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1. Full Text MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer
by Hart, Peter C and Mao, Mao and De Abreu, Andre Luelsdorf P and Ansenberger-Fricano, Kristine and Ekoue, Dede N and Ganini, Douglas and Kajdacsy-Balla, Andre and Diamond, Alan M and Minshall, Richard D and Consolaro, Marcia E. L and Santos, Janine H and Bonini, Marcelo G
Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, pp. 6053 - 6053
Manganese superoxide dismutase (MnSOD/SOD2) is a mitochondria-resident enzyme that governs the types of reactive oxygen species egressing from the organelle to... 
HYPOXIA-INDUCIBLE FACTOR | LIFE-SPAN | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | EPITHELIAL-CELLS | MANGANESE SUPEROXIDE-DISMUTASE | MULTIDISCIPLINARY SCIENCES | INHIBIT APOPTOSIS | C-MYC | CELL-CYCLE PROGRESSION | BREAST | Mitochondria - enzymology | RNA, Small Interfering - genetics | AMP-Activated Protein Kinases - metabolism | Colonic Neoplasms - genetics | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Humans | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Phosphofructokinase-1 - genetics | Superoxide Dismutase - antagonists & inhibitors | Male | Glycolysis - genetics | Breast Neoplasms - enzymology | Prostatic Neoplasms - genetics | Mitochondria - genetics | Female | Hexokinase - genetics | Superoxide Dismutase - metabolism | Prostatic Neoplasms - pathology | Oxidation-Reduction | Pyruvate Kinase - metabolism | Signal Transduction | AMP-Activated Protein Kinases - antagonists & inhibitors | Hydrogen Peroxide - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Colonic Neoplasms - enzymology | Hexokinase - metabolism | Neoplasm Staging | Phosphofructokinase-1 - metabolism | Pyruvate Kinase - genetics | AMP-Activated Protein Kinases - genetics | RNA, Small Interfering - metabolism | Index Medicus
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2. Full Text Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
by Chiche, Johanna and Ilc, Karine and Laferrière, Julie and Trottier, Eric and Dayan, Frédéric and Mazure, Nathalie M and Brahimi-Horn, M. Christiane and Pouysségur, Jacques
Cancer Research, ISSN 0008-5472, 01/2009, Volume 69, Issue 1, pp. 358 - 368
Acidosis of the tumor microenvironment is typical of a malignant phenotype, particularly in hypoxic tumors. All cells express multiple isoforms of carbonic... 
INVASION | CARBONIC-ANHYDRASE-9 | MOLECULAR PHYSIOLOGY | ONCOLOGY | NA+/H+ EXCHANGERS | LACTATE | COTRANSPORTER | EXTRACELLULAR PH | EXPRESSION | CANCER-THERAPY | FIBROBLASTS | Cell Hypoxia - physiology | Carbonic Anhydrases - biosynthesis | Cricetulus | Humans | Antigens, Neoplasm - biosynthesis | Cell Growth Processes - physiology | Cytoplasm - metabolism | Male | Acidosis - metabolism | Colonic Neoplasms - metabolism | Carbonic Anhydrases - metabolism | Antigens, Neoplasm - metabolism | Fibroblasts | Spheroids, Cellular | Carbonic Anhydrase IX | Cytoplasm - enzymology | Cricetinae | Enzyme Induction | Animals | Mice, Nude | Colonic Neoplasms - pathology | Cell Line, Tumor | Colonic Neoplasms - enzymology | Mice | Acidosis - enzymology | Hydrogen-Ion Concentration | Index Medicus | Antigens, Neoplasm | Carbonic Anhydrases | Cell Growth Processes | Cell Hypoxia | Life Sciences | Development Biology | Acidosis | Cytoplasm | Colonic Neoplasms
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3. Full Text PTEN-Deficient Cancers Depend on PIK3CB
by Susan Wee and Dmitri Wiederschain and Sauveur-Michel Maira and Alice Loo and Christine Miller and Rosalie deBeaumont and Frank Stegmeier and Yung-Mae Yao and Christoph Lengauer
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2008, Volume 105, Issue 35, pp. 13057 - 13062
Deregulation of the PI3K signaling pathway is observed in many human cancers and occurs most frequently through loss of PTEN phosphatase tumor suppressor... 
