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Biological & pharmaceutical bulletin, 2018, Volume 41, Issue 2, p. 272
Methylglyoxal, a highly reactive dicarbonyl compound, is formed as a by-product of glycolysis and plays an important role in the pathogenesis of diabetic... 
GTP-Binding Protein alpha Subunits, Gs - metabolism | Retina - drug effects | Oxadiazoles - administration & dosage | GTP-Binding Protein alpha Subunits, Gs - chemistry | Retina - metabolism | Injections, Intravenous | Pyruvaldehyde - administration & dosage | Intravitreal Injections | Albuterol - pharmacology | Male | Adrenergic beta-2 Receptor Agonists - pharmacology | Receptors, Adrenergic, beta-2 - chemistry | Dose-Response Relationship, Drug | Pyruvaldehyde - metabolism | Oxadiazoles - pharmacology | Albuterol - administration & dosage | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - agonists | Vasodilator Agents - pharmacology | Retinal Vessels - metabolism | Colforsin - pharmacology | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - antagonists & inhibitors | Colforsin - administration & dosage | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - metabolism | GTP-Binding Protein alpha Subunits, Gs - antagonists & inhibitors | Retinal Vessels - drug effects | Calcium Channel Blockers - pharmacology | Arterioles - drug effects | Rats, Sprague-Dawley | Receptors, Adrenergic, beta-2 - metabolism | Peptides - pharmacology | Calcium Channel Agonists - administration & dosage | Animals | Arterioles - metabolism | Adrenergic beta-2 Receptor Antagonists - administration & dosage | Adrenergic beta-2 Receptor Antagonists - metabolism | Adrenergic beta-2 Receptor Agonists - administration & dosage | Calcium Channel Agonists - pharmacology | Vasodilation - drug effects | Vasodilator Agents - administration & dosage
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2014, Volume 124, Issue 7, pp. 2935 - 2946
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 03/2008, Volume 177, Issue 5, pp. 506 - 515
Rationale: Sildenafil has been implicated in the activation of cystic fibrosis transmembrane conductance regulator (CFTR) protein. The effect was observed in... 
Nasal potential difference | Cystic fibrosis | Sildenafil | Chloride transport | Phosphodiesterase inhibitors | chloride transport | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | SODIUM-CHANNELS | PROTEIN-KINASE | sildenafil | TRANSMEMBRANE CONDUCTANCE REGULATOR | DELTA-F508 | nasal potential difference | RESPIRATORY SYSTEM | cystic fibrosis | MOUSE MODEL | NITRIC-OXIDE | INHIBITORS | phosphodiesterase inhibitors | ERECTILE DYSFUNCTION | CRITICAL CARE MEDICINE | Piperazines - administration & dosage | Phosphodiesterase 5 Inhibitors | Imidazoles - administration & dosage | Imidazoles - pharmacokinetics | Purines - administration & dosage | Sildenafil Citrate | Colforsin - metabolism | Chlorides - metabolism | Ion Transport - drug effects | Nasal Mucosa - metabolism | Piperazines - pharmacokinetics | Disease Models, Animal | Membrane Potentials - drug effects | Mice, Inbred CFTR | Phosphodiesterase Inhibitors - pharmacokinetics | Cystic Fibrosis - metabolism | Purines - pharmacokinetics | Injections, Intraperitoneal | Phosphodiesterase Inhibitors - pharmacology | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Sulfones - pharmacokinetics | Protein Modification, Translational | Phosphodiesterase Inhibitors - administration & dosage | Animals | Triazines - administration & dosage | Vardenafil Dihydrochloride | Mice | Sulfones - administration & dosage | Triazines - pharmacokinetics | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Alcohol & Alcoholism, ISSN 0735-0414, 2009, Volume 44, Issue 5, pp. 443 - 448
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2017, Volume 12, Issue 11, pp. e0178881 - e0178881
Glioma is the most malignant type of primary central nervous system tumors, and has an extremely poor prognosis. One potential therapeutic approach is to... 
NEURAL STEM-CELLS | FUNCTIONAL-NEURONS | MULTIDISCIPLINARY SCIENCES | MOUSE | HUMAN FIBROBLASTS | GENERATION | BRAIN | Optical Imaging | Small Molecule Libraries - administration & dosage | Humans | Glioma - genetics | Glioma - pathology | Cyclic AMP - genetics | Neurons - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Neurons - drug effects | Pyridines - administration & dosage | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Pyrimidines - administration & dosage | Rats | Colforsin - administration & dosage | Cellular Reprogramming - drug effects | Xenograft Model Antitumor Assays | Cyclic AMP - antagonists & inhibitors | Animals | Glycogen Synthase Kinase 3 - genetics | Signal Transduction - drug effects | Cell Differentiation - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Glioma - drug therapy | Care and treatment | Glycogen | Gliomas | Physiological aspects | Genetic aspects | Cyclic adenylic acid | Research | Drugs | Biotechnology | Spinal cord | Transcription factors | Laboratories | Brain tumors | Brain cancer | Cytology | Central nervous system | Neurosurgery | Gliogenesis | Kinases | Angiogenesis | Signal transduction | Antitumor agents | Pathways | Rodents | Fibroblasts | Life sciences | Growth factors | Medical research | Adenosine monophosphate | AMP | Neurons | Therapeutic applications | Cyclic AMP | Cell division | Glycogen synthase kinase 3 | Gene expression | Conversion | Neurological diseases | Medicine | Studies | Signaling | Inhibitors | Glioma | Stem cells | Forskolin | Alzheimers disease | Tumors | Index Medicus
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 06/2010, Volume 35, Issue 7, pp. 1605 - 1617
The mossy fiber synapses onto hippocampal CA3 neurons show unique molecular features and a wide dynamic range of plasticity. Although acute stress has been... 
Mossy fiber | Adenosine | Long-term potentiation | CAMP | Stress | Phosphodiesterase | stress | PSYCHIATRY | BEHAVIORAL STRESS | LTP | cAMP | SYNAPTIC PLASTICITY | NEUROSCIENCES | adenosine | CYCLIC-AMP | 2 FORMS | SYNAPSES | RECEPTOR ACTIVATION | PHARMACOLOGY & PHARMACY | RAT HIPPOCAMPUS | phosphodiesterase | mossy fiber | DENTATE GYRUS | long-term potentiation | Corticosterone - administration & dosage | Synaptosomes - drug effects | Stress, Psychological - prevention & control | Electric Stimulation | Spironolactone - administration & dosage | Biophysical Phenomena - drug effects | Male | Hippocampus - drug effects | Synaptosomes - metabolism | Xanthines - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Excitatory Postsynaptic Potentials - physiology | Mossy Fibers, Hippocampal - physiopathology | Long-Term Potentiation - drug effects | Long-Term Potentiation - physiology | Anti-Inflammatory Agents - administration & dosage | Corticosterone - blood | Spironolactone - analogs & derivatives | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Mineralocorticoid Receptor Antagonists - administration & dosage | Colforsin - pharmacology | Mice, Inbred C57BL | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology | Hippocampus - pathology | Cyclic AMP - pharmacology | Stress, Psychological - pathology | Phosphodiesterase Inhibitors - administration & dosage | Animals | Adrenalectomy - methods | Mice | In Vitro Techniques | Index Medicus | Plasticity | Glutamate | Original | Biological Psychiatry | Neurophysiology
Journal Article