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JOURNAL OF THORACIC ONCOLOGY, ISSN 1556-0864, 10/2019, Volume 14, Issue 10, pp. 1828 - 1838
Introduction: This first-time-in-humans study assessed the safety, pharmacokinetics (PK), pharmacodynamics (PD), and clinical activity of GSK2879552 in... 
Pharmacodynamics | INHIBITION | GSK2879552 | Small cell lung carcinoma | COREST | ONCOLOGY | RESPIRATORY SYSTEM | Safety | DIFFERENTIATION | Pharmacokinetics | Index Medicus
Journal Article
Biological psychiatry, ISSN 0006-3223, 7/2014, Volume 76, Issue 1, pp. 47 - 56
Journal Article
Journal Article
Epigenetics, ISSN 1559-2294, 11/2014, Volume 9, Issue 11, pp. 1485 - 1495
Gene transcription is tightly regulated at different levels to ensure that the transcriptome of the cell is appropriate for developmental stage and cell type.... 
complex family | protein complex | MBT protein | transcriptional regulation | CoREST | Complex family | Protein complex | Transcriptional regulation | posterior sex combs | BRG1 | ZINC-FINGER | malignant brain tumor | Rpd3 | Scm-related gene containing 4 mbt domains | SLC | polycomb responsive element | DP-1 | YY1 | LSD1 | L3MBTL | GENETICS & HEREDITY | Salvador-Warts-Hippo | polycomb group | LINT | heterochromatin protein 1 | SFMBT1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-CoR | HP1 | sucrose non-fermenting | NRSF | ES cell | Drosophila Lethal 3 malignant brain tumor | histone | BRAF-histone deacetylase complex 80 | human Brahma | HDAC | nucleosome remodeling and deacetylase | corepressor | TUMOR-SUPPRESSOR GENE | SNF | POLYCOMB-GROUP PROTEINS | ELM2 | PHD | PhoRC | Pho | sex combs extra | E2F | MBT | Pho repressive complex | SWI | HMTase | SWH | ADA2 | brahma associated protein | histone deacetylas | NPA1 | adenosine triphosphate | lethal 3 malignant brain tumor | lmbt interacting 1 | repressor element 1 silencing transcription factor | NuRD | TRANSCRIPTIONAL REPRESSOR COMPLEX | ATP | CHD | PRE | lmbt interacting | PBAP | RNA | embryonic stem cells | sex combs on midleg | REMODELING COMPLEX | sex combs on midleg-like | brahma Related Gene 1 | zinc finger | transcription start site | lethal 3 malignant brain tumor-like | DNMT | malignant brain tumor signature | ZNF | PcG | retinoblastoma | STRUCTURAL BASIS | lysine-specific demethylase 1 | dimerization partner 1 | CoREST REST | lmbt | Psc | ying-yang 1 | hBRM | Lint-1 | CELL-CYCLE PROGRESSION | DNA-BINDING PROTEIN | polyhomeotic | lysine | nucleosome assembly protein | pleiohomeotic | dLmbt | SANT | TSS | BHC80 | polycomb | EGL-27 and MTA1 homology 2 | DNA methyltransferase | ribonucleic acid | polycomb repressive complex 1 | SCML | histone methylase | reduced potassium dependency 3 | HISTONE LYSINE METHYLATION | deoxyribonucleic acid | neural-restrictive silencing factor | plant homeo domain | E2 transcription Factor | polybromo-associated BAP | Sfmbt | MBTS | BAP | REST | switching defective | chromo domain helicase DNA binding | Sce | PRC1 | DNA | TFIIIB | SEX-COMB | Scm | Protein Structure, Tertiary | Chromatin - metabolism | Humans | Co-Repressor Proteins - metabolism | Multiprotein Complexes - genetics | DNA-Binding Proteins - genetics | Drosophila Proteins - metabolism | Co-Repressor Proteins - genetics | Nerve Tissue Proteins - genetics | DNA-Binding Proteins - metabolism | Nerve Tissue Proteins - metabolism | Multiprotein Complexes - metabolism | Animals | Chromatin - genetics | Evolution, Molecular
Journal Article
Journal Article
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 10/2019, Volume 9
One of the hallmarks of acute myeloid leukemia (AML) is a block in cellular differentiation. Recent studies have shown that small molecules targeting Lysine... 
KDM1A/LSD1 inhibitors | GFI1B | histone modifications | acute myeloid leukemia | GFI1 | CoREST
Journal Article
Cell Reports, ISSN 2211-1247, 03/2018, Volume 22, Issue 13, pp. 3641 - 3659
Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid leukemia (AML) with translocations. The assumption has been that... 
acetylation | acute myeloid leukemia | MLL | GFI1 | methylation | LSD1 | AML CELLS | HISTONE DEMETHYLASE LSD1 | POLYAMINE OXIDASE | COMPLEX | COREST | EMBRYONIC STEM-CELLS | GROWTH | SNAG | REVERSIBLE INHIBITORS | CANCER | CELL BIOLOGY
Journal Article