Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (40324) 40324
Publication (6900) 6900
Book Review (4077) 4077
Book Chapter (347) 347
Conference Proceeding (101) 101
Newspaper Article (92) 92
Book / eBook (79) 79
Newsletter (79) 79
Reference (32) 32
Dissertation (24) 24
Magazine Article (19) 19
Web Resource (7) 7
Data Set (4) 4
Government Document (4) 4
Streaming Video (3) 3
Paper (2) 2
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (35109) 35109
animals (16707) 16707
biochemistry & molecular biology (12598) 12598
humans (12370) 12370
male (6895) 6895
rats (6645) 6645
enzymes and coenzymes (6209) 6209
enzymes (5489) 5489
kinetics (5152) 5152
coenzymes (4810) 4810
metabolism (4454) 4454
research (4435) 4435
cell biology (4390) 4390
mice (4277) 4277
physiological aspects (4218) 4218
molecular sequence data (4082) 4082
female (3858) 3858
proteins (3781) 3781
amino acid sequence (3584) 3584
analysis (3316) 3316
article (3263) 3263
oxidation-reduction (3156) 3156
microbiology (3061) 3061
escherichia-coli (2920) 2920
phosphorylation (2894) 2894
mutation (2815) 2815
acyl coenzyme a - metabolism (2798) 2798
biosynthesis (2678) 2678
protein binding (2606) 2606
expression (2585) 2585
coenzymes - metabolism (2558) 2558
substrate specificity (2534) 2534
gene expression (2495) 2495
binding sites (2434) 2434
biophysics (2374) 2374
coenzyme a - metabolism (2369) 2369
bacteria (2270) 2270
liver - metabolism (2194) 2194
models, molecular (2180) 2180
biotechnology & applied microbiology (2141) 2141
environment and public health (2141) 2141
acetyl coenzyme a - metabolism (2118) 2118
fatty acids - metabolism (2092) 2092
coenzyme a (2060) 2060
fatty acids (2028) 2028
multidisciplinary sciences (2001) 2001
oxidative stress (1949) 1949
genetic aspects (1943) 1943
biochemistry (1934) 1934
protein (1792) 1792
lipids (1757) 1757
genes (1756) 1756
biological phenomena, cell phenomena, and immunity (1733) 1733
saccharomyces-cerevisiae (1732) 1732
catalysis (1723) 1723
mitochondria (1706) 1706
coenzyme-a reductase (1691) 1691
cells, cultured (1672) 1672
liver - enzymology (1662) 1662
identification (1657) 1657
research article (1651) 1651
coenzyme a ligases - metabolism (1644) 1644
cells (1636) 1636
cell line (1629) 1629
liver (1627) 1627
gene (1616) 1616
endocrinology & metabolism (1602) 1602
pharmacology & pharmacy (1590) 1590
base sequence (1581) 1581
purification (1530) 1530
crystal-structure (1472) 1472
macromolecular substances (1472) 1472
signal transduction (1469) 1469
coenzyme q (1442) 1442
ubiquinone - analogs & derivatives (1434) 1434
escherichia coli - genetics (1430) 1430
recombinant proteins - metabolism (1426) 1426
cholesterol (1409) 1409
coenzyme-a (1396) 1396
in vitro techniques (1384) 1384
genetics & heredity (1375) 1375
hydrogen-ion concentration (1373) 1373
time factors (1353) 1353
bacterial proteins - metabolism (1344) 1344
life sciences (1338) 1338
coenzyme (1337) 1337
cloning, molecular (1331) 1331
adenosine triphosphate - metabolism (1322) 1322
protein conformation (1310) 1310
mitochondria - metabolism (1306) 1306
lipid metabolism (1295) 1295
biology (1279) 1279
adult (1258) 1258
fungi (1247) 1247
models, biological (1241) 1241
nad - metabolism (1237) 1237
plant sciences (1236) 1236
activation (1232) 1232
nad (1228) 1228
protein structure, tertiary (1227) 1227
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (47) 47
Chemistry (A D Allen) - Stacks (9) 9
UofT at Mississauga - Stacks (8) 8
Collection Dvlpm't (Acquisitions) - Vendor file (7) 7
Online Resources - Online (6) 6
Engineering & Comp. Sci. - Stacks (3) 3
UofT at Scarborough - Stacks (3) 3
Collection Dvlpm't (Acquisitions) - Closed Orders (2) 2
Chemistry (A D Allen) - May be requested in 6-10 wks (1) 1
Gerstein Science - Periodical Stacks (1) 1
Online (1) 1
Online Resources - Pharmacy (1) 1
UTL at Downsview - May be requested (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (39523) 39523