Protein isoforms | Cell growth | HCT116 cells | Cell lines | Lipids | Down regulation | Genetic mutation | Heterologous transplantation | Tumors | Cancer | BREAST-CARCINOMA | B-CELL | GENE | PATHWAY | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | DRUG DISCOVERY | HIGH-FREQUENCY | TUMOR-SUPPRESSOR | PHOSPHOINOSITIDE 3-KINASES | MUTATIONS | Cell Proliferation | Humans | Male | Transplantation, Heterologous | Phosphatidylinositol 3-Kinases - metabolism | Phosphoproteins - metabolism | Phosphatidylinositol 3-Kinases - deficiency | Proto-Oncogene Proteins c-akt - metabolism | Prostatic Neoplasms - pathology | PTEN Phosphohydrolase - deficiency | Signal Transduction | Cell Survival | Down-Regulation | Neoplasms - enzymology | PTEN Phosphohydrolase - metabolism | Mutation - genetics | Animals | Class I Phosphatidylinositol 3-Kinases | Mice, Nude | Colonic Neoplasms - pathology | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Colonic Neoplasms - enzymology | Mice | Neoplasms - pathology | Physiological aspects | Phosphatidylinositol | Tumor suppressor genes | Genetic aspects | Health aspects | Index Medicus | Biological Sciences
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4. Full Text Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon, and lung cancer
by Miar, Ana and Hevia, David and Muñoz-Cimadevilla, Henar and Astudillo, Aurora and Velasco, Julio and Sainz, Rosa M and Mayo, Juan C
Free Radical Biology and Medicine, ISSN 0891-5849, 08/2015, Volume 85, pp. 45 - 55
The role of manganese-dependent superoxide dismutase (SOD2/MnSOD) during tumor progression has been studied for several decades with controversial results.... 
Hydrogen peroxidase | Redox state | Colon cancer | Catalase | Lung cancer | Peroxidase | SOD2 | Prostate cancer | Glutathione | Glutathione Peroxidase - metabolism | Prostatic Neoplasms - pathology | Superoxide Dismutase - genetics | Lung Neoplasms - enzymology | Humans | RNA, Messenger - genetics | Lung Neoplasms - pathology | Male | Case-Control Studies | Disease Progression | Catalase - metabolism | Neoplasm Metastasis | Colonic Neoplasms - pathology | Biomarkers, Tumor - metabolism | Prostatic Neoplasms - enzymology | Female | Colonic Neoplasms - enzymology | Superoxide Dismutase - metabolism | Index Medicus
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5. Full Text Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
by Huang, Emina H and Hynes, Mark J and Zhang, Tao and Ginestier, Christophe and Dontu, Gabriela and Appelman, Henry and Fields, Jeremy Z and Wicha, Max S and Boman, Bruce M
Cancer Research, ISSN 0008-5472, 04/2009, Volume 69, Issue 8, pp. 3382 - 3389
Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and... 
PHENOTYPIC CHARACTERIZATION | ADHESION | POPULATION | CANCER CELLS | MECHANISM | ONCOLOGY | FAMILIAL ADENOMATOUS POLYPOSIS | IDENTIFICATION | TUMORS | EXPRESSION | CD44 | Immunohistochemistry | Stem Cells - immunology | Colon - enzymology | Peptides | Antigens, CD - biosynthesis | Humans | Aldehyde Dehydrogenase - biosynthesis | Colon - immunology | Transplantation, Heterologous | Biomarkers, Tumor | Retinal Dehydrogenase | Flow Cytometry | Stem Cells - enzymology | Colonic Neoplasms - immunology | Colon - pathology | Epithelial Cells - pathology | Hyaluronan Receptors - biosynthesis | Mice, SCID | AC133 Antigen | Cell Transformation, Neoplastic - metabolism | Glycoproteins - biosynthesis | Cell Transformation, Neoplastic - immunology | Animals | Colonic Neoplasms - pathology | Epithelial Cells - immunology | Epithelial Cells - enzymology | Stem Cells - pathology | Mice, Inbred NOD | Colonic Neoplasms - enzymology | Mice | Cell Transformation, Neoplastic - pathology | Isoenzymes - biosynthesis | Index Medicus | Life Sciences | Cellular Biology | Cancer
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6. Full Text Intrinsic resistance to MEK inhibition in kras mutant lung and colon cancer through transcriptional induction of ERBB3
by Sun, Chong and Hobor, Sebastijan and Bertotti, Andrea and Zecchin, Davide and Huang, Sidong and Galimi, Francesco and Cottino, Francesca and Prahallad, Anirudh and Grernrum, Wipawadee and Tzani, Anna and Schlicker, Andreas and Wessels, Lodewyk F.A and Smit, Egbert F and Thunnissen, Erik and Halonen, Pasi and Lieftink, Cor and Beijersbergen, Roderick L and DiNicolantonio, Federica and Bardelli, Alberto and Trusolino, Livio and Bernards, Rene
Cell Reports, ISSN 2211-1247, 10/2014, Volume 7, Issue 1, pp. 86 - 93
There are no effective therapies for the ~30% of human malignancies with mutant RAS oncogenes. Using a kinome-centered synthetic lethality screen, we find that... 
