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Osteoarthritis and Cartilage, ISSN 1063-4584, 12/2017, Volume 25, Issue 12, pp. 1952 - 1961
To investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ABT-981, a human dual variable domain immunoglobulin simultaneously... 
ABT-981 | Interleukin-1 | Safety | Osteoarthritis | Pharmacokinetic | Clinical study | RHEUMATOID-ARTHRITIS | CYTOKINES | INTERLEUKIN-1 RECEPTOR ANTAGONIST | RECOMBINANT INTERLEUKIN-1 | RHEUMATOLOGY | III COLLAGENS | CARTILAGE | COLLAGENASE PRODUCTION | DOUBLE-BLIND | ORTHOPEDICS | EXPRESSION | Interleukin-1beta - drug effects | Neutrophils - cytology | Vimentin - drug effects | Collagen Type II - drug effects | Vimentin - metabolism | Humans | Middle Aged | Collagen Type III - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | Collagen Type II - metabolism | C-Reactive Protein - metabolism | Peptides - metabolism | Injections, Subcutaneous | Female | C-Reactive Protein - drug effects | Leukocyte Count | Vascular Endothelial Growth Factor A - drug effects | Aggrecans - drug effects | Interleukin-1beta - antagonists & inhibitors | Citrullination | Severity of Illness Index | Immunoglobulins - pharmacology | Cartilage Oligomeric Matrix Protein - drug effects | Collagen Type I - metabolism | Injection Site Reaction | Interleukin-1alpha - antagonists & inhibitors | Aggrecans - metabolism | Collagen Type III - drug effects | Peptides - drug effects | Cartilage Oligomeric Matrix Protein - metabolism | Collagen Type I - drug effects | Aged | Erythema | Immunoglobulins - therapeutic use | Osteoarthritis, Knee - drug therapy | Osteoarthritis, Knee - metabolism
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 24, Issue 2, pp. 315 - 324
Summary Objective The aetiology of OA is not fully understood although several adipokines such as leptin are known mediators of disease progression. Since... 
Rheumatology | Smad1 | Human chondrocytes | Hip osteoarthritis | β-Catenin | Dedifferentiation | Leptin | COLLAGEN | RHEUMATOLOGY | DIFFERENTIATED PHENOTYPE | HYPERTROPHY | IN-VITRO | SYNOVIAL FIBROBLASTS | HUMAN OSTEOARTHRITIC CARTILAGE | SIGNALING PATHWAY | beta-Catenin | ARTICULAR CHONDROCYTES | ORTHOPEDICS | KNEE OSTEOARTHRITIS | EXPRESSION | Receptors, Transforming Growth Factor beta - genetics | Humans | Leptin - metabolism | Middle Aged | Male | Lymphotoxin-alpha - metabolism | RNA, Messenger - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Lymphotoxin-alpha - genetics | Cartilage, Articular - metabolism | Smad5 Protein - metabolism | Smad2 Protein - genetics | Aged, 80 and over | Smad2 Protein - drug effects | Protein-Serine-Threonine Kinases - metabolism | Collagen Type X - drug effects | SOX9 Transcription Factor - metabolism | Matrix Metalloproteinase 13 - genetics | Smad2 Protein - metabolism | Prednisolone - pharmacology | beta Catenin - metabolism | Matrix Metalloproteinase 13 - metabolism | Glycogen Synthase Kinase 3 - genetics | Receptors, Transforming Growth Factor beta - drug effects | Activin Receptors, Type II - genetics | Protein-Serine-Threonine Kinases - drug effects | Activin Receptors, Type II - metabolism | Osteoarthritis, Hip - metabolism | Glycogen Synthase Kinase 3 - drug effects | Activin Receptors, Type II - drug effects | Chondrocytes - drug effects | Collagen Type X - metabolism | beta Catenin - drug effects | Smad1 Protein - genetics | Adult | Female | Smad5 Protein - genetics | Chondrocytes - metabolism | RNA, Messenger - drug effects | Cell Dedifferentiation - drug effects | Cartilage, Articular - cytology | Lymphotoxin-alpha - drug effects | Protein-Serine-Threonine Kinases - genetics | Collagen Type X - genetics | SOX9 Transcription Factor - drug effects | Matrix Metalloproteinase 13 - drug effects | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - genetics | Osteoarthritis, Hip - genetics | Smad5 Protein - drug effects | Core Binding Factor Alpha 1 Subunit - drug effects | Wnt Signaling Pathway - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Wnt Signaling Pathway - genetics | Glucocorticoids - pharmacology | Smad1 Protein - metabolism | Aged | Smad1 Protein - drug effects | Cartilage, Articular - drug effects | In Vitro Techniques | Cell Dedifferentiation - genetics | Core Binding Factor Alpha 1 Subunit - genetics
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 24, Issue 1, pp. 178 - 187
Summary Objective To determine whether mandibular condylar cartilage degradation induced by experimentally abnormal occlusion could be ameliorated via systemic... 