Russian (303) 303
German (281) 281
French (193) 193
Japanese (171) 171
Italian (133) 133
Chinese (46) 46
Polish (42) 42
Spanish (24) 24
Ukrainian (17) 17
Turkish (12) 12
Slovak (7) 7
Czech (5) 5
Norwegian (5) 5
Danish (4) 4
Dutch (4) 4
Hungarian (4) 4
Korean (4) 4
Portuguese (4) 4
Finnish (2) 2
Arabic (1) 1
Bulgarian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B
by Alexander E. Kelly and Cristina Ghenoiu and John Z. Xue and Christian Zierhut and Hiroshi Kimura and Hironori Funabiki
Science, ISSN 0036-8075, 10/2010, Volume 330, Issue 6001, pp. 235 - 239
A hallmark of mitosis is the appearance of high levels of histone phosphorylation, yet the roles of these modifications remain largely unknown. Here, we... 
Phosphorylation | Spermatozoa | Chromatin | Calcium | Mitosis | Metaphase | REPORTS | Cell cycle | Histones | Ova | Chromosomes | SMAC/DIABLO | COMPLEX | INHIBITION | CHROMATIN | MECHANISM | STRUCTURAL BASIS | INCENP | MULTIDISCIPLINARY SCIENCES | SPINDLE | BINDING | CHROMOSOMAL PASSENGERS | Chromatin - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Xenopus laevis | Molecular Sequence Data | Aurora Kinases | Centromere - metabolism | Survivin | Threonine - metabolism | Xenopus Proteins - chemistry | Animals | Spindle Apparatus - metabolism | Cell Division | Chromosomes - metabolism | Protein Binding | Xenopus Proteins - metabolism | Protein Interaction Domains and Motifs | Enzyme Activation | Histones - metabolism | Protein-Serine-Threonine Kinases - metabolism | Physiological aspects | Threonine | Properties | Phosphotransferases | Proteins | Cell division | Biochemistry | Kinases | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain
by Leishman, Emma and Mackie, Ken and Luquet, Serge and Bradshaw, Heather B
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 06/2016, Volume 1861, Issue 6, pp. 491 - 500
A leading hypothesis of -acyl ethanolamine (NAE) biosynthesis, including the endogenous cannabinoid anandamide (AEA), is that it depends on hydrolysis of... 
Lipidomics | Lipoamine | Endogenous cannabinoid biosynthesis | NAPE-PLD | Anandamide | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARACHIDONIC-ACID CASCADE | IDENTIFICATION | CELL BIOLOGY | INACTIVATION | BIOPHYSICS | BIOSYNTHESIS | ACYLETHANOLAMINES | ENDOCANNABINOIDS | MICE | PROSTAGLANDIN | N-ACYL ETHANOLAMINE | Endocannabinoids - metabolism | Glycine - analogs & derivatives | Arachidonic Acid - metabolism | Glycine - metabolism | Thalamus - metabolism | Mesencephalon - metabolism | Brain Stem - metabolism | Chromatography, High Pressure Liquid | Dinoprost - metabolism | Corpus Striatum - metabolism | Cerebral Cortex - metabolism | Brain - metabolism | Tandem Mass Spectrometry | Arachidonic Acids - metabolism | Phospholipase D - genetics | Cerebellum - metabolism | Lipid Metabolism | Glycerides - metabolism | Polyunsaturated Alkamides - metabolism | Phospholipase D - metabolism | Mice, Knockout | Dinoprostone - metabolism | Hippocampus - metabolism | Animals | Hypothalamus - metabolism | Ethanolamines - metabolism | Lipids - analysis | Phosphatidylethanolamines - metabolism | Glycerin | Hydrolysis | Enzymes | Brain | Analysis | Physiological aspects | Glycerol | Phospholipases | Ethanolamines | Arachidonic acid | Glycine | Unsaturated fatty acids | Lipase | Saturated fatty acids
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
by Metallo, Christian M and Gameiro, Paulo A and Bell, Eric L and Mattaini, Katherine R and Yang, Juanjuan and Hiller, Karsten and Jewell, Christopher M and Johnson, Zachary R and Irvine, Darrell J and Guarente, Leonard and Kelleher, Joanne K and Vander Heiden, Matthew G and Iliopoulos, Othon and Stephanopoulos, Gregory
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7381, pp. 380 - 384
Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty-acid synthesis and protein acetylation. In the conventional view of mammalian cell... 
