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1. Full Text Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: A pilot, open-label study
by Mansur, Rodrigo B and Ahmed, Juhie and Cha, Danielle S and Woldeyohannes, Hanna O and Subramaniapillai, Mehala and Lovshin, Julie and Lee, Jung G and Lee, Jae-Hon and Brietzke, Elisa and Reininghaus, Eva Z and Sim, Kang and Vinberg, Maj and Rasgon, Natalie and Hajek, Tomas and McIntyre, Roger S
Journal of Affective Disorders, ISSN 0165-0327, 01/2017, Volume 207, pp. 114 - 120
There is a paucity of treatments that are capable of reliably and robustly improving cognitive function in adults with mood disorders. Glucagon-like peptide-1... 
Bipolar disorder | Insulin resistance | Glucagon-like peptide-1 | Cognition | Major depressive disorder | Liraglutide | PEPTIDE-1 RECEPTOR | AMYLOID DEPOSITION | PSYCHIATRY | ALZHEIMERS-DISEASE | CLINICAL NEUROLOGY | EXECUTIVE FUNCTION | INSULIN-RESISTANCE | DOUBLE-BLIND | HEART-RATE | IMPAIRED GLUCOSE-METABOLISM | Cognitive Dysfunction - drug therapy | Mood Disorders - drug therapy | Mood Disorders - psychology | Nausea - chemically induced | Verbal Learning | Humans | Middle Aged | Male | Treatment Outcome | Affect | Bipolar Disorder - drug therapy | Bipolar Disorder - psychology | Depressive Disorder, Major - psychology | Pilot Projects | Stroop Test | Liraglutide - therapeutic use | Cognitive Dysfunction - psychology | Adult | Female | Incretins - therapeutic use | Executive Function | Depressive Disorder, Major - drug therapy | Medical research | Neural circuitry | Glucagon | Medicine, Experimental | Cognition disorders | Psychiatric services | Psychophysiology | Depression, Mental
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2. Full Text Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's Disease dementia
by Claxton, Amy and Baker, Laura D and Hanson, Angela and Trittschuh, Emily H and Cholerton, Brenna and Morgan, Amy and Callaghan, Maureen and Arbuckle, Matthew and Behl, Colin and Craft, Suzanne
Journal of Alzheimer's Disease, ISSN 1387-2877, 2015, Volume 44, Issue 3, pp. 897 - 906
Previous trials have shown promising effects of intranasally administered insulin for adults with Alzheimer's disease dementia (AD) or amnestic mild cognitive... 
intranasal drug administration | clinical trials | mild cognitive impairment | insulin | Alzheimer's disease | randomized | AMYLOID PRECURSOR PROTEIN | APOLIPOPROTEIN-E GENOTYPE | NEUROSCIENCES | BETA | NPH INSULIN | THERAPY | MEMORY | GLUCOSE | RESISTANCE | ALBUMIN | BRAIN | Apolipoprotein E4 - genetics | Area Under Curve | Humans | Male | Insulin Detemir | Dose-Response Relationship, Drug | Hypoglycemic Agents - administration & dosage | Time Factors | Mental Status Schedule | Cognitive Dysfunction - genetics | Female | Cognitive Dysfunction - drug therapy | Glucose Tolerance Test | Alzheimer Disease - drug therapy | Memory, Short-Term - drug effects | Treatment Outcome | Administration, Intranasal | Psychomotor Disorders - drug therapy | Psychomotor Disorders - etiology | Neuropsychological Tests | Insulin - metabolism | Insulin, Long-Acting - administration & dosage | Analysis of Variance | Alzheimer Disease - genetics | Longitudinal Studies
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3. Full Text Vitamin E for Alzheimer's dementia and mild cognitive impairment
by Farina, Nicolas and Llewellyn, David and Isaac, Mokhtar Gad El Kareem Nasr and Tabet, Naji
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 01/2017, Volume 2017, Issue 1, pp. CD002854 - CD002854
Background Vitamin E occurs naturally in the diet. It has several biological activities, including functioning as an antioxidant to scavenge toxic free... 
