Agents - pharmacology | Neoplastic Stem Cells - drug effects | Tissue Array Analysis | Humans | Stem Cells - metabolism | Glycolysis - drug effects | Glioma - metabolism | Oligomycins - pharmacology | Neoplastic Stem Cells - metabolism | Adenosine Triphosphate - metabolism | Deoxyglucose - pharmacology | Glioma - pathology | Oxygen Consumption | Positron-Emission Tomography - methods | Clone Cells - metabolism | Blotting, Western | Lactates - metabolism | Energy Metabolism | Glucose - pharmacokinetics | Cell Line, Tumor | Glucose - metabolism | Stem Cells - drug effects | Proteasome Endopeptidase Complex - metabolism | Physiological aspects | Cell metabolism | Research | Diagnosis | Gliomas | Glucose | Metabolism | Pyruvate kinase | Brain tumors | Acidification | Oxygen consumption | imaging | Emissions | Glucose metabolism | Progeny | Mitochondria | Oxidative phosphorylation | Glioma cells | Cell cycle | Metabolic pathways | Lactic acid | ATP | Positron emission tomography | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 494, Issue 7436, pp. 247 - 250
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7570, pp. 538 - 542
Bromodomain and extra terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a newtherapeutic opportunity by directly targeting... 
SELECTIVE-INHIBITION | ACCURATE | CHROMATIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | MUTATIONS | SEQUENCING DATA | CANCER | DISCOVERY | Chromatin - metabolism | Transcription, Genetic - drug effects | Clone Cells - drug effects | Neoplastic Stem Cells - drug effects | Epigenesis, Genetic | Humans | Leukemia, Myeloid, Acute - metabolism | Molecular Targeted Therapy | Neoplastic Stem Cells - metabolism | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Gene Expression Regulation, Neoplastic - drug effects | Hematopoietic Stem Cells - drug effects | Benzodiazepines - pharmacology | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Clone Cells - metabolism | beta Catenin - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Clone Cells - pathology | Wnt Signaling Pathway - drug effects | Genes, myc - genetics | Hematopoietic Stem Cells - cytology | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Proteins | Leukemia | Cloning | Cell cycle | Stem cells | Epigenetics | Apoptosis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7488, pp. 328 - 333
In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly... 
BREAST-CANCER | RELAPSE | ACUTE NONLYMPHOCYTIC LEUKEMIA | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | PANCREATIC-CANCER | DNA METHYLTRANSFERASE | CLONAL EVOLUTION | ACUTE MYELOID-LEUKEMIA | DNMT3A MUTATIONS | MYELODYSPLASTIC SYNDROMES | Clone Cells - cytology | Neoplasm Transplantation | Neoplastic Stem Cells - cytology | Neoplastic Stem Cells - drug effects | Humans | Hematopoietic Stem Cells - pathology | DNA (Cytosine-5-)-Methyltransferases - metabolism | Heterografts | Neoplastic Stem Cells - metabolism | T-Lymphocytes - metabolism | Hematopoiesis | Cell Division | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Female | Cell Differentiation | T-Lymphocytes - pathology | Nuclear Proteins - genetics | Hematopoietic Stem Cells - drug effects | Leukemia, Myeloid, Acute - pathology | Isocitrate Dehydrogenase - genetics | Hematopoietic Stem Cells - metabolism | Mice, SCID | Mutation - genetics | Clone Cells - metabolism | Remission Induction | Cell Lineage | DNA (Cytosine-5-)-Methyltransferases - genetics | Animals | Clone Cells - pathology | Leukemia, Myeloid, Acute - diagnosis | Hematopoietic Stem Cells - cytology | Mice, Inbred NOD | Mice | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Acute leukemia | Genetic aspects | Diagnosis | Identification and classification | Hematopoietic stem cells | Index Medicus
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 7, pp. 708 - 717
The transcription factors Batf3 and IRF8 are required for the development of CD8 alpha(+) conventional dendritic cells (cDCs), but the basis for their actions... 
TRANSCRIPTION FACTORS | REGULATORY FACTOR-4 | STEM-CELLS | SUPER-ENHANCERS | SUBSET DEVELOPMENT | BONE-MARROW | IN-VIVO | DENDRITIC CELL-DEVELOPMENT | IMMUNOLOGY | EXPRESSION | T-CELLS | Stem Cells - immunology | Basic-Leucine Zipper Transcription Factors - metabolism | Oligonucleotide Array Sequence Analysis | CD24 Antigen - metabolism | Dendritic Cells - immunology | Interferon Regulatory Factors - metabolism | Molecular Sequence Data | Basic-Leucine Zipper Transcription Factors - immunology | Transcriptome - immunology | Mice, 129 Strain | Stem Cells - metabolism | Flow Cytometry | Base Sequence | Bone Marrow Cells - immunology | Clone Cells - immunology | Receptors, Immunologic - immunology | Dendritic Cells - metabolism | Repressor Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Interferon Regulatory Factors - genetics | Repressor Proteins - genetics | Mice, Transgenic | Transcriptome - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Clone Cells - metabolism | Sequence Homology, Nucleic Acid | CD8 Antigens - immunology | Mice, Knockout | CD8 Antigens - metabolism | Interferon Regulatory Factors - immunology | Animals | Repressor Proteins - immunology | Protein Binding | CD24 Antigen - immunology | Bone Marrow Cells - metabolism | Receptors, Immunologic - metabolism | Index Medicus
Journal Article