DRUG-SENSITIVITY | MELANOMA | PHOSPHORYLATION | BAD | KINASE | C-MYC | RECEPTOR | MYC PROTEIN STABILITY | BRAF | RAS ONCOGENES | CELL BIOLOGY | Lung Neoplasms - drug therapy | RNA, Small Interfering - genetics | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Receptor, ErbB-3 - metabolism | Colonic Neoplasms - drug therapy | Humans | Receptor, ErbB-2 - metabolism | ras Proteins - metabolism | Apoptosis - genetics | Lung Neoplasms - pathology | Receptor, ErbB-2 - antagonists & inhibitors | MAP Kinase Kinase Kinases - antagonists & inhibitors | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Lung Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | MAP Kinase Kinase Kinases - metabolism | Receptor, ErbB-3 - genetics | Receptor, ErbB-3 - biosynthesis | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Colonic Neoplasms - pathology | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Colonic Neoplasms - enzymology | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | RNA, Small Interfering - administration & dosage | Index Medicus
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7. Full Text COX‐2 is expressed in human pulmonary, colonic, and mammary tumors
by Soslow, Robert A and Dannenberg, Andrew J and Rush, Demaretta and Woerner, B. M and Khan, K. Nasir and Masferrer, J and Koki, Alane T
Cancer, ISSN 0008-543X, 12/2000, Volume 89, Issue 12, pp. 2637 - 2645
BACKGROUND. The cyclooxygenase (COX) enzyme catalyzes the formation of prostaglandins, which can affect cell proliferation and alter the response of the immune... 
colon carcinoma | cancer prevention | lung carcinoma | breast carcinoma | COX‐2 | cyclooxygenase | immunohistochemistry | Immunohistochemistry | Breast carcinoma | Cyclooxygenase | COX-2 | Cancer prevention | Lung carcinoma | Colon carcinoma | CYCLOOXYGENASE-2 GENE-EXPRESSION | HUMAN BREAST-CANCER | CARCINOGENESIS | INHIBITION | EPITHELIAL-CELLS | ONCOLOGY | CHEMOPREVENTIVE ACTIVITY | COLORECTAL-CANCER | ANTIINFLAMMATORY AGENT | PHORBOL ESTER | UP-REGULATION | Prostaglandin-Endoperoxide Synthases - biosynthesis | Colon - enzymology | Lung - pathology | Lung Neoplasms - enzymology | Breast - enzymology | Colon - pathology | Cyclooxygenase 2 | Humans | Cyclooxygenase 1 | Neoplasms - enzymology | Lung Neoplasms - pathology | Lung - enzymology | Membrane Proteins | Breast Neoplasms - enzymology | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Colonic Neoplasms - enzymology | Isoenzymes - biosynthesis | Neoplasms - pathology | Breast - pathology | Index Medicus | Abridged Index Medicus
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8. Full Text Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer
by Carpentino, Joseph E and Hynes, Mark J and Appelman, Henry D and Tong, Zheng and Steindler, Dennis A and Scott, Edward W and Huang, Emina H
Cancer Research, ISSN 0008-5472, 10/2009, Volume 69, Issue 20, pp. 8208 - 8215
Patients with chronic ulcerative colitis are at increased risk of developing colorectal cancer. Although current hypotheses suggest that sporadic colorectal... 
