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Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 4/2018, Volume 200, Issue 8, pp. 3000 - 3007
Co-inhibitory receptors, such as CTLA-4 and PD-1, play a critical role in maintaining immune homeostasis by dampening T cell responses. Recently, they have... 
agonistic antibodies | blocking antibodies | TIGIT | co-stimulation
Journal Article
Circulation Journal, ISSN 1346-9843, 2017, Volume 81, Issue 12, p. 1945
Background:Increased inflammatory activity destabilizes the atherosclerotic lesion and may lead to atherothrombosis and symptomatic cardiovascular disease.... 
4-1BB | Leukocytes | Co-stimulation | Cytokines | Atherosclerosis
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 11/2014, Volume 193, Issue 10, pp. 5056 - 5064
Expression of the co-stimulatory receptor 4-1BB is induced by T cell receptor recognition of antigen, while 4-1BB ligand is highly expressed on activated... 
co-stimulation | vaccine | dendritic cell
Journal Article
11/2011
The Tumor necrosis factor receptor (TNFR) family member 4-1BB and its TNF family ligand, 4-1BBL, are important in modulating multiple stages of the CD8 T cell... 
Co-stimulation | CD8 memory T cells | 0982 | Influenza | 4-1BB | Tumor immunotherapy | CD8 T cells
Dissertation
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 5/2013, Volume 190, Issue 10, pp. 5030 - 5036
The butyrophilin-related protein Btn2a2 was up-regulated on murine antigen presenting cells including CD19+ B cells, CD11b+ F4/80+ peritoneal macrophages, and... 
Co-stimulation | Signal Transduction | Suppression | T cells
Journal Article
Cancer research, ISSN 0008-5472, 12/2017, Volume 77, Issue 24, pp. 7049 - 7058
T cell-based immunotherapies are a promising approach for patients with advanced cancers. However, various obstacles limit T cell efficacy, including... 
lowering TCR threshold | T cell co-stimulation | Cancer immunotherapy | modified CD8 co-receptor | MyD88 signaling
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 03/2008, Volume 180, Issue 5, pp. 2967 - 2980
Objective: Interaction of ICOS with its ligand (ICOSL, B7-H2) promotes T cell responses. As CD4(+)CD25(high)Foxp(3+) naturally occurring T regulatory cells in... 
ACTIVATION | DENDRITIC CELLS | MICROENVIRONMENT | TOLERANCE | CO-STIMULATION | CD28 | PERIPHERAL-BLOOD | COSTIMULATION | INDUCTION | IMMUNOLOGY | AUTOIMMUNE-DISEASE
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2013, Volume 4, pp. 53 - 53
Dendritic cells (DCs) are central in maintaining the intricate balance between immunity and tolerance by orchestrating adaptive immune responses. Being the... 
Tolerance | Activation | T cell priming | Co-stimulation | Dendritic cells | Co-inhibition | dendritic cells | IMMUNOLOGY | activation | co-inhibition | co-stimulation | tolerance | Dendritic Cells
Journal Article
Cancer Research, ISSN 0008-5472, 12/2013, Volume 73, Issue 24, pp. 7189 - 7198
Journal Article
Expert Review of Clinical Immunology, ISSN 1744-666X, 07/2018, Volume 14, Issue 7, pp. 535 - 537
Journal Article
International Immunology, ISSN 0953-8178, 4/2008, Volume 20, Issue 4, pp. 471 - 483
CTLA-4·Ig was originally designed as an immunosuppressive agent capable of interfering with the co-stimulation of T cells. In the present study, we demonstrate... 
Co-stimulation | CTLA-4·Ig | Regulatory T cells
Journal Article
Medicina (Buenos Aires), ISSN 0025-7680, 10/2018, Volume 78, Issue 5, pp. 336 - 348
Recent understanding of the mechanisms that control immune system homeostasis and orchestrate antitumor responses has prompted the development of novel... 
biomarkers | immunotherapy | cancer | chimeric antigen receptors | immunological checkpoints | co-stimulation
Journal Article
by Betts, BC and Yu, XZ
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 07/2019, Volume 10, pp. 1797 - 1797
Journal Article
Molecular Immunology, ISSN 0161-5890, 02/2015, Volume 63, Issue 2, pp. 406 - 411
Memory T cells resist co-stimulatory blockade and present a unique therapeutic challenge in transplantation and autoimmune diseases. Herein, we determined... 
Memory T cells | Tolerogenic | Co-stimulation | Gene expression
Journal Article
AMERICAN JOURNAL OF TRANSPLANTATION, ISSN 1600-6135, 03/2005, Volume 5, Issue 3, pp. 443 - 453
Current success in organ transplantation is dependent upon the use of calcineurin-inhibitor-based immunosuppressive regimens. Unfortunately, current... 
SURGERY | INHIBITS TH1 | SPARES TH2 | CTLA4-lg | co-stimulation | RENAL-ALLOGRAFT REJECTION | non-human primate | COSTIMULATORY PATHWAYS | transplantation | T-CELL-ACTIVATION | IN-VIVO | CD28 | CENTRAL-NERVOUS-SYSTEM | CTLA-4 | AUTOIMMUNE-DISEASE
Journal Article
FRONTIERS IN ONCOLOGY, ISSN 2234-943X, 02/2015, Volume 5
Recent studies have highlighted the therapeutic efficacy of immunotherapy, a class of cancer treatments that utilize the patient's own immune system to destroy... 
OX40 | PD-1 BLOCKADE | EFFECTOR FUNCTION | REGULATORY T | CANCER-IMMUNOTHERAPY | co-stimulation | IMMUNOSTIMULATORY MONOCLONAL-ANTIBODIES | TUMOR-INFILTRATING LYMPHOCYTES | THERAPEUTIC ANTITUMOR IMMUNITY | ONCOLOGY | RECEPTOR IN-VIVO | immunotherapy | T-CELL-ACTIVATION | COSTIMULATORY MOLECULE | CTLA-4 | cancer | PD-1
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2018, Volume 61, Issue 24, pp. 10957 - 10975
The modulation of immune checkpoint receptors has been one of the most successful, exciting, and explored approaches for cancer immunotherapy. Currently,... 
CHEMISTRY, MEDICINAL | ANTI-GITR MAB | SMALL-MOLECULE INHIBITORS | CRYSTAL-STRUCTURE | CO-STIMULATION | COMBINED NIVOLUMAB | HUMAN CTLA-4 | B7 FAMILY | CANCER-IMMUNOTHERAPY | MONOCLONAL-ANTIBODIES | T-CELLS
Journal Article
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