FLUX ANALYSIS | DISTRIBUTIONS | FATTY-ACID SYNTHESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | HYDROXYLATION | CELL-PROLIFERATION | SUPPRESSION | HIF-ALPHA | CANCER | DEHYDROGENASE | CD8-Positive T-Lymphocytes - cytology | Palmitic Acid - metabolism | Isocitrate Dehydrogenase - deficiency | Humans | Glutamine - metabolism | Kidney Neoplasms - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Oxygen - metabolism | Cell Hypoxia | Basic Helix-Loop-Helix Transcription Factors - metabolism | Acetyl Coenzyme A - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Ketoglutaric Acids - metabolism | Lipogenesis | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Carbon - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Oxidation-Reduction | Carcinoma, Renal Cell - pathology | Cells, Cultured | Isocitrate Dehydrogenase - genetics | Acetyl Coenzyme A - metabolism | Citric Acid Cycle | Carcinoma, Renal Cell - metabolism | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Kidney Neoplasms - pathology | Physiological aspects | Hypoxia | Research | Lipid metabolism | Electron transport | Proteins | Confidence intervals | Metabolites | Lipids | Biosynthesis | Glucose | Experiments | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation
by Ng Shyh-Chang and Jason W. Locasale and Costas A. Lyssiotis and Yuxiang Zheng and Ren Yi Teo and Sutheera Ratanasirintrawoot and Jin Zhang and Tamer Onder and Juli J. Unternaehrer and Hao Zhu and John M. Asara and George Q. Daley and Lewis C. Cantley
Science, ISSN 0036-8075, 1/2013, Volume 339, Issue 6116, pp. 222 - 226
Threonine is the only amino acid critically required for the pluripotency of mouse embryonic stem cells (mESCs), but the detailed mechanism remains unclear. We... 
Enzymes | Protein metabolism | Cellular metabolism | Metabolites | REPORTS | Stem cells | Histones | Amino acids | Physiological regulation | Methylation | Amino acid metabolism | GLYCINE | CHROMATIN | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | MOUSE | SELF-RENEWAL | CANCER | Embryonic Stem Cells - metabolism | Glycine - metabolism | Embryonic Stem Cells - cytology | Epigenesis, Genetic | Threonine - metabolism | Cellular Reprogramming | Culture Media | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Pluripotent Stem Cells - cytology | Cells, Cultured | Alcohol Oxidoreductases - metabolism | Transcription Factors - genetics | Acetyl Coenzyme A - metabolism | Pluripotent Stem Cells - metabolism | Transcription Factors - metabolism | Animals | Metabolic Networks and Pathways | Fibroblasts - cytology | Mice | Histones - metabolism | S-Adenosylmethionine - metabolism | Threonine | Physiological aspects | Embryonic stem cells | Properties | S-adenosylmethionine | Proteins | Cellular biology | Metabolism | Index Medicus | Genetics | Mass spectrometry
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Reductive carboxylation supports growth in tumour cells with defective mitochondria
by Mullen, Andrew R and Wheaton, William W and Jin, Eunsook S and Chen, Pei-Hsuan and Sullivan, Lucas B and Cheng, Tzuling and Yang, Youfeng and Linehan, W. Marston and Chandel, Navdeep S and Deberardinis, Ralph J
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7381, pp. 385 - 388
Mitochondrial metabolism provides precursors to build macromolecules in growing cancer cells(1,2). In normally functioning tumour cell mitochondria, oxidative... 
