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PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 6, p. e0179501
Innovative therapies for solid tumors are urgently needed. Recently, therapies that harness the host immune system to fight cancer cells have successfully... 
CD2 | THERAPY | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | GENES | IMMUNOMODULATORY ACTION | MECHANISMS | MOLECULES | SGI-110 | Colonic Neoplasms - genetics | DNA Methylation - immunology | DNA, Neoplasm - metabolism | Humans | Antigens, Neoplasm - biosynthesis | Ovarian Neoplasms - pathology | Male | Colonic Neoplasms - metabolism | Testicular Neoplasms - pathology | Ovarian Neoplasms - genetics | Colonic Neoplasms - immunology | Female | Ovarian Neoplasms - metabolism | Caco-2 Cells | Antigens, Neoplasm - genetics | Testicular Neoplasms - genetics | Antigens, Neoplasm - immunology | Testicular Neoplasms - metabolism | Antigen Presentation - genetics | DNA Methylation - genetics | Testicular Neoplasms - immunology | Animals | Colonic Neoplasms - pathology | DNA, Neoplasm - immunology | Mice | DNA, Neoplasm - genetics | Ovarian Neoplasms - immunology | Colon cancer | Tumor antigens | Physiological aspects | Development and progression | Genetic aspects | Research | Methylation | Ovarian cancer | Therapy | Biotechnology | Animal models | Ovarian carcinoma | Medical innovations | CD58 antigen | Antigen processing | Genomes | Tissues | Cancer therapies | Immunotherapy | Surgery | Cell cycle | DNA methylation | Inhibition | Colon | Drug dosages | Deoxyribonucleic acid--DNA | Immune system | Antigen presentation | Antigens | Tumor cells | Melanoma | Tumor cell lines | Gene expression | Ribonucleic acid--RNA | Patients | Medicine | Inhibitors | Epigenetics | Solid tumors | Tumors | Cancer | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Cancer immunology, immunotherapy, ISSN 1432-0851, 2005, Volume 55, Issue 7, pp. 808 - 818
This study was designed to determine the characteristics of tumour cell-derived microvesicles (TMV) and their interactions with human monocytes. TMV were shed... 
Monocytes | Biomedicine | Immunology | Transfer | Oncology | Cancer Research | mRNA | CCR6 | Tumour-derived microvesicles | CANCER-CELLS | SURVIVAL | monocytes | APOPTOSIS | ACTIVATION | PHAGOCYTOSIS | ADHESION MOLECULES | IMMUNOLOGY | transfer | PLATELET MICROPARTICLES | PLASMA | ONCOLOGY | MEMBRANE-VESICLES | ENDOTHELIAL MICROPARTICLES | tumour-derived microvesicles | RNA, Messenger - immunology | Adenocarcinoma - ultrastructure | Tetradecanoylphorbol Acetate - pharmacology | Humans | Neoplasm Proteins - immunology | RNA, Messenger - analysis | Cell Line, Tumor - drug effects | Gene Expression Profiling | Monocytes - immunology | Membrane Proteins - analysis | Basigin - genetics | Basigin - immunology | Antigens, Neoplasm - analysis | Neoplasm Proteins - genetics | Receptors, Chemokine | Receptors, Cytokine - genetics | Antigens, Neoplasm - immunology | Cell Survival | Adenocarcinoma - immunology | RNA, Messenger - genetics | HLA Antigens - immunology | Pancreatic Neoplasms - ultrastructure | Immunophenotyping | Membrane Proteins - immunology | Cell Membrane - ultrastructure | Neoplasms - ultrastructure | Chemotaxis | Hyaluronan Receptors - genetics | Particle Size | Cell Line, Tumor - ultrastructure | Lung Neoplasms - immunology | Colorectal Neoplasms - immunology | Neoplasms - immunology | Cell Line, Tumor - immunology | Pancreatic Neoplasms - immunology | Colorectal Neoplasms - ultrastructure | Lung Neoplasms - ultrastructure | Neoplasm Proteins - analysis | Receptors, Cytokine - immunology | Cell Membrane - immunology | Genes, MHC Class I | Hyaluronan Receptors - immunology | Apoptosis | Growth factors | Messenger RNA | Tumors
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2013, Volume 39, Issue 4, pp. 782 - 795
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2017, Volume 357, Issue 6349, pp. 409 - 413
The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed... 
