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British Journal of Cancer, ISSN 0007-0920, 02/2018, Volume 118, Issue 3, pp. 428 - 434
Background: Periodontal pathogens have been linked to oral and gastrointestinal (orodigestive) carcinogenesis. However, the exact mechanisms remain unknown.... 
chymotrypsin-like proteinase | Treponema denticola | periodontopathogen | COLLAGENASE-2 MMP-8 | PORPHYROMONAS-GINGIVALIS | PANCREATIC-CANCER | TISSUE INHIBITORS | PERIODONTAL-DISEASE | METALLOPROTEINASES | ONCOLOGY | gastrointestinal cancer | ALPHA-1-ANTITRYPSIN | EXPRESSION | oral cancer | HUMAN NEUTROPHIL | PROGRESSION | Digestive System Neoplasms - metabolism | Pancreatic Neoplasms - chemistry | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Treponema denticola - enzymology | Mouth Neoplasms - metabolism | Stomach Neoplasms - pathology | Tonsillar Neoplasms - chemistry | Complement C1q - metabolism | Colonic Neoplasms - metabolism | Head and Neck Neoplasms - metabolism | Esophageal Neoplasms - pathology | Tonsillar Neoplasms - metabolism | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Head and Neck Neoplasms - chemistry | Matrix Metalloproteinase 9 - metabolism | Adenocarcinoma - metabolism | Matrix Metalloproteinase 8 - metabolism | Esophageal Neoplasms - metabolism | Digestive System Neoplasms - pathology | Colonic Neoplasms - chemistry | Stomach Neoplasms - chemistry | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Tonsillar Neoplasms - pathology | Pancreatic Neoplasms - pathology | Carcinoma, Squamous Cell - chemistry | Mouth Neoplasms - chemistry | Head and Neck Neoplasms - pathology | Cell Transformation, Neoplastic - immunology | Digestive System Neoplasms - chemistry | alpha 1-Antichymotrypsin - metabolism | Colonic Neoplasms - pathology | Chymases - analysis | Mouth Neoplasms - pathology | Molecular Diagnostics
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 6, p. e0179501
Innovative therapies for solid tumors are urgently needed. Recently, therapies that harness the host immune system to fight cancer cells have successfully... 
CD2 | THERAPY | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | GENES | IMMUNOMODULATORY ACTION | MECHANISMS | MOLECULES | SGI-110 | Colonic Neoplasms - genetics | DNA Methylation - immunology | DNA, Neoplasm - metabolism | Humans | Antigens, Neoplasm - biosynthesis | Ovarian Neoplasms - pathology | Male | Colonic Neoplasms - metabolism | Testicular Neoplasms - pathology | Ovarian Neoplasms - genetics | Colonic Neoplasms - immunology | Female | Ovarian Neoplasms - metabolism | Caco-2 Cells | Antigens, Neoplasm - genetics | Testicular Neoplasms - genetics | Antigens, Neoplasm - immunology | Testicular Neoplasms - metabolism | Antigen Presentation - genetics | DNA Methylation - genetics | Testicular Neoplasms - immunology | Animals | Colonic Neoplasms - pathology | DNA, Neoplasm - immunology | Mice | DNA, Neoplasm - genetics | Ovarian Neoplasms - immunology | Colon cancer | Tumor antigens | Physiological aspects | Development and progression | Genetic aspects | Research | Methylation | Ovarian cancer | Therapy | Biotechnology | Animal models | Ovarian carcinoma | Medical innovations | CD58 antigen | Antigen processing | Genomes | Tissues | Cancer therapies | Immunotherapy | Surgery | Cell cycle | DNA methylation | Inhibition | Colon | Drug dosages | Deoxyribonucleic acid--DNA | Immune system | Antigen presentation | Antigens | Tumor cells | Melanoma | Tumor cell lines | Gene expression | Ribonucleic acid--RNA | Patients | Medicine | Inhibitors | Epigenetics | Solid tumors | Tumors | Cancer | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2011, Volume 331, Issue 6017, pp. 593 - 596
Satellite repeats in heterochromatin are transcribed into noncoding RNAs that have been linked to gene silencing and maintenance of chromosomal integrity.... 