Rheumatology | Strontium | Cartilage | Subchondral bone | NBD (NEMO-binding domain) peptide | Temporomandibular joint | Osteoarthritis | Dental occlusion | TGF-BETA | CHONDROCYTES | BLOCKS OSTEOCLASTOGENESIS | RHEUMATOLOGY | TRABECULAR BONE | SUBCHONDRAL BONE LOSS | RANELATE | INHIBITION | TEMPOROMANDIBULAR-JOINT | ORTHOPEDICS | NF-KAPPA-B | KNEE OSTEOARTHRITIS | Immunohistochemistry | RANK Ligand - metabolism | Collagen Type II - drug effects | Tumor Necrosis Factor-alpha - genetics | ADAM Proteins - drug effects | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Proteoglycans - drug effects | Collagen Type II - metabolism | Cartilage, Articular - metabolism | Interleukin-1beta - metabolism | Malocclusion | Receptor Activator of Nuclear Factor-kappa B - metabolism | Aggrecans - drug effects | Real-Time Polymerase Chain Reaction | ADAMTS5 Protein | NF-KappaB Inhibitor alpha | Proteoglycans - metabolism | I-kappa B Proteins - drug effects | Aggrecans - metabolism | ADAM Proteins - metabolism | Tumor Necrosis Factor-alpha - drug effects | Strontium - pharmacology | Mice | Osteoprotegerin - metabolism | ADAM Proteins - genetics | Interleukin-1beta - drug effects | Tumor Necrosis Factor-alpha - metabolism | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Receptor Activator of Nuclear Factor-kappa B - drug effects | Transcription Factor RelA - genetics | RANK Ligand - drug effects | Mandibular Condyle - pathology | Osteoprotegerin - genetics | Female | Mandibular Condyle - drug effects | Osteoprotegerin - drug effects | RNA, Messenger - drug effects | Mice, Inbred C57BL | Aggrecans - genetics | Osteoclasts - metabolism | Collagen Type II - genetics | Peptides - pharmacology | RANK Ligand - genetics | Animals | Transcription Factor RelA - metabolism | Receptor Activator of Nuclear Factor-kappa B - genetics | Transcription Factor RelA - drug effects | Cartilage, Articular - drug effects | Mandibular Condyle - metabolism | Dental Occlusion | Osteoclasts - drug effects | Peptides
Journal Article
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 24, Issue 2, pp. 325 - 334
Summary Objective Norepinephrine (NE) was measured in synovial fluid of trauma patients and sympathetic nerve fibers were detected in healthy and... 
Rheumatology | Norepinephrine | IL-1β | Sympathetic nervous system | Osteoarthritis | Articular chondrocytes | APOPTOSIS | STEM-CELLS | IL-1 beta | CHONDROGENIC DIFFERENTIATION | RHEUMATOLOGY | CARTILAGE | SYMPATHETIC-NERVE FIBERS | BONE | SUBSTANCE-P | RECEPTORS | ORTHOPEDICS | EXPRESSION | Immunohistochemistry | Norepinephrine - pharmacology | Tyrosine 3-Monooxygenase - metabolism | Interleukin-1beta - pharmacology | Collagen Type II - drug effects | Chondrocytes - immunology | Humans | Middle Aged | Interleukin-8 - drug effects | Male | Collagen Type II - metabolism | Chondrocytes - drug effects | Receptors, Adrenergic, alpha - drug effects | Receptors, Adrenergic - drug effects | Matrix Metalloproteinases - drug effects | Interleukins - immunology | Polymerase Chain Reaction | Aged, 80 and over | Female | Osteoarthritis, Knee - immunology | Cell Culture Techniques | Receptors, Adrenergic, beta - drug effects | Receptors, Adrenergic, beta - metabolism | Chondrocytes - metabolism | Receptors, Adrenergic, alpha - metabolism | Tissue Inhibitor of Metalloproteinases - drug effects | Cartilage, Articular - cytology | Glycosaminoglycans - metabolism | Receptors, Adrenergic - metabolism | Inflammation | Matrix Metalloproteinase 13 - drug effects | Tyrosine 3-Monooxygenase - drug effects | Knee Joint - cytology | Tissue Inhibitor of Metalloproteinases - metabolism | Matrix Metalloproteinase 13 - metabolism | Adrenergic alpha-Agonists - pharmacology | Aged | Matrix Metalloproteinases - metabolism | Interleukin-8 - immunology | Osteoarthritis, Knee - metabolism | Physiological aspects | Noradrenaline
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2013, Volume 21, Issue 7, pp. 990 - 998
Summary Objective Pro-inflammatory cytokines play an important role in inducing cartilage degradation during osteoarthritis pathogenesis. Muscle is a tissue... 
Rheumatology | Cartilage tissue engineering | Myokines | Pro-inflammatory | Cytokines | Osteoarthritis | Stem cells | CARTILAGE METABOLISM | SILK SCAFFOLDS | INTERLEUKIN-1-BETA | NECROSIS-FACTOR-ALPHA | RHEUMATOLOGY | ANABOLIC CYTOKINES | MESENCHYMAL STEM-CELLS | DEGENERATION | SKELETAL-MUSCLE | DIFFERENTIATION | ORTHOPEDICS | Cell Cycle Proteins - drug effects | Gene Products, gag - drug effects | Chondrocytes - cytology | Interleukin-1beta - pharmacology | Apoptosis - drug effects | Collagen Type II - drug effects | Humans | Caspase 3 - metabolism | Ki-67 Antigen - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Case-Control Studies | Collagen Type II - metabolism | Chondrocytes - drug effects | Myoblasts - drug effects | Mesenchymal Stromal Cells - cytology | Myoblasts - metabolism | Collagen Type X - metabolism | Matrix Metalloproteinases - drug effects | Myoblasts - cytology | Aggrecans - drug effects | Chondrocytes - metabolism | Collagen Type X - drug effects | Fibroblasts - metabolism | Mesenchymal Stromal Cells - drug effects | Cell Cycle Proteins - metabolism | Mesenchymal Stromal Cells - metabolism | Aggrecans - metabolism | Gene Products, gag - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Core Binding Factor Alpha 1 Subunit - drug effects | Fibroblasts - drug effects | Cell Proliferation - drug effects | Fibroblasts - cytology | Matrix Metalloproteinases - metabolism | Developmental biology
Journal Article
European Urology, ISSN 0302-2838, 2016, Volume 70, Issue 6, pp. 1032 - 1041
Journal Article
Journal Article