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Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 05/2017, Volume 15, Issue 5, pp. 931 - 937
Essentials FXaI16L is a recombinant zymogen‐like variant of activated coagulation factor X (FXa). A phase 1 dose escalation clinical trial of FXaI16L was... 
clinical trial | hematologic agents | hemorrhagic disorders | blood coagulation factor | activated partial thromboplastin time | PF‐05230907 | PF-05230907 | HUMAN-PLASMA | ACTIVATION | PROTEIN | BYPASS | FACTOR-VIII | SPONTANEOUS INTRACEREBRAL HEMORRHAGE | THROMBIN GENERATION | INHIBITION | HEMOPHILIA-A | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Factor Xa - administration & dosage | Injections, Intravenous | Area Under Curve | Fibrin Fibrinogen Degradation Products - metabolism | Humans | Prothrombin Time | Half-Life | Male | Metabolic Clearance Rate | Recombinant Proteins | Healthy Volunteers | Young Adult | Peptide Hydrolases - blood | Antithrombin III | Coagulants - administration & dosage | Peptide Fragments - blood | Adult | Coagulants - pharmacokinetics | Factor Xa - adverse effects | Factor Xa - immunology | Double-Blind Method | Factor Xa - pharmacokinetics | Biomarkers - blood | Blood Coagulation - drug effects | Partial Thromboplastin Time | Adolescent | Prothrombin | Antibodies - blood | Coagulants - adverse effects | Coagulants - immunology | Coagulation factor X | Pharmacodynamics | Intravenous administration | Toxicity | Coagulation | Clinical trials | Thrombin | Antithrombin | Hemorrhage | Bleeding | Antibody response | Proenzymes | Thromboplastin | Coagulation factors | Immunogenicity | Plasma levels | Pharmacokinetics
Journal Article
Journal Article
Journal Article
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, ISSN 1538-7933, 02/2010, Volume 8, Issue 2, pp. 269 - 275
Background: Prophylactic factor (F) VIII has been shown to reduce bleeds and arthropathy in patients with severe hemophilia A. Objectives: Assuming that the... 
pharmacokinetics | hemophilia A | FVIII | prophylaxis | Pharmacokinetics | Hemophilia A | Prophylaxis | EFFICACY | SAFETY | FACTOR-IX | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | AGE | Drug Costs | Prospective Studies | Factor VIII - pharmacokinetics | Humans | Middle Aged | Child, Preschool | Half-Life | Hemarthrosis - etiology | Infant | Hemarthrosis - blood | Young Adult | Drug Dosage Calculations | Factor VIII - economics | Computer Simulation | Coagulants - administration & dosage | Adult | Coagulants - pharmacokinetics | Child | Hemophilia A - economics | Severity of Illness Index | Drug Administration Schedule | Infusions, Parenteral | Treatment Outcome | Clinical Trials as Topic | Coagulants - blood | Hemarthrosis - economics | Hemophilia A - blood | Hemophilia A - complications | Coagulants - economics | Models, Biological | Cost-Benefit Analysis | Adolescent | Factor VIII - administration & dosage | Aged | Drug Monitoring | Hemarthrosis - prevention & control | Hemophilia A - drug therapy | Blood coagulation factor VIII | Drug therapy | Medicine, Preventive | Children's hospitals | Hemophilia | Preventive health services | Pharmaceutical Sciences | Basic Medicine | PHARMACY | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | Medicinska och farmaceutiska grundvetenskaper | FARMACI | Farmaceutiska vetenskaper | MEDICINE
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 04/2010, Volume 8, Issue 4, pp. 730 - 736
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 07/2013, Volume 11, Issue 7, pp. 1260 - 1268
Journal Article
Journal Article
Journal Article