GENE | MULTIDISCIPLINARY SCIENCES | LIVER | LINE | ROS | PARAGANGLIOMA | FLUX | MUTATIONS | CANCER | DEHYDROGENASE | GLUTAMINE-METABOLISM | Neoplasms - metabolism | Electron Transport | Electron Transport Complex III - metabolism | Kidney Neoplasms - genetics | Humans | Carcinoma, Renal Cell - genetics | Glutamine - metabolism | Kidney Neoplasms - metabolism | Electron Transport Complex I - metabolism | Cell Hypoxia | Fumarate Hydratase - metabolism | NADP - metabolism | Carcinoma, Renal Cell - pathology | Mitochondria - metabolism | Fumarate Hydratase - genetics | Mitochondria - pathology | Acetyl Coenzyme A - metabolism | Carcinoma, Renal Cell - metabolism | Animals | Cell Line, Tumor | Glucose - metabolism | Isocitrate Dehydrogenase - metabolism | Kidney Neoplasms - pathology | Citric Acid - metabolism | Mice | Neoplasms - pathology | Control | Cytochrome b | Cancer cells | Physiological aspects | Carboxylation | Genetic aspects | Mitochondrial DNA | Research | Lipids | Mutation | Metabolites | Cancer | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease
by Min, Hae-Ki and Kapoor, Ashwani and Fuchs, Michael and Mirshahi, Faridoddin and Zhou, Huiping and Maher, James and Kellum, John and Warnick, Russell and Contos, Melissa J and Sanyal, Arun J
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | Index Medicus | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text NAD+ -dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response
by Liu, Tie Fu and Vachharajani, Vidula T and Yoza, Barbara K and McCall, Charles E
Journal of Biological Chemistry, ISSN 0021-9258, 07/2012, Volume 287, Issue 31, pp. 25758 - 25769
The early initiation phase of acute inflammation is anabolic and primarily requires glycolysis with reduced mitochondrial glucose oxidation for energy, whereas... 
MACROPHAGE-MEDIATED INFLAMMATION | HOMEOSTASIS | T-CELL MEMORY | METABOLISM | ADIPONECTIN | INSULIN-RESISTANCE | IMMUNOSUPPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTOXIN TOLERANCE | SEPSIS | DIFFERENTIATION | Sirtuin 1 - metabolism | Humans | Monocyte-Macrophage Precursor Cells - immunology | Glucose Transporter Type 1 - metabolism | Monocyte-Macrophage Precursor Cells - metabolism | Leukocytes - immunology | Heat-Shock Proteins - genetics | Monocyte-Macrophage Precursor Cells - physiology | Nicotinamide Phosphoribosyltransferase - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Sepsis - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | NAD - biosynthesis | Fatty Acids - metabolism | Cell Line | Sepsis - immunology | Cytokines - metabolism | Oxidation-Reduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Transcription Factors - genetics | Toll-Like Receptor 4 - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Adaptation, Physiological - immunology | Animals | Carrier Proteins - metabolism | Energy Metabolism | Lipopolysaccharides - pharmacology | Glucose - metabolism | Glycolysis | Mice | Leukocytes - metabolism | Sirtuins - metabolism | Index Medicus | NAD | Sirtuins | Immunology | Acute Inflammation | Bioenergetics | PGC-1 | Sepsis | HIF-1α | Biosensors | Macrophages | Metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Large‐scale 13C‐flux analysis reveals distinct transcriptional control of respiratory and fermentative metabolism in Escherichia coli
by Haverkorn van Rijsewijk, Bart R B and Nanchen, Annik and Nallet, Sophie and Kleijn, Roelco J and Sauer, Uwe
Molecular Systems Biology, ISSN 1744-4292, 2011, Volume 7, Issue 1, pp. 477 - n/a
Despite our increasing topological knowledge on regulation networks in model bacteria, it is largely unknown which of the many co‐occurring regulatory events... 