PHENOTYPIC CHARACTERIZATION | SURVEILLANCE COLONOSCOPY | INFLAMMATORY-BOWEL-DISEASE | EPITHELIAL-CELLS | ONCOLOGY | COLORECTAL-CANCER | ULCERATIVE-COLITIS | CRYPT | DYSPLASIA | STROMA | IDENTIFICATION | Precancerous Conditions - etiology | Colon - enzymology | Adenocarcinoma - pathology | Stromal Cells - pathology | Adenocarcinoma - etiology | Humans | Spheroids, Cellular - pathology | Colitis - pathology | Spheroids, Cellular - enzymology | Immunoenzyme Techniques | Stromal Cells - enzymology | Flow Cytometry | Neoplastic Stem Cells - pathology | Precancerous Conditions - pathology | Aldehyde Dehydrogenase - metabolism | Colonic Neoplasms - etiology | Precancerous Conditions - enzymology | Cytokines - metabolism | Colon - pathology | Adenocarcinoma - enzymology | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Colitis - enzymology | Colonic Neoplasms - pathology | Fluorescent Antibody Technique | Protein Array Analysis | Mice, Inbred NOD | Colonic Neoplasms - enzymology | Mice | Neoplastic Stem Cells - enzymology | Index Medicus | Xenograft | Colitis | tumor microenvironment | Aldehyde dehydrogenase | Colon Cancer | Colon sphere
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9. Full Text The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase
by Zakikhani, Mahvash and Dowling, Ryan J.O and Sonenberg, Nahum and Pollak, Michael N
Cancer Prevention Research, ISSN 1940-6207, 10/2008, Volume 1, Issue 5, pp. 369 - 375
Population studies provide evidence that obesity and insulin resistance are associated not only with elevated serum insulin levels and reduced serum... 
MAMMALIAN TARGET | INSULIN | MORTALITY | OXIDATION | BREAST-CANCER CELLS | METABOLIC SYNDROME | OBESITY | ONCOLOGY | GROWTH | TRANSLATION INITIATION | RECEPTORS | Prostatic Neoplasms - metabolism | AMP-Activated Protein Kinases - metabolism | Colonic Neoplasms - genetics | Ribosomal Protein S6 Kinases - metabolism | Humans | Male | Colonic Neoplasms - metabolism | Prostatic Neoplasms - genetics | Carcinoma - enzymology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Tumor Cells, Cultured | Carcinoma - pathology | Cytostatic Agents - pharmacology | Drug Evaluation, Preclinical | Prostatic Neoplasms - pathology | Adiponectin - pharmacology | AMP-Activated Protein Kinases - antagonists & inhibitors | Metformin - pharmacology | RNA, Small Interfering - pharmacology | Enzyme Activation - drug effects | HT29 Cells | Colonic Neoplasms - pathology | Prostatic Neoplasms - enzymology | Carcinoma - genetics | Cell Proliferation - drug effects | Colonic Neoplasms - enzymology | Carcinoma - metabolism | HeLa Cells | Index Medicus
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10. Full Text O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy
by Mi, Wenyi and Gu, Yuchao and Han, Cuifang and Liu, Haiyan and Fan, Qiong and Zhang, Xinling and Cong, Qi and Yu, Wengong
BBA - Molecular Basis of Disease, ISSN 0925-4439, 04/2011, Volume 1812, Issue 4, pp. 514 - 519
O-GlcNAc is a monosaccharide attached to serine or threonine hydroxyl moieties on numerous nuclear and cytoplasmic proteins; O-GlcNAcylation is dynamically... 
Immunohistochemistry | Colon cancer | O-GlcNAc | Lung cancer | X-CHROMOSOME | METASTASIS | PHOSPHORYLATION | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | VIABILITY | MAMMALIAN-CELLS | BREAST-CANCER | BIOPHYSICS | METABOLISM | GENE-EXPRESSION | STRESS | Lung Neoplasms - genetics | Colonic Neoplasms - genetics | Cell Proliferation | Lung Neoplasms - enzymology | beta-N-Acetylhexosaminidases - metabolism | Humans | Gene Expression Regulation, Neoplastic | N-Acetylglucosaminyltransferases - genetics | Lung Neoplasms - pathology | N-Acetylglucosaminyltransferases - metabolism | Acetylglucosamine - metabolism | Gene Expression Regulation, Enzymologic | Neoplasm Invasiveness - pathology | Colonic Neoplasms - pathology | Acetylglucosamine - analogs & derivatives | Cell Line, Tumor | Colonic Neoplasms - enzymology | Acetylation | beta-N-Acetylhexosaminidases - genetics | Neoplasm Invasiveness - genetics | Development and progression | Breast cancer | Analysis | Life Sciences | Biochemistry, Molecular Biology
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11. Full Text Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4
by Soni, Rajeev and O'Reilly, Terence and Furet, Pascal and Muller, Lionel and Stephan, Christine and Zumstein-Mecker, Sabine and Fretz, Heinz and Fabbro, Doriano and Chaudhuri, Bhabatosh
Journal of the National Cancer Institute, ISSN 0027-8874, 03/2001, Volume 93, Issue 6, pp. 436 - 446
Background: Cyclin-dependent kinase 4 (Cdk4) represents a prime target for the treatment of cancer because most human cancers are characterized by... 