Alzheimer Disease [drug therapy] | INCREASED OXIDATIVE DAMAGE | LIPID-PEROXIDATION | RANDOMIZED-CLINICAL-TRIAL | Humans | ALPHA-TOCOPHEROL | Cognitive Dysfunction [drug therapy] | CEREBROSPINAL-FLUID | MITOCHONDRIAL-DNA | E-SUPPLEMENTATION | Antioxidants [therapeutic use] | Disease Progression | Randomized Controlled Trials as Topic | MEDICINE, GENERAL & INTERNAL | Outcome Assessment ( Health Care) | ANTIOXIDANT VITAMINS | Vitamin E [therapeutic use] | DOUBLE-BLIND | FUNCTIONAL DECLINE | Cognitive Dysfunction - drug therapy | alpha-Tocopherol - therapeutic use | Antioxidants - therapeutic use | Outcome Assessment (Health Care) | Vitamin E - therapeutic use | Alzheimer Disease - drug therapy | Index Medicus
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4. Full Text Inflammation and gut-brain axis link obesity to cognitive dysfunction: plausible pharmacological interventions
by Solas, Maite and Milagro, Fermin I and Ramírez, María J and Martínez, J Alfredo
Current Opinion in Pharmacology, ISSN 1471-4892, 12/2017, Volume 37, pp. 87 - 92
Obesity prevalence is increasing steadily throughout the world's population in most countries and in parallel the prevalence of metabolic disorders including... 
METABOLIC SYNDROME | HIGH-FAT DIET | MICROBIOME | DISEASE | BODY-MASS INDEX | PHARMACOLOGY & PHARMACY | MECHANISMS | MICE | ADIPOSE-TISSUE | LIFE | IMPAIRMENT | Alzheimer Disease - microbiology | Cognitive Dysfunction - drug therapy | Inflammation - microbiology | Obesity - drug therapy | Humans | Alzheimer Disease - drug therapy | Obesity - microbiology | Anti-Obesity Agents - therapeutic use | Cognitive Dysfunction - microbiology | Brain - drug effects | Animals | Gastrointestinal Microbiome - drug effects | Anti-Inflammatory Agents - therapeutic use | Probiotics - therapeutic use
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5. Full Text Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy
by Pauletti, Alberto and Terrone, Gaetano and Shekh-Ahmad, Tawfeeq and Salamone, Alessia and Ravizza, Teresa and Rizzi, Massimo and Pastore, Anna and Pascente, Rosaria and Liang, Li-Ping and Villa, Bianca R and Balosso, Silvia and Abramov, Aney Y and van Vliet, Erwin A and del Giudice, Ennio and Aronica, Eleonora and Antoine, Daniel J and Patel, Manisha and Walker, Matthew C and Vezzani, Annamaria
Brain, ISSN 0006-8950, 2017, Volume 140, Issue 7, pp. 1885 - 1899
Epilepsy therapy is based on antiseizure drugs that treat the symptom, seizures, rather than the disease and are ineffective in up to 30% of patients. There... 