CELL LUNG-CANCER | SURVIVAL | COLORECTAL CARCINOMAS | RECEIVING NIVOLUMAB | IMMUNOTHERAPY | MICROSATELLITE INSTABILITY | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | NEOANTIGENS | CHECKPOINT BLOCKADE | LYMPHOCYTES | Neoplastic Syndromes, Hereditary - immunology | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Neoplastic Syndromes, Hereditary - mortality | Young Adult | Colorectal Neoplasms - therapy | Brain Neoplasms - immunology | DNA Mismatch Repair | Aged, 80 and over | Adult | Female | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Biomarkers, Tumor - antagonists & inhibitors | Colorectal Neoplasms - mortality | Antibodies, Monoclonal, Humanized - therapeutic use | Antigens, Neoplasm - immunology | Brain Neoplasms - genetics | Disease-Free Survival | Colorectal Neoplasms - immunology | Cell Cycle Checkpoints - drug effects | Brain Neoplasms - therapy | Neoplastic Syndromes, Hereditary - therapy | T-Lymphocytes - immunology | Aged | Mutation | Programmed Cell Death 1 Receptor - immunology | Colorectal cancer | Genetic aspects | Nucleotide sequencing | Health aspects | DNA repair | Methods | Tumors | DNA sequencing | Yeast | PD-1 protein | Antibodies | Clinical trials | Genomes | Functional analysis | Lymphocytes T | Patients | Survival | Colon cancer | Immune checkpoint | Immunotherapy | Mismatch repair | Pancreatic cancer | Biomarkers | Colon | Solid tumors | Genetic recombination | Repair | Cancer | Apoptosis
Journal Article
Advances in Chronic Kidney Disease, ISSN 1548-5595, 2014, Volume 21, Issue 1, pp. 106 - 113
Kidney transplant recipients are at increased risk for development of malignancy compared with the general population, and malignancies occur at an earlier... 
Nephrology | Immunosuppression | Malignancy | Kidney transplant | Cancer screening | AZATHIOPRINE | RISK | HUMAN-PAPILLOMAVIRUS | RECIPIENTS | MAMMOGRAPHY | CIGARETTE-SMOKING | NONMELANOMA SKIN-CANCER | UROLOGY & NEPHROLOGY | INFECTION | IMMUNOSUPPRESSIVE DRUGS | EPSTEIN-BARR-VIRUS | Kidney Neoplasms - epidemiology | Breast Neoplasms - immunology | Humans | Uterine Cervical Neoplasms - epidemiology | Kidney Neoplasms - immunology | Lymphoproliferative Disorders - immunology | Neoplasms - diagnosis | Kidney Transplantation - statistics & numerical data | Carcinoma, Renal Cell - immunology | Colorectal Neoplasms - diagnosis | Kidney Neoplasms - diagnosis | Skin Neoplasms - diagnosis | Female | Anus Neoplasms - epidemiology | Breast Neoplasms - epidemiology | Colorectal Neoplasms - epidemiology | Kidney Failure, Chronic - surgery | Uterine Cervical Neoplasms - diagnosis | Skin Neoplasms - immunology | Early Detection of Cancer | Uterine Cervical Neoplasms - immunology | Skin Neoplasms - epidemiology | Lymphoproliferative Disorders - epidemiology | Anus Neoplasms - diagnosis | Carcinoma, Renal Cell - epidemiology | Anus Neoplasms - immunology | Colorectal Neoplasms - immunology | Lymphoproliferative Disorders - diagnosis | Neoplasms - immunology | Carcinoma, Renal Cell - diagnosis | Immunosuppressive Agents - adverse effects | Breast Neoplasms - diagnosis | Immunocompromised Host | Neoplasms - epidemiology
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2014, Volume 289, Issue 48, pp. 33481 - 33491
Lectin galactoside-binding soluble 3 binding protein (LGALS3BP, also called Mac-2 binding protein) is a heavily glycosylated secreted molecule that has been... 
