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European Journal of Pharmacology, ISSN 0014-2999, 2009, Volume 607, Issue 1, pp. 135 - 142
Journal Article
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 12/2017, Volume 25, Issue 12, pp. 1952 - 1961
To investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ABT-981, a human dual variable domain immunoglobulin simultaneously... 
ABT-981 | Interleukin-1 | Safety | Osteoarthritis | Pharmacokinetic | Clinical study | RHEUMATOID-ARTHRITIS | CYTOKINES | INTERLEUKIN-1 RECEPTOR ANTAGONIST | RECOMBINANT INTERLEUKIN-1 | RHEUMATOLOGY | III COLLAGENS | CARTILAGE | COLLAGENASE PRODUCTION | DOUBLE-BLIND | ORTHOPEDICS | EXPRESSION | Interleukin-1beta - drug effects | Neutrophils - cytology | Vimentin - drug effects | Collagen Type II - drug effects | Vimentin - metabolism | Humans | Middle Aged | Collagen Type III - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | Collagen Type II - metabolism | C-Reactive Protein - metabolism | Peptides - metabolism | Injections, Subcutaneous | Female | C-Reactive Protein - drug effects | Leukocyte Count | Vascular Endothelial Growth Factor A - drug effects | Aggrecans - drug effects | Interleukin-1beta - antagonists & inhibitors | Citrullination | Severity of Illness Index | Immunoglobulins - pharmacology | Cartilage Oligomeric Matrix Protein - drug effects | Collagen Type I - metabolism | Injection Site Reaction | Interleukin-1alpha - antagonists & inhibitors | Aggrecans - metabolism | Collagen Type III - drug effects | Peptides - drug effects | Cartilage Oligomeric Matrix Protein - metabolism | Collagen Type I - drug effects | Aged | Erythema | Immunoglobulins - therapeutic use | Osteoarthritis, Knee - drug therapy | Osteoarthritis, Knee - metabolism
Journal Article
Journal of Periodontology, ISSN 0022-3492, 06/2012, Volume 83, Issue 6, pp. 787 - 796
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 10/2007, Volume 25, Issue 28, pp. 4431 - 4437
Journal Article
Journal of Periodontal Research, ISSN 0022-3484, 06/2012, Volume 47, Issue 3, pp. 299 - 308
Lee S‐I, Kang K‐L, Shin S‐I, Herr Y, Lee Y‐M, Kim E‐C. Endoplasmic reticulum stress modulates nicotine‐induced extracellular matrix degradation in human... 
matrix metalloproteinase | nicotine | cell death | endoplasmic reticulum stress | extracellular matrix | Extracellular matrix | Matrix metalloproteinase | Cell death | Endoplasmic reticulum stress | Nicotine | APOPTOSIS | ER STRESS | TISSUE INHIBITORS | GINGIVAL CREVICULAR FLUID | FACTOR-KAPPA-B | METALLOPROTEINASES | JNK ACTIVATION | DENTISTRY, ORAL SURGERY & MEDICINE | CIGARETTE-SMOKE CONDENSATE | GENE-EXPRESSION | PC12 CELLS | Transcription Factor CHOP - genetics | Apoptosis - drug effects | Matrix Metalloproteinase 8 - drug effects | Humans | Thiourea - pharmacology | Periodontal Ligament - drug effects | Periodontal Ligament - cytology | Transcription Factor CHOP - drug effects | Matrix Metalloproteinase 2 - drug effects | Periodontal Ligament - enzymology | Matrix Metalloproteinases - drug effects | Endoplasmic Reticulum - drug effects | CCAAT-Enhancer-Binding Proteins - drug effects | Cell Death - drug effects | Endoplasmic Reticulum - enzymology | Eukaryotic Initiation Factor-2 - antagonists & inhibitors | Cell Line | Cell Survival - drug effects | Matrix Metalloproteinase 1 - drug effects | Protein Kinases - analysis | Endoplasmic Reticulum Stress - drug effects | Extracellular Matrix - drug effects | Heat-Shock Proteins - drug effects | RNA, Small Interfering - pharmacology | Elastin - drug effects | Fibronectins - drug effects | Nicotine - toxicity | Cinnamates - pharmacology | Nicotine - antagonists & inhibitors | Extracellular Matrix - enzymology | MAP Kinase Signaling System - drug effects | Collagen Type I - drug effects | Eukaryotic Initiation Factor-2 - drug effects | Matrix Metalloproteinase 9 - drug effects | Thiourea - analogs & derivatives | NF-kappa B - drug effects | Proto-Oncogene Proteins c-akt - drug effects
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 08/2016, Volume 311, Issue 2, pp. E335 - E345
It has been argued whether insulin accelerates or prevents atherosclerosis. Although results from in vitro studies have been conflicting, recent in vivo mice... 