cognitive deficit | HMGB1 | neuronal cell loss | neuroinflammation | spontaneous seizures | KAINATE MODEL | TEMPORAL-LOBE EPILEPSY | ILAE COMMISSION | STATUS EPILEPTICUS | N-ACETYLCYSTEINE | NEUROSCIENCES | CLINICAL NEUROLOGY | CELL-DEATH | NITRIC-OXIDE | MOBILITY GROUP BOX-1 | SUPEROXIDE-DISMUTASE | Biomarkers - metabolism | Cognitive Dysfunction - drug therapy | Rats | Epilepsy - metabolism | Male | Nerve Degeneration - diet therapy | Biomarkers - blood | HMGB1 Protein - biosynthesis | HMG-Box Domains - drug effects | Hippocampus - metabolism | Animals | Isothiocyanates - therapeutic use | HMGB1 Protein - metabolism | Acetylcysteine - pharmacology | Epilepsy - drug therapy | Neurons - metabolism | Acetylcysteine - therapeutic use | Cognitive Dysfunction - complications | Oxidative Stress - drug effects | Drug Therapy, Combination | HMGB1 Protein - blood | Isothiocyanates - pharmacology | Astrocytes - metabolism | Disease Models, Animal | Editor's Choice | Original
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6. Full Text Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment
by Bakker, Arnold and Krauss, Gregory L and Albert, Marilyn S and Speck, Caroline L and Jones, Lauren R and Stark, Craig E and Yassa, Michael A and Bassett, Susan S and Shelton, Amy L and Gallagher, Michela
Neuron, ISSN 0896-6273, 05/2012, Volume 74, Issue 3, pp. 467 - 474
Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's disease, including amnestic mild cognitive impairment (aMCI).... 
PATTERN SEPARATION | NEURONAL-ACTIVITY | ACTIVATION | CODES | MEMORY | CA3 | HIGH-RESOLUTION FMRI | ALZHEIMERS-DISEASE | RISK | NEUROSCIENCES | Humans | Middle Aged | Male | Statistics as Topic | Hippocampus - drug effects | Case-Control Studies | Piracetam - therapeutic use | Aged, 80 and over | Female | Cognitive Dysfunction - drug therapy | Choice Behavior - drug effects | Hippocampus - blood supply | Double-Blind Method | Amnesia - complications | Nootropic Agents - therapeutic use | Cognitive Dysfunction - pathology | Cognitive Dysfunction - etiology | Oxygen - blood | Neuropsychological Tests | Magnetic Resonance Imaging | Image Processing, Computer-Assisted | Piracetam - analogs & derivatives | Brain Mapping | Aged | Photic Stimulation | Hippocampus - physiopathology | Studies | Hypothesis testing | Brain | Hypotheses | Hyperactivity | Memory | Cognitive ability | Drug dosages | Age | Animal cognition | Drugs | Animal models | Dentate gyrus | Scanning | Neurodegenerative diseases | Circuits | Alzheimer's disease | Etiracetam | Hippocampus
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7. Full Text Statins prevent cognitive impairment after sepsis by reverting neuroinflammation, and microcirculatory/endothelial dysfunction
by Reis, Patricia A and Alexandre, Pedro C.B and D’Avila, Joana C and Siqueira, Luciana D and Antunes, Barbara and Estato, Vanessa and Tibiriça, Eduardo V and Verdonk, Franck and Sharshar, Tarek and Chrétien, Fabrice and Castro-Faria-Neto, Hugo C and Bozza, Fernando A
Brain, Behavior, and Immunity, ISSN 0889-1591, 2016, Volume 60, pp. 293 - 303
Highlights • Sepsis induces neuroinflammation, endothelial dysfunction and cognitive decline in mice; • Statins prevent cognitive impairment after sepsis... 
Psychiatry | Allergy and Immunology | Sepsis | Neuroinflammation | Cognition | Statin | Endothelium | MORTALITY | PSYCHIATRY | RATS | MODEL | IMMUNOLOGY | NEUROSCIENCES | THERAPY | TRAUMATIC BRAIN-INJURY | DISEASE | MITOCHONDRIAL DYSFUNCTION | ROSUVASTATIN | Cognitive Dysfunction - drug therapy | Cytokines - metabolism | Male | Sepsis - complications | Hippocampus - drug effects | Blood-Brain Barrier - drug effects | Microcirculation - drug effects | Cognitive Dysfunction - prevention & control | Blood-Brain Barrier - metabolism | Hippocampus - metabolism | Sepsis - drug therapy | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Leukocytes - drug effects | Mice | Leukocytes - metabolism | Disease Models, Animal | Statins | Animal experimentation | Immunohistochemistry | Vasodilators | Analysis
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8. Full Text N-acetylcysteine in a double-blind randomized placebo-controlled trial: Toward biomarker-guided treatment in early psychosis
by Conus, Philippe and Seidman, Larry J and Fournier, Margot and Xin, Lijing and Cleusix, Martine and Baumann, Philipp S and Ferrari, Carina and Cousins, Ann and Alameda, Luis and Gholam-Rezaee, Mehdi and Golay, Philippe and Jenni, Raoul and Woo, T.-U. Wilson and Keshavan, Matcheri S and Eap, Chin B and Wojcik, Joanne and Cuenod, Michel and Buclin, Thierry and Gruetter, Rolf and Do, Kim Q
Schizophrenia Bulletin, ISSN 0586-7614, 03/2018, Volume 44, Issue 2, pp. 317 - 327
Biomarker-guided treatments are needed in psychiatry, and previous data suggest oxidative stress may be a target in schizophrenia. A previous add-on trial with... 
