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Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7552, pp. 322 - 327
Na+/Cl--coupled biogenic amine transporters are the primary targets of therapeutic and abused drugs, ranging from antidepressants to the psychostimulants... 
BIOGENIC-AMINE TRANSPORTERS | COCAINE BINDING | SEROTONIN TRANSPORTER | SUBSTRATE TRANSPORT | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | RAT-BRAIN SYNAPTOSOMES | CONFORMATIONAL DYNAMICS | ALTERNATING-ACCESS | TRANSMITTER UPTAKE | MAMMALIAN-CELLS | Dopamine - chemistry | Dopamine Plasma Membrane Transport Proteins - metabolism | Cocaine - metabolism | Molecular Conformation | Crystallography, X-Ray | Dopamine Plasma Membrane Transport Proteins - chemistry | Methamphetamine - chemistry | Sodium - metabolism | Antidepressive Agents - metabolism | Antidepressive Agents - chemistry | Chlorides - metabolism | Central Nervous System Stimulants - metabolism | Dextroamphetamine - chemistry | Protein Stability | Binding Sites | Dopamine - metabolism | Cocaine - chemistry | Dextroamphetamine - metabolism | Neurotransmitter Agents - metabolism | Models, Molecular | Phenethylamines - metabolism | Cocaine - analogs & derivatives | Methamphetamine - metabolism | Neurotransmitter Agents - chemistry | Animals | Dopamine - analogs & derivatives | Drosophila melanogaster - chemistry | Central Nervous System Stimulants - chemistry | Ligands | Physiological aspects | Neurotransmitters | Dopamine | Research | Neurological research | Biological transport | Methamphetamines | Mutagenesis | Antidepressants | Nervous system | Cocaine | Binding sites
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 01/2012, Volume 52, Issue 1, pp. 208 - 217
Glutamate-mediated excitotoxicity is involved in many acute and chronic brain diseases. Homer proteins, a new member of the postsynaptic scaffolding proteins,... 
Homer | Reactive oxygen species | Mitochondria | Endoplasmic reticulum | Excitotoxicity | APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISCHEMIA | COCAINE | IP3 RECEPTORS | NEUROTOXICITY | PROGRAMMED CELL-DEATH | UNFOLDED PROTEIN RESPONSE | CALCIUM | ENDOCRINOLOGY & METABOLISM | Transcription Factor CHOP - genetics | Reactive Oxygen Species - metabolism | Gene Expression - drug effects | eIF-2 Kinase - metabolism | Endoplasmic Reticulum - metabolism | Neurons - cytology | Cerebral Cortex - cytology | Cerebral Cortex - metabolism | Heat-Shock Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein Isoforms - metabolism | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Endoplasmic Reticulum - drug effects | Homer Scaffolding Proteins | Membrane Potential, Mitochondrial | Neurons - metabolism | Cerebral Cortex - drug effects | Neurons - drug effects | Glutamic Acid - adverse effects | Protein-Serine-Threonine Kinases - metabolism | eIF-2 Kinase - genetics | Cell Survival - drug effects | Caspase 12 - genetics | Down-Regulation | Heat-Shock Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Rats | Mitochondria - metabolism | Caspase 12 - metabolism | Mitochondria - drug effects | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Signal Transduction - drug effects | Primary Cell Culture | Transcription Factor CHOP - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Inositol 1,4,5-Trisphosphate Receptors - genetics | Protein Isoforms - genetics | Cytochrome c | Proteins | Inositol | Mitochondrial DNA | Glutamate | Neurons | Calcium (intracellular) | Cell survival | Central nervous system | Cortex | Intracellular signalling | Glutamic acid receptors | siRNA | Signal transduction | Neurotoxicity | Transfection | Homer protein | Initiation factor eIF-2 | Glutamic acid receptors (metabotropic) | Injuries | Apoptosis | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1292 - 1300
Polymorphisms in the cytochrome P450 2D6 (CYP2D6) gene are a major cause of pharmacokinetic variability in human. Although the poor metabolizer phenotype is... 