central metabolism | gene regulatory networks | respiratory growth | fermentative growth | transcriptional regulation | Carbon - metabolism | Galactose - metabolism | Escherichia coli Proteins - metabolism | Carbon Isotopes - metabolism | Transcription Factors - genetics | Acetyl Coenzyme A - metabolism | Oxygen - metabolism | Citric Acid Cycle | Transcription Factors - metabolism | Phosphoenolpyruvate - metabolism | Glyoxylates - metabolism | Escherichia coli - genetics | Escherichia coli - metabolism | Escherichia coli Proteins - genetics | Glucose - metabolism | Glycolysis | Isotope Labeling | Transcription, Genetic | Escherichia coli - growth & development | Gene Expression Regulation, Bacterial | Cyclic AMP - metabolism | Tricarboxylic acid cycle | Metabolomics | Regulators | Hexose | Transcription factors | Catabolite repression | Growth rate | Escherichia coli | Pyruvic acid | Biomass | Glucose | Saccharomyces | Overflow | Glucose metabolism | Control | Metabolic flux | Pathways | Partitioning | Clonal deletion | E coli | Pentose | Dependence | Deletion | Bacteria | Glyoxylate cycle | Carbon 13 | Escherichia | Fluctuations | Hexoses | Cyclic AMP | Knowledge management | Fluxes | Metabolism | Fermentation | Substrates | Mutants | Splitting | Derepression | Catabolism | Regulation | Metabolic pathways | Intracellular | Respiration | Galactose | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion
by Li, Ning and Li, Bin and Brun, Thierry and Deffert-Delbouille, Christine and Mahiout, Zahia and Daali, Youssef and Ma, Xiao-Juan and Krause, Karl-Heinz and Maechler, Pierre
Diabetes, ISSN 0012-1797, 11/2012, Volume 61, Issue 11, pp. 2842 - 2850
In insulin-secreting cells, expression of NADPH oxidase (NOX), a potent source of ROS, has been reported, along with controversial findings regarding its... 
SIGNAL-TRANSDUCTION | NAD(P)H OXIDASE | RESPIRATORY BURST | OXIDATIVE STRESS | PROTEIN | ISLETS | SUPEROXIDE-PRODUCTION | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | DEPENDENT PATHWAY | Islets of Langerhans - drug effects | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Humans | NADPH Oxidases - metabolism | Secretory Vesicles - metabolism | Insulin-Secreting Cells - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Islets of Langerhans - metabolism | Isoenzymes - metabolism | Islets of Langerhans - cytology | NADPH Oxidases - genetics | Insulin-Secreting Cells - cytology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | Insulin Secretion | Cyclic AMP-Dependent Protein Kinases - metabolism | Second Messenger Systems - drug effects | Glucagon-Like Peptide 1 - metabolism | Isoenzymes - genetics | Tissue Culture Techniques | Mice, Inbred C57BL | NADPH Oxidases - antagonists & inhibitors | Cells, Cultured | Gene Silencing | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Mice, Knockout | Cyclic AMP - antagonists & inhibitors | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Secretory Vesicles - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Cyclic AMP - agonists | Isoenzymes - antagonists & inhibitors | Oxidases | Physiological aspects | Pancreatic beta cells | Research | Analysis | NADP (Coenzyme) | Index Medicus | Abridged Index Medicus | Islet Studies
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Compartmentation of Metabolism of the C12-, C9-, and C5-n-dicarboxylates in Rat Liver, Investigated by Mass Isotopomer Analysis: ANAPLEROSIS FROM DODECANEDIOATE
by Jin, Zhicheng and Bian, Fang and Tomcik, Kristyen and Kelleher, Joanne K and Zhang, Guo-Fang and Brunengraber, Henri
The Journal of biological chemistry, ISSN 0021-9258, 07/2015, Volume 290, Issue 30, pp. 18671 - 18677
We investigated the compartmentation of the catabolism of dodecanedioate (DODA), azelate, and glutarate in perfused rat livers, using a combination of... 
