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Nature Biotechnology, ISSN 1087-0156, 01/2015, Volume 33, Issue 1, pp. 102 - 106
Probing gene function in the mammalian brain can be greatly assisted with methods to manipulate the genome of neurons in vivo. The clustered, regularly... 
MECP2 | RETT-SYNDROME | REPRESSION | DUAL-RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TRANSCRIPTION | NEURONS | CAS9 | MODEL | CPG-BINDING PROTEIN-2 | EXPRESSION | Clustered Regularly Interspaced Short Palindromic Repeats - physiology | Streptococcus pyogenes - genetics | Animals | Physiological aspects | Nucleases | Genetic aspects | Research | Genes | Neurophysiology | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7571, pp. 136 - 139
Journal Article
Nature genetics, ISSN 1061-4036, 11/2017, Volume 49, Issue 12, pp. 1674 - 1675
The CRISPR-Cas9 system enables global screens of gene function with high sensitivity and specificity, but off-target effects have been reported for CRISPR... 
RNA, Guide | Genes, Essential | Sensitivity and Specificity | CRISPR-Cas Systems | Clustered Regularly Interspaced Short Palindromic Repeats | DNA Copy Number Variations | Copy number variations | Drug interactions | Genetic research | Genetic engineering | Genetic aspects | Research | Health aspects | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2017, Volume 23, Issue 1, pp. 60 - 68
Forward genetic screens with CRISPR-Cas9 genome editing enable high-resolution detection of genetic vulnerabilities in cancer cells. We conducted genome-wide... 
MEDICINE, RESEARCH & EXPERIMENTAL | RNF43 | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | CANCER | CELL BIOLOGY | ESSENTIAL GENES | INHIBITION | GROWTH | MUTATIONAL LANDSCAPE | WNT | RECEPTORS | Frizzled Receptors - antagonists & inhibitors | Neoplasm Transplantation | Oncogene Proteins - genetics | Pancreatic Neoplasms - metabolism | Colorectal Neoplasms - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Molecular Targeted Therapy | RNA, Messenger - metabolism | Carcinoma, Pancreatic Ductal - genetics | Adenocarcinoma - metabolism | Flow Cytometry | Organoids - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Adenocarcinoma - genetics | Real-Time Polymerase Chain Reaction | Colorectal Neoplasms - metabolism | Frizzled Receptors - metabolism | Pancreatic Neoplasms - genetics | DNA-Binding Proteins - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Antibodies - pharmacology | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Cell Cycle Checkpoints - drug effects | Fluorescent Antibody Technique | Organoids - drug effects | Cell Line, Tumor | Mice | Care and treatment | Pancreatic cancer | Innovations | Development and progression | Genotype | Genetic engineering | Cellular signal transduction | Genetic aspects | Health aspects | Cell proliferation | Adenocarcinoma | Therapy | Wnt protein | Frizzled protein | Xenotransplantation | Colorectal carcinoma | Antibodies | Genomes | Cell surface | Genetic screening | Proteins | Receptors | Organoids | Xenografts | Inhibition | Pancreas | Recombinant | CRISPR | Immunoglobulins | Screens | Signaling | Mutation | Cancer | Tumors | Index Medicus
Journal Article