IN-VITRO | 2D6 | DRUGS | CATALYTIC ACTIVITY | PHARMACOLOGY & PHARMACY | HUMAN CYTOCHROME-P450 ENZYMES | HUMAN LIVER-MICROSOMES | LOW-AFFINITY | CLINICAL-PRACTICE | DEBRISOQUINE | EXPRESSION | Microsomes - metabolism | Quinidine - chemistry | Tramadol - chemistry | Humans | Dextromethorphan - metabolism | Imipramine - chemistry | Propylamines - pharmacokinetics | Codeine - chemistry | Debrisoquin - metabolism | Enzyme Inhibitors - chemistry | Fluoxetine - analogs & derivatives | Quinidine - pharmacokinetics | Propylamines - chemistry | Cocaine - chemistry | Cytochrome P-450 CYP2D6 - genetics | Recombinant Proteins - antagonists & inhibitors | Debrisoquin - chemistry | Enzyme Inhibitors - metabolism | Hydroxylation | Cocaine - pharmacokinetics | Ethanolamines - chemistry | Tramadol - pharmacokinetics | Nortriptyline - metabolism | Fluoxetine - metabolism | Cytochrome P-450 CYP2D6 - metabolism | Kinetics | Thioridazine - metabolism | Cytochrome P-450 CYP2D6 Inhibitors | Nortriptyline - chemistry | Cocaine - metabolism | Fluoxetine - pharmacokinetics | Debrisoquin - pharmacokinetics | Ethanolamines - pharmacokinetics | Codeine - metabolism | Enzyme Inhibitors - pharmacokinetics | Thioridazine - pharmacokinetics | Atomoxetine Hydrochloride | Codeine - pharmacokinetics | Thioridazine - chemistry | Dextromethorphan - pharmacokinetics | Molecular Structure | Quinidine - metabolism | Recombinant Proteins - metabolism | Imipramine - pharmacokinetics | Nortriptyline - pharmacokinetics | Dextromethorphan - chemistry | Fluoxetine - chemistry | Tramadol - metabolism | Ethanolamines - metabolism | Imipramine - metabolism | Polymorphism, Single Nucleotide | Propylamines - metabolism
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2017, Volume 7, Issue 1, p. 40648
Journal Article
Blood, ISSN 0006-4971, 06/2010, Volume 115, Issue 23, pp. 4951 - 4962
Cocaine abuse hastens the neurodegeneration often associated with advanced HIV-1 infection. The mechanisms, in part, revolve around the neuroinflammatory... 
PROTEIN-KINASE-C | SIGNALING PATHWAYS | ENDOTHELIAL-CELLS | COCAINE | CHEMOATTRACTANT PROTEIN-1 | HUMAN-IMMUNODEFICIENCY-VIRUS | CHEMOKINE RECEPTORS | HEMATOLOGY | BLOOD-BRAIN-BARRIER | NF-KAPPA-B | HIV-1 INVASION | HIV-1 | Microglia - metabolism | Mitogen-Activated Protein Kinase Kinases - genetics | Dopamine Uptake Inhibitors - adverse effects | Membrane Microdomains - metabolism | Male | Monocytes - metabolism | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Cocaine-Related Disorders - genetics | Cell Movement - genetics | Brain - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Cocaine-Related Disorders - metabolism | MAP Kinase Signaling System - genetics | HIV Infections - pathology | Monocytes - pathology | src-Family Kinases - metabolism | Microglia - pathology | Chemokine CCL2 - metabolism | Cocaine - adverse effects | Receptors, sigma - metabolism | Neurodegenerative Diseases - pathology | Dopamine Uptake Inhibitors - pharmacology | Gene Expression Regulation - genetics | HIV Infections - genetics | Cocaine-Related Disorders - pathology | Rats | Chemokine CCL2 - genetics | Neurodegenerative Diseases - genetics | Receptors, sigma - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Gene Expression Regulation - drug effects | Phosphatidylinositol 3-Kinases - genetics | Cell Movement - drug effects | Cocaine - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Neurodegenerative Diseases - chemically induced | NF-kappa B - genetics | Brain - pathology | Mice | src-Family Kinases - genetics | Membrane Microdomains - pathology | Membrane Microdomains - genetics | HIV Infections - metabolism | Vascular Biology | HIV Infections | Membrane Microdomains | Brain | pathology | src-Family Kinases | Cocaine-Related Disorders | Phosphatidylinositol 3-Kinases | MAP Kinase Signaling System | Receptors | genetics | Mitogen-Activated Protein Kinase Kinases | NF-kappa B | pharmacology | Dopamine Uptake Inhibitors | sigma | Neurodegenerative Diseases | chemically induced | Gene Expression Regulation | Cell and Molecular Biology | drug effects | Knockout | Microglia | Monocytes | adverse effects | metabolism | Cocaine | Chemokine CCL2 | Cell- och molekylärbiologi | Cell Movement
Journal Article
Science, ISSN 0036-8075, 10/2010, Volume 330, Issue 6002, pp. 385 - 390
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 2015, Volume 35, Issue 20, pp. 7927 - 7937
Journal Article
Science, ISSN 0036-8075, 3/2007, Volume 315, Issue 5816, pp. 1267 - 1270
Journal Article
Psychoneuroendocrinology, ISSN 0306-4530, 06/2017, Volume 80, pp. 147 - 154
Journal Article