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1. Full Text TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study
by Plenge, Robert M and Seielstad, Mark and Padyukov, Leonid and Lee, Annette T and Remmers, Elaine F and Ding, Bo and Liew, Anthony and Khalili, Houman and Chandrasekaran, Alamelu and Davies, Leela R.L and Li, Wentian and Tan, Adrian K.S and Bonnard, Carine and Ong, Rick T.H and Thalamuthu, Anbupalam and Pettersson, Sven and Liu, Chunyu and Tian, Chao and Chen, Wei V and Carulli, John P and Beckman, Evan M and Altshuler, David and Alfredsson, Lars and Criswell, Lindsey A and Amos, Christopher I and Seldin, Michael F and Kastner, Daniel L and Klareskog, Lars and Gregersen, Peter K
The New England Journal of Medicine, ISSN 0028-4793, 09/2007, Volume 357, Issue 12, pp. 1199 - 1209
A genomewide association study of North American and Swedish patients with rheumatoid arthritis who were seropositive for autoantibodies against cyclic... 
COLLAGEN-INDUCED ARTHRITIS | MEDICINE, GENERAL & INTERNAL | FAMILIES | SHARED EPITOPE | POWER | MONOCLONAL-ANTIBODY | PTPN22 | WIDE ASSOCIATION | LINKAGE | IDENTIFICATION | SUSCEPTIBILITY GENES | Complement C5 - genetics | Genetic Predisposition to Disease | Protein Tyrosine Phosphatase, Non-Receptor Type 22 | Autoantibodies - blood | Humans | Risk Factors | TNF Receptor-Associated Factor 1 - genetics | Genotype | Logistic Models | Peptides, Cyclic - immunology | Chromosome Mapping | Sequence Analysis, DNA | Case-Control Studies | HLA-DR Antigens - genetics | Linkage Disequilibrium | Chromosomes, Human, Pair 9 - genetics | Arthritis, Rheumatoid - genetics | Protein Tyrosine Phosphatases - genetics | HLA-DRB1 Chains | Polymorphism, Single Nucleotide | Arthritis, Rheumatoid - immunology | Quantitative trait loci | Tumor necrosis factor | Rheumatoid arthritis | Physiological aspects | Genetic aspects | Research | Risk factors | Genealogy | Disease | Rheumatology | Rheumatic diseases | Genetics | Genomes | Index Medicus | Abridged Index Medicus
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2. Full Text MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis
by Mariola Kurowska-Stolarska and Stefano Alivernini and Lucy E. Ballantine and Darren L. Asquith and Neal L. Millar and Derek S. Gilchrist and James Reilly and Michelle Ierna and Alasdair R. Fraser and Bartosz Stolarski and Charles McSharry and Axel J. Hueber and Derek Baxter and John Hunter and Steffen Gay and Foo Y. Liew and Iain B. McInnes
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 27, pp. 11193 - 11198
MicroRNA (miRNA) species (miR) regulate mRNA translation and are implicated as mediators of disease pathology via coordinated regulation of molecular effector... 
Myeloid cells | MicroRNA | Messenger RNA | Cytokines | Synovial membrane | Rheumatoid arthritis | Collagens | Arthritis | Inflammation | Macrophages | RHEUMATOID-ARTHRITIS | PATHOGENESIS | COLLAGEN-INDUCED ARTHRITIS | AUTOIMMUNE INFLAMMATION | SYNOVIAL TISSUE | ROLES | MULTIDISCIPLINARY SCIENCES | DEFICIENT MICE | INDUCTION | EXPRESSION | T-CELLS | Arthritis, Experimental - genetics | Humans | Inositol Polyphosphate 5-Phosphatases | Synovial Membrane - immunology | Synovial Membrane - pathology | MicroRNAs - metabolism | Case-Control Studies | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | Arthritis, Rheumatoid - metabolism | Base Sequence | Inflammation Mediators - metabolism | Phosphoric Monoester Hydrolases - genetics | Osteoarthritis - immunology | Osteoarthritis - metabolism | Arthritis, Experimental - immunology | Synovial Membrane - metabolism | Osteoarthritis - genetics | Arthritis, Rheumatoid - pathology | Mice, Knockout | Arthritis, Rheumatoid - genetics | Animals | Mice | MicroRNAs - genetics | Arthritis, Rheumatoid - immunology | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Cytokines - biosynthesis | Physiological aspects | Genetic aspects | Health aspects | Proteins | Ribonucleic acid--RNA | Gene expression | Cells | Inositol | Translation | Autoantibodies | Therapeutic applications | Helper cells | Data processing | Homology | Src protein | Synovial fluid | Collagen | miRNA | Osteoarthritis | Tumor necrosis factor- alpha | Index Medicus | Biological Sciences
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3. Full Text Interleukin‐6 Receptor Blockade Enhances CD39+ Regulatory T Cell Development in Rheumatoid Arthritis and in Experimental Arthritis
by Thiolat, A and Semerano, L and Pers, Y. M and Biton, J and Lemeiter, D and Portales, P and Quentin, J and Jorgensen, C and Decker, P and Boissier, M.‐C and Louis‐Plence, P and Bessis, N
Arthritis & Rheumatology, ISSN 2326-5191, 02/2014, Volume 66, Issue 2, pp. 273 - 283
Objective. The rationale for blocking interleukin-6 (IL-6) in rheumatoid arthritis (RA) lies chiefly in the proinflammatory effect of this cytokine. Few... 
COLLAGEN-INDUCED ARTHRITIS | INHIBITION | DISEASE | AMERICAN-COLLEGE | PERIPHERAL-BLOOD | INDUCTION | DIFFERENTIATION | RHEUMATOLOGY | EXPRESSION | IL-6 | TH17 CELLS | T-Lymphocytes, Regulatory - metabolism | Arthritis, Experimental - drug therapy | Antibodies, Anti-Idiotypic - pharmacology | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Receptors, Interleukin-6 - antagonists & inhibitors | Receptors, Interleukin-6 - drug effects | T-Lymphocytes, Regulatory - pathology | Antigens, CD - metabolism | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | Arthritis, Rheumatoid - metabolism | Th17 Cells - drug effects | Arthritis, Rheumatoid - drug therapy | Antibodies, Monoclonal, Humanized - pharmacology | Female | Mice, Inbred DBA | Antibodies, Anti-Idiotypic - therapeutic use | Disease Models, Animal | Th17 Cells - pathology | Antibodies, Monoclonal, Humanized - therapeutic use | Antibodies, Monoclonal - pharmacology | Apyrase - metabolism | Arthritis, Rheumatoid - pathology | Phenotype | T-Lymphocytes, Regulatory - drug effects | Animals | Cell Proliferation - drug effects | Mice | Cytokines | Rheumatism | Rheumatoid arthritis | Index Medicus | Abridged Index Medicus | Life Sciences
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4. Full Text Signalling, inflammation and arthritis: NF-κB and its relevance to arthritis and inflammation
by Simmonds, R.E and Foxwell, B.M
Rheumatology, ISSN 1462-0324, 05/2008, Volume 47, Issue 5, pp. 584 - 590
In the synovial cells of patients with RA, activation of the nuclear factor-kappa B (NF-kappa B) pathway results in the transactivation of a multitude of... 
Signalling pathways | NF-κB | Review | RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | ONCOPROTEIN BCL-3 | SYNOVIAL TISSUE | INDUCIBLE NUCLEAR-PROTEIN | TNF PROMOTER REGION | PROINFLAMMATORY CYTOKINES | RHEUMATOLOGY | HEAT-SHOCK-PROTEIN | NF-kappa B | TOLL-LIKE RECEPTOR-4 | signalling pathways | review | GENE-EXPRESSION
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5. Full Text Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?
by van Baarsen, Lisa G. M and Lebre, Maria C and van der Coelen, Dennis and Aarrass, Saïda and Tang, Man W and Ramwadhdoebe, Tamara H and Gerlag, Daniëlle M and Tak, Paul P
Arthritis research & therapy, ISSN 1478-6354, 2014, Volume 16, Issue 4, pp. 426 - 426
Accumulating evidence suggests an important role for interleukin 17 (IL-17) in the pathogenesis of several inflammatory diseases, including rheumatoid... 
COLLAGEN-INDUCED ARTHRITIS | CARTILAGE DESTRUCTION | INFLAMMATION | AUTOIMMUNE ARTHRITIS | MAST-CELLS | DOUBLE-BLIND | ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY | RHEUMATOLOGY | TH17 | T-CELLS | PROOF-OF-CONCEPT | Immunohistochemistry | Humans | Interleukin-17 - analysis | Middle Aged | Male | Osteoarthritis - drug therapy | Arthritis, Rheumatoid - metabolism | Arthritis, Rheumatoid - drug therapy | Arthritis, Psoriatic - drug therapy | Adult | Female | Receptors, Interleukin-17 - analysis | Arthritis, Psoriatic - metabolism | Antirheumatic Agents - therapeutic use | Receptors, Interleukin-17 - biosynthesis | Osteoarthritis - immunology | Osteoarthritis - metabolism | Interleukin-17 - biosynthesis | Synovial Membrane - metabolism | Microscopy, Confocal | Arthritis, Psoriatic - immunology | Image Processing, Computer-Assisted | Fluorescent Antibody Technique | Aged | Arthritis, Rheumatoid - immunology | Index Medicus | Research
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6. Full Text Animal models of rheumatoid arthritis (I): Pristane-induced arthritis in the rat
by Tuncel, Jonatan and Haag, Sabrina and Hoffmann, Markus H and Yau, Anthony C. Y and Hultqvist, Malin and Olofsson, Peter and Bäcklund, Johan and Nandakumar, Kutty Selva and Weidner, Daniela and Fischer, Anita and Leichsenring, Anna and Lange, Franziska and Haase, Claus and Lu, Shemin and Gulko, Percio S and Steiner, Günter and Holmdahl, Rikard
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, pp. e0155936 - e0155936
Background To facilitate the development of therapies for rheumatoid arthritis ( RA), the Innovative Medicines Initiative BTCure has combined the experience... 
COLLAGEN-INDUCED ARTHRITIS | ADJUVANT-INDUCED ARTHRITIS | MULTIDISCIPLINARY SCIENCES | AUTOIMMUNE ARTHRITIS | DISEASE | FREUND ADJUVANT | DA RATS | INFLAMMATORY ARTHRITIS | F344 RATS | MAJOR HISTOCOMPATIBILITY COMPLEX | T-CELLS | Arthritis, Experimental - pathology | Animals | Arthritis, Experimental - chemically induced | Rats | Female | Male | Terpenes - toxicity | Arthritis, Rheumatoid - chemically induced | Immunosuppressive Agents - toxicity | Arthritis, Rheumatoid - pathology | Disease Models, Animal | Physiology, Pathological | Rheumatoid arthritis | Analysis | Physiological aspects | Models | Research | Drug discovery | Animal models | Disease | Cyclosporins | Pathogenesis | Biochemistry | Genomes | Arthritis | Immunology | Etanercept | Lymphocytes | Chronology | Age | Chronic illnesses | Antigens | Immunization | Dexamethasone | Internal medicine | Rheumatology | Inflammation | Biophysics | Housing | Pristane | Age factors | Disease control | Medicine | Reproducibility | Collagen | Index Medicus
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7. Full Text Animal models of rheumatoid arthritis
by Asquith, Darren L and Miller, Ashley M and McInnes, Iain B and Liew, Foo Y
European Journal of Immunology, ISSN 0014-2980, 08/2009, Volume 39, Issue 8, pp. 2040 - 2044
Animal models have been used extensively in studies of rheumatoid arthritis pathogenesis. Despite the inherent limitations of all animal models, several rodent... 
Rheumatoid | Model | Arthritis | Animal | Collagen | COLLAGEN-INDUCED ARTHRITIS | ZYMOSAN-INDUCED ARTHRITIS | ANTIBODY-INDUCED ARTHRITIS | MONOCLONAL-ANTIBODY | IMMUNOLOGY | AUTOIMMUNE ARTHRITIS | ANTIGEN-INDUCED ARTHRITIS | GLUCOSE-6-PHOSPHATE ISOMERASE | ADJUVANT ARTHRITIS | T-CELLS | SELF-TOLERANCE | Humans | Tumor Necrosis Factor-alpha - genetics | ZAP-70 Protein-Tyrosine Kinase - genetics | Mice, Transgenic | Arthritis, Experimental - immunology | Arthritis, Rheumatoid - pathology | Arthritis, Experimental - pathology | Point Mutation | Arthritis, Rheumatoid - genetics | Animals | Mice | Arthritis, Rheumatoid - immunology | Disease Models, Animal | Index Medicus
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8. Full Text Chronic Active Arthritis Driven by Macrophages Without Involvement of T Cells: A Novel Experimental Model of Rheumatoid Arthritis
by Hagert, Cecilia and Sareila, Outi and Kelkka, Tiina and Nandakumar, Kutty Selva and Collin, Mattias and Xu, Bingze and Guérard, Simon and Bäcklund, Johan and Jalkanen, Sirpa and Holmdahl, Rikard
Arthritis and Rheumatology, ISSN 2326-5191, 08/2018, Volume 70, Issue 8, pp. 1343 - 1353
Objective. To develop a new chronic rheumatoid arthritis model that is driven by the innate immune system. Methods. Injection of a cocktail of 4 monoclonal... 
COLLAGEN-INDUCED ARTHRITIS | PROTEIN | CLODRONATE-CONTAINING LIPOSOMES | FC-GAMMA RECEPTORS | II COLLAGEN | DENDRITIC CELLS | REDUCED OXIDATIVE BURST | ANTIBODY-INDUCED ARTHRITIS | NCF1 GENE | RHEUMATOLOGY | BALB/C MICE
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9. Full Text Transcriptional Regulation of CD4+T Cell Differentiation in Experimentally Induced Arthritis and Rheumatoid Arthritis
by Kondo, Y and Yokosawa, M and Kaneko, S and Furuyama, K and Segawa, S and Tsuboi, H and Matsumoto, I and Sumida, T
ARTHRITIS & RHEUMATOLOGY, ISSN 2326-5191, 05/2018, Volume 70, Issue 5, pp. 653 - 661
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation of the joint synovium and infiltration by activated inflammatory... 
COLLAGEN-INDUCED ARTHRITIS | GROWTH-FACTOR-BETA | ROR-GAMMA-T | FOLLICULAR-HELPER-CELLS | AUTOIMMUNE ARTHRITIS | BONE EROSION | DOUBLE-BLIND | T(H)17 DIFFERENTIATION | RHEUMATOLOGY | JOINT INFLAMMATION | TH17 CELLS
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10. Full Text NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
by Roman-Blas, J.A and Jimenez, S.A
Osteoarthritis and Cartilage, ISSN 1063-4584, 2006, Volume 14, Issue 9, pp. 839 - 848
The family of nuclear factor-kappaB (NF-κB) transcription factors is intimately involved in the regulation of expression of numerous genes in the setting of... 
Cartilage | NF-κB | Transcription factors | Osteoarthritis | Rheumatoid arthritis | COLLAGEN-INDUCED ARTHRITIS | transcription factors | osteoarthritis | cartilage | IKK-ALPHA | HUMAN ARTICULAR CHONDROCYTES | RHEUMATOLOGY | DEPENDENT GENE-EXPRESSION | rheumatoid arthritis | MICE LACKING | NF-kappa B | LIVER DEGENERATION | TNF-ALPHA | ORTHOPEDICS | SIGNAL-TRANSDUCTION PATHWAY | OXIDE-INDUCED APOPTOSIS
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11. Full Text Anti-arthritis effect of a novel quinazoline derivative through inhibiting production of TNF-α mediated by TNF-α converting enzyme in murine collagen-induced arthritis model
by Pu, Yuzhi and Cao, Dong and Xie, Caifeng and Pei, Heying and Li, Dan and Tang, Minghai and Chen, Lijuan
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2015, Volume 462, Issue 4, pp. 288 - 293
TNF-α is a dominant inflammatory mediator in the pathogenesis of inflammatory diseases including rheumatoid arthritis. In our research, we discovered... 
TNF-α converting enzyme | Quinazoline | TNF-α | Rheumatoid arthritis | Collagen-induced arthritis | RHEUMATOID-ARTHRITIS | CYTOKINES | TNF-alpha | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | TNF-alpha converting enzyme | ADAM17 | BIOPHYSICS | INFLAMMATION | EXPRESSION | ADAM17 Protein | Cell Line | Arthritis, Experimental - drug therapy | Enzyme-Linked Immunosorbent Assay | RNA, Messenger - genetics | Tumor Necrosis Factor-alpha - genetics | Male | Collagen - administration & dosage | ADAM Proteins - metabolism | Animals | Quinazolines - therapeutic use | Mice, Inbred DBA | Mice | Quinazolines - pharmacology | Tumor Necrosis Factor-alpha - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Disease Models, Animal | Index Medicus
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12. Full Text IL-17 receptor and its functional significance in psoriatic arthritis
by Raychaudhuri, Siba P and Raychaudhuri, Smriti K and Genovese, Mark C
Molecular and Cellular Biochemistry, ISSN 0300-8177, 1/2012, Volume 359, Issue 1, pp. 419 - 429
To delineate the functional significance of IL-17 Receptor (IL-17RA) and characterize the IL-17 producing T cell (Th17) subpopulation in psoriatic arthritis... 
Life Sciences | Biochemistry, general | Psoriasis | Synoviocytes/FLS | Medical Biochemistry | Oncology | T h 17 cells | Synovial tissue | IL-17/IL-17R | Cardiology | Psoriatic arthritis | T | 17 cells | RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | PROINFLAMMATORY CYTOKINES | HUMAN KERATINOCYTES | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | NERVE GROWTH-FACTOR | T-HELPER-CELLS | CELL BIOLOGY | FIBROBLAST-LIKE SYNOVIOCYTES | MATRIX METALLOPROTEINASES | T(h)17 cells | TH17 CELLS | Matrix Metalloproteinase 3 | Arthritis, Rheumatoid - etiology | Humans | Receptors, Interleukin-17 - immunology | Antibodies, Blocking - pharmacology | Interleukin-8 | Case-Control Studies | Interleukin-6 | Synovial Fluid - immunology | Arthritis, Psoriatic - immunology | Arthritis, Psoriatic - pathology | Th17 Cells - immunology | Arthritis, Psoriatic - etiology | Arthritis, Rheumatoid - immunology | Rheumatoid factor | Antirheumatic agents | T cells | Osteoarthritis | Analysis | Proteins | Arthritis | Gene expression | Neurons | Rheumatoid arthritis | Cells | Index Medicus
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13. Full Text Endogenous IL-22 plays a dual role in arthritis: Regulation of established arthritis via IFN-γ responses
by Justa, Shivali and Zhou, Xiaoqun and Sarkar, Sujata
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, pp. e93279 - e93279
Objective: IL-22 is elevated in patients with inflammatory arthritis and correlates with disease activity. IL-22 deficient mice have reduced incidence of... 
RHEUMATOID-ARTHRITIS | B-CELLS | COLLAGEN-INDUCED ARTHRITIS | INTERFERON-GAMMA | INTERLEUKIN 22 | PROTECTIVE ROLE | MULTIDISCIPLINARY SCIENCES | AIRWAY INFLAMMATION | DEFICIENT MICE | T-CELLS | TH17 CELLS | Th1 Cells - pathology | Arthritis, Experimental - genetics | Interleukin-17 - immunology | Male | Th1 Cells - immunology | Arthritis, Experimental - pathology | Interleukins - genetics | Arthritis, Experimental - chemically induced | Interleukins - immunology | Female | Mice, Inbred DBA | Interferon-gamma - genetics | Interferon-gamma - deficiency | Severity of Illness Index | Receptors, Interleukin - immunology | Signal Transduction | Gene Expression Regulation - immunology | Interleukin-17 - genetics | Antibodies, Neutralizing - pharmacology | Arthritis, Experimental - immunology | Receptors, Interleukin - genetics | Freund's Adjuvant | Interleukins - antagonists & inhibitors | Mice, Knockout | Animals | Collagen | Interferon-gamma - immunology | Mice | Interleukin 22 | Lymphocytes T | Arthritis | Immunology | Histopathology | Lymphocytes | Rodents | Enzyme-linked immunosorbent assay | Recombinant | Immunization | Cytokines | Cloning | Rheumatology | Inflammation | Gene expression | Disease control | Interleukin 17 | CD4 antigen | Freund's adjuvant | Antigen-presenting cells | γ-Interferon | Interleukin 10 | Lymphomas | Interferon | Neutralization | Index Medicus
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