Apolipoprotein E-null mice | Nitric oxide synthase | Insulin | Atherosclerosis | atherosclerosis | ARTERIAL INJURY | PHYSIOLOGY | insulin | ATTENUATES ATHEROSCLEROSIS | apolipoprotein E-null mice | ACCELERATES ATHEROSCLEROSIS | ENDOTHELIAL-CELLS | DEFICIENT | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | SMOOTH-MUSCLE-CELLS | nitric oxide synthase | CORONARY-HEART-DISEASE | NEOINTIMAL GROWTH | EXPRESSION | Phosphoproteins - drug effects | Actins - metabolism | Nitric Oxide Synthase - drug effects | Actins - drug effects | Male | Aorta - metabolism | Phosphoproteins - metabolism | Necrosis | Sinus of Valsalva - metabolism | Collagen - drug effects | Nitric Oxide Synthase Type III - metabolism | Sinus of Valsalva - pathology | Plaque, Atherosclerotic - pathology | NG-Nitroarginine Methyl Ester - pharmacology | Insulin - pharmacology | Macrophages - pathology | Plaque, Atherosclerotic - metabolism | Aorta - drug effects | Enzyme Inhibitors - pharmacology | Hypoglycemic Agents - pharmacology | Mice, Knockout | Aorta - pathology | Collagen - metabolism | Animals | Sinus of Valsalva - drug effects | Apolipoproteins E - genetics | Nitric Oxide Synthase Type I - metabolism | Macrophages - drug effects | Mice | Nitric Oxide Synthase - metabolism | Nitric Oxide Synthase Type I - drug effects | Nitric Oxide Synthase Type III - drug effects | Physiological aspects | Atherosclerotic plaque | Nitric oxide
Journal Article
The American Journal of Pathology, ISSN 0002-9440, 2004, Volume 165, Issue 1, pp. 237 - 246
Journal Article
by He, W and Zhang, J and Niu, Z and Yu, Q and Wang, Z and Zhang, R and Su, L and Fu, L and Smith, A.J and Cooper, P.R
Journal of Dental Research, ISSN 0022-0345, 5/2014, Volume 93, Issue 5, pp. 496 - 501
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2008, Volume 579, Issue 1, pp. 40 - 49
Osteoporosis is a reduction in skeletal mass due to an imbalance between bone resorption and bone formation. Bone morphogenetic protein (BMP) plays important... 
Bone morphogenetic protein | p38 | Osteoblasts | Coumarin | ERK | OSTHOLE | ACTIVATION | coumarin | KINASE | ANGELICA-PUBESCENS | RECEPTOR | FIBRILLOGENESIS | bone morphogenetic protein | IN-VITRO | RAT OSTEOBLASTS | PHARMACOLOGY & PHARMACY | osteoblasts | GROWTH-FACTOR | CELL-DIFFERENTIATION | Phosphorylation | Extracellular Signal-Regulated MAP Kinases - drug effects | Alkaline Phosphatase - metabolism | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Smad Proteins, Receptor-Regulated - drug effects | Bone Morphogenetic Proteins - metabolism | Transforming Growth Factor beta - drug effects | Bone Morphogenetic Proteins - drug effects | Tibia - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | RNA, Messenger - drug effects | Collagen Type I - metabolism | Furocoumarins - pharmacology | Bone Morphogenetic Protein 2 | Osteoblasts - drug effects | Osteogenesis - drug effects | Cells, Cultured | Rats | Smad Proteins, Receptor-Regulated - metabolism | Methoxsalen - analogs & derivatives | Reverse Transcriptase Polymerase Chain Reaction | Tibia - drug effects | Rats, Sprague-Dawley | Alkaline Phosphatase - drug effects | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | Methoxsalen - pharmacology | Collagen Type I - drug effects | Osteoblasts - metabolism | Transforming Growth Factor beta - metabolism
Journal Article