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Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 140, pp. 1 - 7
Steroid receptor coactivators (SRCs) are essential regulators of nuclear hormone receptor function. SRCs coactivate transcription mediated by hormone... 
Transcription | Hormone-dependent cancer | Drug development | Coregulator | Steroid receptor coactivator | ANDROGEN RECEPTOR | ACTIVATION | AIB1 | CELL-PROLIFERATION | HISTONE ACETYLTRANSFERASE | TRANSCRIPTIONAL COACTIVATOR | BREAST-CANCER | STRUCTURAL BASIS | ESTROGEN | PHARMACOLOGY & PHARMACY | EXPRESSION | Neoplasms, Hormone-Dependent - metabolism | Drug Resistance, Multiple | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Nuclear Receptor Coactivator 1 - chemistry | Nuclear Receptor Coactivator 2 - metabolism | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Neoplasms, Hormone-Dependent - immunology | Nuclear Receptor Coactivator 2 - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Nuclear Receptor Coactivator 1 - metabolism | Nuclear Receptor Coactivator 3 - chemistry | Drug Design | Anti-Inflammatory Agents - therapeutic use | Antineoplastic Agents - pharmacology | Protein Interaction Domains and Motifs | Nuclear Receptor Coactivator 3 - antagonists & inhibitors | Nuclear Receptor Coactivator 1 - antagonists & inhibitors | Anti-Inflammatory Agents - pharmacology | Neoplasm Proteins - chemistry | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Nuclear Receptor Coactivator 2 - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Nuclear Receptor Coactivator 3 - metabolism | Ligands | Neoplasms, Hormone-Dependent - drug therapy | Drugs | Medical colleges | Estrogen | DNA binding proteins | Metastasis | Chemotherapy | Epidermal growth factor | Interleukins | Methyltransferases | Pancreatic cancer | Physiological aspects | Progesterone | Drug therapy | Protein binding | Cancer
Journal Article
Journal Article
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2011, Volume 56, Issue 1, pp. 210 - 217
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 02/2012, Volume 120, Issue 3, pp. 419 - 429
Mitochondrial dysfunction is a prominent feature of Alzheimers disease (AD) brain. Our prior studies demonstrated reduced mitochondrial number in susceptible... 
proliferator-activated receptor gamma coactivator 1α | mitochondrial transcription factor A | nuclear respiratory factors | Alzheimer's disease | mitochondrial biogenesis | proliferator-activated receptor gamma coactivator 1a | ACTIVATION | PROTEIN | OXIDATIVE DAMAGE | PGC-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | AXONAL-TRANSPORT | NEUROSCIENCES | AMYLOID-BETA | COACTIVATOR PGC-1 | MOUSE MODEL | A-BETA | EXPRESSION | Humans | Middle Aged | Male | Mitochondrial Proteins - genetics | Nuclear Respiratory Factors - metabolism | Alzheimer Disease - pathology | Electron Transport Complex IV - metabolism | Dose-Response Relationship, Drug | CREB-Binding Protein - metabolism | Organelle Biogenesis | Transfection - methods | Mitochondrial Proteins - metabolism | Adenosine Triphosphate - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Amyloid beta-Protein Precursor - metabolism | Aged, 80 and over | Female | Hippocampus - ultrastructure | RNA Interference - physiology | Neuroblastoma - pathology | Alzheimer Disease - physiopathology | DNA, Mitochondrial - metabolism | Heat-Shock Proteins - metabolism | Enzyme Inhibitors - pharmacology | Gene Expression Regulation - physiology | Mitochondria - metabolism | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Neuroblastoma - ultrastructure | Cell Line, Tumor | Trans-Activators - metabolism | Aged | Cytochrome c | Neurosciences | Neurons | Amyloid beta-protein | Cytochrome oxidase | Mitochondrial DNA | Disease susceptibility | Biosynthesis | Neurochemistry | Mitochondria | Cellular biology | Alzheimers disease | Molecular biology | mitochondrial transcription factor A (TFAM) | nuclear respiratory factors (NRF) | proliferator-activated receptor gamma coactivator 1alpha (PGC-1a)
Journal Article
Cancer Cell, ISSN 1535-6108, 08/2015, Volume 28, Issue 2, pp. 240 - 252
By integrating growth pathways on which cancer cells rely, steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) represent emerging targets in cancer... 