LUNG CANCERS | TYROSINE PHOSPHORYLATION | ONCOLOGY | CDK4 | PRB PHOSPHORYLATION | RETINOBLASTOMA-PROTEIN | SENESCENCE | P16(INK4A) | GROWTH SUPPRESSION | EXPRESSION | CANCER CELL-LINES | Osteosarcoma - drug therapy | Cyclin-Dependent Kinases - metabolism | Osteosarcoma - enzymology | Colonic Neoplasms - drug therapy | Humans | Enzyme Inhibitors - pharmacology | Transplantation, Heterologous | Pyrimidines - pharmacology | Genes, Retinoblastoma - drug effects | Blotting, Western | Precipitin Tests | Animals | Antineoplastic Agents - pharmacology | Colonic Neoplasms - enzymology | Mice | S Phase - drug effects | Cyclin-Dependent Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Tumor Cells, Cultured | Care and treatment | Cancer | Index Medicus
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12. Full Text Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage
by Conti, Chiara and Leo, Elisabetta and Eichler, Gabriel S and Sordet, Olivier and Martin, Melvenia M and Fan, Angela and Aladjem, Mirit I and Pommier, Yves
Cancer Research, ISSN 0008-5472, 06/2010, Volume 70, Issue 11, pp. 4470 - 4480
Protein acetylation is a reversible process regulated by histone deacetylases (HDAC) that is often altered in human cancers. Suberoylanilide hydroxamic acid... 
H2AX | SINGLE-CELL | ONCOLOGY | SUBEROYLANILIDE HYDROXAMIC ACID | INITIATION | ACETYLATION | CHROMATIN CHALLENGES | BREAKS | DYNAMICS | STRESS | SACCHAROMYCES-CEREVISIAE | Colonic Neoplasms - genetics | Histone Deacetylases - genetics | DNA Replication - drug effects | Colonic Neoplasms - drug therapy | Down-Regulation | HCT116 Cells | Humans | Histone Deacetylases - deficiency | Histones - biosynthesis | Histone Deacetylases - metabolism | Breast Neoplasms - drug therapy | Breast Neoplasms - enzymology | Breast Neoplasms - genetics | DNA, Neoplasm - biosynthesis | Vorinostat | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | Colonic Neoplasms - enzymology | DNA Damage | DNA, Neoplasm - genetics | Hydroxamic Acids - pharmacology | Index Medicus | replication | acetylation | epigenetic | DNA repair | HDAC
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13. Full Text MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis
by Cook, Rebecca S and Jacobsen, Kristen M and Wofford, Anne M and DeRyckere, Deborah and Stanford, Jamie and Prieto, Anne L and Redente, Elizabeth and Sandahl, Melissa and Hunter, Debra M and Strunk, Karen E and Graham, Douglas K and Earp Iii, H. Shelton
Journal of Clinical Investigation, ISSN 0021-9738, 08/2013, Volume 123, Issue 8, pp. 3231 - 3242
MerTK, a receptor tyrosine kinase (RTK) of the TYRO3/AXL/MerTK family, is expressed in myeloid lineage cells in which it acts to suppress proinflammatory... 
MEDICINE, RESEARCH & EXPERIMENTAL | CLEARANCE | MAMMARY-TUMORS | AXL | MACROPHAGES | APOPTOTIC CELLS | THERAPEUTIC TARGETS | EXPRESSION | RECEPTOR TYROSINE KINASE | PROGRESSION | FAMILY | Mammary Neoplasms, Experimental - immunology | Neoplasm Transplantation | Gene Expression Regulation, Neoplastic | Transcriptome | Tumor Microenvironment | Male | Disease Resistance - immunology | Leukocytes - enzymology | Melanoma, Experimental - immunology | Colonic Neoplasms - immunology | c-Mer Tyrosine Kinase | Mammary Neoplasms, Experimental - pathology | Female | Proto-Oncogene Proteins | Cytokines - genetics | Mammary Neoplasms, Experimental - enzymology | Melanoma, Experimental - enzymology | Cytokines - metabolism | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Tumor Burden | Receptor Protein-Tyrosine Kinases | CD8-Positive T-Lymphocytes - enzymology | Mice, Knockout | Animals | Colonic Neoplasms - pathology | Colonic Neoplasms - enzymology | Mice | Control | Growth | Physiological aspects | Genetic aspects | Research | Leukocytes | Metastasis | Tyrosine metabolism | Tumors | Wound healing | Lymphocytes | Rodents | Breast cancer | Kinases | Immune system | Index Medicus | Abridged Index Medicus
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