Tumor cell line | Artificial satellites | RNA | Lungs | Genes | Liver | REPORTS | Cell lines | Pancreas | Tumors | Cancer | RNAS | ELEMENTS | DIFFERENTIATION | DATABASE | PERVASIVE TRANSCRIPTION | MULTIDISCIPLINARY SCIENCES | Colonic Neoplasms - genetics | RNA, Untranslated - metabolism | Humans | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Male | Gene Expression Profiling | RNA, Neoplasm - metabolism | RNA, Untranslated - genetics | Heterochromatin - chemistry | Carcinoma, Pancreatic Ductal - genetics | Ovarian Neoplasms - genetics | DNA Methylation | Carcinoma in Situ - genetics | Prostatic Neoplasms - genetics | Neoplasms - genetics | Neurosecretory Systems - metabolism | Female | Transcription, Genetic | Lung Neoplasms - genetics | Prostatic Neoplasms - pathology | Gene Expression | Carcinoma in Situ - pathology | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | Animals | Heterochromatin - genetics | Long Interspersed Nucleotide Elements | Mice, Nude | Colonic Neoplasms - pathology | RNA, Neoplasm - genetics | DNA, Satellite - genetics | Mice | DNA, Neoplasm - genetics | Neoplasms - pathology | Epithelial cells | Analysis | Microsatellites (Genetics) | Genetic aspects | Gene expression | Health aspects | Biomarkers | Chromatin | Pancreatic cancer | Deoxyribonucleic acid--DNA
Journal Article
Cancer Research, ISSN 0008-5472, 09/2010, Volume 70, Issue 17, pp. 6804 - 6814
Mutational activation of KRAS is a common event in human tumors. Identification of the key signaling pathways downstream of mutant KRAS is essential for our... 
ACTIVATED PROTEIN-KINASE | EPITHELIAL-CELLS | PI3K | GENE | ONCOLOGY | RAS | PLECKSTRIN-HOMOLOGY-DOMAIN | AKT | MEK INHIBITORS | PHASE-I | HUMAN CANCER | Cyclin D1 - metabolism | Lung Neoplasms - drug therapy | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | Pancreatic Neoplasms - metabolism | Colonic Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | ras Proteins - metabolism | Lung Neoplasms - pathology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Colonic Neoplasms - metabolism | Pancreatic Neoplasms - drug therapy | Diphenylamine - analogs & derivatives | Benzamides - pharmacology | Cell Growth Processes - genetics | MAP Kinase Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | HCT116 Cells | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Cyclin D1 - biosynthesis | MAP Kinase Kinase Kinases - metabolism | Gene Knockout Techniques | Phosphatidylinositol 3-Kinases - genetics | Animals | Class I Phosphatidylinositol 3-Kinases | MAP Kinase Signaling System - drug effects | Cyclin D1 - genetics | Colonic Neoplasms - pathology | Alleles | Cell Line, Tumor | Mice | Mutation | Proto-Oncogene Proteins c-akt - antagonists & inhibitors
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, p. e0142433
Introduction Advances in high-throughput technologies have generated diverse informative molecular markers for cancer outcome prediction. Long non-coding RNA... 
BIOMARKERS | SURVIVAL | PROFILES | CLINICAL UTILITY | PACKAGE | MULTIDISCIPLINARY SCIENCES | GENE SELECTION | VALIDATION | GENOME | Predictive Value of Tests | Colonic Neoplasms - genetics | Prognosis | Lung Neoplasms - mortality | Uterine Neoplasms - pathology | Humans | Colonic Neoplasms - diagnosis | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | MicroRNAs - metabolism | Gene Expression Profiling | Ovarian Neoplasms - mortality | RNA, Messenger - metabolism | Ovarian Neoplasms - genetics | DNA Methylation | Biomarkers, Tumor - metabolism | Uterine Neoplasms - mortality | Female | Uterine Neoplasms - diagnosis | Lung Neoplasms - genetics | Uterine Neoplasms - genetics | Colonic Neoplasms - mortality | Ovarian Neoplasms - diagnosis | RNA, Messenger - genetics | Proportional Hazards Models | RNA, Long Noncoding - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Survival Analysis | Breast Neoplasms - mortality | Biomarkers, Tumor - genetics | Breast Neoplasms - diagnosis | MicroRNAs - genetics | Lung Neoplasms - diagnosis | RNA, Long Noncoding - metabolism | Care and treatment | Cancer patients | MicroRNA | Diagnosis | Research | Methylation | Health aspects | Risk factors | Cancer | Aerospace medicine | Independent variables | Performance prediction | mRNA | Regression analysis | Ribonucleic acid--RNA | Survival | Studies | Medical prognosis | Computer applications | DNA methylation | Biomarkers | miRNA | Non-coding RNA | Deoxyribonucleic acid--DNA | RNA | Ribonucleic acid | Deoxyribonucleic acid | DNA
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 2014, Volume 20, Issue 4, pp. 837 - 846
Purpose: Metastasis and drug resistance are the major limitations in the survival and management of patients with cancer. This study aimed to identify the... 