BREAST-CANCER | OVEREXPRESSION | ACTIVATION | INHIBITION | AMPLIFICATION | ONCOGENIC RAS | ONCOLOGY | ESTROGEN | AIB1 | EXPRESSION | SRC-3 | CELL BIOLOGY | Neoplasms - metabolism | Small Molecule Libraries - pharmacology | Cyclohexanones - chemistry | Reactive Oxygen Species - metabolism | Pyridines - chemistry | Humans | Immunoblotting | Neoplasms - prevention & control | Nuclear Receptor Coactivator 2 - metabolism | Small Molecule Libraries - metabolism | Nuclear Receptor Coactivator 1 - metabolism | Nuclear Receptor Coactivator 1 - genetics | MCF-7 Cells | Neoplasms - genetics | RNA Interference | Protein Binding - drug effects | HEK293 Cells | Molecular Structure | Cell Survival - drug effects | Drug Screening Assays, Antitumor - methods | Endoplasmic Reticulum Stress - drug effects | Nuclear Receptor Coactivator 3 - genetics | Cyclohexanones - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Cyclohexanones - metabolism | Xenograft Model Antitumor Assays | Small Molecule Libraries - chemistry | Pyridines - metabolism | Tumor Burden - drug effects | Nuclear Receptor Coactivator 3 - metabolism | Cell Line, Tumor | Pyridines - pharmacology | HeLa Cells | Mutation | Oxidative Stress - drug effects | Nuclear Receptor Coactivator 2 - genetics | Epigenetic inheritance | Therapeutics | Cancer cells | Stress (Physiology) | Chemical properties | Diagnosis | Cancer | Homeopathy | Materia medica and therapeutics
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2015, Volume 125, Issue 7, pp. 2808 - 2824
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e95243
Members of the steroid receptor coactivator (SRC) family are overexpressed in numerous types of cancers. In particular, steroid receptor coactivator 3 (SRC-3)... 
BREAST-CANCER | GROWTH-INHIBITION | MULTIDISCIPLINARY SCIENCES | TAMOXIFEN RESISTANCE | TRAIL-INDUCED APOPTOSIS | P160 COACTIVATORS | TRANSCRIPTIONAL COACTIVATOR | HISTONE ACETYLTRANSFERASE | PROGESTERONE-RECEPTOR | OVARIAN-CANCER | CANCER CELL-PROLIFERATION | Neoplasms - metabolism | Humans | Antineoplastic Agents, Phytogenic - chemistry | Nuclear Receptor Coactivator 2 - metabolism | Neoplasm Proteins - metabolism | Neoplasms - drug therapy | Nuclear Receptor Coactivator 1 - metabolism | Protein-Arginine N-Methyltransferases - metabolism | Trichothecenes - pharmacology | Proteolysis - drug effects | p300-CBP Transcription Factors - metabolism | Signal Transduction - drug effects | Nuclear Receptor Coactivator 3 - metabolism | Trichothecenes - chemistry | HeLa Cells | Nuclear Receptor Coactivator 3 - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - pharmacology | Antimitotic agents | Complications and side effects | Dosage and administration | Genetic aspects | Research | Antineoplastic agents | Drug therapy | Tumors | Drugs | Transcription factors | Liver | Estrogen | Chemoresistance | High-throughput screening | Cytotoxicity | Event-related potentials | Insulin-like growth factors | Kinases | Metastases | Signal transduction | Receptors | Cell growth | p300 Protein | Pathways | Src protein | Gene expression | Nuclear receptors | Collagenase 3 | Gelatinase A | Signaling | Hepatocytes | Steroid receptor coactivator 1 | Transduction | Cell migration | Cancer
Journal Article