Glutathione peroxidase | Schizophrenia | Prefrontal cortex | Neurocognition | Glutathione | MRS | OXIDATIVE STRESS | neurocognition | NEGATIVE SYMPTOMS | PSYCHIATRY | glutathione | prefrontal cortex | NEUROCOGNITIVE DEFICITS | schizophrenia | CEREBROSPINAL-FLUID | 1ST-EPISODE SCHIZOPHRENIA | PHARMACOLOGICAL-TREATMENT | GLUTATHIONE PRECURSOR | ACETYL-CYSTEINE | glutathione peroxidase | CONSENSUS COGNITIVE BATTERY | Schizophrenia - metabolism | Outcome Assessment (Health Care) | Psychotic Disorders - complications | Humans | Male | Schizophrenia - complications | Young Adult | Glutathione Peroxidase | Psychotic Disorders - physiopathology | Prefrontal Cortex - drug effects | Glutathione - drug effects | Schizophrenia - physiopathology | Adult | Female | Acetylcysteine - administration & dosage | Cognitive Dysfunction - drug therapy | Double-Blind Method | Magnetic Resonance Spectroscopy | Oxidation-Reduction | Cognitive Dysfunction - metabolism | Antioxidants - pharmacology | Cognitive Dysfunction - etiology | Cognitive Dysfunction - physiopathology | Psychotic Disorders - metabolism | Acetylcysteine - pharmacology | Adolescent | Antioxidants - administration & dosage | Prefrontal Cortex - metabolism | Biomarkers | Psychotic Disorders - drug therapy | Schizophrenia - drug therapy | Regular
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9. Full Text Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study
by Yasar, Sevil and Xia, Jin and Yao, Wenliang and Furberg, Curt D and Xue, Qian-Li and Mercado, Carla I and Fitzpatrick, Annette L and Fried, Linda P and Kawas, Claudia H and Sink, Kaycee M and Williamson, Jeff D and DeKosky, Steven T and Carlson, Michelle C and GEM Study Investigators and Ginkgo Evaluation of Memory (GEM) Study Investigators and For the Ginkgo Evaluation of Memory (GEM) Study Investigators
Neurology, ISSN 0028-3878, 09/2013, Volume 81, Issue 10, pp. 896 - 903
OBJECTIVES:The aim of this study was to determine whether use of diuretics, angiotensin-1 receptor blockers (ARB), angiotensin-converting enzyme inhibitors... 
