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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2014, Volume 289, Issue 36, pp. 24898 - 24910
Indian hedgehog (Ihh) is essential for chondrocyte differentiation and endochondral ossification and acts with parathyroid hormone-related peptide in a... 
OSTEOBLAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | PTH/PTHRP RECEPTOR | IHH | GENE-REGULATION | GROWTH-PLATE | RUNX2 CONTRIBUTES | CIS-ENHANCER | BONE-DEVELOPMENT | CHONDROCYTE DIFFERENTIATION | Oncogene Proteins - genetics | Chondrocytes - cytology | Humans | Zinc Finger Protein Gli2 | Cercopithecus aethiops | Hedgehog Proteins - metabolism | Molecular Sequence Data | Immunoblotting | Core Binding Factor Alpha 1 Subunit - metabolism | Promoter Regions, Genetic - genetics | Collagen Type X - metabolism | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | Base Sequence | HEK293 Cells | Smad1 Protein - genetics | Trans-Activators - genetics | Chondrocytes - metabolism | Cell Line | Signal Transduction | Gene Expression Regulation | Oncogene Proteins - metabolism | Collagen Type X - genetics | Reverse Transcriptase Polymerase Chain Reaction | Microscopy, Confocal | Animals | Cell Line, Tumor | Protein Binding | Smad1 Protein - metabolism | Trans-Activators - metabolism | Mice | Zinc Finger Protein GLI1 | COS Cells | Kruppel-Like Transcription Factors - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Gene Regulation | Smads | Chondrocyte | Transcription | Maturation | Calcification | Gli2-responsive Element | Col10a1 | Differentiation | Hedgehog Signaling Pathway | Gli1 | Runx2
Journal Article
Developmental Cell, ISSN 1534-5807, 03/2012, Volume 22, Issue 3, pp. 597 - 609
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2012, Volume 287, Issue 31, pp. 26060 - 26067
Journal Article
European Cells and Materials, ISSN 1473-2262, 2012, Volume 24, pp. 118 - 135
Chondrocyte hypertrophy is one of the key physiological processes involved in the longitudinal growth of long bones, yet regulation of hypertrophy is becoming... 
Epigenetics | Hypoxia | Chondrogenesis | Co-culture | Biomaterials | Hypertrophy | Mesenchymal stem cells | hypoxia | TRANSCRIPTION FACTOR RUNX2 | MATERIALS SCIENCE, BIOMATERIALS | HORMONE-RELATED PEPTIDE | REDUCED OXYGEN-TENSION | PROMOTES CHONDROGENIC DIFFERENTIATION | ENGINEERING, BIOMEDICAL | BONE-MARROW | HUMAN ARTICULAR CHONDROCYTES | epigenetics | CELL & TISSUE ENGINEERING | GROWTH-PLATE CHONDROCYTES | IN-VITRO CHONDROGENESIS | coculture | mesenchymal stem cells | GENE-EXPRESSION | PARATHYROID-HORMONE | chondrogenesis | biomaterials | ORTHOPEDICS | Bone and Bones - pathology | Matrix Metalloproteinases - genetics | Cartilage - pathology | Epigenesis, Genetic | Humans | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Core Binding Factor Alpha 1 Subunit - metabolism | Cell Differentiation - genetics | Collagen Type X - metabolism | Bone and Bones - metabolism | Osteoarthritis - pathology | Mesenchymal Stem Cells - metabolism | Chondrocytes - metabolism | Chondrocytes - pathology | Gene Expression Regulation | Osteoarthritis - metabolism | Collagen Type X - genetics | Signal Transduction - genetics | Cartilage - metabolism | Osteoarthritis - genetics | Mesenchymal Stem Cells - pathology | Matrix Metalloproteinases - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | co-culture
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 10/2016, Volume 68, Issue 10, pp. 2432 - 2443
Journal Article
Journal Article
Matrix Biology, ISSN 0945-053X, 09/2018, Volume 70, pp. 102 - 122
Intervertebral disc degeneration and associated low back and neck pain is a ubiquitous health condition that affects millions of people world-wide, and causes... 