BREAST-CANCER | CYCLOPHILIN-C | NK CELLS | MAC-2-BINDING PROTEIN | LUNG-CARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | GROUP-B STREPTOCOCCUS | C-ASSOCIATED PROTEIN | SIALIC-ACID DIVERSITY | ANTIGEN 90K | Prostatic Neoplasms - metabolism | Tumor Escape | Colorectal Neoplasms - genetics | Humans | Sialic Acid Binding Ig-like Lectin 3 - immunology | Antigens, Neoplasm - biosynthesis | Neoplasm Proteins - immunology | Male | Neoplasm Proteins - metabolism | Prostatic Neoplasms - immunology | Prostatic Neoplasms - genetics | HEK293 Cells | Female | Neoplasm Proteins - genetics | Carrier Proteins - immunology | Colorectal Neoplasms - metabolism | Sialic Acid Binding Ig-like Lectin 3 - metabolism | Glycoproteins - genetics | Sialic Acid Binding Ig-like Lectin 3 - genetics | Antigens, Neoplasm - genetics | Prostatic Neoplasms - pathology | Antigens, Neoplasm - immunology | Carrier Proteins - biosynthesis | Immunologic Factors - immunology | Gene Expression Regulation, Neoplastic - immunology | Immunologic Factors - genetics | Glycoproteins - biosynthesis | Carrier Proteins - genetics | Glycoproteins - immunology | Animals | Colorectal Neoplasms - immunology | Up-Regulation - immunology | Biomarkers, Tumor - genetics | Mice | Colorectal Neoplasms - pathology | Biomarkers, Tumor - immunology | Biomarkers, Tumor - biosynthesis | Immunologic Factors - biosynthesis | Galectin | Sialic Acid | LGALS3BP | Glycobiology | Tumor Immunology | Glycobiology and Extracellular Matrices | Siglecs | Cancer
Journal Article
Molecular therapy, ISSN 1525-0016, 2017, Volume 25, Issue 5, pp. 1248 - 1258
Chimeric antigen receptor T (CAR-T) cells have shown promising efficacy in treatment of hematological malignancies, but its applications in solid tumors need... 
safety and efficacy | phase I | dose escalating | colorectal carcinoma | CAR-T | CEA | MEDICINE, RESEARCH & EXPERIMENTAL | CD8(+) | RESPONSE CRITERIA | VIVO | SUBSETS | CELL THERAPY | CHIMERIC ANTIGEN RECEPTOR | ANTITUMOR-ACTIVITY | B-CELL | IMMUNOTHERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | CARCINOEMBRYONIC ANTIGEN | Dose-Response Relationship, Immunologic | Humans | Middle Aged | Mutant Chimeric Proteins - genetics | Carcinoembryonic Antigen - genetics | Male | Liver Neoplasms - therapy | Lymphocyte Depletion | T-Lymphocytes - transplantation | Neoplasm Recurrence, Local - immunology | Neoplasm Recurrence, Local - pathology | Colorectal Neoplasms - therapy | Neoplasm Recurrence, Local - diagnostic imaging | Protein Engineering | Female | Receptors, Antigen, T-Cell - immunology | Liver Neoplasms - secondary | Gene Expression | Immunotherapy, Adoptive | Carcinoembryonic Antigen - immunology | Lymphocyte Activation | Adenocarcinoma - immunology | Neoplasm Recurrence, Local - therapy | Liver Neoplasms - immunology | Colorectal Neoplasms - diagnostic imaging | Liver Neoplasms - diagnostic imaging | Adenocarcinoma - secondary | Magnetic Resonance Imaging | Colorectal Neoplasms - immunology | Adenocarcinoma - therapy | T-Lymphocytes - cytology | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Aged | Receptors, Antigen, T-Cell - genetics | Adenocarcinoma - diagnostic imaging | Colorectal Neoplasms - pathology | Cytotoxicity, Immunologic | Cell proliferation | Antigens | Research & development--R&D | Liver | Colorectal carcinoma | Lymphocytes T | Metastasis | Radiation therapy | Patients | Embryos | Fever | Metastases | Inflammatory bowel disease | Carcinoembryonic antigen | Magnetic resonance imaging | Computed tomography | Lymphocytes | Peripheral blood | Nonsteroidal anti-inflammatory drugs | Solid tumors | Positron emission tomography | Tumors | Original
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2010, Volume 138, Issue 6, pp. 2101 - 2114.e5
The connection between inflammation and tumorigenesis is well-established and in the last decade has received a great deal of supporting evidence from genetic,... 
Gastroenterology and Hepatology | Inflammation | Cytokines | Immunity | Colon Cancer | CHRONIC INTESTINAL INFLAMMATION | COLITIS-ASSOCIATED CANCER | SEVERE CROHNS-DISEASE | EPITHELIAL-MESENCHYMAL TRANSITION | TUMOR-NECROSIS-FACTOR | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | KINASE-I-EPSILON | TOLL-LIKE RECEPTORS | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | GENOME-WIDE ASSOCIATION | Colonic Neoplasms - genetics | Colonic Neoplasms - prevention & control | Colonic Neoplasms - drug therapy | Colorectal Neoplasms - genetics | Humans | Inflammatory Bowel Diseases - immunology | Gene Expression Regulation, Neoplastic | Colon - immunology | Cell Transformation, Neoplastic - genetics | Colonic Neoplasms - immunology | Colorectal Neoplasms - drug therapy | Inflammation Mediators - metabolism | Inflammatory Bowel Diseases - genetics | Anti-Inflammatory Agents - therapeutic use | Inflammatory Bowel Diseases - complications | Anticarcinogenic Agents - therapeutic use | Inflammatory Bowel Diseases - drug therapy | Genetic Predisposition to Disease | Cytokines - metabolism | Risk Assessment | Signal Transduction | Neoplasm Invasiveness | Risk Factors | Colorectal Neoplasms - prevention & control | Colonic Neoplasms - secondary | Cell Transformation, Neoplastic - immunology | Animals | Colorectal Neoplasms - immunology | Colorectal Neoplasms - secondary | Colon - microbiology | Dendritic cells | Measles-mumps-rubella vaccine | Biological response modifiers | Sulfates | Risk factors | Dextran | Prostaglandins | Colon cancer | Gastrointestinal diseases | Vascular endothelial growth factor | Growth factors | Tumors
Journal Article
Clinical Immunology, ISSN 1521-6616, 2016, Volume 166-167, pp. 48 - 58
Abstract We designed a phase I trial to investigate the safety, immune responses and clinical benefits of a five-peptide cancer vaccine in combination with... 
Allergy and Immunology | Translational research | Five-peptide cancer vaccine | Cyclophosphamide | Regulatory T cells | INTERLEUKIN-2 | IMMUNE-RESPONSE | LUNG | TESTIS ANTIGENS | IMMUNOLOGY | EPITOPE-PEPTIDES | IDENTIFICATION | BREAST-CANCER | IMMUNOTHERAPY | COLORECTAL-CANCER | REGULATORY T-CELLS | Lung Neoplasms - drug therapy | Cyclophosphamide - administration & dosage | Colorectal Neoplasms - genetics | Humans | Middle Aged | HLA-A24 Antigen - genetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Epitopes - administration & dosage | Male | Cyclophosphamide - adverse effects | Peptides - administration & dosage | Dose-Response Relationship, Drug | Epitopes - immunology | Neoplasms - genetics | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Colorectal Neoplasms - drug therapy | Leukopenia - chemically induced | Aged, 80 and over | Adult | Female | Vaccines, Subunit - adverse effects | Lung Neoplasms - genetics | Stomach Neoplasms - genetics | HLA-A24 Antigen - immunology | Drug Administration Schedule | Cancer Vaccines - administration & dosage | Peptides - immunology | Kaplan-Meier Estimate | Cancer Vaccines - adverse effects | Treatment Outcome | Cyclophosphamide - immunology | Vaccines, Subunit - immunology | Stomach Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols - immunology | Neoplasms - drug therapy | Stomach Neoplasms - immunology | Cancer Vaccines - immunology | Lung Neoplasms - immunology | Colorectal Neoplasms - immunology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoplasms - immunology | Vaccines, Subunit - administration & dosage | T-Lymphocytes - immunology | Aged | Cancer vaccines | Antigens | Chemotherapy | Peptides | Vaccination | Colorectal cancer | Clinical trials | Product development | T cells | Cancer | Tumors
Journal Article
Nature communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, pp. 8840 - 8840
Tumours frequently activate genes whose expression is otherwise biased to the testis, collectively known as cancer-testis antigens (CTAs). The extent to which... 
SCAN BOX | WISP-1 | TUMOR PROGRESSION | SMURF2 | BIK | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | RECEPTOR | FAMILY PROTEINS | GROWTH-FACTOR | CELL-DEATH | Neoplasm Transplantation | Prognosis | Adenocarcinoma of Lung | Lung Neoplasms - mortality | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Immunoblotting | Triple Negative Breast Neoplasms - immunology | Neoplasms - genetics | HEK293 Cells | Apoptosis Regulatory Proteins - genetics | Adenocarcinoma - genetics | Smad7 Protein - genetics | Real-Time Polymerase Chain Reaction | Wnt Signaling Pathway | Colorectal Neoplasms - mortality | Lung Neoplasms - genetics | Transforming Growth Factor beta - immunology | Antigens, Neoplasm - genetics | Cell Line | Signal Transduction | Cell Survival | Membrane Proteins - genetics | Adenocarcinoma - immunology | HCT116 Cells | Carcinogenesis - genetics | Proportional Hazards Models | Neoplasms - mortality | Triple Negative Breast Neoplasms - mortality | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Lung Neoplasms - immunology | Animals | Colorectal Neoplasms - immunology | Transforming Growth Factor beta - genetics | Triple Negative Breast Neoplasms - genetics | Neoplasms - immunology | Fluorescent Antibody Technique | Cell Line, Tumor | Mice, Inbred NOD | In Vitro Techniques | Ubiquitin-Protein Ligases - genetics | Adenocarcinoma - mortality | Index Medicus
Journal Article