Propionic Acidemia - drug therapy | Liver - pathology | Dicarboxylic Acids - metabolism | Propionic Acidemia - diet therapy | Humans | Propionic Acidemia - metabolism | Amino Acid Metabolism, Inborn Errors - diet therapy | Amino Acid Metabolism, Inborn Errors - metabolism | Malonyl Coenzyme A - metabolism | Amino Acid Metabolism, Inborn Errors - genetics | Fatty Acids - genetics | Myocardium - metabolism | Fatty Acids - metabolism | Oxidation-Reduction | Liver - metabolism | Metabolism, Inborn Errors - metabolism | Rats | Myocardium - pathology | Propionic Acidemia - genetics | Mitochondria - metabolism | Coenzyme A - metabolism | Metabolism, Inborn Errors - genetics | Peroxisomes - metabolism | Citric Acid Cycle - genetics | Animals | Glutarates - metabolism | Metabolism, Inborn Errors - drug therapy | Amino Acid Metabolism, Inborn Errors - drug therapy | Index Medicus | coenzyme A (CoA) | liver | cell compartmentalization | fatty acid metabolism | β-oxidation | liver metabolism | peroxisome | Metabolism | isotopic tracer
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Dysregulated hepatic methionine metabolism drives homocysteine elevation in diet-induced nonalcoholic fatty liver disease
by Pacana, Tommy and Cazanave, Sophie and Verdianelli, Aurora and Patel, Vaishali and Min, Hae-Ki and Mirshahi, Faridoddin and Quinlivan, Eoin and Sanyal, Arun J
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, pp. e0136822 - e0136822
Methionine metabolism plays a central role in methylation reactions, production of glutathione and methylarginines, and modulating homocysteine levels. The... 
AMINO-ACID-METABOLISM | OXIDATIVE STRESS | DNA METHYLATION | LIQUID-CHROMATOGRAPHY | NITRIC-OXIDE SYNTHASE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | FOLLOW-UP | STEATOHEPATITIS | ONE-CARBON METABOLISM | MASS-SPECTROMETRY | Glycine N-Methyltransferase - metabolism | Blood Chemical Analysis | Homocysteine - metabolism | Glutathione - biosynthesis | Diet, High-Fat | Female | Metabolic Networks and Pathways - physiology | Cysteine - metabolism | Dipeptides - metabolism | Betaine-Homocysteine S-Methyltransferase - metabolism | Acyl Coenzyme A - metabolism | B-Lymphocytes - metabolism | Methionine - metabolism | Liver - metabolism | Mice, Inbred C57BL | Metabolome | Adenosylhomocysteinase - metabolism | Methionine Adenosyltransferase - metabolism | DNA Methylation - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Cystathionine beta-Synthase - metabolism | Random Allocation | Animals | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - metabolism | Mice | Fatty liver | Physiological aspects | Development and progression | Genetic aspects | Research | Homocysteine | Amino acid metabolism | Transcription factors | Adenosylmethionine | High cholesterol diet | Bcl-2 protein | Laboratories | Liver | Glycine | Caspase-3 | Proteins | Elevation | Arginine | Betaine | Rodents | DNA methylation | Deoxyribonucleic acid--DNA | Glutathione | Phosphatidylethanolamine | Liver diseases | Nutrition | 5-Methyltetrahydrofolate-homocysteine S-methyltransferase | Methionine | Glycine N-methyltransferase | c-Jun protein | Caspase | Betaine-homocysteine S-methyltransferase | Gene expression | Metabolism | Fatty acids | Lymphoma | Fatty-acid synthase | Cholesterol | Molecular chains | Substrates | Depletion | Lymphocytes B | Diet | Nitric oxide | Fibrosis | DNA methyltransferase | Methylation | Nuclear reactions | Polymethyl methacrylate | B-cell lymphoma | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights