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BBA - Molecular Cell Research, ISSN 0167-4889, 02/2014, Volume 1843, Issue 2, pp. 372 - 386
(CRNDE) is a novel gene that is activated early in colorectal cancer but whose regulation and functions are unknown. CRNDE transcripts are recognized as long... 
lncRNA | IGF1 | Insulin | CRNDE | Colorectal cancer | Warburg effect | LncRNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IncRNA | CELL-PROLIFERATION | GLUCOSE-TRANSPORT | MUSCLE-CELLS | CELL BIOLOGY | COLON-CANCER | RECTAL-CANCER | COLORECTAL-CANCER | MUTATIONS | CARBOHYDRATE-METABOLISM | EXPRESSION | GROWTH-FACTOR-I | Insulin-Like Growth Factor I - pharmacology | Glucose Transporter Type 4 - metabolism | TOR Serine-Threonine Kinases - metabolism | Colorectal Neoplasms - genetics | Humans | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | raf Kinases - metabolism | RNA Interference | Metabolism - drug effects | Insulin-Like Growth Factor II - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Colorectal Neoplasms - metabolism | Metabolism - genetics | Insulin - pharmacology | RNA, Messenger - genetics | RNA, Long Noncoding - genetics | Signal Transduction - genetics | Transcriptome - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | Insulin-Like Growth Factor II - metabolism | Gene Expression Regulation - drug effects | Insulin - metabolism | Lactates - metabolism | Signal Transduction - drug effects | Models, Biological | Cell Line, Tumor | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Colorectal Neoplasms - pathology | RNA, Long Noncoding - metabolism | Insulin-Like Growth Factor I - metabolism | Mitogen-Activated Protein Kinases - metabolism | RNA, Small Interfering - metabolism | RNA | Genes | Analysis | Physiological aspects | Glucose | Gene expression | Dextrose | Epigenetic inheritance
Journal Article
Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, pp. 7629 - 7629
Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in... 
GLP-1 SECRETION | FXR | BILE-ACID RECEPTORS | GLUCOSE-HOMEOSTASIS | OBESITY | MULTIDISCIPLINARY SCIENCES | RAT SMALL-INTESTINE | MICE | TYPE-2 DIABETES-MELLITUS | METABOLIC-RATE | EXPRESSION | Colon - cytology | Intestinal Mucosa - metabolism | Sequestering Agents - pharmacology | Humans | Ileum - metabolism | RNA, Messenger - metabolism | Colesevelam Hydrochloride - pharmacology | Obesity - genetics | Glucagon-Like Peptide 1 - genetics | Jejunum - metabolism | Insulin-Secreting Cells - metabolism | Proglucagon - drug effects | Diet, High-Fat | Jejunum - cytology | Enteroendocrine Cells - metabolism | Ileum - cytology | Proglucagon - metabolism | Insulin Secretion | Glucagon-Like Peptide 1 - metabolism | Signal Transduction | Bile Acids and Salts - metabolism | Nuclear Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Colon - metabolism | Mice, Knockout | Obesity - metabolism | Transcription Factors - metabolism | Insulin - metabolism | Animals | Glycolysis | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice, Obese | Mice | Proglucagon - genetics | Receptors, G-Protein-Coupled - genetics | Blood Glucose - metabolism | Anticholesteremic Agents - pharmacology | Intestines - cytology | Index Medicus | Cell and Molecular Biology | Endokrinologi och diabetes | Multidisciplinary Sciences | Cell- och molekylärbiologi | Endocrinology and Diabetes
Journal Article
Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7413, pp. 665 - 669
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the... 
IN-VITRO | INHIBITION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | UBIQUITYLATION | SMALL-INTESTINE | COLON | BETA-CATENIN | LGR5 | CANCER | NEGATIVE REGULATOR | Oncogene Proteins - genetics | Receptors, Wnt - antagonists & inhibitors | Cell Proliferation | Receptors, G-Protein-Coupled - metabolism | Humans | Ubiquitin - metabolism | Paneth Cells - pathology | Stem Cells - cytology | Receptors, Wnt - metabolism | Stem Cells - metabolism | DNA-Binding Proteins - deficiency | Adenoma - metabolism | DNA-Binding Proteins - metabolism | Endocytosis | Ubiquitination | Lysosomes - metabolism | Stem Cells - enzymology | Tumor Suppressor Proteins - deficiency | Organoids - metabolism | Tumor Suppressor Proteins - genetics | HEK293 Cells | Colorectal Neoplasms - metabolism | Paneth Cells - metabolism | Tumor Suppressor Proteins - metabolism | Organoids - pathology | Oncogene Proteins - metabolism | Organoids - cytology | Ubiquitin-Protein Ligases - metabolism | Frizzled Receptors - metabolism | DNA-Binding Proteins - genetics | beta Catenin - metabolism | Animals | Wnt Signaling Pathway - drug effects | Adenoma - pathology | Ubiquitin-Protein Ligases - deficiency | Oncogene Proteins - deficiency | Mice | Receptors, G-Protein-Coupled - genetics | Colorectal Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Colorectal cancer | Physiological aspects | Development and progression | Research | Gene expression | Risk factors | Proteins | Epidermal growth factor | Mutation | Kinases | Rodents | Stem cells | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, pp. e14062 - e14062
Background: The cancer stem cell theory hypothesizes that cancers are perpetuated by cancer stem cells (CSC) or tumor initiating cells (TIC) possessing... 
COLON-CANCER | POPULATION | MARKER | MULTIDISCIPLINARY SCIENCES | GROWTH | HYALURONAN | PLURIPOTENCY | FLOW-CYTOMETRY | IDENTIFICATION | CD133(+) | TUMORS | Immunohistochemistry | Humans | Lung Neoplasms - metabolism | Middle Aged | Glycoproteins - metabolism | Peptides - genetics | Immunoblotting | Lung Neoplasms - pathology | Male | Transplantation, Heterologous | Gene Expression Profiling | Antigens, CD - genetics | Antigens, CD - metabolism | Neoplasms, Experimental - pathology | Octamer Transcription Factor-3 - genetics | Flow Cytometry | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Hyaluronan Receptors - metabolism | Neoplasms, Experimental - genetics | Neoplastic Stem Cells - pathology | Female | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Glycoproteins - genetics | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | AC133 Antigen | Hyaluronan Receptors - genetics | Animals | Polycomb Repressive Complex 1 | Mice, Nude | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Aged | Mice | Neoplasms, Experimental - metabolism | Squamous cell carcinoma | Lung cancer, Non-small cell | Analysis | Stem cells | Flow cytometry | Biotechnology | Laboratories | Heart surgery | Oct-4 protein | Lung | Lung cancer | Colorectal cancer | Stem cell transplantation | Proteins | Allografts | Epidermal growth factor | CD44 antigen | Xenografts | Cell cycle | CD34 antigen | Subpopulations | Cell survival | Tumor cells | Markers | Non-small cell lung carcinoma | Tumor cell lines | Cisplatin | Studies | Polymerase chain reaction | Pathology | Cytometry | Properties (attributes) | Medical prognosis | Cell lines | In vivo methods and tests | Pluripotency | Tumors | Apoptosis | Cancer | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 07/2015, Volume 6, Issue 1, pp. 7735 - 7735
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2017, Volume 7, Issue 1, pp. 43412 - 43412
This study was conducted to investigate impacts of dietary protein levels on gut bacterial community and gut barrier. The intestinal microbiota of finishing... 
POSTWEANING DIARRHEA | HOST METABOLISM | CELLS | FINISHING PIGS | HOMEOSTASIS | PIGLETS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MODULATING INTESTINAL PERMEABILITY | BUTYRATE | PROMOTES | Dietary Proteins - administration & dosage | Peptostreptococcus - drug effects | Tight Junction Proteins - genetics | Receptors, G-Protein-Coupled - metabolism | Colon - drug effects | Ileum - metabolism | Escherichia - metabolism | Escherichia - classification | Fatty Acids, Volatile - metabolism | Intestinal Mucosa - drug effects | Occludin - metabolism | Genetic Variation | Polycomb Repressive Complex 1 - genetics | Dietary Proteins - metabolism | Ileum - drug effects | Swine | Shigella - metabolism | Tight Junction Proteins - metabolism | Firmicutes - isolation & purification | Intestinal Mucosa - microbiology | Peptostreptococcus - isolation & purification | Colon - metabolism | Gastrointestinal Microbiome - drug effects | Claudin-1 - genetics | Escherichia - drug effects | Receptors, G-Protein-Coupled - genetics | Escherichia - isolation & purification | Firmicutes - drug effects | Animal Feed | Peptostreptococcus - classification | Intestinal Mucosa - metabolism | Polycomb Repressive Complex 1 - metabolism | Shigella - classification | Gastrointestinal Microbiome - physiology | Clostridium - isolation & purification | Shigella - drug effects | Clostridium - classification | Occludin - genetics | Claudin-1 - metabolism | Biogenic Amines - metabolism | Diet, Protein-Restricted - methods | Firmicutes - metabolism | Digestion - drug effects | Firmicutes - classification | Shigella - isolation & purification | Peptostreptococcus - metabolism | Digestion - physiology | Gene Expression Regulation - drug effects | Animals | Clostridium - metabolism | Colon - microbiology | Ileum - microbiology | Clostridium - drug effects | Amines | Digestive system | Mucosa | Ileum | Studies | Proteins | Protein composition | Metabolites | Intestine | Fish | Intestinal microflora | Colon | Digestive tract | Biogenic amines | Colonization | Index Medicus
Journal Article
Gut, ISSN 0017-5749, 05/2017, Volume 66, Issue 5, pp. 823 - 838
ObjectiveInterleukin (IL)-36R signalling plays a proinflammatory role in different organs including the skin, but the expression of IL-36R ligands and their... 
STEM-CELLS | IL-1-ALPHA | REPAIR | ANTAGONIST | ULCERATIVE-COLITIS | RECEPTOR | MICE | IL-1-BETA | LIGAND | GASTROENTEROLOGY & HEPATOLOGY | INFLAMMATORY BOWEL DISEASES | Dextran Sulfate | Intestinal Mucosa - metabolism | Cell Proliferation | Epithelial Cells - metabolism | Lipocalin-2 - biosynthesis | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Colitis - genetics | Humans | Receptors, Interleukin-1 - genetics | Cytoplasm - metabolism | Wound Healing | Inflammatory Bowel Diseases - metabolism | Receptors, Interleukin - metabolism | Cell Nucleus - metabolism | Colitis - chemically induced | Interleukin-6 - metabolism | Fibroblasts - metabolism | Calgranulin B - biosynthesis | Interleukin-1 - metabolism | Cytokines - metabolism | Myeloid Differentiation Factor 88 - genetics | Signal Transduction - genetics | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Macrophages - metabolism | Animals | Colitis - metabolism | Ligands | Chemokines - metabolism | Mice | Myeloid Differentiation Factor 88 - metabolism | Fibroblasts | Intestines | Care and treatment | Cellular signal transduction | Research | Epithelial cells | Cell proliferation | Animal models | Mucosa | Genomes | CD14 antigen | Interleukin 6 | Signal transduction | Intestine | Rodents | Tumor necrosis factor-TNF | Colony-stimulating factor | Colon | Wound healing | Bacterial infections | Cytokines | Granulocyte-macrophage colony-stimulating factor | Lipocalin | Inflammation | Epithelium | Ribonucleic acid--RNA | Inflammatory bowel disease | Dextran | Sodium | Biopsy | MyD88 protein | Skin | Colitis | Chemokines | Cytoplasm | Index Medicus | Abridged Index Medicus
Journal Article
Applied and Environmental Microbiology, ISSN 0099-2240, 04/2012, Volume 78, Issue 7, pp. 2179 - 2189
Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
TRANSLOCATOR DOMAIN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | NEISSERIA-MENINGITIDIS | URINARY-TRACT | CHROMOSOMAL GENES | MICROBIOLOGY | H-NS | INFLUENZAE HIA AUTOTRANSPORTER | YERSINIA | EXPRESSION | ADHESIN YADA | BIOFILM FORMATION | Colon - cytology | Epithelial Cells - metabolism | Virulence Factors - genetics | Fimbriae Proteins - metabolism | Humans | Biofilms - growth & development | Extracellular Matrix - metabolism | Molecular Sequence Data | Adhesins, Escherichia coli - genetics | Escherichia coli O157 - pathogenicity | Uropathogenic Escherichia coli - metabolism | Uropathogenic Escherichia coli - pathogenicity | Urinary Bladder - cytology | Urinary Bladder - microbiology | Caco-2 Cells | Rectum - microbiology | Amino Acid Sequence | Adhesins, Escherichia coli - metabolism | Escherichia coli O157 - genetics | Escherichia coli O157 - metabolism | Escherichia coli Infections - microbiology | Escherichia coli Proteins - metabolism | Uropathogenic Escherichia coli - genetics | Sequence Analysis, DNA | Bacterial Adhesion | Fimbriae Proteins - genetics | Rectum - cytology | Epithelial Cells - microbiology | Cell Line, Tumor | Escherichia coli Proteins - genetics | Virulence Factors - metabolism | Colon - microbiology | Gene Expression Regulation, Bacterial | Carrier proteins | Bacterial proteins | Escherichia coli | Physiological aspects | Microbiological synthesis | Chemical properties | Research | Protein binding | Gram-negative bacteria | Mutation | E coli | Microbiology | Cells | Binding sites | Index Medicus | Extracellular Matrix/metabolism | Bacterial | Adhesins | Uropathogenic Escherichia coli/genetics/metabolism/pathogenicity | Fimbriae Proteins/genetics/metabolism | Escherichia coli O157/genetics/metabolism/pathogenicity | Escherichia coli/genetics/metabolism | Biofilms/growth & development | Epithelial Cells/metabolism/microbiology | Life Sciences | Tumor | Cell Line | Gene Expression Regulation | Escherichia coli Proteins/genetics/metabolism | Colon/cytology/microbiology | Bacteriology | Rectum/cytology/microbiology | Microbiology and Parasitology | DNA | Escherichia coli Infections/microbiology | Sequence Analysis | Urinary Bladder/cytology/microbiology | Virulence Factors/genetics/metabolism | Genetics and Molecular Biology
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2010, Volume 39, Issue 4, pp. 493 - 506
A transient inflammatory signal can initiate an epigenetic switch from nontransformed to cancer cells via a positive feedback loop involving NF-κB, Lin28,... 
RNA | HUMDISEASE | SIGNALING | Signaling | Humdisease | BREAST-CANCER | MICRORNA MIR-21 | TARGET | TRANSFORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | EMBRYONIC STEM-CELLS | LET-7 | IDENTIFICATION | NF-KAPPA-B | EXPRESSION | BINDING | CELL BIOLOGY | Colonic Neoplasms - genetics | Cell Proliferation | Epigenesis, Genetic | Humans | Transcriptional Activation | MicroRNAs - metabolism | NF-kappa B - metabolism | Colonic Neoplasms - metabolism | Inflammation - metabolism | Adenocarcinoma - metabolism | RNA Interference | Cell Transformation, Neoplastic - genetics | Proto-Oncogene Proteins c-akt - metabolism | Binding Sites | Colonic Neoplasms - therapy | Tumor Suppressor Proteins - metabolism | Signal Transduction | HCT116 Cells | Computational Biology | Mammary Glands, Human - pathology | Tumor Burden | Breast Neoplasms - genetics | Adenocarcinoma - therapy | Mice, Nude | Mice | Proto-Oncogene Proteins c-myc - genetics | Kinetics | Cell Movement | Deubiquitinating Enzyme CYLD | Gene Expression Regulation, Neoplastic | Mammary Glands, Human - metabolism | Breast Neoplasms - metabolism | Transfection | Tumor Suppressor Proteins - genetics | Inflammation Mediators - metabolism | Female | Adenocarcinoma - genetics | STAT3 Transcription Factor - metabolism | Promoter Regions, Genetic | Receptors, Estrogen - genetics | Neoplasm Invasiveness | PTEN Phosphohydrolase - metabolism | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | HT29 Cells | Xenograft Model Antitumor Assays | Algorithms | Animals | Breast Neoplasms - pathology | Inflammation - genetics | Cell Transformation, Neoplastic - pathology | Genes, src | Medical colleges | Inflammation | Colon cancer | Cancer | Adenocarcinoma | Index Medicus | microRNAs | cancer | transformation | transcription factors | inflammation | STAT3
Journal Article