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Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1292 - 1300
Polymorphisms in the cytochrome P450 2D6 (CYP2D6) gene are a major cause of pharmacokinetic variability in human. Although the poor metabolizer phenotype is... 
IN-VITRO | 2D6 | DRUGS | CATALYTIC ACTIVITY | PHARMACOLOGY & PHARMACY | HUMAN CYTOCHROME-P450 ENZYMES | HUMAN LIVER-MICROSOMES | LOW-AFFINITY | CLINICAL-PRACTICE | DEBRISOQUINE | EXPRESSION | Microsomes - metabolism | Quinidine - chemistry | Tramadol - chemistry | Humans | Dextromethorphan - metabolism | Imipramine - chemistry | Propylamines - pharmacokinetics | Codeine - chemistry | Debrisoquin - metabolism | Enzyme Inhibitors - chemistry | Fluoxetine - analogs & derivatives | Quinidine - pharmacokinetics | Propylamines - chemistry | Cocaine - chemistry | Cytochrome P-450 CYP2D6 - genetics | Recombinant Proteins - antagonists & inhibitors | Debrisoquin - chemistry | Enzyme Inhibitors - metabolism | Hydroxylation | Cocaine - pharmacokinetics | Ethanolamines - chemistry | Tramadol - pharmacokinetics | Nortriptyline - metabolism | Fluoxetine - metabolism | Cytochrome P-450 CYP2D6 - metabolism | Kinetics | Thioridazine - metabolism | Cytochrome P-450 CYP2D6 Inhibitors | Nortriptyline - chemistry | Cocaine - metabolism | Fluoxetine - pharmacokinetics | Debrisoquin - pharmacokinetics | Ethanolamines - pharmacokinetics | Codeine - metabolism | Enzyme Inhibitors - pharmacokinetics | Thioridazine - pharmacokinetics | Atomoxetine Hydrochloride | Codeine - pharmacokinetics | Thioridazine - chemistry | Dextromethorphan - pharmacokinetics | Molecular Structure | Quinidine - metabolism | Recombinant Proteins - metabolism | Imipramine - pharmacokinetics | Nortriptyline - pharmacokinetics | Dextromethorphan - chemistry | Fluoxetine - chemistry | Tramadol - metabolism | Ethanolamines - metabolism | Imipramine - metabolism | Polymorphism, Single Nucleotide | Propylamines - metabolism | Index Medicus
Journal Article
Journal Article
The Clinical Journal of Pain, ISSN 0749-8047, 06/2019, Volume 35, Issue 6, pp. 481 - 486
AIMS/OBJECTIVES/BACKGROUND:Children represent a patient demographic composed of multiple, unique subpopulations differentiated by rapidly changing age-related... 
developmental | pain | TRAMADOL DISPOSITION | enzymes | CLINICAL NEUROLOGY | CANCER-PATIENTS | MORPHINE CONSUMPTION | PHARMACOKINETICS | children | CYP2D6 | pharmacology | BREAST-FED NEONATE | INFANTS | ANESTHESIOLOGY | metabolism | RECEPTOR GENE | CODEINE | opioids | Pediatric pharmacology | Pain in children | Opioids | Drug metabolism | Research | Drug therapy | Pediatric research | Health aspects
Journal Article
The Plant Journal, ISSN 0960-7412, 03/2012, Volume 69, Issue 6, pp. 1052 - 1063
Opium poppy ( Papaver somniferum ) remains the sole commercial source for several pharmaceutical alkaloids including the narcotic analgesics codeine and... 