TRIAL | BILOBA | DEMENTIA | DOUBLE-BLIND | PREVENTION | MILD COGNITIVE IMPAIRMENT | HYPERTENSION | MIDLIFE BLOOD-PRESSURE | PROGRESSION | CLINICAL NEUROLOGY | MEDICATION USE | Cognitive Dysfunction - drug therapy | Memory - drug effects | Cognitive Dysfunction - ethnology | Double-Blind Method | Humans | Risk Factors | Calcium Channel Blockers - therapeutic use | Male | Antihypertensive Agents - therapeutic use | Ginkgo biloba | Alzheimer Disease - prevention & control | Alzheimer Disease - ethnology | Aged, 80 and over | Cognitive Dysfunction - psychology | Female | Aged | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Angiotensin Receptor Antagonists - therapeutic use | Longitudinal Studies | Alzheimer Disease - psychology | Memory - physiology
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10. Full Text Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients
by Ma, Qing and Ma, Qing and Vaida, Florin and Vaida, Florin and Wong, Jenna and Wong, Jenna and Sanders, Chelsea A and Sanders, Chelsea A and Kao, Yu-ting and Kao, Yu-ting and Croteau, David and Croteau, David and Clifford, David B and Clifford, David B and Collier, Ann C and Collier, Ann C and Gelman, Benjamin B and Gelman, Benjamin B and Marra, Christina M and Marra, Christina M and McArthur, Justin C and McArthur, Justin C and Morgello, Susan and Morgello, Susan and Simpson, David M and Simpson, David M and Heaton, Robert K and Heaton, Robert K and Grant, Igor and Grant, Igor and Letendre, Scott L and Letendre, Scott L and CHARTER Grp and CHARTER Group and for the CHARTER Group
Journal of NeuroVirology, ISSN 1355-0284, 4/2016, Volume 22, Issue 2, pp. 170 - 178
Neurocognitive (NC) complications continue to afflict a substantial proportion of HIV-infected people taking effective antiretroviral therapy (ART). One... 
Neurology | Neurosciences | Neurotoxicity | Biomedicine | Immunology | Lopinavir/ritonavir | Infectious Diseases | Long-term antiretroviral therapy | Efavirenz | Neurocognitive function | Hepatitis C virus coinfection | Virology | Long-termantiretroviral therapy | SUB-SAHARAN AFRICA | NEURONAL INJURY | COGNITIVE IMPAIRMENT | DISORDERS | VETERANS AGING COHORT | ANTIRETROVIRAL THERAPY | NEUROSCIENCES | INDIVIDUALS | VIROLOGY | NEUROPSYCHOLOGICAL PERFORMANCE | CENTRAL-NERVOUS-SYSTEM | HEPATITIS-C | Memory - drug effects | Verbal Learning - drug effects | Coinfection | Hepatitis C - drug therapy | Humans | Middle Aged | Male | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Hepatitis C - immunology | Cognitive Dysfunction - immunology | HIV-1 - physiology | Ritonavir - therapeutic use | Adult | Anti-HIV Agents - therapeutic use | Female | Hepacivirus - physiology | Hepatitis C - complications | Cognitive Dysfunction - complications | CD4-Positive T-Lymphocytes - virology | Drug Therapy, Combination | Cognitive Dysfunction - drug therapy | Benzoxazines - administration & dosage | Benzoxazines - adverse effects | CD4 Lymphocyte Count | Cognitive Dysfunction - physiopathology | Neuropsychological Tests | HIV Infections - complications | HIV Infections - drug therapy | Hepatitis C - physiopathology | Lopinavir - therapeutic use | HIV Infections - physiopathology | CD4-Positive T-Lymphocytes - drug effects | Executive Function - drug effects | Index Medicus | Lopinavir | ritonavir
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11. Vortioxetine: A Review in Cognitive Dysfunction in Depression
by Frampton, James E
Drugs, ISSN 0012-6667, 11/2016, Volume 76, Issue 17, pp. 1675 - 1682
Vortioxetine (Brintellix (R); Trintellix (R)), a generally efficacious and well tolerated antidepressant agent, is approved in the EU and USA for the treatment... 
N-BACK TASK | ANTIDEPRESSANT | EFFICACY | SAFETY | PERFORMANCE | TOLERABILITY | REDUCES BOLD SIGNAL | DOUBLE-BLIND | DISORDER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | ELDERLY-PATIENTS | Cognitive Dysfunction - drug therapy | Humans | Anti-Anxiety Agents - pharmacology | Sulfides - therapeutic use | Piperazines - therapeutic use | Cognition - drug effects |