YES-ASSOCIATED PROTEIN | 1ST-LINE TREATMENT | METASTASIS | ONCOLOGY | COLORECTAL-CANCER | GROWTH | RESISTANCE | SELF-RENEWAL | YAP | IRINOTECAN | FLUOROURACIL | Cell Proliferation | Neoplastic Stem Cells - drug effects | Colonic Neoplasms - drug therapy | Humans | Drug Resistance, Neoplasm | Liver Neoplasms - mortality | Colonic Neoplasms - metabolism | Checkpoint Kinase 2 - metabolism | Fluorouracil - therapeutic use | Cell Nucleus - metabolism | Neoplastic Stem Cells - metabolism | Proto-Oncogene Proteins c-yes - genetics | Biomarkers, Tumor - metabolism | Antimetabolites, Antineoplastic - pharmacology | Neoadjuvant Therapy | Chemotherapy, Adjuvant | Liver Neoplasms - secondary | Neoplasm Micrometastasis - prevention & control | Nuclear Proteins - genetics | Colonic Neoplasms - mortality | Gene Expression | Proto-Oncogene Proteins c-yes - metabolism | Kaplan-Meier Estimate | Liver Neoplasms - drug therapy | Proportional Hazards Models | Nuclear Proteins - metabolism | Transcription Factors - genetics | Protein Transport | HT29 Cells | Transcription Factors - metabolism | Disease-Free Survival | Antimetabolites, Antineoplastic - therapeutic use | Cell Cycle Checkpoints | Colonic Neoplasms - pathology | Liver Neoplasms - metabolism | Fluorouracil - pharmacology | Index Medicus | Adjuvant chemotherapy | Colon liver metastases | Predictive survival markers | Chemoresistance | Colon cancer stem cells
Journal Article
Human Pathology, ISSN 0046-8177, 2012, Volume 43, Issue 10, pp. 1755 - 1763
Summary Mucin 16 (cancer antigen 125) is a cell surface glycoprotein that plays a role in promoting cancer cell growth in ovarian cancer. The aims of this... 
Pathology | Digestive tract adenocarcinoma | MUC16 | CA125 | DIAGNOSIS | TUMOR-MARKERS | SERUM CA125 | CA 125 | PERITONEAL METASTASIS | BARRETTS-ESOPHAGUS | PATHOLOGY | IDENTIFICATION | MESOTHELIN | MEMBRANE-BOUND MUCINS | GASTRIC-CANCER | OVARIAN | Immunohistochemistry | Digestive System Neoplasms - metabolism | Adenocarcinoma - pathology | Digestive System Neoplasms - mortality | Pancreatic Neoplasms - metabolism | Prognosis | Humans | Middle Aged | Stomach Neoplasms - metabolism | Male | Stomach Neoplasms - pathology | Colonic Neoplasms - metabolism | Membrane Proteins - analysis | Esophageal Neoplasms - pathology | Adenocarcinoma - metabolism | CA-125 Antigen - biosynthesis | Esophageal Neoplasms - metabolism | Digestive System Neoplasms - pathology | Esophageal Neoplasms - mortality | Female | CA-125 Antigen - analysis | Pancreatic Neoplasms - mortality | Colonic Neoplasms - mortality | Biomarkers, Tumor - analysis | Pancreatic Neoplasms - pathology | Kaplan-Meier Estimate | Blotting, Western | Membrane Proteins - biosynthesis | Colonic Neoplasms - pathology | Cell Line, Tumor | Aged | Neoplasm Staging | Stomach Neoplasms - mortality | Adenocarcinoma - mortality | Antigens | Patient outcomes | Pancreatic cancer | Oncology, Experimental | Colorectal cancer | Mucins | Research | Esophageal cancer | Cancer | Proteins | Tumors | Ovarian cancer
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 513, Issue 7518, pp. 382 - 387
Journal Article