specialized metabolism | benzylisoquinoline alkaloids | functional genomics | metabolic engineering | opium poppy | virus‐induced gene silencing | virus-induced gene silencing | PAPAVER-SOMNIFERUM | SALUTARIDINOL 7-O-ACETYLTRANSFERASE | CALIFORNIA POPPY | RNAI SUPPRESSION | CODEINONE REDUCTASE | SOMATIC EMBRYOGENESIS | CELL-CULTURES | PLANT SCIENCES | ALKALOID BIOSYNTHESIS | MOLECULAR-CLONING | NORCOCLAURINE SYNTHASE | Genes, Plant | Plant Viruses - genetics | Agrobacterium tumefaciens - genetics | Morphine - biosynthesis | Substrate Specificity | Immunoblotting | Papaver - genetics | Chromatography, High Pressure Liquid | Gene Knockdown Techniques - methods | Alcohol Oxidoreductases - genetics | Morphinans - metabolism | Gene Expression Regulation, Plant | Papaver - enzymology | Plant Viruses - metabolism | Plant Proteins - metabolism | NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases | Metabolic Engineering - methods | Oxidoreductases - metabolism | Oxidoreductases - genetics | Gene Silencing | Morphine - metabolism | Genetic Vectors - metabolism | Alcohol Oxidoreductases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Genetic Vectors - genetics | Gene Expression Regulation, Enzymologic | Plant Proteins - genetics | Agrobacterium tumefaciens - metabolism | Benzylisoquinolines - metabolism | Papaver - metabolism | Plant biology | Enzymes | Biosynthesis | Flowers & plants | Narcotics | Gene expression | Drugs | Post-transcription | Transcription | Antibodies | Morphine | Naltrexone | Codeine | Polymerase chain reaction | Alkaloids | Gene silencing | reductase | Analgesics | Buprenorphine | oxycodone | genomics | Pharmaceuticals | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 04/2004, Volume 32, Issue 4, pp. 447 - 454
Oxycodone undergoes N -demethylation to noroxycodone and O -demethylation to oxymorphone. The cytochrome P450 (P450) isoforms capable of mediating the... 
NEUROPATHIC PAIN | 3A CYP3A | PHARMACOKINETICS | POOR METABOLIZERS | PHARMACOLOGY & PHARMACY | CONTROLLED-RELEASE OXYCODONE | CANCER PAIN | N-DEMETHYLATION | CODEINE | RECEPTOR-BINDING | POSTOPERATIVE PAIN | Intestines - drug effects | Microsomes - metabolism | Intestinal Mucosa - metabolism | Morphinans - antagonists & inhibitors | Oxidoreductases, N-Demethylating - genetics | Quinidine - antagonists & inhibitors | Cytochrome P-450 CYP3A | Humans | Microsomes, Liver - metabolism | Aryl Hydrocarbon Hydroxylases - genetics | DNA, Complementary - genetics | Cytochrome P-450 Enzyme System - metabolism | Ketoconazole - metabolism | Metabolic Clearance Rate | Ketoconazole - pharmacology | Microsomes - drug effects | Morphinans - metabolism | Oxymorphone - metabolism | Microsomes, Liver - drug effects | Quinidine - adverse effects | Biotransformation | Protein Binding - drug effects | Molecular Structure | Oxidoreductases, N-Demethylating - metabolism | Oxycodone - metabolism | Cytochrome P-450 CYP2D6 - genetics | Cytochrome P-450 CYP2D6 - pharmacology | Morphinans - chemistry | Aryl Hydrocarbon Hydroxylases - pharmacology | Oxycodone - pharmacology | Oxymorphone - chemistry | Quinidine - pharmacology | Microsomes, Liver - chemistry | Aryl Hydrocarbon Hydroxylases - metabolism | Intestines - ultrastructure | Oxidoreductases, N-Demethylating - pharmacology | Methylation - drug effects | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Kinetics | Index Medicus
Journal Article
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 9/2016, Volume 408, Issue 23, pp. 6283 - 6294
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 10/2019, Volume 168, pp. 184 - 192
Despite their widespread popularity as sport and companion animals and published and anecdotal reports of vast difference in drug disposition and... 
Equine | Metabolism | Cytochrome P450 | Codeine | Polymorphism | Morphine | Metabolites | Liver | Investigations | Genetic polymorphisms | Cytochrome P-450 | Index Medicus
Journal Article
Addiction Biology, ISSN 1355-6215, 03/2019, Volume 24, Issue 2, pp. 228 - 238
Journal Article