Animal models | SM/J | LG/J | Intervertebral disc degeneration | Matrix degradation | Nucleus pulposus | Hypertrophy | LOW-BACK-PAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | INBRED STRAINS | BONE MICROSTRUCTURE | MECHANICAL-PROPERTIES | LUMBAR | AGGRECAN | CELL BIOLOGY | NUCLEUS PULPOSUS CELLS | ARTICULAR-CARTILAGE | MICE | EXPRESSION | Annulus Fibrosus - metabolism | Humans | Alkaline Phosphatase - metabolism | Pyrophosphatases - genetics | Extracellular Matrix - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Wnt Proteins - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Intervertebral Disc Degeneration - metabolism | Intervertebral Disc Degeneration - pathology | Collagen Type X - metabolism | Wnt Proteins - genetics | Annulus Fibrosus - pathology | Cell Death | Female | Chondrocytes - metabolism | Disease Models, Animal | Intervertebral Disc Degeneration - genetics | Chondrocytes - pathology | Alkaline Phosphatase - genetics | Phosphoric Diester Hydrolases - metabolism | Nucleus Pulposus - metabolism | Signal Transduction | Glycosaminoglycans - metabolism | Matrix Metalloproteinase 13 - genetics | Gene Expression Regulation | Nucleus Pulposus - pathology | Collagen Type X - genetics | Mice, Transgenic | Phosphoric Diester Hydrolases - genetics | Aggrecans - metabolism | Aggrecans - genetics | Matrix Metalloproteinase 13 - metabolism | Pyrophosphatases - metabolism | Animals | Connective Tissue Growth Factor - genetics | Mice | Extracellular Matrix - pathology | Connective Tissue Growth Factor - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Homeostasis - genetics | Physiological aspects | Endothelial growth factors | Cell death | Collagen | Analysis | Cells | intervertebral disc degeneration | matrix degradation | hypertrophy | nucleus pulposus
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 24, Issue 2, pp. 315 - 324
Summary Objective The aetiology of OA is not fully understood although several adipokines such as leptin are known mediators of disease progression. Since... 
Rheumatology | Smad1 | Human chondrocytes | Hip osteoarthritis | β-Catenin | Dedifferentiation | Leptin | COLLAGEN | RHEUMATOLOGY | DIFFERENTIATED PHENOTYPE | HYPERTROPHY | IN-VITRO | SYNOVIAL FIBROBLASTS | HUMAN OSTEOARTHRITIC CARTILAGE | SIGNALING PATHWAY | beta-Catenin | ARTICULAR CHONDROCYTES | ORTHOPEDICS | KNEE OSTEOARTHRITIS | EXPRESSION | Receptors, Transforming Growth Factor beta - genetics | Humans | Leptin - metabolism | Middle Aged | Male | Lymphotoxin-alpha - metabolism | RNA, Messenger - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Lymphotoxin-alpha - genetics | Cartilage, Articular - metabolism | Smad5 Protein - metabolism | Smad2 Protein - genetics | Aged, 80 and over | Smad2 Protein - drug effects | Protein-Serine-Threonine Kinases - metabolism | Collagen Type X - drug effects | SOX9 Transcription Factor - metabolism | Matrix Metalloproteinase 13 - genetics | Smad2 Protein - metabolism | Prednisolone - pharmacology | beta Catenin - metabolism | Matrix Metalloproteinase 13 - metabolism | Glycogen Synthase Kinase 3 - genetics | Receptors, Transforming Growth Factor beta - drug effects | Activin Receptors, Type II - genetics | Protein-Serine-Threonine Kinases - drug effects | Activin Receptors, Type II - metabolism | Osteoarthritis, Hip - metabolism | Glycogen Synthase Kinase 3 - drug effects | Activin Receptors, Type II - drug effects | Chondrocytes - drug effects | Collagen Type X - metabolism | beta Catenin - drug effects | Smad1 Protein - genetics | Adult | Female | Smad5 Protein - genetics | Chondrocytes - metabolism | RNA, Messenger - drug effects | Cell Dedifferentiation - drug effects | Cartilage, Articular - cytology | Lymphotoxin-alpha - drug effects | Protein-Serine-Threonine Kinases - genetics | Collagen Type X - genetics | SOX9 Transcription Factor - drug effects | Matrix Metalloproteinase 13 - drug effects | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - genetics | Osteoarthritis, Hip - genetics | Smad5 Protein - drug effects | Core Binding Factor Alpha 1 Subunit - drug effects | Wnt Signaling Pathway - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Wnt Signaling Pathway - genetics | Glucocorticoids - pharmacology | Smad1 Protein - metabolism | Aged | Smad1 Protein - drug effects | Cartilage, Articular - drug effects | In Vitro Techniques | Cell Dedifferentiation - genetics | Core Binding Factor Alpha 1 Subunit - genetics
Journal Article
Journal Article